Immune‐deficient MISTRG mice support expansion of leukaemia‐initiating cells in xenograft models of paediatric acute myeloid leukaemia.

Authors: Connerty, Patrick¹ (AUTHOR), Xie, Jinhan¹ (AUTHOR), El‐Najjar, Fatima¹ (AUTHOR), Trahair, Toby N.^1,2 (AUTHOR), Jayatilleke, Nisitha¹ (AUTHOR), Mayoh, Chelsea¹ (AUTHOR), Lock, Richard B.¹ (AUTHOR) rlock@ccia.org.au

Source: British Journal of Haematology. Feb2025, p1. 5p. 2 Illustrations.

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

Authors: Salik, Basit, Yi, Hangyu, Hassan, Nunki, Santiappillai, Nancy, Vick, Binje, Connerty, Patrick, Duly, Alastair, Trahair, Toby, Woo, Andrew J., Beck, Dominik, Liu, Tao, Spiekermann, Karsten, Jeremias, Irmela, Wang, Jianlong, Kavallaris, Maria, Haber, Michelle, Norris, Murray D., Liebermann, Dan A., D'Andrea, Richard J., Murriel, Christopher, Wang, Jenny Y.

Source: In Cancer Cell 10 August 2020 38(2):263-278

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

Authors: Lynch, Jennifer R., Salik, Basit, Connerty, Patrick, Vick, Binje, Leung, Halina, Pijning, Aster, Jeremias, Irmela, Spiekermann, Karsten, Trahair, Toby, Liu, Tao, Haber, Michelle, Norris, Murray D., Woo, Andrew J., Hogg, Philip, Wang, Jianlong, Wang, Jenny Y.

Source: Leukemia. 33(6):1400-1410

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194084943.0x000001&indx=1&recIds=ETOCvdc_100194084943.0x000001

The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells

Authors: Connerty, Patrick, Bajan, Sarah, Remenyi, Judit, Fuller-Pace, Frances V., Hutvagner, Gyorgy

Source: In BBA - Gene Regulatory Mechanisms October 2016 1859(10):1299-1305

The tip of the iceberg—The roles of long noncoding RNAs in acute myeloid leukemia.

Authors: Connerty, Patrick, Lock, Richard B.

Source: Wiley Interdisciplinary Reviews: RNA; Nov2023, Vol. 14 Issue 6, p1-18, 18p

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia.

Authors: Moles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla

Source: Science Translational Medicine; 5/17/2023, Vol. 15 Issue 696, p1-17, 17p

Subject Terms: BISPECIFIC antibodies, DOXORUBICIN, POLYMERSOMES, MONONUCLEAR leukocytes, LEUKEMIA, CELL receptors, TREATMENT effectiveness

Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells.

Authors: Mesbahi, Yashar, Trahair, Toby N., Lock, Richard B., Connerty, Patrick

Source: Frontiers in Oncology; 2/10/2022, Vol. 12, p1-17, 17p

Subject Terms: HEMATOPOIETIC stem cells, STEM cells, ACUTE myeloid leukemia, AMINO acid metabolism, LIPID metabolism

RNA Binding Proteins in the miRNA Pathway.

Authors: Connerty, Patrick¹ patrick.connerty@student.uts.edu.au, Ahadi, Alireza² alireza.ahadi@uts.edu.au, Hutvagner, Gyorgy² gyorgy.hutvagner@uts.edu.au;

Source: International Journal of Molecular Sciences. 2016, Vol. 17 Issue 1, p31. 16p. 2 Color Photographs, 1 Black and White Photograph, 1 Chart.

Subject Terms: *RNA-binding proteins, *MICRORNA, *ORIGIN of life, *NUCLEOTIDES, *NUCLEIC acids

Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia.

Authors: Connerty, Patrick^1,2,3 (AUTHOR) pconnerty@ccia.org.au, Moles, Ernest^1,2,3,4 (AUTHOR) EMoles@ccia.org.au, de Bock, Charles E.^1,2,3 (AUTHOR) CDeBock@ccia.org.au, Jayatilleke, Nisitha¹ (AUTHOR) njayatilleke@ccia.org.au, Smith, Jenny L.^5,6 (AUTHOR) jlsmith3@fredhutch.org, Meshinchi, Soheil^5,6 (AUTHOR) smeshinc@fredhutch.org, Mayoh, Chelsea^1,2 (AUTHOR) CMayoh@ccia.org.au, Kavallaris, Maria^1,2,3,4 (AUTHOR) MKavallaris@ccia.org.au, Lock, Richard B.^1,2,3 (AUTHOR) rlock@ccia.org.au

Source: Pharmaceutics. Oct2021, Vol. 13 Issue 10, p1681-1681. 1p.

Subject Terms: *THERAPEUTICS, *ACUTE myeloid leukemia, *MONONUCLEAR leukocytes, *LIPIDS, *TRANSCRIPTOMES, *LINCRNA

Company/Entity: UNITED States. Food & Drug Administration

Shwachman–Bodian–Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia

Authors: Dun, Matthew D., Mannan, Abdul, Rigby, Callum J., Butler, Stephen, Toop, Hamish D., Beck, Dominik, Connerty, Patrick, Sillar, Jonathan, Kahl, Richard G. S., Duchatel, Ryan J., Germon, Zacary, Faulkner, Sam, Chi, Mengna, Skerrett-Byrne, David, Murray, Heather C., Flanagan, Hayley, Almazi, Juhura G., Hondermarck, Hubert, Nixon, Brett, De Iuliis, Geoff, Chamberlain, Janis, Alvaro, Frank, de Bock, Charles E., Morris, Jonathan C., Enjeti, Anoop K., Verrills, Nicole M.

Source: Leukemia; December 2020, Vol. 34 Issue: 12 p3393-3397, 5p

Long Non-coding RNAs: Major Regulators of Cell Stress in Cancer.

Authors: Connerty, Patrick, Lock, Richard B., de Bock, Charles E.

Source: Frontiers in Oncology; 3/20/2020, p1-7, 7p

Subject Terms: NON-coding RNA, CANCER cells, APOPTOSIS, OXIDATIVE stress, DNA damage, GENETIC transcription in plants, WARBURG Effect (Oncology)

The tip of the iceberg—The roles of long noncoding RNAsin acute myeloid leukemia

Authors: Connerty, Patrick, Lock, Richard B.

Source: Wiley Interdisciplinary Reviews: RNA; November 2023, Vol. 14 Issue: 6