Constitutive androstane receptor (CAR) functions as a tumor suppressor via regulating stemness in liver cancer

Authors: Sarah Da Won Bae, Romario Nguyen, Lawrence Yuen, Vincent Lam, Jacob George, Liang Qiao

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Subject Terms: CITCO, Constitutive androstane receptor (CAR), Hepatocellular carcinoma (HCC), Liver cancer, Liver cancer stem cells (LCSCs), Tumor suppressor, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/96242bd5821e49de8561bd90e2de49cb

Switch/sucrose nonfermentable complex interacts with constitutive androstane receptor to regulate drug-metabolizing enzymes and transporters in the liver

Authors: Kurosawa, Kiamu ¹, Nakano, Masataka ^{1, 2, ∗}, Yokoseki, Itsuki ¹, Tomii, Mei ¹, Higuchi, Yuichiro ³, Uehara, Shotaro ³, Yoneda, Nao ³, Suemizu, Hiroshi ³, Fukami, Tatsuki ^{1, 2}, Nakajima, Miki ^{1, 2, ∗}

Source: In Drug Metabolism and Disposition February 2025

Isoform-level expression of the constitutive androstane receptor (CAR or NR1I3) transcription factor better predicts the mRNA expression of the cytochrome P450s in human liver samples

Authors: Collins, Joseph M., Wang, Danxin ^∗

Source: In Drug Metabolism and Disposition January 2025 53(1)

Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt‐Foxo1 Pathway

Authors: Mélusine Monrose, Hélène Holota, Guillaume Martinez, Christelle Damon‐Soubeyrand, Laura Thirouard, Emmanuelle Martinot, Edwige Battistelli, Angélique deHaze, Stéphanie Bravard, Christelle Tamisier, Françoise Caira, Charles Coutton, Anne‐Laure Barbotin, Angèle Boursier, Laila Lakhal, Claude Beaudoin, David H. Volle

Source: Advanced Science, Vol 11, Iss 43, Pp n/a-n/a (2024)

Subject Terms: constitutive androstane receptor, Foxo1, repro‐toxicity, spermatogonia, xenobiotic, Science

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Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/5c0cfff5dc2646119bde8165b727621e

Spatial Transcriptomic Study Reveals Heterogeneous Metabolic Adaptation and a Role of Pericentral PPARα/CAR/Ces2a Axis During Fasting in Mouse Liver

Authors: Shiguan Wang, Bowen Xu, Jinyuan Liang, Yawei Feng, Penghu Han, Jing Shen, Xinying Li, Mengqi Zheng, Tingguo Zhang, Cuijuan Zhang, Ping Mi, Yi Zhang, Zhiping Liu, Shiyang Li, Detian Yuan

Source: Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)

Subject Terms: constitutive androstane receptor (CAR), fasting response, liver zonation, metabolic heterogeneity, peroxisome proliferator‐activated receptor alpha (Pparα), spatial transcriptomics, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/86ae09b61b4a4b199f6a6a5d1138824c

Induction of cytochrome P450 via upregulation of CAR and PXR: a potential mechanism for altered florfenicol metabolism by macranthoidin B in vivo

Authors: Si-cong Li, Bin Wang, Min Zhang, Qin Yin, Zi-yi Yang, Xu-ting Li, Ge Liang

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: macranthoidin B, cytochrome P450, constitutive androstane receptor, pregnane X receptor, florfenicol, pharmacokinetics, Therapeutics. Pharmacology, RM1-950

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Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1460948/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/70c8ed3a7b3d495f8a5627e44871e219

CYP P450 and non-CYP P450 Drug Metabolizing Enzyme Families Exhibit Differential Sensitivities towards Proinflammatory Cytokine Modulation

Authors: de Jong, Laura M., Harpal, Chandan, van den Berg, Dirk-Jan, Hoekstra, Menno, Peter, Nienke J., Rissmann, Robert, Swen, Jesse J., Manson, Martijn L. ^*

Source: In Drug Metabolism and Disposition December 2024 52(12):1429-1437

Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor

Authors: Xiao Cheng, Vijaya Bhaskar Baki, Matthew Moran, Baolong Liu, Jiujiu Yu, Miaoyun Zhao, Qingsheng Li, Jean-Jack Riethoven, Channabasavaiah B. Gurumurth, Edward N. Harris, Xinghui Sun

Source: Molecular Metabolism, Vol 86, Iss , Pp 101977- (2024)

Subject Terms: Matrin-3, Constitutive androstane receptor, Steatosis, Stress response, Signaling, Gene expression, Internal medicine, RC31-1245

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Relation: http://www.sciencedirect.com/science/article/pii/S221287782400108X; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/d17136cbcd9146458760bd3e5f1829c2

Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

Authors: Wenjie Tang, Xuan Xiang, Houfu Wang, Wentao Zhou, Liuqin He, Yulong Yin, Tiejun Li

Source: Animal Nutrition, Vol 16, Iss , Pp 23-33 (2024)

Subject Terms: Zinc lactate, Intestinal barrier, Oxidative stress, Inflammation, Constitutive androstane receptor, Gut microbiota, Animal culture, SF1-1100

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Relation: http://www.sciencedirect.com/science/article/pii/S2405654523001324; https://doaj.org/toc/2405-6545

Access URL: https://doaj.org/article/a140d94833ba4a47a8a364be28e301f2

Cytochrome P450 and UDP-Glucuronosyltransferase Expressions, Activities, and Induction Abilities in 3D-Cultured Human Renal Proximal Tubule Epithelial Cells

Authors: Hashiba, Shiori, Nakano, Masataka ^*, Yokoseki, Itsuki, Takahashi, Etsushi, Kondo, Masayuki, Jimbo, Yoichi, Ishiguro, Naoki, Arakawa, Hiroshi, Fukami, Tatsuki, Nakajima, Miki ^*

Source: In Drug Metabolism and Disposition September 2024 52(9):949-956

Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance

Authors: Goettel, Manuela ^{a, ⁎}, Werner, Christoph ^a, Honarvar, Naveed ^b, Gröters, Sibylle ^b, Fegert, Ivana ^a, Haines, Corinne ^{c, 1}, Chatham, Lynsey R. ^{c, 2}, Vardy, Audrey ^c, Lake, Brian G. ^d

Source: In Toxicology June 2024 505

Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application

Authors: Tatiana A. Fedotcheva, Maria E. Uspenskaya, Darya N. Ulchenko, Nikolay L. Shimanovsky

Source: Pharmaceuticals, Vol 17, Iss 9, p 1186 (2024)

Subject Terms: androstenes, DHEA, 5-AED, nuclear receptors, membrane receptors, constitutive androstane receptor CAR, Medicine, Pharmacy and materia medica, RS1-441

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Relation: https://www.mdpi.com/1424-8247/17/9/1186; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/ad2315f0fe87475bbf1cabfc5b18df4b

Risk Assessment of Displaced Sediment by an Extreme Event Cyclone in a Peri-Urban Zone Using Bioassays and Analytical Chemistry

Authors: Louis A. Tremblay, Daisuke Nakajima, Satoshi Endo, Mayuko Yagishita, Hannah Ludlow, Ariana Mackay, Olivier Champeau

Source: Toxics, Vol 12, Iss 8, p 558 (2024)

Subject Terms: New Zealand, Microtox, mussel embryo test, yeast two-hybrid assay, aryl hydrocarbon receptor, constitutive androstane receptor, Chemical technology, TP1-1185

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Relation: https://www.mdpi.com/2305-6304/12/8/558; https://doaj.org/toc/2305-6304

Access URL: https://doaj.org/article/4df24622689749308630757df7799459

Xenobiotic-sensing nuclear receptors as targets for phthalates-induced lung injury and antagonism of lycopene

Authors: Shi, Yu-Sheng ^{a, 1}, Zhao, Yi ^{a, b, c, 1}, Li, Xue-Nan ^{a, b, c}, Li, Mu-Zi ^a, Li, Jin-Long ^{a, b, c, ∗}

Source: In Chemosphere January 2023 312 Part 1

Atypical functions of xenobiotic receptors in lipid and glucose metabolism

Authors: Wang Jingyuan, Lu Peipei, Xie Wen

Source: Medical Review, Vol 2, Iss 6, Pp 611-624 (2022)

Subject Terms: aryl hydrocarbon receptor, constitutive androstane receptor, lipid metabolism, pregnane x receptor, xenobiotic receptors, Medicine

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Relation: https://doaj.org/toc/2749-9642

Access URL: https://doaj.org/article/c605b3583f4a4fcd864bea75eff309e2

Coumarin and Its Derivatives

Contributors: Matos, Maria João

Subject Terms: coumarin, hydroxyl-modified coumarin, photophysical, thermal and structural characterization, Glycyrrhiza uralensis, glycyrol, liquiritigenin, cholinesterases, human monoamine oxidases, kinetics, docking simulation, chalcone, neurodegenerative diseases, adenosine receptors, binding affinity, docking, 4-hydroxy-7-methoxycoumarin, macrophage, inflammation, NF-κB, MAPK, calanolides, pseudocalanolides, calanolide A, Calophyllum, Calophyllaceae, anti-HIV, reverse transcriptase, non-nucleoside reverse transcriptase inhibitors (NNRTIs), osthole, umbelliferone, esculin, 4-hydroxycoumarin, sorafenib, apoptosis, autophagy, Yin Chen Hao, constitutive androstane receptor, scoparone, coumarins, quorum sensing, QS inhibitors, plant-derived molecules, Chromobacterium violaceum, immunoproteasome, psoralen core, non-peptidic, electrophilic compounds, warhead scan, inflammatory bowel disease, isocoumarin, Crohn’s disease, ulcerative colitis, glutathione, oxidative stress, complementary therapies, intestinal inflammation, benzopyrones, five-membered aromatic heterocycles, furan, pyrrole, thiophene, selenophen, dihydrocoumarin-fused dihydropyranones, 3-aroylcoumarines, benzyl 2,3-butadienoate, 6’-(4-biphenyl)-β-iso-cinchonine, biological applications, drug discovery, fluorescent probes, warfarin, acenocoumarol, mechanical valve, time in therapeutic range, anticoagulation, Ruta chalepensis, Rutaceae, chalepin, chalepensin, bioactivity, biosynthesis, coumarin3-carboxamides, pyranocoumarins, anticancer activity, antibacterial activity, free radical polymerization, LED, photocomposites, direct laser write, analytical methods, model plant, natural genetic variation, natural products, simple coumarins, chalcocoumarin, MAO-B, molecular dynamics, in silico studies, dye-sensitized solar cells, coumarin dyes, thieno [3,2-b] thiophene, charge transfer, ethynylaryl, esculetin, antiplatelet activity, impedance aggregometry, COX, polyphenols, pyrazole, imidazole, thiazole, oxazole, triazole, thiadiazole, curcumin, curcumin–coumarin hybrids, neuroprotection, monoamine oxidase inhibition, cholinesterase inhibition, scavenging activity, Escherichia coli, biotransformation, ferulenol, structural annotation, in silico tools, Research and information: general, Biology, life sciences

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Access URL: https://directory.doabooks.org/handle/20.500.12854/77168
https://mdpi.com/books/pdfview/book/4786

AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors

Authors: Leonida Rakateli, Rosanna Huchzermeier, Emiel P. C. van der Vorst

Source: Cells, Vol 12, Iss 23, p 2752 (2023)

Subject Terms: lipid metabolism, cardiometabolic diseases, xenobiotic receptors, aryl hydrocarbon receptor, pregnane X receptor, constitutive androstane receptor, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/23/2752; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/eef165e01ac04eb0997c75f4f4ca8453

CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders

Authors: Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Véronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal

Source: Cells, Vol 12, Iss 18, p 2218 (2023)

Subject Terms: NAFLD, sexual dimorphism, constitutive androstane receptor, high-fat diet, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/18/2218; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/723b4e568dd542d3a783abf73120936d

Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation

Authors: Yue Gao, Shicheng Fan, Hua Li, Yiming Jiang, Xinpeng Yao, Shuguang Zhu, Xiao Yang, Ruimin Wang, Jianing Tian, Frank J. Gonzalez, Min Huang, Huichang Bi

Source: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 727-737 (2021)

Subject Terms: Constitutive androstane receptor, Nuclear receptors, Hepatomegaly, Liver enlargement, Liver regeneration, Yes-associated protein, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S2211383520308182; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/fa24103f7b074f3983c2d072fbc3e240

Nuclear receptors and non-alcoholic fatty liver disease: An update

Authors: Xiao Yang, Frank J. Gonzalez, Min Huang, Huichang Bi

Source: Liver Research, Vol 4, Iss 2, Pp 88-93 (2020)

Subject Terms: Nuclear receptors (NRs), Non-alcoholic fatty liver disease (NAFLD), Pregnane X receptor (PXR), Constitutive androstane receptor (CAR), Farnesoid X receptor (FXR), Peroxisome proliferator activated receptor (PPAR), Diseases of the digestive system. Gastroenterology, RC799-869

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Relation: http://www.sciencedirect.com/science/article/pii/S2542568420300088; https://doaj.org/toc/2542-5684

Access URL: https://doaj.org/article/96c1b87ba73a404c9f52313208b89394