Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury

Authors: Nicole Labusek, Yanis Mouloud, Christian Köster, Eva Diesterbeck, Tobias Tertel, Constanze Wiek, Helmut Hanenberg, Peter A. Horn, Ursula Felderhoff-Müser, Ivo Bendix, Bernd Giebel, Josephine Herz

Source: Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-21 (2023)

Subject Terms: Neonatal encephalopathy, Hypoxia–ischemia, Neuroinflammation, Neuroregeneration, Mesenchymal stromal cells, Extracellular vesicles, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/1880-8190

Access URL: https://doaj.org/article/b4dc79ed4c2e48f19a57a34a599d13ea

Cell-based BSEP trans-inhibition: A novel, non-invasive test for diagnosis of antibody-induced BSEP deficiency

Authors: Jan Stindt, Carola Dröge, Elke Lainka, Simone Kathemann, Eva-Doreen Pfister, Ulrich Baumann, Amelie Stalke, Enke Grabhorn, Mohammad Ali Shagrani, Yael Mozer-Glassberg, Jane Hartley, Marianne Wammers, Caroline Klindt, Paulina Philippski, Roman Liebe, Diran Herebian, Ertan Mayatepek, Thomas Berg, Anjona Schmidt-Choudhury, Constanze Wiek, Helmut Hanenberg, Tom Luedde, Verena Keitel

Source: JHEP Reports, Vol 5, Iss 7, Pp 100690- (2023)

Subject Terms: AIBD, Progressive familial intrahepatic cholestasis type 2, Non-invasive diagnostic test, Anti-BSEP antibody, Liver transplantation, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555923000216; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/e0f0ced14a1a400c90fd20022215385d

Profiling the 3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level

Authors: Margaretha A. Skowron, Katharina Eul, Alexa Stephan, Gillian F. Ludwig, Gamal A. Wakileh, Arthur Bister, Christian Söhngen, Katharina Raba, Patrick Petzsch, Gereon Poschmann, Edmund Osei Kuffour, Daniel Degrandi, Shafaqat Ali, Constanze Wiek, Helmut Hanenberg, Carsten Münk, Kai Stühler, Karl Köhrer, Elvira Mass, Daniel Nettersheim

Source: Molecular Oncology, Vol 16, Iss 17, Pp 3107-3127 (2022)

Subject Terms: cisplatin resistance, extracellular matrix, germ cell tumors, tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/ffe3528d607a4047bb2b60d1084aaa8d

Proteomic and transcriptomic profiles of human urothelial cancer cells with histone deacetylase 5 overexpression

Authors: Ananda Ayyappan Jaguva Vasudevan, Michèle J. Hoffmann, Gereon Poschmann, Patrick Petzsch, Constanze Wiek, Kai Stühler, Karl Köhrer, Wolfgang A. Schulz, Günter Niegisch

Source: Scientific Data, Vol 9, Iss 1, Pp 1-7 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/31a9b4a026c34b6694b497aa3c502bac

A novel CD34-derived hinge for rapid and efficient detection and enrichment of CAR T cells

Authors: Arthur Bister, Tabea Ibach, Corinna Haist, Denise Smorra, Katharina Roellecke, Martin Wagenmann, Kathrin Scheckenbach, Norbert Gattermann, Constanze Wiek, Helmut Hanenberg

Source: Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 534-546 (2021)

Subject Terms: chimeric antigen receptor, CAR, hinge, CD34, detection, MACS enrichment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770521001522; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/00a59fbab47c466695dfcb76861adbf7

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

Authors: David Schlütermann, Niklas Berleth, Jana Deitersen, Nora Wallot-Hieke, Olena Friesen, Wenxian Wu, Fabian Stuhldreier, Yadong Sun, Lena Berning, Annabelle Friedrich, María José Mendiburo, Christoph Peter, Constanze Wiek, Helmut Hanenberg, Anja Stefanski, Kai Stühler, Björn Stork

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6972ad6fb1594ad394a0391385e1a71d

The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas

Authors: Luka de Vos, Ingela Grünwald, Emma Grace Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich

Source: Epigenetics, Vol 15, Iss 11, Pp 1195-1212 (2020)

Subject Terms: cd28, cd80, cd86, ctla4, icos, dna methylation, immune checkpoint, hnscc, prognosis, tumour microenvironment, hpv, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/57166499a8bc49da998576e00116f167

Genetic Engineering and Enrichment of Human NK Cells for CAR-Enhanced Immunotherapy of Hematological Malignancies

Authors: Maren Soldierer, Arthur Bister, Corinna Haist, Aniththa Thivakaran, Sevgi Can Cengiz, Stephanie Sendker, Nina Bartels, Antonia Thomitzek, Denise Smorra, Maryam Hejazi, Markus Uhrberg, Kathrin Scheckenbach, Cornelia Monzel, Constanze Wiek, Dirk Reinhardt, Naghmeh Niktoreh, Helmut Hanenberg

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: human NK cells, chimeric antigen receptor, genetic engineering, lentiviral vectors (LVS), adoptive cellular immunotherapy, transduction, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.847008/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f102cedf2f6e4a91b9262405441f2aea

Epigenetic Priming of Bladder Cancer Cells With Decitabine Increases Cytotoxicity of Human EGFR and CD44v6 CAR Engineered T-Cells

Authors: Camilla M. Grunewald, Corinna Haist, Carolin König, Patrick Petzsch, Arthur Bister, Elfriede Nößner, Constanze Wiek, Kathrin Scheckenbach, Karl Köhrer, Günter Niegisch, Helmut Hanenberg, Michèle J. Hoffmann

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: epigenetic inhibitors, bladder cancer, chimeric antigen receptor, immunotherapy, T-cell, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.782448/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/512c4135cac04c4ea5c0bf21f0fa8e19

DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients’ survival, immune cell infiltrates, mutational load, and interferon γ signature

Authors: Verena Sailer, Ulrike Sailer, Emma Grace Bawden, Romina Zarbl, Constanze Wiek, Timo J. Vogt, Joern Dietrich, Sophia Loick, Ingela Grünwald, Marieta Toma, Carsten Golletz, Andreas Gerstner, Glen Kristiansen, Friedrich Bootz, Kathrin Scheckenbach, Jennifer Landsberg, Dimo Dietrich

Source: EBioMedicine, Vol 48, Iss , Pp 341-352 (2019)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396419306498; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/19f13459f3a443e282ec3bbaa5759ff0

Upregulation of the long non-coding RNA CASC9 as a biomarker for squamous cell carcinoma

Authors: Madeleine Sassenberg, Johanna Droop, Wolfgang A. Schulz, Dimo Dietrich, Sophia Marie Loick, Constanze Wiek, Kathrin Scheckenbach, Nadine T. Gaisa, Michèle J. Hoffmann

Source: BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)

Subject Terms: Head-and-neck carcinoma, HNSCC, Squamous cell carcinoma, Biomarker, Long non-coding RNA, CASC9, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-019-6021-6; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/115d49ac3a2c49debea39eedcc596b40

HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for 'Off-the-Shelf' Immunotherapy

Authors: Keven Hoerster, Markus Uhrberg, Constanze Wiek, Peter A. Horn, Helmut Hanenberg, Stefan Heinrichs

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: NK cells, B2M knockout, HLA class I, off-the-shelf, allogeneic, genome editing, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.586168/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0287831f3ff941d5a6039e67b90ff70d

Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

Authors: Leonie Drews, Marcel Zimmermann, Philipp Westhoff, Dominik Brilhaus, Rebecca E. Poss, Laura Bergmann, Constanze Wiek, Peter Brenneisen, Roland P. Piekorz, Tabea Mettler-Altmann, Andreas P. M. Weber, Andreas S. Reichert

Source: Disease Models & Mechanisms, Vol 13, Iss 10 (2020)

Subject Terms: hepatic encephalopathy, hyperammonemia, mitochondria, tca cycle, glutamate dehydrogenase, brain energy metabolism, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/13/10/dmm047134; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/a98e16054ed149a2bca13acdf13b0d47

Effects of novel HDAC inhibitors on urothelial carcinoma cells

Authors: Aline Kaletsch, Maria Pinkerneil, Michèle J. Hoffmann, Ananda A. Jaguva Vasudevan, Chenyin Wang, Finn K. Hansen, Constanze Wiek, Helmut Hanenberg, Christoph Gertzen, Holger Gohlke, Matthias U. Kassack, Thomas Kurz, Wolfgang A. Schulz, Günter Niegisch

Source: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-18 (2018)

Subject Terms: Histone deacetylase HDAC4, Class IIA HDACs, Histone deacetylase inhibitor, Urothelial bladder cancer, Cell cycle arrest, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13148-018-0531-y; https://doaj.org/toc/1868-7075; https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/e87d19bc77ef4eaa9cb7bb52c1e09692

The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling

Authors: Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher, Sebastian Heikaus

Source: Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-14 (2017)

Subject Terms: ARC, Apoptosis, Bcl-2 family, renal cell carcinoma (RCC), ABT-263, TRAIL, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12964-017-0170-5; https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/719614e47c2b4761a2747fcd0330dbeb

Subcellular Localization and Mitotic Interactome Analyses Identify SIRT4 as a Centrosomally Localized and Microtubule Associated Protein

Authors: Laura Bergmann, Alexander Lang, Christoph Bross, Simone Altinoluk-Hambüchen, Iris Fey, Nina Overbeck, Anja Stefanski, Constanze Wiek, Andreas Kefalas, Patrick Verhülsdonk, Christian Mielke, Dennis Sohn, Kai Stühler, Helmut Hanenberg, Reiner U. Jänicke, Jürgen Scheller, Andreas S. Reichert, Mohammad Reza Ahmadian, Roland P. Piekorz

Source: Cells, Vol 9, Iss 9, p 1950 (2020)

Subject Terms: sirtuin, SIRT4, interactome, centrosome, mitosis, HDAC6, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/9/1950; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/a6074553cc1f43e5aa630ee3f5397b69

Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures

Authors: Oscar P. B. Wiklander, R. Beklem Bostancioglu, Joshua A. Welsh, Antje M. Zickler, Florian Murke, Giulia Corso, Ulrika Felldin, Daniel W. Hagey, Björn Evertsson, Xiu-Ming Liang, Manuela O. Gustafsson, Dara K. Mohammad, Constanze Wiek, Helmut Hanenberg, Michel Bremer, Dhanu Gupta, Mikael Björnstedt, Bernd Giebel, Joel Z. Nordin, Jennifer C. Jones, Samir EL Andaloussi, André Görgens

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: exosomes, microvesicles, extracellular vesicles, extracellular vesicle flow cytometry, bead-based flow cytometry, exosome analysis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.01326/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a6a6d7e767944fd78fe871876b07b319

Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.

Authors: Eva M Schmidt, Constanze Wiek, Oliver T Parkinson, Katharina Roellecke, Marcel Freund, Michael Gombert, Nadine Lottmann, Charles A Steward, Christof M Kramm, Vladimir Yarov-Yarovoy, Allan E Rettie, Helmut Hanenberg

Source: PLoS ONE, Vol 10, Iss 9, p e0137110 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4565547?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/261fb5b8bb424db787a397f4d477e106

A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.

Authors: Ioannis Gavvovidis, Isabell Rost, Marc Trimborn, Frank J Kaiser, Josephine Purps, Constanze Wiek, Helmut Hanenberg, Heidemarie Neitzel, Detlev Schindler

Source: PLoS ONE, Vol 7, Iss 8, p e40387 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3431399?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2272c1b9132c4f0c8323584a0b883d3a

DLK-1 as a Marker to Distinguish Unrestricted Somatic Stem Cells and Mesenchymal Stromal Cells in Cord Blood.

Authors: Simone Maria Kluth, Anja Buchheiser, Amelie Pia Houben, Stefanie Geyh, Thomas Krenz, Teja Falk Radke, Constanze Wiek, Helmut Hanenberg, Petra Reinecke, Peter Wernet, Gesine Kögler

Source: Stem Cells & Development; Oct2010, Vol. 19 Issue 10, p1471-1483, 13p