Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells

Authors: Nicholas L. Truex, Aurélie Rondon, Simon L. Rössler, Cameron C. Hanna, Yehlin Cho, Bin-You Wang, Coralie M. Backlund, Emi A. Lutz, Darrell J. Irvine, Bradley L. Pentelute

Source: ACS Central Science, Vol 9, Iss 9, Pp 1835-1845 (2023)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2374-7951

Access URL: https://doaj.org/article/3b8544d1b1234d348b85508d3574f3fb

Identification of Highly Cross-Reactive Mimotopes for a Public T Cell Response in Murine Melanoma

Authors: Beth E. Grace, Coralie M. Backlund, Duncan M. Morgan, Byong H. Kang, Nishant K. Singh, Brooke D. Huisman, C. Garrett Rappazzo, Kelly D. Moynihan, Laura Maiorino, Connor S. Dobson, Taeyoon Kyung, Khloe S. Gordon, Patrick V. Holec, Overbeck C. Takou Mbah, Daniel Garafola, Shengwei Wu, J. Christopher Love, K. Dane Wittrup, Darrell J. Irvine, Michael E. Birnbaum

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: mimotope, endogenous retrovirus, T cell receptor, antigen, melanoma, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.886683/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/974ae2fd3083480d86e6565189e0552e

Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression

Authors: Kim Bich Nguyen, Malte Roerden, Christopher J Copeland, Coralie M Backlund, Nory G Klop-Packel, Tanaka Remba, Byungji Kim, Nishant K Singh, Michael E Birnbaum, Darrell J Irvine, Stefani Spranger

Source: eLife, Vol 12 (2023)

Subject Terms: neoantigens, heterogeneity, cross-presenting DC, checkpoint blockade, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/85263; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/9322e2334e694187a616ac7046594ee7