Clinical spectrum of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia in individuals of Korean ancestry

Authors: Jae Rim Kim, Suin Lee, Sang Won Seo, Ja-Hyun Jang, Yeon Lim Suh, Jeong Ho Park, Seung-yeon Lee, Hyo Jin Son, Hee Jung Kwon, Eun-Joo Kim, Duk L. Na, Hyemin Jang, Hee Jin Kim

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025)

Subject Terms: Adult-onset leukodystrophy with axonal spheroids and pigmented glia, CSF1R gene, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b6ab695211e446588ba727c42c06361a

Modulating tumor-associated macrophages through CSF1R inhibition: a potential therapeutic strategy for HNSCC

Authors: Kaiting Chen, Xiaochen Li, Shuyi Dong, Yu Guo, Ziyin Luo, Shi-Min Zhuang, Jie Liu, Tianrun Liu, Jing Liao, Weiping Wen

Source: Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-16 (2025)

Subject Terms: HNSCC, TAMs, CSF1R inhibitors, Cisplatin, Combination therapy, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/dfe36eb7d00943ed80bf6ef2654f1550

Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis

Authors: Lingliang Zhang, Lingling Huang, Yuhang Zhou, Jian Meng, Liang Zhang, Yunqiang Zhou, Naizhen Zheng, Tiantian Guo, Shanshan Zhao, Zijie Wang, Yuanhui Huo, Yingjun Zhao, Xiao-fen Chen, Honghua Zheng, David M. Holtzman, Yun-wu Zhang

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-23 (2024)

Subject Terms: β-amyloid, Alzheimer’s disease, C1q, CD2AP, CSF1R, Disease-associated microglia, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/32ed5d0d0809434eb92ab41921cbf04c

miR-449, identified through antiandrogen exposure, mitigates functional biomarkers associated with ovarian cancer risk

Authors: Xia Wang, Ho-Hyung Woo, Michelle Wei, Steven Gibson, Mitzi Miranda, Demaretta Rush, Janiel Cragun, Wenxin Zheng, Guang Yao, Setsuko K. Chambers

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: MicroRNA, CSF1R, Androgen receptor, Flutamide, Ovarian cancer risk, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/1b9cc834ec814382a6f610737feaff87

Multiple allostery in the regulation of PDGFR beta kinase activities

Authors: Zhang Yanfeng, Wang Meimei, Shao Guangcan, Shang Qingbin, Dong Mengqiu, Qin Xiaohong, Mi Li-Zhi

Source: Acta Biochimica et Biophysica Sinica, Vol 57, Pp 344-355 (2024)

Subject Terms: allosteric regulation, symmetric dimerization, kinase insert, platelet-derived growth factor receptor beta (PDGFRβ), colony stimulating factor 1 receptor (CSF1R), Biochemistry, QD415-436, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1672-9145

Access URL: https://doaj.org/article/b311f71e0efd4ebe8bc6b2de6dad34eb

Unveiling the Molecular Links Between Atrial Fibrillation and Atherosclerosis: Insights into Shared Pathogenesis and Ferroptosis Diagnostic Biomarkers

Authors: Xu B, Li H, Chen H, Teng D, Gong L, Zhong L, Yang J

Source: Journal of Inflammation Research, Vol Volume 17, Pp 8813-8830 (2024)

Subject Terms: atrial fibrillation, af, atherosclerosis, as, ferroptosis, csf1r, itgam, nupr1, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/unveiling-the-molecular-links-between-atrial-fibrillation-and-atherosc-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Access URL: https://doaj.org/article/2bf2e825a7044dd3b876417a4624cc7f

Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage population density

Authors: Stephen C. Gironda, Samuel W. Centanni, Jeffrey L. Weiner

Source: Brain, Behavior, & Immunity - Health, Vol 43, Iss , Pp 100933- (2025)

Subject Terms: Early life stress, Alcohol, Microglia, Light-Sheet Fluorescence Microscopy, CSF1R inhibition, Macrophage, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666354624002114; https://doaj.org/toc/2666-3546

Access URL: https://doaj.org/article/e1ff2ea637264f1881718c41d950513d

Tracking changes in functionality and morphology of repopulated microglia in young and old mice

Authors: Zuzanna M. Luczak-Sobotkowska, Patrycja Rosa, Maria Banqueri Lopez, Natalia Ochocka, Anna Kiryk, Anna M. Lenkiewicz, Martin Furhmann, Aleksander Jankowski, Bozena Kaminska

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)

Subject Terms: Microglial heterogeneity, CSF1R inhibitors, Microglia repopulation, ScRNA-seq, Transcriptomics, Aging, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/7b63ae1d625e4e7d930374676c4a0f47

Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism

Authors: Jiao Meng, Pengming Pan, Gengshuo Guo, Anqi Chen, Xiangbao Meng, Heli Liu

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)

Subject Terms: Autism, Microglia, CSF1R inhibitor, Cntnap2 knockout mouse, Valproic acid-exposed mouse, Pharmacological heterogeneity, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/77b7a0f9f4b2458a913ab3f6913bb31c

Suppression of inner blood-retinal barrier breakdown and pathogenic Müller glia activation in ischemia retinopathy by myeloid cell depletion

Authors: Lingli Zhou, Zhenhua Xu, Haining Lu, Hongkwan Cho, Yangyiran Xie, Grace Lee, Kaoru Ri, Elia J. Duh

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-16 (2024)

Subject Terms: Microglia, Macrophages, Csf1r, Müller glia, Blood-retinal barrier, Neuroinflammation, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/8cb0084117dc4cfc9d87846b0b1230c0

Deciphering glial contributions to CSF1R-related disorder via single-nuclear transcriptomic profiling: a case study

Authors: Jie Pan, Jaume Fores-Martos, Claire Delpirou Nouh, Tanner D. Jensen, Kristen Vallejo, Romain Cayrol, Saman Ahmadian, Euan A. Ashley, Michael D. Greicius, Inma Cobos

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-21 (2024)

Subject Terms: ALSP, HDLS, CSF1R, Microglia, Macrophage, Oligodendrocyte, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/274c1c8cf2c746b398593b20211d6b78

Therapeutic advances in Tenosynovial giant cell Tumor: Targeting the CSF1/CSF1R axis

Authors: Assi, Tarek ^{a, b, ⁎}, Moussa, Tania ^b, Ngo, Carine ^c, Faron, Matthieu ^c, Verret, Benjamin ^c, Lévy, Antonin ^c, Honoré, Charles ^c, Hénon, Clémence ^c, Péchoux, Cécile Le ^c, Bahleda, Rastilav ^c, Vibert, Julien ^c, Cesne, Axel Le ^{a, c}

Source: In Cancer Treatment Reviews March 2025 134

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

Authors: Jennifer Stables, Reiss Pal, Barry M. Bradford, Dylan Carter-Cusack, Isis Taylor, Clare Pridans, Nemat Khan, Trent M. Woodruff, Katharine M. Irvine, Kim M. Summers, Neil A. Mabbott, David A. Hume

Source: Neurobiology of Disease, Vol 203, Iss , Pp 106743- (2024)

Subject Terms: CSF1R, Macrophage, Kinase-dead, Leukoencephalopathy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996124003450; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/50e9fb735e7344ee8935456482dec788

Microglial depletion rescues spatial memory impairment caused by LPS administration in adult mice

Authors: Tao Zong, Na Li, Fubing Han, Junru Liu, Mingru Deng, Vincent Li, Meng Zhang, Yu Zhou, Ming Yu

Source: PeerJ, Vol 12, p e18552 (2024)

Subject Terms: LPS, Neuroinflammation, Memory impairment, Microglia, CSF1R inhibitor, Mice, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/18552.pdf; https://peerj.com/articles/18552/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/f5e23bb3cb7a4226ba25ace1fe7eb892

Targeting colony‐stimulating factor 1 receptor: From therapeutic drugs to diagnostic radiotracers

Authors: Xiaochuan Zha, Wenxue Hui, Dengfeng Cheng, Hongcheng Shi, Zonghua Luo

Source: iRADIOLOGY, Vol 2, Iss 1, Pp 35-65 (2024)

Subject Terms: colony‐stimulating factor 1 receptor (CSF1R), CSF1R inhibitor, neuroinflammation imaging, positron emission tomography (PET), radiotracer, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2834-2860; https://doaj.org/toc/2834-2879

Access URL: https://doaj.org/article/e6dd4cd2ca7e436790bc528372221502

Targeting CSF1R in myeloid-derived suppressor cells: insights into its immunomodulatory functions in colorectal cancer and therapeutic implications

Authors: Xin Tong, Shifeng Qiao, Zhe Dong, Xiaohui Zhao, Xiaxia Du, Wei Niu

Source: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-20 (2024)

Subject Terms: Colorectal cancer, Myeloid-derived suppressor cells, CSF1R, JAK/STAT3, LNCs@CSF1R siRNA, Anti-PD-1, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/b17265069d3e435fa65bbf1991643438

Assessing Chitinases and Neurofilament Light Chain as Biomarkers for Adult-Onset Leukodystrophies

Authors: Paulo de Lima Serrano, Thaiane de Paulo Varollo Rodrigues, Leslyê Donato Pinto, Indiara Correia Pereira, Igor Braga Farias, Renan Brandão Rambaldi Cavalheiro, Patrícia Marques Mendes, Kaliny Oliveira Peixoto, João Paulo Barile, Daniel Delgado Seneor, Eduardo Gleitzmann Correa Silva, Acary Souza Bulle Oliveira, Wladimir Bocca Vieira de Rezende Pinto, Paulo Sgobbi

Source: Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4309-4323 (2024)

Subject Terms: leukoencephalopathy, leukodystrophy, biomarker, chitotriosidase, CSF1R, adult-onset leukoencephalopathy with axonal spheroids and pigmented glia, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/46/5/262; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

Access URL: https://doaj.org/article/d3771228b9ee4469b6ffb34d490f9b85

Icariin maintaining TMEM119-positive microglial population improves hippocampus-associated memory in senescent mice in relation to R-3-hydroxybutyric acid metabolism

Authors: Ma, Rong ^⁎, Zhou, Yuge, Huang, Weifan, Kong, Xiaoni ^⁎⁎

Source: In Journal of Ethnopharmacology 31 January 2025 340

Unveiling the contribution of tumor-associated macrophages in driving epithelial-mesenchymal transition: a review of mechanisms and therapeutic Strategies

Authors: Yijia Zhang, Xiaofei Ding, Xue Zhang, Ye Li, Rui Xu, Hai-Jun Li, Daiying Zuo, Guang Chen

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: TAM, tumor associated macrophage, TME, tumor microenvironment, EMT, epithelialmesenchymal transition, ECM, extracellular matrix, CSF1R, colony-stimulating factor 1 receptor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1404687/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/5181cfe6c6524cf78497e78f84773d76

Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota

Authors: Shan Su, Ting Liu, Jia-Yi Zheng, Hai-Cui Wu, Vincent W. Keng, Shi-Jie Zhang, Xiao-Xiao Li

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: colitis, macrophage, Csf1r, Src, gut microbiota, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1375781/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d69c7a4b23684ecf83d0bace12e506ae