BMP4 and Temozolomide Synergize in the Majority of Patient-Derived Glioblastoma Cultures.

Authors: Verploegh, Iris S. C.^1,2 (AUTHOR) i.verploegh@erasmusmc.nl, Conidi, Andrea^2,3 (AUTHOR), El Hassnaoui, Hoesna¹ (AUTHOR), Verhoeven, Floor A. M.¹ (AUTHOR), Korporaal, Anne L.² (AUTHOR), Ntafoulis, Ioannis¹ (AUTHOR), van den Hout, Mirjam C. G. N.^2,4 (AUTHOR), Brouwer, Rutger W. W.^2,4 (AUTHOR), Lamfers, Martine L. M.¹ (AUTHOR), van IJcken, Wilfred F. J.^2,4 (AUTHOR), Huylebroeck, Danny² (AUTHOR), Leenstra, Sieger¹ (AUTHOR) s.leenstra@erasmusmc.nl

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p10176. 14p.

Subject Terms: *BONE morphogenetic proteins, *DRUG synergism, *MEDICAL research, *INHIBITION of cellular proliferation, *TEMOZOLOMIDE, *CANCER stem cells

Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis

Authors: de Haan, Willeke, Dheedene, Wouter, Apelt, Katerina, Décombas-Deschamps, Sofiane, Vinckier, Stefan, Verhulst, Stefaan, Conidi, Andrea, Deffieux, Thomas, Staring, Michael W, Vandervoort, Petra, Caluwé, Ellen, Lox, Marleen, Mannaerts, Inge, Takagi, Tsuyoshi, Jaekers, Joris, Berx, Geert, Haigh, Jody, Topal, Baki, Zwijsen, An, Higashi, Yujiro, van Grunsven, Leo A, van IJcken, Wilfred F J, Mulugeta, Eskeatnaf, Tanter, Mickael, Lebrin, Franck P G, Huylebroeck, Danny, Luttun, Aernout

Source: Cardiovascular research. 118(5):1262-1275

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100147369590.0x000001&indx=1&recIds=ETOCvdc_100147369590.0x000001

Zeb2 regulates the balance between retinal interneurons and Müller glia by inhibition of BMP–Smad signaling

Authors: Menuchin-Lasowski, Yotam, Dagan, Bar, Conidi, Andrea, Cohen-Gulkar, Mazal, David, Ahuvit, Ehrlich, Marcelo, Giladi, Pazit Oren, Clark, Brian S., Blackshaw, Seth, Shapira, Keren, Huylebroeck, Danny, Henis, Yoav I., Ashery-Padan, Ruth

Source: In Developmental Biology 1 December 2020 468(1-2):80-92

Integrative and perturbation‐based analysis of the transcriptional dynamics of TGFβ/BMP system components in transition from embryonic stem cells to neural progenitors

Authors: Dries, Ruben, Stryjewska, Agata, Coddens, Kathleen, Okawa, Satoshi, Notelaers, Tineke, Birkhoff, Judith, Dekker, Mike, Verfaillie, Catherine M., Sol, Antonio, Mulugeta, Eskeatnaf, Conidi, Andrea, Grosveld, Frank G., Huylebroeck, Danny

Source: Stem cells. 38(2):202-217

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099854524.0x000001&indx=1&recIds=ETOCvdc_100099854524.0x000001

Phenotype and genotype of 87 patients with Mowat–Wilson syndrome and recommendations for care

Authors: Ivanovski, Ivan, Djuric, Olivera, Caraffi, Stefano Giuseppe, Santodirocco, Daniela, Pollazzon, Marzia, Rosato, Simonetta, Cordelli, Duccio Maria, Abdalla, Ebtesam, Accorsi, Patrizia, Adam, Margaret P., Ajmone, Paola Francesca, Badura-Stronka, Magdalena, Baldo, Chiara, Baldi, Maddalena, Bayat, Allan, Bigoni, Stefania, Bonvicini, Federico, Breckpot, Jeroen, Callewaert, Bert, Cocchi, Guido, Cuturilo, Goran, De Brasi, Daniele, Devriendt, Koenraad, Dinulos, Mary Beth, Hjortshøj, Tina Duelund, Epifanio, Roberta, Faravelli, Francesca, Fiumara, Agata, Formisano, Debora, Giordano, Lucio, Grasso, Marina, Grønborg, Sabine, Iodice, Alessandro, Iughetti, Lorenzo, Kuburovic, Vladimir, Kutkowska-Kazmierczak, Anna, Lacombe, Didier, Lo Rizzo, Caterina, Luchetti, Anna, Malbora, Baris, Mammi, Isabella, Mari, Francesca, Montorsi, Giulia, Moutton, Sebastien, Møller, Rikke S., Muschke, Petra, Nielsen, Jens Erik Klint, Obersztyn, Ewa, Pantaleoni, Chiara, Pellicciari, Alessandro, Pisanti, Maria Antonietta, Prpic, Igor, Poch-Olive, Maria Luisa, Raviglione, Federico, Renieri, Alessandra, Ricci, Emilia, Rivieri, Francesca, Santen, Gijs W., Savasta, Salvatore, Scarano, Gioacchino, Schanze, Ina, Selicorni, Angelo, Silengo, Margherita, Smigiel, Robert, Spaccini, Luigina, Sorge, Giovanni, Szczaluba, Krzysztof, Tarani, Luigi, Tone, Luis Gonzaga, Toutain, Annick, Trimouille, Aurelien, Te Valera, Elvis rci, Vergano, Samantha Schrier, Zanotta, Nicoletta, Zenker, Martin, Conidi, Andrea, Zollino, Marcella, Rauch, Anita, Zweier, Christiane, Garavelli, Livia

Source: In Genetics in Medicine September 2018 20(9):965-975

Differentiation of Mouse Enteric Nervous System Progenitor Cells Is Controlled by Endothelin 3 and Requires Regulation of Ednrb by SOX10 and ZEB2

Authors: Watanabe, Yuli, Stanchina, Laure, Lecerf, Laure, Gacem, Nadjet, Conidi, Andrea, Baral, Viviane, Pingault, Veronique, Huylebroeck, Danny, Bondurand, Nadege

Source: In Gastroenterology April 2017 152(5):1139-1150

Directed Migration of Cortical Interneurons Depends on the Cell-Autonomous Action of Sip1

Authors: van den Berghe, Veronique, Stappers, Elke, Vandesande, Bram, Dimidschstein, Jordane, Kroes, Roel, Francis, Annick, Conidi, Andrea, Lesage, Flore, Dries, Ruben, Cazzola, Silvia, Berx, Geert, Kessaris, Nicoletta, Vanderhaeghen, Pierre, van IJcken, Wilfred, Grosveld, Frank G., Goossens, Steven, Haigh, Jody J., Fishell, Gord, Goffinet, André, Aerts, Stein, Huylebroeck, Danny, Seuntjens, Eve

Source: In Neuron 9 January 2013 77(1):70-82

Local delivery of hrBMP4 as an anticancer therapy in patients with recurrent glioblastoma: a first-in-human phase 1 dose escalation trial.

Authors: Bos, Eelke M., Binda, Elena, Verploegh, Iris S.C., Wembacher, Eva, Hoefnagel, Daphna, Balvers, Rutger K., Korporaal, Anne L., Conidi, Andrea, Warnert, Esther A. H., Trivieri, Nadia, Visioli, Alberto, Zaccarini, Paola, Caiola, Laura, van Wijck, Rogier, van der Spek, Peter, Huylebroeck, Danny, Leenstra, Sieger, Lamfers, Martine L.M., Ram, Zvi, Westphal, Manfred

Source: Molecular Cancer; 8/10/2023, Vol. 22 Issue 1, p1-9, 9p

Subject Terms: GLIOBLASTOMA multiforme, BONE morphogenetic proteins, CANCER stem cells, MAGNETIC resonance imaging, TUMOR growth

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

Authors: Conidi, Andrea, Cazzola, Silvia, Beets, Karen, Coddens, Kathleen, Collart, Clara, Cornelis, Frederique, Cox, Luk, Joke, Debruyn, Dobreva, Mariya P., Dries, Ruben, Esguerra, Camila, Francis, Annick, Ibrahimi, Abdelilah, Kroes, Roel, Lesage, Flore, Maas, Elke, Moya, Ivan, Pereira, Paulo N.G., Stappers, Elke, Stryjewska, Agata, van den Berghe, Veronique, Vermeire, Liesbeth, Verstappen, Griet, Seuntjens, Eve, Umans, Lieve, Zwijsen, An, Huylebroeck, Danny

Source: In Cytokine and Growth Factor Reviews 2011 22(5):287-300

Zeb2 DNA-Binding Sites in Neuroprogenitor Cells Reveal Autoregulation and Affirm Neurodevelopmental Defects, Including in Mowat-Wilson Syndrome.

Authors: Birkhoff, Judith C., Korporaal, Anne L., Brouwer, Rutger W. W., Nowosad, Karol, Milazzo, Claudia, Mouratidou, Lidia, van den Hout, Mirjam C. G. N., van IJcken, Wilfred F. J., Huylebroeck, Danny, Conidi, Andrea

Source: Genes; Mar2023, Vol. 14 Issue 3, p629, 26p

Subject Terms: IMMUNOPRECIPITATION, EMBRYONIC stem cells, NEURAL development, BINDING sites, PROGENITOR cells, SYNDROMES

Comparative single-cell RNA-sequencing profiling of BMP4-treated primary glioma cultures reveals therapeutic markers.

Authors: Verploegh, Iris S C, Conidi, Andrea, Brouwer, Rutger W W, Balcioglu, Hayri E, Karras, Panagiotis, Makhzami, Samira, Korporaal, Anne, Marine, Jean-Christophe, Lamfers, Martine, IJcken, Wilfred F J Van, Leenstra, Sieger, Huylebroeck, Danny

Source: Neuro-Oncology; Dec2022, Vol. 24 Issue 12, p2133-2145, 13p

Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis.

Authors: Haan, Willeke de, Dheedene, Wouter, Apelt, Katerina, Décombas-Deschamps, Sofiane, Vinckier, Stefan, Verhulst, Stefaan, Conidi, Andrea, Deffieux, Thomas, Staring, Michael W, Vandervoort, Petra, Caluwé, Ellen, Lox, Marleen, Mannaerts, Inge, Takagi, Tsuyoshi, Jaekers, Joris, Berx, Geert, Haigh, Jody, Topal, Baki, Zwijsen, An, Higashi, Yujiro

Source: Cardiovascular Research; Apr2022, Vol. 118 Issue 5, p1262-1275, 14p

Subject Terms: HEPATIC fibrosis, LIVER cells, CARBON tetrachloride, ENDOTHELIAL cells, TRANSCRIPTION factors

Four Amino Acids within a Tandem QxVx Repeat in a Predicted Extended α-Helix of the Smad-Binding Domain of Sip1 Are Necessary for Binding to Activated Smad Proteins.

Authors: Conidi, Andrea^1,2, van den Berghe, Veronique¹, Leslie, Kris², Stryjewska, Agata¹, Xue, Hua³, Chen, Ye-Guang³, Seuntjens, Eve¹, Huylebroeck, Danny^1,2 danny.huylebroeck@med.kuleuven.be

Source: PLoS ONE. Oct2013, Vol. 8 Issue 10, p1-16. 16p.

Subject Terms: *TANDEM repeats, *AMINO acids, *SMAD proteins, *HELIX (Mollusks), *CARRIER proteins, *ZINC-finger proteins, *GENETIC transcription, *PROTEIN-protein interactions, *EMBRYOLOGY

Aptamers and Their Potential to Selectively Target Aspects of EGF, Wnt/ß-Catenin and TGFß-Smad Family Signaling.

Authors: Conidi, Andrea¹ andrea.conidi@med.kuleuven.be, van den Berghe, Veronique¹ veronique.vandenberghe@med.kuleuven.be, Huylebroeck, Danny¹ danny.huylebroeck@med.kuleuven.be

Source: International Journal of Molecular Sciences. Apr2013, Vol. 14 Issue 4, p6690-6719. 30p. 6 Diagrams, 3 Charts.

Subject Terms: *APTAMERS, *EPIDERMAL growth factor, *WNT proteins, *CATENINS, *TRANSFORMING growth factors, *CELLULAR signal transduction, *PROTEIN-protein interactions

Targeted chromatin conformation analysis identifies novel distal neural enhancers of ZEB2 in pluripotent stem cell differentiation.

Authors: Birkhoff, Judith C, Brouwer, Rutger W W, Kolovos, Petros, Korporaal, Anne L, Bermejo-Santos, Ana, Boltsis, Ilias, Nowosad, Karol, Hout, Mirjam C G N van den, Grosveld, Frank G, IJcken, Wilfred F J van, Huylebroeck, Danny, Conidi, Andrea

Source: Human Molecular Genetics; Aug2020, Vol. 29 Issue 15, p2535-2550, 16p

Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb.

Authors: Deryckere, Astrid, Stappers, Elke, Dries, Ruben, Peyre, Elise, van den Berghe, Veronique, Conidi, Andrea, Zampeta, F. Isabella, Francis, Annick, Bresseleers, Marjolein, Stryjewska, Agata, Vanlaer, Ria, Maas, Elke, Smal, Ihor V., van IJcken, Wilfred F. J., Grosveld, Frank G., Nguyen, Laurent, Huylebroeck, Danny, Seuntjens, Eve

Source: Development (09501991); May2020, Vol. 147 Issue 10, p1-15, 15p

Subject Terms: OLFACTORY bulb, DEVELOPMENTAL neurobiology, SMAD proteins, NEURONAL differentiation, INTERNEURONS, FETAL tissues, NEURAL stem cells

Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricularsubventricular zone to the olfactory bulb.

Authors: Deryckere, Astrid, Stappers, Elke, Dries, Ruben, Peyre, Elise, van den Berghe, Veronique, Conidi, Andrea, Zampeta, F. Isabella, Francis, Annick, Bresseleers, Marjolein, Stryjewska, Agata, Vanlaer, Ria, Maas, Elke, Smal, Ihor V., van IJcken, Wilfred F. J., Grosveld, Frank G., Nguyen, Laurent, Huylebroeck, Danny, Seuntjens, Eve

Source: Development (09501991); Apr2020, Vol. 147 Issue 7, p1-38, 55p

Subject Terms: OLFACTORY bulb, DEVELOPMENTAL neurobiology, SMAD proteins, NEURONAL differentiation, INTERNEURONS, FETAL tissues, NEURAL stem cells

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Zeb2 controls the output of the young postnatal neurogenic niche

Authors: Stappers, Elke, Deryckere, Astrid, Dries, Ruben, Conidi, Andrea, van den Berghe, Veronique, Zampeta, Isabella Foteini-Izampela, Peyre, Elise, Stryjewska, Agata, Francis, Annick, Van Laer, Ria, Kessaris, Nicoletta, Nguyen, Laurent, Huylebroeck, Danny, Seuntjens, Eve

Source: In Mechanisms of Development July 2017 145 Supplement:S128-S129