Controlling Pericellular Oxygen Tension in Cell Culture Reveals Distinct Breast Cancer Responses to Low Oxygen Tensions

Authors: Zachary J. Rogers, Thibault Colombani, Saad Khan, Khushbu Bhatt, Alexandra Nukovic, Guanyu Zhou, Benjamin M. Woolston, Cormac T. Taylor, Daniele M. Gilkes, Nikolai Slavov, Sidi A. Bencherif

Source: Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)

Subject Terms: anoxia, breast cancer, cancer metabolism, cell culture, hypoxia, hypoxia‐inducible factors, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/1068060eb74c48a59b7780c76e69d254

Faecalibacterium prausnitzii promotes intestinal epithelial IL-18 production through activation of the HIF1α pathway

Authors: Raphael R. Fagundes, Gabriela Bravo-Ruiseco, Shixian Hu, Sarah J. Kierans, Rinse K. Weersma, Cormac T. Taylor, Gerard Dijkstra, Hermie J. M. Harmsen, Klaas Nico Faber

Source: Frontiers in Microbiology, Vol 14 (2023)

Subject Terms: HIF1α, IL-18, intestine, epithelial-bacteria interaction, HoxBan in vitro coculture system, Faecalibacterium, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2023.1298304/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/5f37fa2f42fd405ca3fe8ff2670a47dc

Targeting hypoxia-inducible factor-1 alpha suppresses Helicobacter pylori-induced gastric injury via attenuation of both cag-mediated microbial virulence and proinflammatory host responses

Authors: Jennifer M. Noto, M. Blanca Piazuelo, Judith Romero-Gallo, Alberto G. Delgado, Giovanni Suarez, Konstantina Akritidou, Miguel Girod Hoffman, Juan Carlos Roa, Cormac T. Taylor, Richard M. Peek

Source: Gut Microbes, Vol 15, Iss 2 (2023)

Subject Terms: Helicobacter pylori, gastric inflammation, gastric cancer, hypoxia-inducible factor-1 alpha (HIF-1α), dimethyloxalylglycine (DMOG), prolyl hydroxylase (PHD), Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/5ca1554c76e54c8382886b3806ff21b3

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer

Authors: Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, Jonathan M. Harnoss

Source: JCI Insight, Vol 7, Iss 22 (2022)

Subject Terms: Inflammation, Oncology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/a20876b916204a5480cf7df3a59468fb

HIF1α-Dependent Induction of TFRC by a Combination of Intestinal Inflammation and Systemic Iron Deficiency in Inflammatory Bowel Disease

Authors: Raphael R. Fagundes, Arno R. Bourgonje, Shixian Hu, Ruggero Barbieri, Bernadien H. Jansen, Nienke Sinnema, Tjasso Blokzijl, Cormac T. Taylor, Rinse K. Weersma, Klaas Nico Faber, Gerard Dijkstra

Source: Frontiers in Physiology, Vol 13 (2022)

Subject Terms: HIF1α, TFRC, iron deficiency, inflammation, inflammatory bowel disease, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2022.889091/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/e4a7a598a9e746c48a15192845949bc6

Non-dipping nocturnal blood pressure correlates with obstructive sleep apnoea severity in normotensive subjects and may reverse with therapy

Authors: Sophie J. Crinion, Jana Kleinerova, Brian Kent, Geraldine Nolan, Cormac T. Taylor, Silke Ryan, Walter T. McNicholas

Source: ERJ Open Research, Vol 7, Iss 3 (2021)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://openres.ersjournals.com/content/7/3/00338-2021.full; https://doaj.org/toc/2312-0541

Access URL: https://doaj.org/article/36b68107a5004d3ab3c67fe1020f54c9

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses

Authors: Moritz J. Strowitzki, Gwendolyn Kimmer, Julian Wehrmann, Alina S. Ritter, Praveen Radhakrishnan, Vanessa M. Opitz, Christopher Tuffs, Marvin Biller, Julia Kugler, Ulrich Keppler, Jonathan M. Harnoss, Johannes Klose, Thomas Schmidt, Alfonso Blanco, Cormac T. Taylor, Martin Schneider

Source: JCI Insight, Vol 6, Iss 8 (2021)

Subject Terms: Gastroenterology, Inflammation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/76b029c8965e460eac6d2501514203de

Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier FunctionSummary

Authors: Mario C. Manresa, Cormac T. Taylor

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 3, Pp 303-315 (2017)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X17300358; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/a21cd237032a42898676917038349492

Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines

Authors: Mykyta I. Malkov, Chee Teik Lee, Cormac T. Taylor

Source: Cells, Vol 10, Iss 9, p 2340 (2021)

Subject Terms: hypoxia, HIF, HIF-1α, inflammation, TNF-α, IL-1β, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/9/2340; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/bfdc95fe18b947c587e0315d28d64f73

Increased Virulence of Bloodstream Over Peripheral Isolates of P. aeruginosa Identified Through Post-transcriptional Regulation of Virulence Factors

Authors: Caitríona Hickey, Bettina Schaible, Scott Nguyen, Daniel Hurley, Shabarinath Srikumar, Séamus Fanning, Eric Brown, Bianca Crifo, David Matallanas, Siobhán McClean, Cormac T. Taylor, Kirsten Schaffer

Source: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Subject Terms: infection, virulence, bloodstream, pseudomonas, proteomics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcimb.2018.00357/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/adcaf4dce143402196a01b3f82dae03e

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

Authors: Javier Rodriguez, Ruth Pilkington, Amaya Garcia Munoz, Lan K. Nguyen, Nora Rauch, Susan Kennedy, Naser Monsefi, Ana Herrero, Cormac T. Taylor, Alex von Kriegsheim

Source: Cell Reports, Vol 14, Iss 11, Pp 2745-2760 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716301462; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/00ee3bfef4a149938e0c86349229f870

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

Authors: Moritz J. Strowitzki, Eoin P. Cummins, Cormac T. Taylor

Source: Cells, Vol 8, Iss 5, p 384 (2019)

Subject Terms: hypoxia, prolyl hydroxylation, hypoxia-inducible factor, mass spectrometry, HIF-prolyl hydroxylases, factor inhibiting HIF, Cep192, IKK-β, p105, p53, FOXO3a, OTUB1, MAPK6, RIPK4, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/8/5/384; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/6f279bdbc63143f4986b347c3a48a102

Hypoxia in the Gut

Authors: Cormac T. Taylor, PhD

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 1, Pp 61-62 (2018)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X1730139X; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/fb19c337daea47cbb8d8af862e48c241

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans.

Authors: Cormac T. Taylor¹

Source: Physiology. Oct2010, Vol. 25 Issue 5, p272-279. 8p.

Subject Terms: *METAZOA, *MOLECULAR evolution, *OXYGEN, *BIOSENSORS, *PHYSIOLOGICAL control systems, *TRANSCRIPTION factors, *ATMOSPHERIC chemistry

SUMO, hypoxia and the regulation of metabolism.

Authors: Terence A. Agbor¹, Cormac T. Taylor¹

Source: Biochemical Society Transactions. 2008, Vol. 36 Issue 3, p445-448. 4p.

Subject Terms: *HYPOXEMIA, *METABOLIC regulation, *MOLECULAR dynamics, *PROTEIN-protein interactions, *PROTEIN structure, *UBIQUITIN

Mitochondria and cellular oxygen sensing in the HIF pathway.

Authors: Cormac T. Taylor¹

Source: Biochemical Journal. 2008, Vol. 409 Issue 1, p19-26. 8p.

Subject Terms: *MITOCHONDRIA, *CELL respiration, *OXYGEN, *GLUCOSE, *HYPOXEMIA, *METABOLISM

Effects of Heat Shock and Hypoxia on Neonatal Neutrophil Lipopolysaccharide Responses: Altered Apoptosis, Toll-Like Receptor-4 and CD11b Expression Compared with Adults.

Authors: Eleanor J. Molloy, Amanda J. O’Neill, Belinda T. Doyle, Julie J. Grantham, Cormac T. Taylor, Margaret Sheridan-Pereira, John M. Fitzpatrick, David W. Webb, R. William G. Watson

Source: Biology of the Neonate; 2006, Vol. 90 Issue 1, p34-39, 6p

Cholera Toxin Potentiates Influences of IFN-? Through Activation of NF-?B and Release of Tumor Necrosis Factor-a.

Authors: Richard S. Blumberg, Richard S. Pitman, Cormac T. Taylor, Sean P. Colgan

Source: Journal of Interferon & Cytokine Research; Apr2005, Vol. 25 Issue 4, p209-219, 11p

Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells.

Authors: Ronan N. T. Coffey, Colm Morrissey, Cormac T. Taylor, John M. Fitzpatrick, R. William G. Watson

Source: Cancer (0008543X); Mar2005, Vol. 103 Issue 7, p1363-1374, 12p

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