Drosophila Cul3 contributes to Diap2-mediated innate immune signaling for antimicrobial defense

Authors: Fanrui Kong, Zixuan Wang, Chuchu Zhang, Yihua Xiao, Muhammad Abdul Rehman Saeed, Weini Li, Akira Goto, Qingshuang Cai, Shanming Ji

Source: hLife, Vol 3, Iss 1, Pp 38-51 (2025)

Subject Terms: Cullin-3 (Cul3), death-associated inhibitor of apoptosis 2 (Diap2), death-related ced-3/Nedd2-like caspase (Dredd) ubiquitination, antimicrobial immune defense, Drosophila melanogaster, Medicine

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2949928324000841; https://doaj.org/toc/2949-9283

Access URL: https://doaj.org/article/0aff5124589d467397f8f600e6824638

Genome-wide association study of subfoveal choroidal thickness in a longitudinal cohort of older adults

Authors: Hyeong Min Kim, Kwangsic Joo, Minji Kim, Young Joo Park, Ji Won Han, Ki Woong Kim, Sejoon Lee, Se Joon Woo

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Age-related macular degeneration (AMD), Single nucleotide polymorphism (SNP), Choroidal thickness, GWAS, CUL3, FAM124B, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/18bf0f660f84484c9a4139fc8c70fd69

Camk2n1 deficiency reduces the NaCl cotransporter activity through the CUL3/KLHL3/WNK4 complex in the kidney

Authors: Zhang, Ya ^{a, 1}, Zhang, Zihao ^{b, 1}, Jiang, Gengru ^a, Zhang, Chong ^{a, ⁎}

Source: In European Journal of Pharmacology 5 March 2025 990

EHMT2‐mediated R‐loop formation promotes the malignant progression of prostate cancer via activating Aurora B

Authors: Yuyang Zhang, Mingqin Su, Yiming Chen, Li Cui, Wei Xia, Renfang Xu, Dong Xue, Xiansheng Zhang, Xingliang Feng

Source: Clinical and Translational Medicine, Vol 15, Iss 1, Pp n/a-n/a (2025)

Subject Terms: Aurora B, CIN, CUL3, EHMT2, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/9b7a0f44ce0d49be847dc1f99de416c2

CUL3-related neurodevelopmental disorder: Clinical phenotype of 20 new individuals and identification of a potential phenotype-associated episignature

Authors: Liselot van der Laan, Ananília Silva, Lotte Kleinendorst, Kathleen Rooney, Sadegheh Haghshenas, Peter Lauffer, Yasemin Alanay, Pratibha Bhai, Alfredo Brusco, Sonja de Munnik, Bert B.A. de Vries, Angelica Delgado Vega, Marc Engelen, Johanna C. Herkert, Ron Hochstenbach, Saskia Hopman, Sarina G. Kant, Ryutaro Kira, Mitsuhiro Kato, Boris Keren, Hester Y. Kroes, Michael A. Levy, Ngu Lock-Hock, Saskia M. Maas, Grazia M.S. Mancini, Carlo Marcelis, Naomichi Matsumoto, Takeshi Mizuguchi, Alessandro Mussa, Cyril Mignot, Anu Närhi, Ann Nordgren, Rolph Pfundt, Abeltje M. Polstra, Slavica Trajkova, Yolande van Bever, Marie José van den Boogaard, Jasper J. van der Smagt, Tahsin Stefan Barakat, Mariëlle Alders, Marcel M.A.M. Mannens, Bekim Sadikovic, Mieke M. van Haelst, Peter Henneman

Source: HGG Advances, Vol 6, Iss 1, Pp 100380- (2025)

Subject Terms: CUL3, intellectual disability, DNA methylation, episignature, NEDAUS, genotype-phenotype correlation, Genetics, QH426-470

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Relation: http://www.sciencedirect.com/science/article/pii/S2666247724001209; https://doaj.org/toc/2666-2477

Access URL: https://doaj.org/article/4d2c1e6771da43cd9a0c73ae48b1b4d3

The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation

Authors: Yao, Yao ¹, Hong, Sungki ¹, Yoshida, Shota ¹, Swaroop, Vinamra ¹, Curtin, Brady ¹, Inoki, Ken ^{1, 2, 3, 4, ∗}

Source: In Cell Reports 28 January 2025 44(1)

CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription

Authors: Cacioppo, Roberta ^{1, 5}, Gillis, Alexander ^{2, 3, 4, 5}, Shlamovitz, Iván ^{1, 5}, Zeller, Andrew ^{1, 5}, Castiblanco, Daniela ¹, Crisp, Alastair ¹, Haworth, Benjamin ¹, Arabiotorre, Angela ^{2, 3, 4}, Abyaneh, Pegah ¹, Bao, Yu ¹, Sale, Julian E. ¹, Berry, Scott ^{2, 3, 4, ∗}, Tufegdžić Vidaković, Ana ^{1, 6, ∗∗}

Source: In Molecular Cell 19 December 2024 84(24):4808-4823

Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint

Authors: Blears, Daniel ^{1, 2, 5}, Lou, Jiangman ^{1, 5}, Fong, Nova ³, Mitter, Richard ⁴, Sheridan, Ryan M. ³, He, Dandan ¹, Dirac-Svejstrup, A. Barbara ¹, Bentley, David ³, Svejstrup, Jesper Q. ^{1, 6, ∗}

Source: In Molecular Cell 19 December 2024 84(24):4790-4807

Insights into the diverse mechanisms and effects of variant CUL3-induced familial hyperkalemic hypertension

Authors: Prashant Sharma, Harish E. Chatrathi

Source: Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)

Subject Terms: CUL3, Hyperkalemia, Hypertension, Post-translational modifications, Substrate-adaptor binding, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/a4c28a9ff0cd4fa99ba581fdd408dc95

Exo-miR-1290-induced by COX-2 overexpression promotes cancer-associated fibroblasts activation and tumor progression by CUL3-Nrf2 pathway in lung adenocarcinoma

Authors: Xiaoming Bai, Jiaofang Shao, Tinghong Duan, Xue Liu, Min Wang, Xuanya Li, Qiang You, Zhiyuan Zhang, Jinshun Pan

Source: Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)

Subject Terms: COX-2, Exo-miR-1290, CUL3, Nrf2, CAFs activation, LUAD, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/e1abfadcd8dd4652b60998d6ed8e1d67

KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway

Authors: Siqi Ying, Qin Guo, Chong Zhang

Source: BMC Nephrology, Vol 24, Iss 1, Pp 1-8 (2023)

Subject Terms: KLHL3, CUL3, WNK4, Potassium, Neddylation, Autophagy, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2369

Access URL: https://doaj.org/article/b778260dc5d540f593e6349977f53ac9

Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination

Authors: Jintao Chen, Qun Xu, Xinyi Wang, Zherong Xu, Xujiao Chen

Source: Experimental Gerontology, Vol 183, Iss , Pp 112318- (2023)

Subject Terms: Cul3, nAChRs, NMJ, Muscle atrophy, Sarcopenia, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0531556523002395; https://doaj.org/toc/1873-6815

Access URL: https://doaj.org/article/143d0e14c6d44bf38bc89efb8024238f

Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells

Authors: Jian Shen, Youqi Li, Menghao Li, Zhiming Li, Huantang Deng, Xiongwei Xie, Jinguang Liu

Source: BioMedical Engineering OnLine, Vol 21, Iss 1, Pp 1-15 (2022)

Subject Terms: CUL3, Vascular smooth muscle cells, Hypertension, Proliferation, Migration, Sonic hedgehog, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1475-925X

Access URL: https://doaj.org/article/b261d31b3bc14a4eb0baa253fac0953a

Current trends of high-risk gene Cul3 in neurodevelopmental disorders

Authors: Ping Lin, Jie Yang, Shumin Wu, Tong Ye, Wenting Zhuang, Wei Wang, Tao Tan

Source: Frontiers in Psychiatry, Vol 14 (2023)

Subject Terms: Cul3, Cullin3-RING E3 ubiquitin ligases, neurodevelopmental disorders (NDDs), autism spectrum disorder (ASD), knockout (KO) mice, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1215110/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/57d35a4046344e6ca3c107d3990aa14b

Integrated analysis of patients with KEAP1/NFE2L2/CUL3 mutations in lung adenocarcinomas

Authors: Xing Jin, Yuansheng Zheng, Zhencong Chen, Fei Wang, Guoshu Bi, Ming Li, Jiaqi Liang, Qihai Sui, Yunyi Bian, Zhengyang Hu, Yulei Qiao, Songtao Xu

Source: Cancer Medicine, Vol 10, Iss 23, Pp 8673-8692 (2021)

Subject Terms: cullin 3 (CUL3), kelch‐like ECH‐associated protein 1 (KEAP1), lung adenocarcinoma (LUAD), mutation, nuclear factor erythroid 2‐like 2 (NFE2L2), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/9bf3bd92b7a34467a1b86e2ceee31faf

G3BP1 modulates SPOP to promote prostate tumorigenesis

Authors: Chandrani Mukhopadhyay, Pengbo Zhou

Source: Molecular & Cellular Oncology, Vol 9, Iss 1 (2022)

Subject Terms: g3bp1, spop, prostate cancer, cul3, ubiquitin ligase, androgen receptor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2372-3556

Access URL: https://doaj.org/article/aadce97cc9064c18a8aa35b03846945a

insomniac links the development and function of a sleep-regulatory circuit

Authors: Qiuling Li, Hyunsoo Jang, Kayla Y Lim, Alexie Lessing, Nicholas Stavropoulos

Source: eLife, Vol 10 (2021)

Subject Terms: neurogenesis, neuroblast, autism, neurodevelopmental disorders, Cul3, sleep disorders, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/65437; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/33c4c12d60c54a53bfaf98eea8593b4c

Irregular Expression of Cellular Stress Response Markers in the Placenta of Women with Chronic Venous Disease

Authors: Cielo García-Montero, Oscar Fraile-Martinez, Sonia Rodriguez-Martín, Rosa M. Funes Moñux, Jose V. Saz, Coral Bravo, Juan A. De Leon-Luis, María Ruiz-Minaya, Leonel Pekarek, Miguel A. Saez, Alberto García-Lledo, Melchor Alvarez-Mon, Julia Bujan, Natalio García-Honduvilla, Miguel A. Ortega

Source: Antioxidants, Vol 11, Iss 11, p 2277 (2022)

Subject Terms: chronic venous disease, placenta, oxidative stress, NRF2, KEAP1, CUL3, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/11/11/2277; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/4e6beae53775454caa6270de2f0f1897

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

Authors: Zhuoyao Chen, Gregory A. Wasney, Sarah Picaud, Panagis Filippakopoulos, Masoud Vedadi, Vincenzo D'Angiolella, Alex N. Bullock

Source: Open Biology, Vol 10, Iss 6 (2020)

Subject Terms: ubiquitin, degradation, e3 ligase, btb domain, kelch, cul3, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2046-2441

Access URL: https://doaj.org/article/b3210ed61c734bbba103d231331f9846

A novel mutation in exon 9 of Cullin 3 gene contributes to aberrant splicing in pseudohypoaldosteronism type II

Authors: Leping Shao, Li Cui, Jingru Lu, Yanhua Lang, Irene Bottillo, Xiangzhong Zhao

Source: FEBS Open Bio, Vol 8, Iss 3, Pp 461-469 (2018)

Subject Terms: CUL3, exonic splicing enhancers, exonic splicing silencers, pseudohypoaldosteronism type II, splicing modulation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/232f481b515647c6b93635db1227f539