Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging.

Authors: Delgado-Goñi, Teresa^1,2 (AUTHOR), Connor-Robson, Natalie^1,3 (AUTHOR), Cioroch, Milena^1,3 (AUTHOR), Paisey, Stephen⁴ (AUTHOR), Marshall, Christopher⁴ (AUTHOR), Lane, Emma L.⁵ (AUTHOR), Hauton, David⁶ (AUTHOR), McCullagh, James⁶ (AUTHOR), Magill, Peter J.^1,7 (AUTHOR), Cragg, Stephanie J.^1,3 (AUTHOR), Mackay, Clare E.^1,2 (AUTHOR), Wade-Martins, Richard^1,3 (AUTHOR), Klein, Johannes C.^1,8 (AUTHOR) johannes.klein@ndcn.ox.ac.uk

Source: Scientific Reports. 5/7/2025, Vol. 15 Issue 1, p1-10. 10p.

Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease

Authors: Kilfeather, Peter ^{1, 2, 3, 5}, Khoo, Jia Hui ^{4, 5}, Wagner, Katherina ¹, Liang, Han ⁴, Caiazza, Maria Claudia ^{1, 2, 3}, An, Yanru ⁴, Zhang, Xingju ⁴, Chen, Xiaoyan ⁴, Connor-Robson, Natalie ¹, Shang, Zhouchun ^{4, ∗}, Wade-Martins, Richard ^{1, 2, 3, 6, ∗∗}

Source: In Cell Reports 26 March 2024 43(3)

Inhibition of striatal dopamine release by the L‐type calcium channel inhibitor isradipine co‐varies with risk factors for Parkinson's.

Authors: Brimblecombe, Katherine R.^1,2,3 (AUTHOR) katherine.brimblecombe@dpag.ox.ac.uk, Connor‐Robson, Natalie^1,2 (AUTHOR), Bataille, Carole J. R.^4,5 (AUTHOR), Roberts, Bradley M.^1,2 (AUTHOR), Gracie, Caitlin¹ (AUTHOR), O'Connor, Bethan¹ (AUTHOR), te Water Naude, Rebecca¹ (AUTHOR), Karthik, Gayathri¹ (AUTHOR), Russell, Angela J.^4,5 (AUTHOR), Wade‐Martins, Richard^1,2,3 (AUTHOR), Cragg, Stephanie J.^1,2,3 (AUTHOR)

Source: European Journal of Neuroscience. Mar2024, Vol. 59 Issue 6, p1242-1259. 18p.

Subject Terms: *DOPAMINERGIC neurons, *RYANODINE receptors, *PARKINSON'S disease, *CALCIUM channels, *DOPAMINE receptors, *DOPAMINE, *SEX (Biology), *SUBSTANTIA nigra

β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins

Authors: Ninkina, Natalia, Millership, Steven J., Peters, Owen M., Connor-Robson, Natalie, Chaprov, Kirill, Kopylov, Arthur T., Montoya, Alex, Kramer, Holger, Withers, Dominic J., Buchman, Vladimir L.

Source: In Journal of Biological Chemistry December 2021 297(6)

Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits

Authors: Simanaviciute, Ugne, Ahmed, Jewel, Brown, Richard E, Connor-Robson, Natalie, Farr, Tracy D., Fertan, Emre, Gambles, Nikki, Garland, Huw, Morton, A. Jennifer, Staiger, Jochen F., Skillings, Elizabeth A., Trueman, Rebecca C., Wade-Martins, Richard, Wood, Nigel I., Wong, Aimee A., Grant, Robyn A. ^*

Source: In Journal of Neuroscience Methods 1 February 2020 331

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes

Authors: Booth, Heather D.E., Wessely, Frank, Connor-Robson, Natalie, Rinaldi, Federica, Vowles, Jane, Browne, Cathy, Evetts, Samuel G., Hu, Michele T., Cowley, Sally A., Webber, Caleb, Wade-Martins, Richard

Source: In Neurobiology of Disease September 2019 129:56-66

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2

Authors: Connor-Robson, Natalie, Booth, Heather, Martin, Jeffrey G., Gao, Benbo, Li, Kejie, Doig, Natalie, Vowles, Jane, Browne, Cathy, Klinger, Laura, Juhasz, Peter, Klein, Christine, Cowley, Sally A., Bolam, Paul, Hirst, Warren, Wade-Martins, Richard

Source: In Neurobiology of Disease July 2019 127:512-526

Are rodent models of Parkinson’s disease behaving as they should?

Authors: Vingill, Siv, Connor-Robson, Natalie, Wade-Martins, Richard

Source: In Behavioural Brain Research 15 October 2018 352:133-141

Assaying Microglia Functions In Vitro.

Authors: Maguire, Emily¹ (AUTHOR) maguiree1@cardiff.ac.uk, Connor-Robson, Natalie¹ (AUTHOR), Shaw, Bethany¹ (AUTHOR), O'Donoghue, Rachel¹ (AUTHOR), Stöberl, Nina¹ (AUTHOR), Hall-Roberts, Hazel¹ (AUTHOR)

Source: Cells (2073-4409). Nov2022, Vol. 11 Issue 21, p3414. 25p.

Subject Terms: *MICROGLIA, *PLURIPOTENT stem cells, *CENTRAL nervous system, *PHAGOCYTOSIS, *IMMUNOMODULATORS, *NEURAL circuitry

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Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism

Authors: Connor-Robson, Natalie, Peters, Owen M., Millership, Steven, Ninkina, Natalia, Buchman, Vladimir L.

Source: In Neurobiology of Aging October 2016 46:107-112

Cell type-specific functions of Alzheimer's disease endocytic risk genes.

Authors: Maninger, Johanna-Katharina, Nowak, Karolina, Goberdhan, Srilakshmi, O'Donoghue, Rachel, Connor-Robson, Natalie

Source: Philosophical Transactions of the Royal Society B: Biological Sciences; 4/8/2024, Vol. 379 Issue 1899, p1-14, 14p

Subject Terms: DISEASE risk factors, CELL physiology, CELL anatomy, GENOME-wide association studies, SYNAPTIC vesicles, COATED vesicles

Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor Phenotype in Transgenic Mice

Authors: Shelkovnikova, Tatyana A., Peters, Owen M., Deykin, Alexey V., Connor-Robson, Natalie, Robinson, Hannah, Ustyugov, Alexey A., Bachurin, Sergey O., Ermolkevich, Tatyana G., Goldman, Igor L., Sadchikova, Elena R., Kovrazhkina, Elena A., Skvortsova, Veronica I., Ling, Shuo-Chien ^**, Da Cruz, Sandrine ^**, Parone, Philippe A. ^**, Buchman, Vladimir L., Ninkina, Natalia N.

Source: In Journal of Biological Chemistry 30 August 2013 288(35):25266-25274

Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.

Authors: Williamson, Matthew G, Madureira, Marta, McGuinness, William, Heon-Roberts, Rachel, Mock, Elliot D, Naidoo, Kalina, Cramb, Kaitlyn M L, Caiazza, Maria-Claudia, Malpartida, Ana B, Lavelle, Martha, Savory, Katrina, Humble, Stewart W, Patterson, Ryan, Davis, John B, Connor-Robson, Natalie, Ryan, Brent J, Wade-Martins, Richard

Source: Human Molecular Genetics; 9/15/2023, Vol. 32 Issue 18, p2808-2821, 14p

Contrasting Effects of α-Synuclein and γ-Synuclein on the Phenotype of Cysteine String Protein α (CSPα) Null Mutant Mice Suggest Distinct Function of these Proteins in Neuronal Synapses

Authors: Ninkina, Natalia, Peters, Owen M., Connor-Robson, Natalie, Lytkina, Olga, Sharfeddin, Essam, Buchman, Vladimir L.

Source: In Journal of Biological Chemistry 28 December 2012 287(53):44471-44477

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.

Authors: Threlfell, Sarah, Mohammadi, Amir Saeid, Ryan, Brent J., Connor-Robson, Natalie, Platt, Nicola J., Anand, Rishi, Serres, Florence, Sharp, Trevor, Bengoa-Vergniory, Nora, Wade-Martins, Richard, Ewing, Andrew, Cragg, Stephanie J., Brimblecombe, Katherine R.

Source: Frontiers in Cellular Neuroscience; 4/15/2021, Vol. 15, pN.PAG-N.PAG, 12p

Subject Terms: MONOAMINE transporters, DOPAMINE, LABORATORY mice, PARKINSON'S disease, BIOLOGY, BINDING sites, DOPAMINE receptors, CHOLESTEROL

"LRRK2: Autophagy and Lysosomal Activity".

Authors: Madureira, Marta, Connor-Robson, Natalie, Wade-Martins, Richard

Source: Frontiers in Neuroscience; 5/25/2020, Vol. 14, p1-19, 19p

Subject Terms: DARDARIN, PARKINSON'S disease, PROTEOLYSIS, GLYCOGEN storage disease type II

LRRK2 interacts with the vacuolar-type H⁺-ATPase pump a1 subunit to regulate lysosomal function.

Authors: Wallings, Rebecca, Connor-Robson, Natalie, Wade-Martins, Richard

Source: Human Molecular Genetics; 8/15/2019, Vol. 28 Issue 16, p2696-2710, 15p

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