Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy

Authors: Terranova, Christopher J., Tang, Ming, Maitituoheti, Mayinuer, Raman, Ayush T., Ghosh, Archit K., Schulz, Jonathan, Amin, Samir B., Orouji, Elias, Tomczak, Katarzyna, Sarkar, Sharmistha, Oba, Junna, Creasy, Caitlin, Wu, Chang-Jiun, Khan, Samia, Lazcano, Rossana, Wani, Khalida, Singh, Anand, Barrodia, Praveen, Zhao, Dongyu, Chen, Kaifu, Haydu, Lauren E., Wang, Wei-Lien, Lazar, Alexander J., Woodman, Scott E., Bernatchez, Chantale, Rai, Kunal

Source: In Cell Reports 20 July 2021 36(3)

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

Authors: Cascone, Tina, McKenzie, Jodi A., Mbofung, Rina M., Punt, Simone, Wang, Zhe, Xu, Chunyu, Williams, Leila J., Wang, Zhiqiang, Bristow, Christopher A., Carugo, Alessandro, Peoples, Michael D., Li, Lerong, Karpinets, Tatiana, Huang, Lu, Malu, Shruti, Creasy, Caitlin, Leahey, Sara E., Chen, Jiong, Chen, Yuan, Pelicano, Helen, Bernatchez, Chantale, Gopal, Y.N. Vashisht, Heffernan, Timothy P., Hu, Jianhua, Wang, Jing, Amaria, Rodabe N., Garraway, Levi A., Huang, Peng, Yang, Peiying, Wistuba, Ignacio I., Woodman, Scott E., Roszik, Jason, Davis, R. Eric, Davies, Michael A., Heymach, John V., Hwu, Patrick, Peng, Weiyi

Source: In Cell Metabolism 1 May 2018 27(5):977-987

Exposure to anti‐PD‐1 causes functional differences in tumor‐infiltrating lymphocytes in rare solid tumors

Authors: Creasy, Caitlin A., Forget, Marie‐Andrée, Singh, Gopal, Tapia, Coya, Xu, Mingxuan, Stephen, Bettzy, Sabir, Sharjeel, Meric‐Bernstam, Funda, Haymaker, Cara, Bernatchez, Chantale, Naing, Aung

Source: European journal of immunology. 49(12):2245-2251

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094313364.0x000001&indx=1&recIds=ETOCvdc_100094313364.0x000001

Utilizing T-cell Activation Signals 1, 2, and 3 for Tumor-infiltrating Lymphocytes (TIL) Expansion: The Advantage Over the Sole Use of Interleukin-2 in Cutaneous and Uveal Melanoma

Authors: Tavera, René J., Forget, Marie-Andrée, Kim, Young Uk, Sakellariou-Thompson, Donastas, Creasy, Caitlin A., Bhatta, Ankit, Fulbright, Orenthial J., Ramachandran, Renjith, Thorsen, Shawne T., Flores, Esteban, Wahl, Arely, Gonzalez, Audrey M., Toth, Christopher, Wardell, Seth, Mansaray, Rahmatu, Radvanyi, Laszlo G., Gombos, Dan S., Patel, Sapna P., Hwu, Patrick, Amaria, Rodabe N., Bernatchez, Chantale, Haymaker, Cara

Source: Journal of immunotherapy. 41(9):399-405

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069101727.0x000001&indx=1&recIds=ETOCvdc_100069101727.0x000001

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy

Authors: Sharma, Meenu, Khong, Hiep, Fa'ak, Faisal, Bentebibel, Salah-Eddine, Janssen, Louise M. E., Chesson, Brent C., Creasy, Caitlin A., Forget, Marie-Andrée, Kahn, Laura Maria S., Pazdrak, Barbara, Karki, Binisha, Hailemichael, Yared, Singh, Manisha, Vianden, Christina, Vennam, Srinivas, Bharadwaj, Uddalak, Tweardy, David J., Haymaker, Cara, Bernatchez, Chantale, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Hurwitz, Michael E., Sznol, Mario, Hwu, Patrick, Hoch, Ute, Addepalli, Murali, Charych, Deborah H., Zalevsky, Jonathan, Diab, Adi, Overwijk, Willem W.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161787268.0x000001&indx=1&recIds=ETOCvdc_100161787268.0x000001

Multi-modal molecular programs regulate melanoma cell state.

Authors: Andrews, Miles C., Oba, Junna, Wu, Chang-Jiun, Zhu, Haifeng, Karpinets, Tatiana, Creasy, Caitlin A., Forget, Marie-Andrée, Yu, Xiaoxing, Song, Xingzhi, Mao, Xizeng, Robertson, A. Gordon, Romano, Gabriele, Li, Peng, Burton, Elizabeth M., Lu, Yiling, Sloane, Robert Szczepaniak, Wani, Khalida M., Rai, Kunal, Lazar, Alexander J., Haydu, Lauren E.

Source: Nature Communications; 7/9/2022, Vol. 13 Issue 1, p1-18, 18p

Subject Terms: EPIGENOMICS, LINCRNA, NON-coding DNA, MELANOMA, PROTEIN microarrays, RNA methylation

Identification of distinct immune landscapes using an automated nine-color multiplex immunofluorescence staining panel and image analysis in paraffin tumor tissues.

Authors: Parra, Edwin R., Zhai, Jie, Tamegnon, Auriole, Zhou, Nicolas, Pandurengan, Renganayaki Krishna, Barreto, Carmelia, Jiang, Mei, Rice, David C., Creasy, Caitlin, Vaporciyan, Ara A., Hofstetter, Wayne L., Tsao, Anne S., Wistuba, Ignacio I., Sepesi, Boris, Haymaker, Cara

Source: Scientific Reports; 2/25/2021, Vol. 11 Issue 1, p1-14, 14p

Subject Terms: IMMUNOFLUORESCENCE, IMAGE analysis, TUMOR microenvironment, BIOMARKERS, PHENOTYPES

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Clinical Success of Adoptive Cell Transfer Therapy Using Tumor Infiltrating Lymphocytes.

Authors: Chacon, Jessica, Ritthipichai, Krit, Sim, Geok, Harao, Michiko, Chen, Jie Qing, Creasy, Caitlin, Bernatchez, Chantale, Hwu, Patrick, Radvanyi, Laszlo

Source: Developments in T Cell Based Cancer Immunotherapies; 2015, p151-181, 31p

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Lymphatic Pump Treatment as an Adjunct to Antibiotics for Pneumonia in a Rat Model

Authors: Hodge, Lisa M., Creasy, Caitlin, Carter, KiahRae, Orlowski, Ashley, Schander, Artur, King, Hollis H.

Source: Journal of Osteopathic Medicine; May 2015, Vol. 115 Issue: 5 p306-316, 11p