Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae)

Authors: Lianza, Mariacaterina, Verdan, Maria Helena, Andrade, Jean Paulo de, Poli, Ferruccio, Almeida, Larissa C. de, Costa-Lotufo, Leticia V., Cunha Neto, Álvaro, Oliveira, Sarah C. C., Bastida, Jaume, Batista, Andrea N. L., Batista Jr., João M., Borges, Warley S.

Source: Journal of the Brazilian Chemical Society. October 2020 31(10)

Subject Terms: narciclasine, galasine, cytotoxic activity, absolute configuration, vibrational circular dichroism

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Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae

Authors: SILVA, ALLYSON Q. DA, NILIN, JEAMYLLE, LOUREIRO, SUSANA, COSTA-LOTUFO, LETICIA V.

Source: Anais da Academia Brasileira de Ciências. January 2020 92(1)

Subject Terms: emerging contaminants, mysids, sublethal effects, pharmaceuticals

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Synthesis and Cytotoxic Evaluation of 1H-1,2,3-Triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones

Authors: CHIPOLINE, INGRID C., ALVES, EVELYNE, BRANCO, PAOLA, COSTA-LOTUFO, LETICIA V., FERREIRA, VITOR F., SILVA, FERNANDO C. DA

Source: Anais da Academia Brasileira de Ciências. January 2018 90(1)

Subject Terms: Naphthoquinones, lawsone, 1,2,3-triazoles, cancer, colon adenocarcinoma, breast adenocarcinoma

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Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Authors: Ávila, Fábio N., Pinto, Francisco C. L., Sousa, Thiciana S., Torres, Maria Conceição M., Costa-Lotufo, Leticia V., Rocha, Danilo D., Vasconcelos, Mayron A. de, Cardoso-Sá, Nairley, Teixeira, Edson H., Albuquerque, Maria Rose Jane R., Silveira, Edilberto R., Pessoa, Otília D. L.

Source: Journal of the Brazilian Chemical Society. June 2017 28(6)

Subject Terms: Plectranthus ornatus, diterpenes, ent-clerodanes, bacteriostatic

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Bioprospecting Anticancer Compounds from the Marine-Derived Actinobacteria Actinomadura sp. Collected at the Saint Peter and Saint Paul Archipelago (Brazil)

Authors: Silva, Amaro E. T., Guimarães, Larissa A., Ferreira, Elthon G., Torres, Maria da Conceição M., Silva, Alison B. da, Branco, Paola C., Oliveira, Francisca Andréa S., Silva, Genivaldo G. Z., Wilke, Diego V., Silveira, Edilberto R., Pessoa, Otília Deusdenia L., Jimenez, Paula C., Costa-Lotufo, Leticia V.

Source: Journal of the Brazilian Chemical Society. March 2017 28(3)

Subject Terms: cytotoxicity, genome mining, marine microorganisms, marine natural products, prodiginine derivatives

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Elucidating the Mode of Action of Marine Natural Products through an Immunoaffinity Fluorescent (IAF) Approach

Authors: La Clair, James J., Fenical, William, Costa-Lotufo, Leticia V.

Source: Journal of the Brazilian Chemical Society. August 2016 27(8)

Subject Terms: marine natural product, mode of action, drug discovery, target identification, confocal microscopy

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Amphidinolide P from the Brazilian octocoral Stragulum bicolor

Authors: Sousa, Thiciana S., Nuzzo, Genoveffa, Torres, Maria C.M., Lopes, Norberto P., Cutignano, Adele, Jimenez, Paula C., Santos, Evelyne A., Gomes, Bruno A., Sardo, Angela, Pessoa, Otilia D.L., Costa-Lotufo, Leticia V., Fontana, Angelo

Source: Revista Brasileira de Farmacognosia. December 2015 25(6)

Subject Terms: Symbiont, Marine natural product, Chromatography, Nuclear magnetic resonance, Marine ecology

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Bioprospecting for bioactives from seaweeds: potential, obstacles and alternatives

Authors: Pereira, Renato C., Costa-Lotufo, Leticia V.

Source: Revista Brasileira de Farmacognosia. August 2012 22(4)

Subject Terms: seaweeds, marine natural products, bioprospection

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Systematic UPLC-ESI-MS/MS study on the occurrence of staurosporine and derivatives in associated marine microorganisms from Eudistoma vannamei

Authors: Andréo, Márcio A., Jimenez, Paula C., Siebra, Josy B. C. N., Costa-Lotufo, Leticia V., Vessecchi, Ricardo, Niehues, Michael, Lopes, João L. C., Lopes, Norberto P.

Source: Journal of the Brazilian Chemical Society. February 2012 23(2)

Subject Terms: Eudistoma vannamei, Streptomyces, staurosporine, LC-MS/MS, ascidian

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Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review

Authors: Ferreira, Paulo Michel P., Costa-Lotufo, Leticia V., Moraes, Manoel O., Barros, Francisco W.A., Martins, Aline M.A., Cavalheiro, Alberto J., Bolzani, Vanderlan S., Santos, Andre G., Pessoa, Claudia

Source: Anais da Academia Brasileira de Ciências. December 2011 83(4)

Subject Terms: Casearia sylvestris, folk uses, pharmacological properties

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Marine natural products

Authors: Lopes, Norberto P., Rezende, Claudia M., Costa-Lotufo, Leticia V., Fenical, William

Source: Revista Brasileira de Farmacognosia. December 2015 25(6)

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HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents

Authors: Waitman, Karoline B., de Almeida, Larissa C., Primi, Marina C., Carlos, Jorge A.E.G., Ruiz, Claudia, Kronenberger, Thales, Laufer, Stefan, Goettert, Marcia Ines, Poso, Antti, Vassiliades, Sandra V., de Souza, Vinícius A.M., Toledo, Mônica F.Z. J., Hassimotto, Neuza M.A., Cameron, Michael D., Bannister, Thomas D., Costa-Lotufo, Letícia V., Machado-Neto, João A., Tavares, Maurício T., Parise-Filho, Roberto

Source: In European Journal of Medicinal Chemistry 5 January 2024 263

Topical delivery of seriniquinone for treatment of skin cancer and fungal infections is enabled by a liquid crystalline lamellar phase

Authors: Miguel, Rodrigo dos A., Hirata, Amanda S., Salata, Giovanna C., Apolinário, Alexsandra C., Barroso, Vinicius M., Ishida, Kelly, La Clair, James J., Fenical, William, Martins, Tereza S., Costa-Lotufo, Leticia V., Lopes, Luciana B.

Source: In European Journal of Pharmaceutical Sciences 1 January 2024 192

Assessing the impact of antineoplastic drugs in the aquatic environment: State of the art and future perspective for freshwater organisms

Authors: Damasceno, Évila Pinheiro, Ribeiro, Fabianne, Costa-Lotufo, Leticia V., Soares, Amadeu M.V.M., Pavlaki, Maria D., Loureiro, Susana

Source: In Environmental Toxicology and Pharmacology April 2023 99

Hyaluronic acid nanoemulsions improve piplartine cytotoxicity in 2D and 3D breast cancer models and reduce tumor development after intraductal administration

Authors: Dartora, Vanessa F.C., Salata, Giovanna C., Passos, Julia S., Branco, Paola C., Silveira, Edilberto, Steiner, Alexandre A., Costa-Lotufo, Leticia V., Lopes, Luciana B.

Source: In International Journal of Biological Macromolecules 31 October 2022 219:84-95

Effects of trabectedin in the zebrafish Danio rerio: from cells to larvae

Authors: Damasceno, Évila Pinheiro, Charlie-Silva, Ives, Machado-Santelli, Glaucia Maria, Garnique, Anali M.B., Machado-Neto, João Agostinho, Teixeira, Simone Aparecida, Jimenez, Paula C., Carneiro, Diana, Soares, Amadeu M.V.M., Costa-Lotufo, Leticia V., Loureiro, Susana, Pavlaki, Maria D.

Source: In Environmental Advances July 2022 8

What can we learn from commercial insecticides? Efficacy, toxicity, environmental impacts, and future developments

Authors: Rezende-Teixeira, Paula, Dusi, Renata G., Jimenez, Paula C., Espindola, Laila S., Costa-Lotufo, Letícia V.

Source: In Environmental Pollution 1 May 2022 300

ANKHD1 contributes to the malignant phenotype of triple‐negative breast cancer cells

Authors: Almeida, Bruna O., Almeida, Larissa C., Costa‐Lotufo, Leticia V., Machado‐Neto, João A.

Source: Cell biology international. 46(9):1433-1446

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157750594.0x000001&indx=1&recIds=ETOCvdc_100157750594.0x000001

The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity

Authors: Kimani, Serah, Chakraborty, Suparna, Irene, Ikponmwosa, de la Mare, Jo, Edkins, Adrienne, du Toit, André, Loos, Ben, Blanckenberg, Angelique, Van Niekerk, Annick, Costa-Lotufo, Leticia V., ArulJothi, KN., Mapolie, Selwyn, Prince, Sharon

Source: In Biochemical Pharmacology August 2021 190

Glycosylated narciclasine alkaloid in Hippeastrum puniceum (Lam.) Kuntze

Authors: Feu, Amanda Eiriz, de Andrade, Jean Paulo, Ayala, Alejandro Pedro, de Almeida, Larissa Costa, Costa-Lotufo, Leticia V., Bastida, Jaume, Ellena, Javier, Borges, Warley de Souza

Source: In South African Journal of Botany January 2021 136:30-34