Augmenting clinical trials in asthma through digital technology, decentralised designs, and person-centric endpoints: opportunities and challenges

Authors: van Boven, Job F M ^{a, *}, Costello, Richard W ^b, Roes, Kit C B ^c, Brusselle, Guy G ^{d, e}, Hansen, Kjeld ^{f, g}, Krishnan, Jerry A ^h, Brightling, Christopher E ⁱ, Roche, Nicolas ^j, Siddiqui, Salman ^k, Kirenga, Bruce J ^l, Pinnock, Hilary ^m, Chan, Amy H Y ⁿ

Source: In The Lancet Respiratory Medicine February 2025 13(2):177-188

Automatic Audio-Based Classification of Patient Inhaler Use: A Pharmacy Based Study

Authors: McNulty, Johnny, Reilly, Richard B., Taylor, Terence E., O'Dwyer, Susan M., Costello, Richard W., Zigel, Yaniv

Source: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE. :2606-2609 Jul, 2019

Relation: 2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

Cliques within the Crowd: Identifying Medical Conference Attendee Subgroups by Their Motivations for Participation

Authors: Ram, Sai Sreenidhi, Stricker, Daniel, Pannetier, Carine, Tabin, Nathalie, Costello, Richard W., Stolz, Daiana, Eva, Kevin W., Huwendiek, Sören

Source: Advances in Health Sciences Education. 2023 28(5):1485-1508.

Peer Reviewed: Y

Page Count: 24

Descriptors: Conferences (Gatherings), Medical Education, Profiles, Motivation, Participation, Attitudes

Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial

Authors: Hale, Elaine Mac, Greene, Garrett, Mulvey, Christopher, Mokoka, Matshediso C, van Boven, Job F M, Cushen, Breda, Sulaiman, Imran, Brennan, Vincent, Lombard, Lorna, Walsh, Joanne, Plunkett, Sinead, McCartan, Thomas A, Kerr, Patrick J, Reilly, Richard B, Hughes, Cian, Kent, Brian D, Jackson, David J, Butler, Marcus, Counihan, Ian, Hayes, James, Faul, John, Kelly, Martin, Convery, Rory, Nanzer, Alexandra M, Fitzgerald, J Mark, Murphy, Desmond M, Heaney, Liam G, Costello, Richard W

Source: Lancet.Respiratory medicine. 11(7):591-601

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193920330.0x000001&indx=1&recIds=ETOCvdc_100193920330.0x000001

Comparative effectiveness of anti‐IL5 and anti‐IgE biologic classes in patients with severe asthma eligible for both

Authors: Pfeffer, Paul E., Ali, Nasloon, Murray, Ruth, Ulrik, Charlotte, Tran, Trung N., Maspero, Jorge, Peters, Matthew, Christoff, George C., Sadatsafavi, Mohsen, Torres‐Duque, Carlos A., Altraja, Alan, Lehtimäki, Lauri, Papadopoulos, Nikolaos G., Salvi, Sundeep, Costello, Richard W., Cushen, Breda, Heffler, Enrico, Iwanaga, Takashi, Al‐Ahmad, Mona, Larenas‐Linnemann, Désirée, Kuna, Piotr, Fonseca, João A., Al‐Lehebi, Riyad, Rhee, Chin Kook, Perez‐de‐Llano, Luis, Perng Steve, Diahn‐Warng, Mahboub, Bassam, Wang, Eileen, Goh, Celine, Lyu, Juntao, Newell, Anthony, Alacqua, Marianna, Belevskiy, Andrey S., Bhutani, Mohit, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Bulow, Anna von, Busby, John, Canonica, Giorgio Walter, Cosio, Borja G., Dorscheid, Delbert R., Muñoz‐Esquerre, Mariana, FitzGerald, J. Mark, Gil, Esther Garcia, Gibson, Peter G., Heaney, Liam G., Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Jackson, David J., Koh, Mariko Siyue, Ko, Hsin‐Kuo Bruce, Lee, Jae Ha, Lehmann, Sverre, Chaves Loureiro, Cláudia, Lúðvíksdóttir, Dóra, Menzies‐Gow, Andrew N., Mitchell, Patrick, Papaioannou, Andriana I., Popov, Todor A., Porsbjerg, Celeste M., Salameh, Laila, Sirena, Concetta, Taillé, Camille, Taube, Christian, Tohda, Yuji, Wechsler, Michael E., Price, David B.

Source: Allergy. 78(7):1934-1948

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186395201.0x000001&indx=1&recIds=ETOCvdc_100186395201.0x000001

Long-Term Cost-Effectiveness of Digital Inhaler Adherence Technologies in Difficult-to-Treat Asthma

Authors: van de Hei, Susanne J., Kim, Chong H., Honkoop, Persijn J., Sont, Jacob K., Schermer, Tjard R.J., MacHale, Elaine, Costello, Richard W., Kocks, Janwillem W.H., Postma, Maarten J., van Boven, Job F.M.

Source: In The Journal of Allergy and Clinical Immunology: In Practice October 2023 11(10):3064-3073

Impact of Initiating Biologics in Patients With Severe Asthma on Long-Term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry

Authors: Chen, Wenjia, Tran, Trung N., Sadatsafavi, Mohsen, Murray, Ruth, Wong, Nigel Chong Boon, Ali, Nasloon, Ariti, Con, Bulathsinhala, Lakmini, Gil, Esther Garcia, FitzGerald, J. Mark, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne-Sofie, Bourdin, Arnaud, von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George C., Cosio, Borja G., Costello, Richard W., Fonseca, João A., Gibson, Peter G., Yoo, Kwang-Ha, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David J., Jones, Rupert C., Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri, Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew N., Newell, Anthony, Sirena, Concetta, Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Perez-de-Llano, Luis, Perng (Steve), Diahn-Warng, Peters, Matthew, Pfeffer, Paul E., Porsbjerg, Celeste M., Popov, Todor A., Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte, Ra, Seung-Won, Wang, Eileen, Wechsler, Michael E., Price, David B.

Source: In The Journal of Allergy and Clinical Immunology: In Practice September 2023 11(9):2732-2747

Changes in inhaler inhalation acoustic features during induced bronchoconstriction: A pilot study

Authors: McCartan, Thomas A., Taylor, Terence E., Sulaiman, Imran, Costello, Richard W., Reilly, Richard B.

Source: 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference of the. :3749-3752 Aug, 2016

Relation: 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial

Authors: Lombard, Lorna, Walsh, Joanne, Plunkett, Sinead, McCartan, Thomas A, Hale, Elaine Mac ^*, Greene, Garrett ^*, Mulvey, Christopher ^*, Mokoka, Matshediso C ^*, van Boven, Job F M, Cushen, Breda, Sulaiman, Imran, Brennan, Vincent, Kerr, Patrick J, Reilly, Richard B, Hughes, Cian, Kent, Brian D, Jackson, David J, Butler, Marcus, Counihan, Ian, Hayes, James, Faul, John, Kelly, Martin, Convery, Rory, Nanzer, Alexandra M, Fitzgerald, J Mark, Murphy, Desmond M, Heaney, Liam G, Costello, Richard W ^*

Source: In The Lancet Respiratory Medicine July 2023 11(7):591-601

Influences of gender and anthropometric features on inspiratory inhaler acoustics and peak inspiratory flow rate

Authors: Taylor, Terence E., Holmes, Martin S., Sulaiman, Imran, Costello, Richard W., Reilly, Richard B.

Source: 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE. :2227-2230 Aug, 2015

Relation: 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

An acoustic method to automatically detect pressurized metered dose inhaler actuations

Authors: Taylor, Terence E., Holmes, Martin S., Sulaiman, Imran, D'Arcy, Shona, Costello, Richard W., Reilly, Richard B.

Source: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE. :4611-4614 Aug, 2014

Relation: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Integrating digital inhalers into clinical care of patients with asthma and chronic obstructive pulmonary disease

Authors: Pleasants, Roy A., Chan, Amy HY., Mosnaim, Giselle, Costello, Richard W., Dhand, Rajiv, Schworer, Stephen A., Merchant, Rajan, Tilley, Stephen L.

Source: In Respiratory Medicine December 2022 205

The Contribution of Oral and Inhaled Glucocorticoids to Adrenal Insufficiency in Asthma

Authors: Brennan, Vincent, Martin-Grace, Julie, Greene, Garrett, Heverin, Karen, Mulvey, Christopher, McCartan, Tom, Lombard, Lorna, Walsh, Joanne, Hale, Elaine Mac, Srinivasan, Shari, O’Reilly, Michael W., Thompson, Chris J., Costello, Richard W., Sherlock, Mark

Source: In The Journal of Allergy and Clinical Immunology: In Practice October 2022 10(10):2614-2623

Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma

Authors: Porsbjerg, Celeste M., Menzies-Gow, Andrew N., Tran, Trung N., Murray, Ruth B., Unni, Bindhu, Audrey Ang, Shi Ling, Alacqua, Marianna, Al-Ahmad, Mona, Al-Lehebi, Riyad, Altraja, Alan, Belevskiy, Andrey S., Björnsdóttir, Unnur S., Bourdin, Arnaud, Busby, John, Canonica, G. Walter, Christoff, George C., Cosio, Borja G., Costello, Richard W., FitzGerald, J. Mark, Fonseca, João A., Hansen, Susanne, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Jackson, David J., Kocks, Janwillem W.H., Kallieri, Maria, Bruce Ko, Hsin-Kuo, Koh, Mariko Siyue, Larenas-Linnemann, Désirée, Lehtimäki, Lauri A., Loukides, Stelios, Lugogo, Njira, Maspero, Jorge, Papaioannou, Andriana I., Perez-de-Llano, Luis, Pitrez, Paulo Márcio, Popov, Todor A., Rasmussen, Linda M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Schmid, Johannes, Siddiqui, Salman, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte, Upham, John W., Wang, Eileen, Wechsler, Michael E., Bulathsinhala, Lakmini, Carter, Victoria, Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Rowlands, Mari-Anne, Price, David B., van Boven, Job F.M.

Source: In The Journal of Allergy and Clinical Immunology: In Practice May 2022 10(5):1202-1216

An acoustic method of automatically evaluating patient inhaler technique

Authors: Holmes, Martin S., D'Arcy, Shona, Costello, Richard W., Reilly, Richard B.

Source: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE. :1322-1325 Jul, 2013

Relation: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Using acoustics to estimate inspiratory flow rate and drug removed from a dry powder inhaler

Authors: Holmes, Martin S., Seheult, Jansen, Geraghty, Colm, D'Arcy, Shona, Costello, Richard W., Reilly, Richard B.

Source: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE. :6866-6869 Jul, 2013

Relation: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Automatic identification and accurate temporal detection of inhalations in asthma inhaler recordings

Authors: Holmes, Martin S., Le Menn, Marine, D'Arcy, Shona, Rapcan, Viliam, MacHale, Elaine, Costello, Richard W., Reilly, Richard B.

Source: 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE. :2595-2598 Aug, 2012

Relation: 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort

Authors: Heaney, Liam G., Perez de Llano, Luis, Al-Ahmad, Mona, Backer, Vibeke, Busby, John, Canonica, Giorgio Walter, Christoff, George C., Cosio, Borja G., FitzGerald, J. Mark, Heffler, Enrico, Iwanaga, Takashi, Jackson, David J., Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Alacqua, Marianna, Altraja, Alan, Bjermer, Leif, Björnsdóttir, Unnur S., Bourdin, Arnaud, Brusselle, Guy G., Buhl, Roland, Costello, Richard W., Hew, Mark, Koh, Mariko Siyue, Lehmann, Sverre, Lehtimäki, Lauri, Peters, Matthew, Taillé, Camille, Taube, Christian, Tran, Trung N., Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Kerkhof, Marjan, Murray, Ruth B., Price, Chris A., Price, David B.

Source: In Chest September 2021 160(3):814-830

Patient-Selected Treatment Goals in Severe Asthma

Authors: Mulvey, Christopher, MacHale, Elaine, Greene, Garrett, Lombard, Lorna, Walsh, Joanne, Plunkett, Sinead, McCartan, Thomas A., Brennan, Vincent, O'Hannigan, Fiona, Mokoka, Matshediso, Costello, Richard W.

Source: In The Journal of Allergy and Clinical Immunology: In Practice July 2021 9(7):2732-2741

Nighttime features derived from topic models for classification of patients with COPD

Authors: Spina, Gabriele, Casale, Pierluigi, Albert, Paul S., Alison, Jennifer, Garcia-Aymerich, Judith, Clarenbach, Christian F., Costello, Richard W., Hernandes, Nidia A., Leuppi, Jörg D., Mesquita, Rafael, Singh, Sally J., Smeenk, Frank W.J.M., Tal-Singer, Ruth, Wouters, Emiel F.M., Spruit, Martijn A., den Brinker, Albertus C.

Source: In Computers in Biology and Medicine May 2021 132