Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

Authors: Awalt, Jon Kyle, Su, Wenyin, Nguyen, William, Loi, Katie, Jarman, Kate E., Penington, Jocelyn S., Ramesh, Saishyam, Fairhurst, Kate J., Yeo, Tomas, Park, Heekuk, Uhlemann, Anne-Catrin, Chandra Maity, Bikash, De, Nirupam, Mukherjee, Partha, Chakraborty, Arnish, Churchyard, Alisje, Famodimu, Mufuliat T., Delves, Michael J., Baum, Jake, Mittal, Nimisha, Winzeler, Elizabeth A., Papenfuss, Anthony T., Chowdury, Mrittika, de Koning-Ward, Tania F., Maier, Alexander G., van Dooren, Giel G., Baud, Delphine, Brand, Stephen, Fidock, David A., Jackson, Paul F., Cowman, Alan F., Dans, Madeline G., Sleebs, Brad E.

Source: In European Journal of Medicinal Chemistry 15 December 2024 280

Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3

Authors: Calic, Petar P.S., Ashton, Trent D., Mansouri, Mahta, Loi, Katie, Jarman, Kate E., Qiu, Deyun, Lehane, Adele M., Roy, Sayantan, Rao, Gunturu P., Maity, Bikash, Wittlin, Sergio, Crespo, Benigno, Gamo, Franciso-Javier, Deni, Ioanna, Fidock, David A., Chowdury, Mrittika, de Koning-Ward, Tania F., Cowman, Alan F., Jackson, Paul F., Baud, Delphine, Brand, Stephen, Laleu, Benoît, Sleebs, Brad E.

Source: In European Journal of Medicinal Chemistry 5 October 2024 276

Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein

Authors: Nguyen, William ^{a, b}, Boulet, Coralie ^c, Dans, Madeline G. ^{a, b}, Loi, Katie ^{a, b}, Jarman, Kate E. ^{a, b}, Watson, Gabrielle M. ^{a, b}, Tham, Wai-Hong ^{a, b}, Fairhurst, Kate J. ^d, Yeo, Tomas ^d, Fidock, David A. ^{d, e}, Wittlin, Sergio ^{f, g}, Chowdury, Mrittika ^{h, i}, de Koning-Ward, Tania F. ^{h, i}, Chen, Gong ^j, Yan, Dandan ^j, Charman, Susan A. ^j, Baud, Delphine ^k, Brand, Stephen ^k, Jackson, Paul F. ^l, Cowman, Alan F. ^{a, b}, Gilson, Paul R. ^c, Sleebs, Brad E. ^{a, b, ⁎}

Source: In European Journal of Medicinal Chemistry 15 April 2024 270

Chemo‐proteomics in antimalarial target identification and engagement

Authors: Bailey, Brodie L., Nguyen, William, Cowman, Alan F., Sleebs, Brad E.

Source: Medicinal research reviews. 43(6):2303-2351

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194648583.0x000001&indx=1&recIds=ETOCvdc_100194648583.0x000001

The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture

Authors: Bullen, Hayley E., Sanders, Paul R., Dans, Madeline G., Jonsdottir, Thorey K., Riglar, David T., Looker, Oliver, Palmer, Catherine S., Kouskousis, Betty, Charnaud, Sarah C., Triglia, Tony, Gabriela, Mikha, Parkyn Schneider, Molly, Chan, Jo‐Anne, Koning‐Ward, Tania F., Baum, Jake, Kazura, James W., Beeson, James G., Cowman, Alan F., Gilson, Paul R., Crabb, Brendan S.

Source: Molecular microbiology. 117(5):1245-1262

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153921609.0x000001&indx=1&recIds=ETOCvdc_100153921609.0x000001

Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax

Authors: Hodder, Anthony N., Christensen, Janni, Scally, Stephen, Triglia, Tony, Ngo, Anna, Birkinshaw, Richard W., Bailey, Brodie, Favuzza, Paola, Dietrich, Melanie H., Tham, Wai-Hong, Czabotar, Peter E., Lowes, Kym, Guo, Zhuyan, Murgolo, Nicholas, Lera Ruiz, Manuel de, McCauley, John A., Sleebs, Brad E., Olsen, David, Cowman, Alan F.

Source: In Structure 7 July 2022 30(7):947-961

Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity

Authors: Ashton, Trent D., Ngo, Anna, Favuzza, Paola, Bullen, Hayley E., Gancheva, Maria R., Romeo, Ornella, Parkyn Schneider, Molly, Nguyen, Nghi, Steel, Ryan W.J., Duffy, Sandra, Lowes, Kym N., Sabroux, Helene Jousset, Avery, Vicky M., Boddey, Justin A., Wilson, Danny W., Cowman, Alan F., Gilson, Paul R., Sleebs, Brad E.

Source: In Bioorganic Chemistry December 2021 117

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Authors: Bailey, Brodie L., Nguyen, William, Ngo, Anna, Goodman, Christopher D., Gancheva, Maria R., Favuzza, Paola, Sanz, Laura M., Gamo, Francisco-Javier, Lowes, Kym N., McFadden, Geoffrey I., Wilson, Danny W., Laleu, Benoît, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.

Source: In Bioorganic Chemistry October 2021 115

Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein

Authors: Sleebs, Brad E., Jarman, Kate E., Frolich, Sonja, Wong, Wilson, Healer, Julie, Dai, Weiwen, Lucet, Isabelle S., Wilson, Danny W., Cowman, Alan F.

Source: In International Journal for Parasitology: Drugs and Drug Resistance December 2020 14:188-200

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Authors: Favuzza, Paola, de Lera Ruiz, Manuel, Thompson, Jennifer K., Triglia, Tony, Ngo, Anna, Steel, Ryan W.J., Vavrek, Marissa, Christensen, Janni, Healer, Julie, Boyce, Christopher, Guo, Zhuyan, Hu, Mengwei, Khan, Tanweer, Murgolo, Nicholas, Zhao, Lianyun, Penington, Jocelyn Sietsma, Reaksudsan, Kitsanapong, Jarman, Kate, Dietrich, Melanie H., Richardson, Lachlan, Guo, Kai-Yuan, Lopaticki, Sash, Tham, Wai-Hong, Rottmann, Matthias, Papenfuss, Tony, Robbins, Jonathan A., Boddey, Justin A., Sleebs, Brad E., Sabroux, Hélène Jousset, McCauley, John A., Olsen, David B., Cowman, Alan F.

Source: In Cell Host & Microbe 8 April 2020 27(4):642-658

Flp/FRT-mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver-stage development.

Authors: McConville, Robyn, Krol, Jelte M. M., Steel, Ryan W. J., O'Neill, Matthew T., Davey, Bethany K., Hodder, Anthony N., Nebl, Thomas, Cowman, Alan F., Kneteman, Norman, Boddey, Justin A.

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/9/2024, Vol. 121 Issue 28, p1-17, 29p

Subject Terms: PLASMODIUM falciparum, SPOROZOITES, CIRCUMSPOROZOITE protein, LIVER proteins, PLASMODIUM berghei

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics

Authors: Nguyen, William, Hodder, Anthony N., de Lezongard, Richard Bestel, Czabotar, Peter E., Jarman, Kate E., O'Neill, Matthew T., Thompson, Jennifer K., Jousset Sabroux, Helene, Cowman, Alan F., Boddey, Justin A., Sleebs, Brad E.

Source: In European Journal of Medicinal Chemistry 25 June 2018 154:182-198

Signal-Mediated Export of Proteins from the Malaria Parasite to the Host Erythrocyte

Authors: Marti, Matthias, Baum, Jake, Rug, Melanie, Tilley, Leann, Cowman, Alan F.

Source: The Journal of Cell Biology, 2005 Nov . 171(4), 587-592.

Access URL: https://www.jstor.org/stable/3658466

Molecular Mechanism for Switching of P. falciparum Invasion Pathways into Human Erythrocytes

Authors: Stubbs, Janine, Simpson, Ken M., Triglia, Tony, Plouffe, David, Tonkin, Christopher J., Duraisingh, Manoj T., Maier, Alexander G., Winzeler, Elizabeth A., Cowman, Alan F.

Source: Science, 2005 Aug . 309(5739), 1384-1387.

Access URL: https://www.jstor.org/stable/3842507

Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex

Authors: Wong, Wilson, Huang, Rick, Menant, Sebastien, Hong, Chuan, Sandow, Jarrod J., Birkinshaw, Richard W., Healer, Julie, Hodder, Anthony N., Kanjee, Usheer, Tonkin, Christopher J., Heckmann, Denise, Soroka, Vladislav, Søgaard, Teit Max Moscote, Jørgensen, Thomas, Duraisingh, Manoj T., Czabotar, Peter E., de Jongh, Willem A., Tham, Wai-Hong, Webb, Andrew I., Yu, Zhiheng, Cowman, Alan F.

Source: Nature. 565(7737):118-121

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193366686.0x000001&indx=1&recIds=ETOCvdc_100193366686.0x000001

Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria

Authors: Studniberg, Stephanie I, Ioannidis, Lisa J, Utami, Retno A S, Trianty, Leily, Liao, Yang, Abeysekera, Waruni, Li‐Wai‐Suen, Connie S N, Pietrzak, Halina M, Healer, Julie, Puspitasari, Agatha M, Apriyanti, Dwi, Coutrier, Farah, Poespoprodjo, Jeanne R, Kenangalem, Enny, Andries, Benediktus, Prayoga, Pak, Sariyanti, Novita, Smyth, Gordon K, Cowman, Alan F, Price, Ric N, Noviyanti, Rintis, Shi, Wei, Garnham, Alexandra L, Hansen, Diana S

Source: Molecular systems biology. 18(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193842088.0x000001&indx=1&recIds=ETOCvdc_100193842088.0x000001

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity

Authors: Richardson, Lachlan W., Ashton, Trent D., Dans, Madeline G., Nguyen, Nghi, Favuzza, Paola, Triglia, Tony, Hodder, Anthony N., Ngo, Anna, Jarman, Kate E., Cowman, Alan F., Sleebs, Brad E.

Source: ChemMedChem. 17(18)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164933294.0x000001&indx=1&recIds=ETOCvdc_100164933294.0x000001

Targeting Malaria Virulence and Remodeling Proteins to the Host Erythrocyte

Authors: Marti, Matthias, Good, Robert T., Rug, Melanie, Knuepfer, Ellen, Cowman, Alan F.

Source: Science, 2004 Dec 01. 306(5703), 1930-1933.

Access URL: https://www.jstor.org/stable/3839833

The Cytoplasmic Domain of the Plasmodium flaciparum Ligand EBA-175 Is Essential for Invasion but Not Protein Trafficking

Authors: Gilberger, Tim-Wolf, Thompson, Jennifer K., Reed, Michael B., Good, Robert T., Cowman, Alan F.

Source: The Journal of Cell Biology, 2003 Jul . 162(2), 317-327.

Access URL: https://www.jstor.org/stable/1621690

Erythrocyte-Binding Antigen 175 Mediates Invasion in Plasmodium falciparum Utilizing Sialic Acid-Dependent and -Independent Pathways

Authors: Duraisingh, Manoj T., Maier, Alexander G., Triglia, Tony, Cowman, Alan F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Apr . 100(8), 4796-4801.

Access URL: https://www.jstor.org/stable/3144021