591: A novel high-throughput screening assay for PTC readthrough modulators relies on the native CFTR gene: Profiling of known compounds

Authors: Liang, F., Jordan, N., Shang, H., Cantu, S., Wang, L., Bell, A., Valley, H., Cheng, Y., Coote, K., Bihler, H., Mense, M.

Source: Journal of cystic fibrosis. 20(2):S280-S281

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144921303.0x000001&indx=1&recIds=ETOCvdc_100144921303.0x000001

614 Sensitized high-throughput screening for translational readthrough promoters in the context of the native cystic fibrosis transmembrane conductance regulator R1162X gene

Authors: Liang, F., Shang, H., Cheng, Y., Wang, L., Cantu, S., Shepard, J., Bell, A., Valley, H., Coote, K., Bihler, H., Mense, M.

Source: Journal of cystic fibrosis. 21(2):S340-S340

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186132973.0x000001&indx=1&recIds=ETOCvdc_100186132973.0x000001

634 Generation of a cystic fibrosis transmembrane conductance regulator R1162X 'TAG' model and comparison of readthrough to the naturally occurring R1162X 'TGA'

Authors: Bukis, K., Cheng, Y., Armstrong, M., Conte, J., Coote, K., Allaire, N., Sivachenko, A., Mense, M., Cotton, C., Valley, H.

Source: Journal of cystic fibrosis. 21(2):S349-S349

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186132757.0x000001&indx=1&recIds=ETOCvdc_100186132757.0x000001

631 Comparing F508del cystic fibrosis transmembrane conductance regulator modulator responses in human primary enteric monolayer and human bronchial epithelial cultures

Authors: Chin, J., Mulligan, M., Harrington, J., Bihler, H., Mense, M., Coote, K.

Source: Journal of cystic fibrosis. 21(2):S347-S347

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186132735.0x000001&indx=1&recIds=ETOCvdc_100186132735.0x000001

641 Building toward the future: The Cystic Fibrosis Foundation Therapeutics Lab as an expanding repository of primary cells with rare genotypes for cystic fibrosis research

Authors: Bailey, V., Mulligan, M., Arnold, K., Patel, D., Bhatt, P., Harrington, J., Bihler, H., Mense, M., Coote, K.

Source: Journal of cystic fibrosis. 21(2):S352-S352

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186132664.0x000001&indx=1&recIds=ETOCvdc_100186132664.0x000001

663 Modulation of cystic fibrosis transmembrane conductance regulator intron 22 alternative polyadenylation use may have therapeutic potential for the treatment of certain 3′ cystic fibrosis transmembrane conductance regulator premature termination codon variants

Authors: Allaire, N., Yoon, J., Armstrong, M., Valley, H., Macadino, C., Sivachenko, A., Conte, J., Tabak, B., Bihler, H., Cheng, Y., Coote, K., Cotton, C., Mense, M.

Source: Journal of cystic fibrosis. 21(2):S363-S363

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186132470.0x000001&indx=1&recIds=ETOCvdc_100186132470.0x000001

WS16.03 LUNAR-CF: an mRNA replacement approach for cystic fibrosis lung disease

Authors: Geller, D., Perez-Garcia, C.G., Pei, Y., Liu, X., Engelhardt, J., Hodges, C., Mense, M., Coote, K., Cheng, Y., Mahoney, J.E., Parker, S., Chivukula, P.

Source: Journal of cystic fibrosis. 21(1):S31-S31

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170624639.0x000001&indx=1&recIds=ETOCvdc_100170624639.0x000001

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines

Authors: Hunt, T., Atherton-Watson, H. C., Axford, J., Collingwood, S. P., Coote, K. J., Cox, B., Czarnecki, S., Danahay, H., Devereux, N., Howsham, C.

Source: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 22(2):929-932

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN304964101&indx=1&recIds=ETOCRN304964101

The guinea-pig tracheal potential difference as an in vivo model for the study of epithelial sodium channel function in the airways

Authors: Coote, K. J., Atherton, H., Young, A., Sugar, R., Burrows, R., Smith, N. J., Schlaeppi, J. M., Groot-Kormelink, P. J., Gosling, M., Danahay, H.

Source: BRITISH JOURNAL OF PHARMACOLOGY. 155(7):1025-1033

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN240800353&indx=1&recIds=ETOCRN240800353

Camostat Attenuates Airway Epithelial Sodium Channel Function in Vivo through the Inhibition of a Channel-Activating Protease

Authors: Coote, K., Atherton-Watson, H.C., Sugar, R., Young, A., MacKenzie-Beevor, A., Gosling, M., Bhalay, G., Bloomfield, G., Dunstan, A., Bridges, R.J., Sabater, J.R., Abraham, W.M., Tully, D., Pacoma, R., Schumacher, A., Harris, J., Danahay, H. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics May 2009 329(2):764-774

Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect

Authors: Stevenson, C. S., Coote, K., Webster, R., Johnston, H., Atherton, H. C., Nicholls, A., Giddings, J., Sugar, R., Jackson, A., Press, N. J.

Source: AMERICAN JOURNAL OF PHYSIOLOGY. 288(3):L514-L522

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN164880794&indx=1&recIds=ETOCRN164880794

MUCOCILIARY CLEARANCE IS ENHANCED IN RAT MODELS OF CIGARETTE SMOKE AND LIPOPOLYSACCHARIDE-INDUCED LUNG DISEASE

Authors: Coote, K., Nicholls, A., Atherton, H. C., Sugar, R., Danahay, H.

Source: EXPERIMENTAL LUNG RESEARCH. 30(1):59-72

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN143607730&indx=1&recIds=ETOCRN143607730

Development and testing of a Faces Scale for the assessment of anxiety in critically ill patients

Authors: McKinley, S., Coote, K., Stein-Parbury, J.

Source: JOURNAL OF ADVANCED NURSING. 41(1):73-79

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN128892000&indx=1&recIds=ETOCRN128892000

328 Cystic Fibrosis Foundation Therapeutics Lab: Omics data repository from cystic fibrosis–relevant in vitro cell models

Authors: Allaire, N., Sivachenko, A., Conte, J., Tabak, B., Armstrong, M., Chado, M., Yoon, J., Mahoney, J., Valley, H., Coote, K., Bihler, H., Cotton, C., Mense, M.

Source: In Journal of Cystic Fibrosis October 2023 22 Supplement 3:S164-S164

307 Development of a robust protocol for functional assessment of CFTR in human primary enteric monolayer cultures grown on permeable filter supports

Authors: Chin, J., Mulligan, M., Patel, D., Arnold, K., Bhatt, P., Harrington, J., Bihler, H., Mense, M., Coote, K.

Source: In Journal of Cystic Fibrosis October 2023 22 Supplement 3:S154-S155

305 Comparing functional responses of nonsense CFTR variants to modulators in human primary enteric monolayer, human bronchial epithelial, and 16hBEge cell cultures

Authors: Chin, J., Mulligan, M., Patel, D., Arnold, K., Bhatt, P., Harrington, J., Cheng, Y., Bihler, H., Mense, M., Coote, K.

Source: In Journal of Cystic Fibrosis October 2023 22 Supplement 3:S153-S154

273 Screening the Calibr ReFRAME drug-repurposing library for efficient functional restoration of native CFTR nonsense variants

Authors: Liang, F., Shang, H., Cheng, Y., Cantu, S., Wang, L., Shepard, J., Coote, K., Bihler, H., Mense, M.

Source: In Journal of Cystic Fibrosis October 2023 22 Supplement 3:S138-S138

258 Standardization and utilization of human induced pluripotent stem cells for in vitro disease modeling of cystic fibrosis

Authors: Atarod, S., Lu, J., Stuffer, A., Momyer, V., Harrington, J., Tabak, B., Coote, K., Cotton, C., Mense, M., Mahoney, J.

Source: In Journal of Cystic Fibrosis October 2023 22 Supplement 3:S130-S131

257 Evaluating genetic components to move toward a highly effective CFTR super exon

Authors: Yan, K., Bell, A., Macadino, C., Conte, J., Armstrong, M., Cheng, Y., Coote, K., Allaire, N., Sivachenko, A., Mense, M., Cotton, C., Valley, H.

Source: In Journal of Cystic Fibrosis October 2023 22 Supplement 3:S130-S130

244 Cystic Fibrosis Foundation Therapeutics Lab: Biorepository expansion to represent a broad range of cystic fibrosis patients

Authors: Arnold, K., Bailey, V., Mulligan, M., Patel, D., Bhatt, P., Harrington, J., Bihler, H., Mense, M., Coote, K.

Source: In Journal of Cystic Fibrosis October 2023 22 Supplement 3:S124-S125