Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML

Authors: Hassan, Nunki, Yi, Hangyu, Malik, Bilal, Gaspard-Boulinc, Lucie, Samaraweera, Saumya E., Casolari, Debora A., Seneviratne, Janith, Balachandran, Anushree, Chew, Tracy, Duly, Alastair, Carter, Daniel R., Cheung, Belamy B., Norris, Murray, Haber, Michelle, Kavallaris, Maria, Marshall, Glenn M., Zhang, Xu Dong, Liu, Tao, Wang, Jianlong, Liebermann, Dan A., D’Andrea, Richard J., Wang, Jenny Y.

Source: In Blood 4 July 2024 144(1):84-98

Novel modes of MPL activation in triple-negative myeloproliferative neoplasms

Authors: Samaraweera, Saumya E., Geukens, Tatjana, Casolari, Debora A., Nguyen, Tran, Sun, Caitlyn, Bailey, Sheree, Moore, Sarah, Feng, Jinghua, Schreiber, Andreas W., Parker, Wendy T., Brown, Anna L., Butcher, Carolyn, Bardy, Peter G., Osborn, Michael, Scott, Hamish S., Talaulikar, Dipti, Grove, Carolyn S., Hahn, Christopher N., D'Andrea, Richard J., Ross, David M.

Source: Pathology. 55(1):77-85

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180536617.0x000001&indx=1&recIds=ETOCvdc_100180536617.0x000001

Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia

Authors: Conn, Vanessa M., Gabryelska, Marta, Toubia, John, Kirk, Kirsty, Gantley, Laura, Powell, Jason A., Cildir, Gökhan, Marri, Shashikanth, Liu, Ryan, Stringer, Brett W., Townley, Scott, Webb, Stuart T., Lin, He, Samaraweera, Saumya E., Bailey, Sheree, Moore, Andrew S., Maybury, Mellissa, Liu, Dawei, Colella, Alex D., Chataway, Timothy, Wallington-Gates, Craig T., Walters, Lucie, Sibbons, Jane, Selth, Luke A., Tergaonkar, Vinay, D’Andrea, Richard J., Pitson, Stuart M., Goodall, Gregory J., Conn, Simon J.

Source: In Cancer Cell 10 July 2023 41(7):1309-1326

Childhood acute myeloid leukemia shows a high level of germline predisposition

Authors: Samaraweera, Saumya E., Wang, Paul P.S., Li, Ka Leung, Casolari, Debora A., Feng, Jinghua, Pinese, Mark, Maung, Kyaw Ze Ya, Leo, Paul, Cowley, Mark, Perkins, Kelly, Smith, Amanda M., Ellis, Jonathan, Wee, Amilia, Hiwase, Devendra K., Scott, Hamish S., Schreiber, Andreas W., Brown, Anna L., Deans, Andrew J., Ross, David M., Moore, Andrew S., Gonda, Thomas J., Hahn, Christopher N., D'Andrea, Richard J.

Source: Blood. 138(22):2293-2298

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183247801.0x000001&indx=1&recIds=ETOCvdc_100183247801.0x000001

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

Authors: Salik, Basit, Yi, Hangyu, Hassan, Nunki, Santiappillai, Nancy, Vick, Binje, Connerty, Patrick, Duly, Alastair, Trahair, Toby, Woo, Andrew J., Beck, Dominik, Liu, Tao, Spiekermann, Karsten, Jeremias, Irmela, Wang, Jianlong, Kavallaris, Maria, Haber, Michelle, Norris, Murray D., Liebermann, Dan A., D'Andrea, Richard J., Murriel, Christopher, Wang, Jenny Y.

Source: In Cancer Cell 10 August 2020 38(2):263-278

RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML

Authors: Brown, Anna L. ^{*, *}, Arts, Peer ^*, Carmichael, Catherine L., Babic, Milena, Dobbins, Julia, Chong, Chan-Eng, Schreiber, Andreas W., Feng, Jinghua, Phillips, Kerry, Wang, Paul P.S., Ha, Thuong, Homan, Claire C., King-Smith, Sarah L., Rawlings, Lesley, Vakulin, Cassandra, Dubowsky, Andrew, Burdett, Jessica, Moore, Sarah, McKavanagh, Grace, Henry, Denae, Wells, Amanda, Mercorella, Belinda, Nicola, Mario, Suttle, Jeffrey, Wilkins, Ella, Li, Xiao-Chun, Michaud, Joelle ^*, Brautigan, Peter, Cannon, Ping, Altree, Meryl, Jaensch, Louise, Fine, Miriam, Butcher, Carolyn, D'Andrea, Richard J., Lewis, Ian D., Hiwase, Devendra K., Papaemmanuil, Elli, Horwitz, Marshall S., Natsoulis, Georges, Rienhoff, Hugh Y., Jr, Patton, Nigel, Mapp, Sally, Susman, Rachel, Morgan, Susan, Cooney, Julian, Currie, Mark, Popat, Uday, Bochtler, Tilmann, Izraeli, Shai, Bradstock, Kenneth, Godley, Lucy A., Krämer, Alwin, Fröhling, Stefan, Wei, Andrew H., Forsyth, Cecily, Mar Fan, Helen, Poplawski, Nicola K., Hahn, Christopher N. ^{*, *}, Scott, Hamish S. ^{*, *}

Source: In Blood Advances 24 March 2020 4(6):1131-1144

Efficacy of combined CDK9/BET inhibition in preclinical models of MLL-rearranged acute leukemia

Authors: McCalmont, Hannah ^*, Li, Ka Leung ^*, Jones, Luke, Toubia, John, Bray, Sarah C., Casolari, Debora A., Mayoh, Chelsea, Samaraweera, Saumya E., Lewis, Ian D., Prinjha, Rab K., Smithers, Nicholas, Wang, Shudong, Lock, Richard B., D'Andrea, Richard J.

Source: In Blood Advances 28 January 2020 4(2):296-300

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

Authors: Wittwer, Nicole L. ¹, Brumatti, Gabriela ^{2, 3}, Marchant, Ceilidh ¹, Sandow, Jarrod J. ^{2, 3}, Pudney, Melanie K. ¹, Dottore, Mara ¹, D'Andrea, Richard J. ^{1, 4}, Lopez, Angel F. ^{1, 4}, Ekert, Paul G. ⁵, Ramshaw, Hayley S. ^{1, 4, *}

Source: In Blood Advances 27 June 2017 1(15):1067-1079

IDH-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation

Authors: Hong, Lih En, Wechalekar, Mihir D., Kutyna, Monika, Small, Annabelle, Lim, Kelly, Thompson-Peach, Chloe, Li, Joule J., Chhetri, Rakchha, Scott, Hamish S., Brown, Anna, Hahn, Christopher N., Yeung, David T., Sajid, Salvia, Robinson, Nirmal, Thomas, Ranjeny, Branford, Susan, D’Andrea, Richard J., Samaraweera, Saumya E., Patnaik, Mrinal, Proudman, Susanna, Thomas, Daniel, Kok, Chung Hoow, Shah, Mithun V., Hiwase, Devendra K.

Source: In Blood 2 May 2024 143(18):1873-1877

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Authors: Powell, Jason A., Lewis, Alexander C., Zhu, Wenying, Toubia, John, Pitman, Melissa R., Wallington-Beddoe, Craig T., Moretti, Paul A.B., Iarossi, Diana, Samaraweera, Saumya E., Cummings, Nik, Ramshaw, Hayley S., Thomas, Daniel, Wei, Andrew H., Lopez, Angel F., D'Andrea, Richard J., Lewis, Ian D., Pitson, Stuart M.

Source: In Blood 9 February 2017 129(6):771-782

Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factor

Authors: Shahrin, Nur Hezrin, Diakiw, Sonya, Dent, Lindsay A., Brown, Anna L., D Andrea, Richard J.

Source: Blood. 128(1):55-59

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN607037485&indx=1&recIds=ETOCRN607037485

Signalling by the βc family of cytokines

Authors: Hercus, Timothy R., Dhagat, Urmi, Kan, Winnie L.T., Broughton, Sophie E., Nero, Tracy L., Perugini, Michelle, Sandow, Jarrod J., D’Andrea, Richard J., Ekert, Paul G., Hughes, Timothy, Parker, Michael W., Lopez, Angel F.

Source: In Cytokine and Growth Factor Reviews June 2013 24(3):189-201

Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors

Authors: Bard-Chapeau, Emilie A., Jeyakani, Justin, Kok, Chung H., Muller, Julius, Chua, Belinda Q., Gunaratne, Jayantha, Batagov, Arsen, Jenjaroenpun, Piroon, Kuznetsov, Vladimir A., Wei, Chia-Lin, D'Andrea, Richard J., Bourque, Guillaume, Jenkins, Nancy A., Copeland, Neal G.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2012 Feb 01. 109(6), 2168-2173.

Access URL: https://www.jstor.org/stable/41477090

The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation

Authors: Brown, Anna L., Salerno, Diana G., Sadras, Teresa, Engler, Grant A., Kok, Chung H., Wilkinson, Christopher R., Samaraweera, Saumya E., Sadlon, Timothy J., Perugini, Michelle, Lewis, Ian D., Gonda, Thomas J., D'Andrea, Richard J.

Source: In Differentiation 2012 83(1):47-59

The vent-like homeobox gene VENTX promotes human myeloid differentiation and is highly expressed in acute myeloid leukemia

Authors: Rawat, Vijay P. S., Arseni, Natalia, Ahmed, Farid, Mulaw, Medhanie A., Thoene, Silvia, Heilmeier, Bernhard, Sadlon, Tim, D'Andrea, Richard J., Hiddemann, Wolfgang, Bohlander, Stefan K., Buske, Christian, Feuring-Buske, Michaela

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Sep . 107(39), 16946-16951.

Access URL: https://www.jstor.org/stable/20779891

MiR-155 as a potential target of IL-3 signaling in primary AML cells

Authors: Sadras, Teresa, Kok, Chung H., Perugini, Michelle, Ramshaw, Hayley S., D'Andrea, Richard J.

Source: Leukemia research. 57:57-59

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100045800983.0x000001&indx=1&recIds=ETOCvdc_100045800983.0x000001

The GM-CSF receptor family: Mechanism of activation and implications for disease

Authors: Hercus, Timothy R., Broughton, Sophie E., Ekert, Paul G., Ramshaw, Hayley S., Perugini, Michelle, Grimbaldeston, Michele, Woodcock, Joanna M., Thomas, Daniel, Pitson, Stuart, Hughes, Timothy, D'Andrea, Richard J., Parker, Michael W., Lopez, Angel F.

Source: Growth factors. 30(2):63-75

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100104094816.0x000001&indx=1&recIds=ETOCvdc_100104094816.0x000001

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit

Authors: Perugini, Michelle, Brown, Anna L., Salerno, Diana G., Booker, Grant W., Stojkoski, Cvetan, Hercus, Timothy R., Lopez, Angel F., Hibbs, Margaret L., Gonda, Thomas J., D'Andrea, Richard J. ^*

Source: In Blood 22 April 2010 115(16):3346-3353

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Authors: Powell, Jason A., Thomas, Daniel, Barry, Emma F., Kok, Chung H., McClure, Barbara J., Tsykin, Anna, To, L. Bik, Brown, Anna, Lewis, Ian D., Herbert, Kirsten, Goodall, Gregory J., Speed, Terence P., Asou, Norio, Jacob, Bindya, Osato, Motomi, Haylock, David N., Nilsson, Susan K., D'Andrea, Richard J., Lopez, Angel F., Guthridge, Mark A.

Source: In Blood 26 November 2009 114(23):4859-4870

Hematopoietic growth factor mimetics: From concept to clinic

Authors: Perugini, Michelle, Varelias, Antiopi, Sadlon, Timothy, D’Andrea, Richard J.

Source: In Cytokine and Growth Factor Reviews 2009 20(1):87-94