Early-stage immunoexpression of inflammatory, angiogenic, and survival markers in tongue epithelium of mice exposed to hookah smoke.

Authors: Pereira, Aldini Beuting¹ (AUTHOR), Michels, Arieli Carini¹ (AUTHOR), Pilati, Sarah Freygang Mendes² (AUTHOR), Modolo, Filipe³ (AUTHOR), Martins, Ana Paula Camargo¹ (AUTHOR), De Paula, Caroline Busatta Vaz¹ (AUTHOR), Nagashima, Seigo¹ (AUTHOR), Noronha, Lúcia¹ (AUTHOR), Fonseca, Ana Clara Prado¹ (AUTHOR), Turmina, Ariane Jéssica Torres¹ (AUTHOR), De Meira, Heloisa Franco¹ (AUTHOR), Ramos, Luisa Gabriela Carneiro¹ (AUTHOR), Da Rosa, Thaís Grupp¹ (AUTHOR), Eckhardt, Thais Maria Dos Santos¹ (AUTHOR), Ignácio, Sérgio Aparecido¹ (AUTHOR), Alanis, Luciana Reis Azevedo¹ (AUTHOR), Souza, Paulo Henrique Couto¹ (AUTHOR), Rached, Rodrigo Nunes¹ (AUTHOR), Jham, Bruno Correia⁴ (AUTHOR), Carneiro, Everdan¹ (AUTHOR)

Source: PLoS ONE. 2/26/2025, Vol. 20 Issue 2, p1-11. 11p.

Subject Terms: *VASCULAR endothelial growth factor receptors, *CYCLOOXYGENASE 2, *NF-kappa B, *LABORATORY mice, *HOOKAHS

Immunohistochemical Investigation of Cyclooxygenase-2 Expression in Rabbit Uterine Adenocarcinoma and the Potential Use of COX-2 Inhibitors in Cancer Therapy.

Authors: Vaccaro, Emanuela¹ (AUTHOR) emanuela.vaccaro@unina.it, Navas, Luigi¹ (AUTHOR) lnavas@unina.it, Ercolano, Martina¹ (AUTHOR) martinaercolano@gmail.com, Piegari, Giuseppe¹ (AUTHOR) giuseppe.piegari@unina.it, Di Napoli, Evaristo¹ (AUTHOR) giuseppe.piegari@unina.it, Papparella, Serenella¹ (AUTHOR) valeria.russo@unina.it, Inverso, Donato² (AUTHOR) inverso.donato@hsr.it, Brunetti, Barbara³ (AUTHOR) b.brunetti@unibo.it, Paciello, Orlando¹ (AUTHOR), Russo, Valeria¹ (AUTHOR)

Source: Animals (2076-2615). Nov2024, Vol. 14 Issue 22, p3169. 14p.

Subject Terms: *CYCLOOXYGENASE 2 inhibitors, *ENDOMETRIAL hyperplasia, *CYCLOOXYGENASE 2, *UTERINE cancer, *ENDOMETRIAL cancer, *ENDOMETRIUM

Two-Step Cell Death Induction by the New 2-Arachidonoyl Glycerol Analog and Its Modulation by Lysophosphatidylinositol in Human Breast Cancer Cells.

Authors: Akimov, Mikhail G.¹ (AUTHOR) amik@oxylipin.ibch.ru, Gretskaya, Natalia M.¹ (AUTHOR) gorevig2000@gmail.com, Gorbacheva, Evgenia I.¹ (AUTHOR) nisreenkhadour75@gmail.com, Khadour, Nisreen^1,2 (AUTHOR) galya24may@gmail.com, Sherstyanykh, Galina D.¹ (AUTHOR) vvbez@ibch.ru, Bezuglov, Vladimir V.¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 2, p820. 17p.

Subject Terms: *TRPV cation channels, *CYCLOOXYGENASE 2 inhibitors, *ANTIOXIDANT analysis, *BREAST cancer, *CELL death, *CANNABINOID receptors

A Novel Platform Featuring Nanomagnetic Ligand Fishing Based on Fixed-Orientation Immobilized Magnetic Beads for Screening Potential Cyclooxygenase-2 Inhibitors from Panax notoginseng Leaves.

Authors: Zhang, Fan¹ (AUTHOR) 18338595752@163.com, Sun, Fan² (AUTHOR) sf18435165322@163.com, Yu, Lequan² (AUTHOR) 18822575726@163.com, Li, Fei² (AUTHOR) lf18641423285@163.com, Liu, Lixia² (AUTHOR) 15689081560@163.com, Cao, Xiaoyan² (AUTHOR) cxysssl@163.com, Zhang, Yi^1,2 (AUTHOR) zhwwxzh@tjutcm.edu.cn, Wu, Lijie¹ (AUTHOR) wulj0816@163.com

Source: Molecules. Dec2024, Vol. 29 Issue 23, p5801. 17p.

Subject Terms: *CYCLOOXYGENASE 2 inhibitors, *LIGANDS (Chemistry), *COMPLEX compounds, *MAGNETIC shielding, *INFRARED spectroscopy

Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea.

Authors: Huang, Shiu-Wen^1,2,3 (AUTHOR), Hsu, Ming Jen^1,3 (AUTHOR), Chen, Hsiu-Chen¹ (AUTHOR), Meleddu, Rita⁴ (AUTHOR), Distinto, Simona⁴ (AUTHOR), Maccioni, Elias⁴ (AUTHOR), Cottiglia, Filippo⁴ (AUTHOR) cottiglf@unica.it

Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2024, Vol. 39 Issue 1, p1-8. 8p.

Subject Terms: *CYCLOOXYGENASE 2, *BENZOFURAN, *BENZOFURANS, *COUMARINS, *LIPOPOLYSACCHARIDES

Synergistic Effect of Caloric Restriction and Cyclooxygenase-2 Inhibitor "Celecoxib" Against IGFs/COX-2 Mediating Chemically Induced Hepatocellular Carcinoma in Rats.

Alternate Title: Efecto Sinérgico de la Restricción Calórica y el Inhibidor de la Ciclooxigenasa-2 "Celecoxib" Contra los IGF/COX-2 que Median el Carcinoma Hepatocelular Inducido Químicamente en Ratas.

Authors: ShamsEldeen, Asmaa Mohammed¹, El Hamzawy, Magda¹, Aboulhoda, Basma Emad², Rashed, Laila³, Alghamdi, Mansour^4,5, Hassan, Fatma E.^1,6 Fatma.e.elsayed@kasralainy.edu.eg

Source: International Journal of Morphology. 2024, Vol. 42 Issue 6, p1628-1637. 10p.

Subject Terms: *CYCLOOXYGENASE 2 inhibitors, *LOW-calorie diet, *SUBCUTANEOUS injections, *PATHOLOGICAL physiology, *HEPATOCELLULAR carcinoma

Development of Novel Gel Formulation of Celecoxib and Bio-active Compounds of Herbs for Pain Management.

Authors: Mudgade, Satish Channappa¹, Dharashivkar, Sanket¹, Malviya, Rajeev¹ rajeevrcp33@gmail.com, Singh, Manisha Masih¹

Source: International Journal of Pharmacy & Life Sciences. Nov2024, Vol. 15 Issue 11, p4-8. 5p.

Subject Terms: *SAFFLOWER oil, *CYCLOOXYGENASE 2 inhibitors, *PAIN management, *BIOACTIVE compounds, *DOSAGE forms of drugs

New 1,2,3‐Triazole‐Tethered Chalcone Derivatives: Synthesis, Bioevaluation and Computational Study.

Authors: Kawale, Ramesh A.^1,2 (AUTHOR), Akolkar, Hemantkumar N.³ (AUTHOR), Shaikh, Mubarak H.¹ (AUTHOR), Khedkar, Vijay M.⁴ (AUTHOR), Raut, Deepak N.⁵ (AUTHOR), Darekar, Nirmala R.¹ (AUTHOR), Wable, Jaidip B.⁶ (AUTHOR), Shelke, Sharad N.^1,7 (AUTHOR) snshelke@yahoo.co.in

Source: Polycyclic Aromatic Compounds. 2024, Vol. 44 Issue 9, p6232-6247. 16p.

Subject Terms: *CYCLOOXYGENASE 2, *CLICK chemistry, *CHEMICAL synthesis, *ANTI-inflammatory agents, *MOLECULES, *CHALCONE

Synthesis and Bioevaluation of New Stable Derivatives of Chrysin-8- C -Glucoside That Modulate the Antioxidant Keap1/Nrf2/HO-1 Pathway in Human Macrophages.

Authors: Ávila-Román, Javier¹ (AUTHOR) javieravila@us.es, Quevedo-Tinoco, Lirenny² (AUTHOR) 0300768x@umich.mx, Oliveros-Ortiz, Antonio J.² (AUTHOR) antonio.oliveros@umich.mx, García-Gil, Sara¹ (AUTHOR) motilva@us.es, Rodríguez-García, Gabriela² (AUTHOR) gabriela.rodriguez@umich.mx, Motilva, Virginia¹ (AUTHOR) etalero@us.es, Gómez-Hurtado, Mario A.² (AUTHOR) mario.gomez@umich.mx, Talero, Elena¹ (AUTHOR)

Source: Pharmaceuticals (14248247). Oct2024, Vol. 17 Issue 10, p1388. 21p.

Subject Terms: *INFLAMMATORY mediators, *CYCLOOXYGENASE 2, *REACTIVE oxygen species, *MEMBRANE permeability (Biology), *PHENOLS

Development, Characterization, and Cellular Toxicity Evaluation of Solid Dispersion-Loaded Hydrogel Based on Indomethacin.

Authors: Dahma, Zaid¹ (AUTHOR) zdahma@ucm.es, Ibáñez-Escribano, Alexandra² (AUTHOR) alexandraibanez@ucm.es, Fonseca-Berzal, Cristina² (AUTHOR) crfonseca@ucm.es, García-Rodríguez, Juan José² (AUTHOR) jjgarc01@ucm.es, Álvarez-Álvarez, Covadonga^1,3 (AUTHOR) covadong@ucm.es, Torrado-Salmerón, Carlos^1,3 (AUTHOR) ctorrado@ucm.es, Torrado-Santiago, Santiago^1,3 (AUTHOR) torrado2@ucm.es, de la Torre-Iglesias, Paloma Marina^1,3 (AUTHOR) torrado2@ucm.es

Source: Polymers (20734360). Aug2024, Vol. 16 Issue 15, p2174. 18p.

Subject Terms: *CYCLOOXYGENASE 2 inhibitors, *DRUG solubility, *X-ray powder diffraction, *DIFFERENTIAL scanning calorimetry, *TOPICAL drug administration, *HYDROGELS

Comparison of MMP-2, MMP-9, COX-2, and PGP Expression in Feline Injection-Site and Feline Noninjection-Site Sarcomas—Pilot Study.

Authors: Wojtkowska, Agata¹ (AUTHOR) agata_wojtkowska@sggw.edu.pl, Małek, Anna¹ (AUTHOR) katarzyna_zabielska@sggw.edu.pl, Giziński, Sławomir² (AUTHOR) slawomir_gizinski@sggw.edu.pl, Sapierzyński, Rafał³ (AUTHOR) rafal_sapierzynski@sggw.edu.pl, Rodo, Anna³ (AUTHOR) anna_rodo@sggw.edu.pl, Sokołowska, Justyna⁴ (AUTHOR) justyna_sokolowska@sggw.edu.pl, Zabielska-Koczywąs, Katarzyna A.¹ (AUTHOR) anna_wojtalewicz@sggw.edu.pl, Wojtalewicz, Anna¹ (AUTHOR) magdalena_walewska@sggw.edu.pl, Walewska, Magdalena¹ (AUTHOR) magdalena_ostrzeszewicz@sggw.edu.pl, Kautz, Ewa² (AUTHOR) ewa_kautz@sgww.edu.pl, Ostrzeszewicz, Magdalena¹ (AUTHOR) roman_lechowski@sggw.edu.pl, Lechowski, Roman¹ (AUTHOR)

Source: Animals (2076-2615). Jul2024, Vol. 14 Issue 14, p2110. 14p.

Subject Terms: *MATRIX metalloproteinases, *CYCLOOXYGENASE 2, *P-glycoprotein, *RANK correlation (Statistics), *FIBROSARCOMA

Drug reaction, cyclooxygenase 2, and alteration on lymphatics.

Authors: Abreu Velez, Ana Maria^1,2 abreuvelez@yahoo.com, Smoller, Bruce R.^1,2, Howard, Michael S.^1,2

Source: Our Dermatology Online / Nasza Dermatologia Online. Jul2024, Vol. 15 Issue 3, p268-271. 4p.

Subject Terms: *DRUG side effects, *CYCLOOXYGENASE 2, *RESPIRATORY infections, *CELL junctions, *DRUG allergy

Unveiling Anticancer Potential of COX-2 and 5-LOX Inhibitors: Cytotoxicity, Radiosensitization Potential and Antimigratory Activity against Colorectal and Pancreatic Carcinoma.

Authors: Bošković, Jelena¹ (AUTHOR), Dobričić, Vladimir¹ (AUTHOR) vladimir@pharmacy.bg.ac.rs, Keta, Otilija² (AUTHOR), Korićanac, Lela² (AUTHOR), Žakula, Jelena² (AUTHOR), Dinić, Jelena³ (AUTHOR), Jovanović Stojanov, Sofija³ (AUTHOR), Pavić, Aleksandar⁴ (AUTHOR), Čudina, Olivera¹ (AUTHOR)

Source: Pharmaceutics. Jun2024, Vol. 16 Issue 6, p826. 13p.

Subject Terms: *CYTOTOXINS, *CYCLOOXYGENASE 2 inhibitors, *COLORECTAL cancer, *POISONS, *RADIATION-sensitizing agents

Silencing KPNA2 Promotes Ferroptosis in Laryngeal Cancer by Activating the FoxO Signaling Pathway.

Authors: Xu, Mimi¹, Hu, Xiaoqi¹, Xiao, Zhixue¹, Zhang, Siyi¹, Lu, Zhongming¹, luzhongming@gdph.org.cn

Source: Biochemical Genetics; Dec2024, Vol. 62 Issue 6, p4867-4883, 17p

Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny.

Authors: Alshaye, Najla A.¹ (AUTHOR) naalshaye@pnu.edu.sa, Elgohary, Mohamed K.² (AUTHOR) mahmoud-elkotamy@eru.edu.eg, Elkotamy, Mahmoud S.² (AUTHOR), Abdel-Aziz, Hatem A.³ (AUTHOR) mohamed-elgohary@eru.edu.eg

Source: Molecules. Mar2024, Vol. 29 Issue 6, p1309. 23p.

Subject Terms: *CYCLOOXYGENASE 2 inhibitors, *CREATININE, *LIVER enzymes, *ACETIC acid derivatives, *STOMACH ulcers, *ARACHIDONIC acid, *CYCLOOXYGENASE 2

Involvement of Cyclooxygenase-2 in Establishing an Immunosuppressive Microenvironment in Tumorspheres Derived from TMZ-Resistant Glioblastoma Cell Lines and Primary Cultures.

Authors: Lombardi, Francesca¹ (AUTHOR) francesca.lombardi@univaq.it, Augello, Francesca Rosaria¹ (AUTHOR) francescarosaria.augello@univaq.it, Artone, Serena² (AUTHOR) serena.artone@graduate.univaq.it, Ciafarone, Alessia³ (AUTHOR) alessia.ciafarone@graduate.univaq.it, Topi, Skender⁴ (AUTHOR) skender.topi@uniel.edu.al, Cifone, Maria Grazia¹ (AUTHOR) mariagrazia.cifone@univaq.it, Cinque, Benedetta¹ (AUTHOR) benedetta.cinque@univaq.it, Palumbo, Paola¹ (AUTHOR) paola.palumbo@univaq.it

Source: Cells (2073-4409). Feb2024, Vol. 13 Issue 3, p258. 17p.

Subject Terms: *CELL lines, *CYCLOOXYGENASE 2, *GLIOBLASTOMA multiforme, *CYCLOOXYGENASE 2 inhibitors, *EXTRACELLULAR vesicles, *PROSTAGLANDIN receptors, *CELL culture

In Silico Docking Studies of Phytochemicals from Oxalis Corniculata for Anti-Inflammatory Effects Targeting COX-4

Authors: Sindhu, R, Reddy, A H Manjunatha, Manokaran, Sumathra, SD, Shruthi

Source: 2024 8th International Conference on Computational System and Information Technology for Sustainable Solutions (CSITSS) Computational System and Information Technology for Sustainable Solutions (CSITSS), 2024 8th International Conference on. :1-5 Nov, 2024

Relation: 2024 8th International Conference on Computational System and Information Technology for Sustainable Solutions (CSITSS)

The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair.

Authors: Volarić, Darian^1,2 (AUTHOR) darian.volaric7@gmail.com, Žauhar, Gordana^3,4 (AUTHOR) gordana.zauhar@uniri.hr, Chen, Jie^5,6 (AUTHOR) jc65@ualberta.ca, Jerbić Radetić, Ana Terezija⁷ (AUTHOR) ana.jerbic.radetic@uniri.hr, Omrčen, Hrvoje⁸ (AUTHOR) hrvoje.omrcen@zzjzpgz.hr, Raič, Antonio⁹ (AUTHOR) araic@student.uniri.hr, Pirović, Roko⁹ (AUTHOR) rpirovic@student.uniri.hr, Cvijanović Peloza, Olga⁷ (AUTHOR) olga.cvijanovic@medri.uniri.hr

Source: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 7, p3882. 16p.

Subject Terms: *BONE regeneration, *CYCLOOXYGENASE 2, *SONICATION, *ULTRASONIC imaging, *BONE grafting, *IMMUNOHISTOCHEMISTRY, *HIGH-intensity focused ultrasound

Regulation of Osteosarcoma Cell Proliferation, Migration, and Invasion by miR-143 and miR-199a Through COX-2 Targeting.

Authors: Bixin, Huang¹ (AUTHOR), Yuling, Zheng¹ (AUTHOR), Ying, Mai¹ (AUTHOR), Jinming, Chen¹ (AUTHOR), Zhang, Zhongqi¹ (AUTHOR) jxzzq11@163.com

Source: Dose-Response. Apr-Jun2024, Vol. 22 Issue 2, p1-12. 12p.

Subject Terms: *CYCLOOXYGENASE 2, *CELL proliferation, *CELLULAR control mechanisms, *REPORTER genes, *WESTERN immunoblotting

Harnessing the synergistic potential of NK1R antagonists and selective COX-2 inhibitors for simultaneous targeting of TNBC cells and cancer stem cells.

Authors: Singh, Madhu Tanya¹ (AUTHOR), Thaggikuppe Krishnamurthy, Praveen¹ (AUTHOR) praveentk7812@gmail.com, Magham, Sai Varshini¹ (AUTHOR)

Source: Journal of Drug Targeting. 2024, Vol. 32 Issue 3, p258-269. 12p.

Subject Terms: *CANCER stem cells, *CYCLOOXYGENASE 2 inhibitors, *TRIPLE-negative breast cancer, *EPIDERMAL growth factor receptors, *NEUROPEPTIDES, *ESTROGEN, *SUBSTANCE P