Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo

Authors: Diahann T. S. L. Jansen, Monique T. A. de Beijer, Robbie J. Luijten, Kitty Kwappenberg, Anna-Sophia Wiekmeijer, Amy L. Kessler, Roel F. A. Pieterman, Rachid Bouzid, Willem-Jan Krebber, Robert A. de Man, Cornelis J. M. Melief, Sonja I. Buschow

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: HBV, HLA, T cell, chronic hepatitis B, therapeutic vaccination, synthetic long peptide, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1163118/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/42979833c13449608bd111357e727466

A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection

Authors: Iris N. Pardieck, Tetje C. van der Sluis, Esmé T. I. van der Gracht, Dominique M. B. Veerkamp, Felix M. Behr, Suzanne van Duikeren, Guillaume Beyrend, Jasper Rip, Reza Nadafi, Elham Beyranvand Nejad, Nils Mülling, Dena J. Brasem, Marcel G. M. Camps, Sebenzile K. Myeni, Peter J. Bredenbeek, Marjolein Kikkert, Yeonsu Kim, Luka Cicin-Sain, Tamim Abdelaal, Klaas P. J. M. van Gisbergen, Kees L. M. C. Franken, Jan Wouter Drijfhout, Cornelis J. M. Melief, Gerben C. M. Zondag, Ferry Ossendorp, Ramon Arens

Source: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/cd51eadba8a3427fbfa02b68f915520a

Targeting the PD-1/PD-L1 Axis in Human Vitiligo

Authors: Marcella Willemsen, Cornelis J. M. Melief, Marcel W. Bekkenk, Rosalie M. Luiten

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: vitiligo, programmed cell death 1 receptor, B7-H1 antigen, immune tolerance, autoimmunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.579022/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/259d75f634c448bc80266435ae8f11d2

Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

Authors: Aurelie Hanoteau, Jared M. Newton, Rosemarie Krupar, Chen Huang, Hsuan-Chen Liu, Angelina Gaspero, Robyn D. Gartrell, Yvonne M. Saenger, Thomas D. Hart, Saskia J. Santegoets, Damya Laoui, Chad Spanos, Falguni Parikh, Padmini Jayaraman, Bing Zhang, Sjoerd H. Van der Burg, Jo A. Van Ginderachter, Cornelis J. M. Melief, Andrew G. Sikora

Source: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-19 (2019)

Subject Terms: Immunotherapy, Tumor microenvironment, Inducible nitric oxide synthase (iNOS), Cyclophosphamide, L-n6-(1-iminoethyl)-lysine (L-NIL), Chemoradiotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-018-0485-9; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/529ee5858b424de6b4b551d4e3d1d450

Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication

Authors: Gijs G. Zom, Marian M. J. H. P. Willems, Selina Khan, Tetje C. van der Sluis, Jan Willem Kleinovink, Marcel G. M. Camps, Gijsbert A. van der Marel, Dmitri V. Filippov, Cornelis J. M. Melief, Ferry Ossendorp

Source: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-13 (2018)

Subject Terms: Toll-like receptor 2, Adjuvant, Cancer vaccine, Peptide vaccination, T cell activation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-018-0455-2; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/709a690ddcf245d583864fadeb597229

Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance

Authors: Cornelis J. M. Melief, Jan H. Kessler

Source: Genome Medicine, Vol 9, Iss 1, Pp 1-3 (2017)

Subject Terms: Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-017-0439-8; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/6aab7b5786dc443a85595570bf6c3c22

Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial

Authors: Hansje-Eva Teulings, Esther P. M. Tjin, Karina J. Willemsen, Stephanie van der Kleij, Sylvia ter Meulen, E. Helen Kemp, Gabrielle Krebbers, Carel J. M. van Noesel, Cornelis L. M. C. Franken, Jan W. Drijfhout, Cornelis J. M. Melief, Ludmila Nieuweboer-Krobotova, Omgo E. Nieweg, Jos A. van der Hage, J. P. Wietze van der Veen, Germaine N. Relyveld, Rosalie M. Luiten

Source: OncoImmunology, Vol 7, Iss 4 (2018)

Subject Terms: melanoma, immunotherapy, vitiligo, cutaneous metastases, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/af615089565341d99d31eb4cf36a8748

Correction: Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C.

Authors: Carmen Elena Gómez, Beatriz Perdiguero, Victoria Jiménez, Abdelali Filali-Mouhim, Khader Ghneim, Elias K. Haddad, Esther D. Quakkerlaar, Julie Delaloye, Alexandre Harari, Thierry Roger, Thomas Duhen, Rafick P. Sékaly, Cornelis J. M. Melief, Thierry Calandra, Federica Sallusto, Antonio Lanzavecchia, Ralf Wagner, Giuseppe Pantaleo, Mariano Esteban

Source: PLoS ONE, Vol 7, Iss 9 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3465169; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/3639a6b4e6374fd2b74863fdbcdc4134

Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication

Authors: Sjoerd H van der Burg, Suzanne van Duikeren, Ramon Arens, Cornelis J M Melief, Tetje C van der Sluis, Ward Vleeshouwers, Floortje J van Haften, Iris N Pardieck, J Fréderique de Graaf, Koen van der Maaden

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/11/11/e007158.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/103d84188abd4c6ba820be7b2a53081b

Peptide emulsions in incomplete Freund’s adjuvant create effective nurseries promoting egress of systemic CD4+ and CD8+ T cells for immunotherapy of cancer

Authors: Craig L Slingluff, Marit M Melssen, Cornelis J M Melief, Caroline T Fisher

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/9/e004709.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/b097e9a4d6bc48179b97981152b135d5

ISA101 and nivolumab for HPV-16+ cancer: updated clinical efficacy and immune correlates of response

Authors: Jing Wang, Lei Feng, Qi Wang, Erminia Massarelli, Renata Ferrarotto, Michael A Curran, Jack Lee, Ignacio Wistuba, Cornelis J M Melief, Bonnie S Glisson, Kimal Rajapakshe, Cristian Coarfa, William William, Luana Guimaraes de Sousa, Jaime Rodriguez Canales, Renee L Chin, Tomas Z Barrese, Faye M Johnson

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/2/e004232.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/34f47116ff354f21a698a6dbad44cf29

Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses

Authors: Victoria A Brentville, Rachael L Metheringham, Ian Daniels, Suha Atabani, Peter Symonds, Katherine W Cook, Mireille Vankemmelbeke, Ruhul Choudhury, Poonam Vaghela, Mohamed Gijon, Ghislaine Meiners, Willem-Jan Krebber, Cornelis J M Melief, Lindy G Durrant

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/1/e000560.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/646c4a138fd4417ea278c37406bd14b0

CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis.

Authors: Mary E. Morgan, Roger P. M. Sutmuller, Hendrik J. Witteveen, Leonie M. van Duivenvoorde, Eric Zanelli, Cornelis J. M. Melief, Alies Snijders, Rienk Offringa, René R. P. de Vries, René E. M. Toes

Source: Arthritis & Rheumatism; May2003, Vol. 48 Issue 5, p1452-1460, 9p

Subject Terms: T cells, AUTOIMMUNE diseases, ARTHRITIS, MONOCLONAL antibodies, IMMUNIZATION

Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions

Authors: Hans Gelderblom, Sjoerd H van der Burg, Ferry Ossendorp, Peggy J de Vos van Steenwijk, Mariette I E van Poelgeest, Inge Roozen, Willem-Jan Krebber, Cornelis J M Melief, Frank M Speetjens, Marij J P Welters, Nikki M Loof, Sanne Boekestijn, Catharina A H Janssen, Marije Slingerland, Gijs G Zom, A Rob P M Valentijn, Nico J Meeuwenoord, Gijs A van der Marel, Dmitri V Filippov

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/10/e005016.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/116d0102ba984134b3b45409c8b1b84b

Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response.

Authors: Rezaul Karim, Bart Tummers, Craig Meyers, Jennifer L Biryukov, Samina Alam, Claude Backendorf, Veena Jha, Rienk Offringa, Gert-Jan B van Ommen, Cornelis J M Melief, Daniele Guardavaccaro, Judith M Boer, Sjoerd H van der Burg

Source: PLoS Pathogens, Vol 9, Iss 5, p e1003384 (2013)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3662672?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/18f1a6ca3a47443597998aa2f40bb378

Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C.

Authors: Carmen Elena Gómez, Beatriz Perdiguero, Victoria Jiménez, Abdelali Filali-Mouhim, Khader Ghneim, Elias K Haddad, Esther D Quakkelaar, Julie Delaloye, Alexandre Harari, Thierry Roger, Thomas Duhen, Rafick P Sékaly, Cornelis J M Melief, Thierry Calandra, Federica Sallusto, Antonio Lanzavecchia, Ralf Wagner, Giuseppe Pantaleo, Mariano Esteban

Source: PLoS ONE, Vol 7, Iss 4, p e35485 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22536391/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d2fbd70e5f1c483eba57e0bcefc85a23

Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes.

Authors: Rezaul Karim, Craig Meyers, Claude Backendorf, Kristina Ludigs, Rienk Offringa, Gert-Jan B van Ommen, Cornelis J M Melief, Sjoerd H van der Burg, Judith M Boer

Source: PLoS ONE, Vol 6, Iss 3, p e17848 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3056770?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ec10371227454d50935dfbbdb65aa0db

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors.

Authors: Esther D Quakkelaar, Anke Redeker, Elias K Haddad, Alexandre Harari, Stella Mayo McCaughey, Thomas Duhen, Abdelali Filali-Mouhim, Jean-Philippe Goulet, Nikki M Loof, Ferry Ossendorp, Beatriz Perdiguero, Paul Heinen, Carmen E Gomez, Karen V Kibler, David M Koelle, Rafick P Sékaly, Federica Sallusto, Antonio Lanzavecchia, Giuseppe Pantaleo, Mariano Esteban, Jim Tartaglia, Bertram L Jacobs, Cornelis J M Melief

Source: PLoS ONE, Vol 6, Iss 2, p e16819 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21347234/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f2fa053478d04f77baca2398b5125f5a

Effective melanoma immunotherapy in mice by the skin-depigmenting agent monobenzone and the adjuvants imiquimod and CpG.

Authors: Jasper G van den Boorn, Debby Konijnenberg, Esther P M Tjin, Daisy I Picavet, Nico J Meeuwenoord, Dmitri V Filippov, J P Wietze van der Veen, Jan D Bos, Cornelis J M Melief, Rosalie M Luiten

Source: PLoS ONE, Vol 5, Iss 5, p e10626 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2869359?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/46314c5ab5e149b893249a1b52bd1621