Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma

Authors: Chiffelle, Johanna ^{1, 2, 7}, Barras, David ^{1, 2, 7}, Pétremand, Rémy ^{1, 2}, Orcurto, Angela ^{2, 3}, Bobisse, Sara ^{1, 2}, Arnaud, Marion ^{1, 2}, Auger, Aymeric ^{1, 2}, Rodrigo, Blanca Navarro ^{1, 2, 3}, Ghisoni, Eleonora ^{1, 2, 3}, Sauvage, Christophe ^{1, 2}, Saugy, Damien ^{1, 2}, Michel, Alexandra ^{1, 2}, Murgues, Baptiste ^{1, 2}, Fahr, Noémie ^{1, 2}, Imbimbo, Martina ^{2, 3}, Ochoa de Olza, Maria ^{2, 3}, Latifyan, Sofiya ^{1, 4}, Crespo, Isaac ^{1, 2}, Benedetti, Fabrizio ^{1, 2}, Genolet, Raphael ^{1, 2}, Queiroz, Lise ^{1, 2}, Schmidt, Julien ^{1, 5}, Homicsko, Krisztian ^{1, 2, 3, 4}, Zimmermann, Stefan ^{2, 3}, Michielin, Olivier ^{1, 4}, Bassani-Sternberg, Michal ^{1, 2}, Kandalaft, Lana E. ^{1, 2, 5}, Dafni, Urania ⁶, Corria-Osorio, Jesus ^{1, 2}, Trueb, Lionel ^{2, 3}, Dangaj Laniti, Denarda ^{1, 2, 8}, Harari, Alexandre ^{1, 2, 8, 9, ∗}, Coukos, George ^{1, 2, 3, 8, ∗∗}

Source: In Immunity 8 October 2024 57(10):2466-2482

An integrated nanoplasmonic biosensor for monitoring cytokine secretion from single cells

Authors: Li, Xiaokang, Soler, Maria, Szydzik, Crispin, Khoshmanesh, Khashayar, Schmidt, Julien, Yesilkoy, Filiz, Belushkin, Alexander, Coukos, George, Mitchell, Arnan, Altug, Hatice

Source: 2019 15th Conference on Ph.D Research in Microelectronics and Electronics (PRIME) Ph.D Research in Microelectronics and Electronics (PRIME), 2019 15th Conference on. :113-116 Jul, 2019

Relation: 2019 15th Conference on Ph.D Research in Microelectronics and Electronics (PRIME)

A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer

Authors: Kandalaft Lana E, Powell Daniel J, Coukos George

Source: Journal of Translational Medicine, Vol 10, Iss 1, p 157 (2012)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/10/1/157; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/124231985c9e439796dcc252bc7ace30

Defining the critical hurdles in cancer immunotherapy

Authors: Fox Bernard A, Schendel Dolores J, Butterfield Lisa H, Aamdal Steinar, Allison James P, Ascierto Paolo, Atkins Michael B, Bartunkova Jirina, Bergmann Lothar, Berinstein Neil, Bonorino Cristina C, Borden Ernest, Bramson Jonathan L, Britten Cedrik M, Cao Xuetao, Carson William E, Chang Alfred E, Characiejus Dainius, Choudhury A Raja, Coukos George, de Gruijl Tanja, Dillman Robert O, Dolstra Harry, Dranoff Glenn, Durrant Lindy G, Finke James H, Galon Jerome, Gollob Jared A, Gouttefangeas Cécile, Grizzi Fabio, Guida Michele, Håkansson Leif, Hege Kristen, Herberman Ronald B, Hodi F Stephen, Hoos Axel, Huber Christoph, Hwu Patrick, Imai Kohzoh, Jaffee Elizabeth M, Janetzki Sylvia, June Carl H, Kalinski Pawel, Kaufman Howard L, Kawakami Koji, Kawakami Yutaka, Keilholtz Ulrich, Khleif Samir N, Kiessling Rolf, Kotlan Beatrix, Kroemer Guido, Lapointe Rejean, Levitsky Hyam I, Lotze Michael T, Maccalli Cristina, Maio Michele, Marschner Jens-Peter, Mastrangelo Michael J, Masucci Giuseppe, Melero Ignacio, Melief Cornelius, Murphy William J, Nelson Brad, Nicolini Andrea, Nishimura Michael I, Odunsi Kunle, Ohashi Pamela S, O'Donnell-Tormey Jill, Old Lloyd J, Ottensmeier Christian, Papamichail Michael, Parmiani Giorgio, Pawelec Graham, Proietti Enrico, Qin Shukui, Rees Robert, Ribas Antoni, Ridolfi Ruggero, Ritter Gerd, Rivoltini Licia, Romero Pedro J, Salem Mohamed L, Scheper Rik J, Seliger Barbara, Sharma Padmanee, Shiku Hiroshi, Singh-Jasuja Harpreet, Song Wenru, Straten Per, Tahara Hideaki, Tian Zhigang, van Der Burg Sjoerd H, von Hoegen Paul, Wang Ena, Welters Marij JP, Winter Hauke, Withington Tara, Wolchok Jedd D, Xiao Weihua, Zitvogel Laurence, Zwierzina Heinz, Marincola Francesco M, Gajewski Thomas F, Wigginton Jon M, Disis Mary L

Source: Journal of Translational Medicine, Vol 9, Iss 1, p 214 (2011)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/9/1/214; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/a5cf6b0d55484f40a970d9cfef5d3474

Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate

Authors: Chiang Cheryl L-L, Maier Dawn A, Kandalaft Lana E, Brennan Andrea L, Lanitis Evripidis, Ye Qunrui, Levine Bruce L, Czerniecki Brian J, Powell Jr Daniel J, Coukos George

Source: Journal of Translational Medicine, Vol 9, Iss 1, p 198 (2011)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/9/1/198; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/640bbe4366f6432086ece7e41fae8fd8

Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes

Authors: Coukos George, June Carl H, Riley James L, Suhoski Megan M, Levine Bruce L, Loisiou Maria, Ye Qunrui, Powell Daniel J

Source: Journal of Translational Medicine, Vol 9, Iss 1, p 131 (2011)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/9/1/131; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/e4af7e75aad340bfacbef309c09f3d11

Clinical translation section: accelerating the pace from bench to bedside

Authors: Kandalaft Lana E, Coukos George

Source: Journal of Translational Medicine, Vol 9, Iss 1, p 116 (2011)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/9/1/116; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/e67a8276e44a42959dd5747a505e67d9

Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy

Authors: Jonak Zdenka, Adams Sarah, Benencia Fabian, Carpenito Carmine, Tsiatas Marinos, Facciabene Andrea, Alagkiozidis Ioannis, June Carl H, Powell Daniel J, Coukos George

Source: Journal of Translational Medicine, Vol 9, Iss 1, p 77 (2011)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/9/1/77; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/523392b9b65048afb0646a2aff28249b

Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18

Authors: Danet-Desnoyers Gwen-äel, Hammond Rachel, Gimotty Phyllis A, Carroll Richard G, Adams Sarah, Jonak Zdenka, Benencia Fabian, Carpenito Carmine, Facciabene Andrea, Alagkiozidis Ioannis, June Carl H, Powell Daniel J, Coukos George

Source: Journal of Translational Medicine, Vol 7, Iss 1, p 104 (2009)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/7/1/104; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/72f8ed3de4054344bbe35b3826b19e2a

Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer

Authors: Coukos George, Reynolds R Kevin, Kueck Angela S, McLean Karen, Silva Ines A, Spahlinger Gregory, Pulaski Heather L, Conejo-Garcia Jose R, Buckanovich Ronald J

Source: Journal of Translational Medicine, Vol 7, Iss 1, p 49 (2009)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/7/1/49; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/b9daec09402f4ae1a895fa39e1db194c

A systematic approach to biomarker discovery; Preamble to 'the iSBTc-FDA taskforce on immunotherapy biomarkers'

Authors: Schendel Dolores, Rivoltini Licia, Ribas Antoni, Potter Douglas M, Palucka A Karolina, Masucci Giuseppe, Malyguine Anatoli, Maecker Holden, Maio Michele, Maccalli Cristina, Kirkwood John M, Kleen Thomas O, Janetzki Sylvia, Håkansson Leif, Dhodapkar Madhav, Coukos George, Chaussabel Damien, Wigginton Jon, Wang Ena, Trinchieri Giorgio, Thurin Magdalena, Khleif Samir N, Lee Peter P, Fox Bernard A, Disis Mary L, Butterfield Lisa H, Seliger Barbara, Selvan Senthamil, Slingluff Craig L, Stroncek David F, Streicher Howard, Wu Xifeng, Zeskind Benjamin, Zhao Yingdong, Zocca Mai-Britt, Zwierzina Heinz, Marincola Francesco M

Source: Journal of Translational Medicine, Vol 6, Iss 1, p 81 (2008)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/6/1/81; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/c606e5bf024e47c7b6ab8f64adad5028

Whole tumor antigen vaccination using dendritic cells: Comparison of RNA electroporation and pulsing with UV-irradiated tumor cells

Authors: Benencia Fabian, Courrèges Maria C, Coukos George

Source: Journal of Translational Medicine, Vol 6, Iss 1, p 21 (2008)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/6/1/21; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/1b854ada62b1403e9ea754e50bf9b7c5

Should tumor VEGF expression influence decisions on combining low-dose chemotherapy with antiangiogenic therapy? Preclinical modeling in ovarian cancer

Authors: Leiby Benjamin, Alagkiozidis Ioannis, Zhang Lin, Mohamed-Hadley Alisha, Krafty Robert T, Holtz David O, Guo Wensheng, Gimotty Phyllis A, Coukos George

Source: Journal of Translational Medicine, Vol 6, Iss 1, p 2 (2008)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.translational-medicine.com/content/6/1/2; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/508f59e9e54d44779fb2184e3f4dc1d3

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

Authors: Racle, Julien, Guillaume, Philippe, Schmidt, Julien, Michaux, Justine, Larabi, Amédé, Lau, Kelvin, Perez, Marta A.S., Croce, Giancarlo, Genolet, Raphaël, Coukos, George, Zoete, Vincent, Pojer, Florence, Bassani-Sternberg, Michal, Harari, Alexandre, Gfeller, David

Source: In Immunity 13 June 2023 56(6):1359-1375

TCR sequencing and cloning methods for repertoire analysis and isolation of tumor-reactive TCRs

Authors: Genolet, Raphael, Bobisse, Sara, Chiffelle, Johanna, Arnaud, Marion, Petremand, Rémy, Queiroz, Lise, Michel, Alexandra, Reichenbach, Patrick, Cesbron, Julien, Auger, Aymeric, Baumgaertner, Petra, Guillaume, Philippe, Schmidt, Julien, Irving, Melita, Kandalaft, Lana E., Speiser, Daniel E., Coukos, George, Harari, Alexandre

Source: In Cell Reports Methods 24 April 2023 3(4)

A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism

Authors: Maric, Tamara, Bazhin, Arkadiy, Khodakivskyi, Pavlo, Mikhaylov, Georgy, Solodnikova, Ekaterina, Yevtodiyenko, Aleksey, Giordano Attianese, Greta Maria Paola, Coukos, George, Irving, Melita, Joffraud, Magali, Cantó, Carles, Goun, Elena

Source: In Biosensors and Bioelectronics 15 January 2023 220

Structure-based optimization of type III indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors

Authors: Röhrig, Ute F., Majjigapu, Somi Reddy, Vogel, Pierre, Reynaud, Aline, Pojer, Florence, Dilek, Nahzli, Reichenbach, Patrick, Ascenção, Kelly, Irving, Melita, Coukos, George, Michielin, Olivier, Zoete, Vincent

Source: Journal of enzyme inhibition and medicinal chemistry. 37(1):1773-1811

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168531206.0x000001&indx=1&recIds=ETOCvdc_100168531206.0x000001

Lighting up the tumor fire with low-dose irradiation

Authors: Herrera, Fernanda G., Romero, Pedro, Coukos, George

Source: Trends in immunology. 43(3):173-179

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156126525.0x000001&indx=1&recIds=ETOCvdc_100156126525.0x000001

T cell receptor precision editing of regulatory T cells for celiac disease.

Authors: Porret, Raphaël, Alcaraz-Serna, Ana, Peter, Benjamin, Bernier-Latmani, Jeremiah, Cecchin, Rebecca, Alfageme-Abello, Oscar, Ermellino, Laura, Hafezi, Morteza, Pace, Eleonora, du Pré, M. Fleur, Lana, Erica, Golshayan, Dela, Velin, Dominique, Eyquem, Justin, Tang, Qizhi, Petrova, Tatiana V., Coukos, George, Irving, Melita, Pot, Caroline, Pantaleo, Giuseppe

Source: Science Translational Medicine; 3/19/2025, Vol. 17 Issue 790, p1-14, 14p

Deciphering the landscape of phosphorylated HLA-II ligands

Authors: Solleder, Marthe ^{1, 2}, Racle, Julien ^{1, 2}, Guillaume, Philippe ¹, Coukos, George ^{1, 3}, Bassani-Sternberg, Michal ^{1, 3, ∗}, Gfeller, David ^{1, 2, 4, ∗∗}

Source: In iScience 20 May 2022 25(5)