Combination MCP-Mod for two-drug combination dose-ranging studies.

Authors: Zhou, Yifan¹ (AUTHOR) yifan.zhou@pfizer.com, Sloan, Abigail¹ (AUTHOR), Menon, Sandeep¹ (AUTHOR), Wang, Ling² (AUTHOR)

Source: Journal of Biopharmaceutical Statistics. Mar2025, Vol. 35 Issue 2, p257-270. 14p.

Subject Terms: *Three-dimensional modeling, Combination drug therapy, Multiple comparisons (Statistics), Factorial experiment designs, Error rates

Efficacy and Safety of Intranasal Dexmedetomidine Combined With Oral Chloral Hydrate for Sedation in Neonatal MRI Procedures: A Single‐Center Retrospective Study.

Authors: Dong, Wenyan¹, Zhu, Lingdi¹, Xu, Linlin¹, Yang, Zhenkun² yangzhkun@njmu.edu.cn, Wu, Shuoxiong¹ wxwushuoxiong@163.com, Mircea-Catalin, Fortofoiu

Source: Journal of Clinical Pharmacy & Therapeutics. 3/24/2025, Vol. 2025, p1-6. 6p.

Subject Terms: *COMBINATION drug therapy, *INTRANASAL administration, *PATIENT safety, *LEANNESS, *RESEARCH funding, *CHLORAL, *SCIENTIFIC observation, *MAGNETIC resonance imaging, *ORAL drug administration, *RETROSPECTIVE studies, *CHILDREN'S hospitals, *DRUG efficacy, *MEDICAL records, *ACQUISITION of data, *COMPARATIVE studies, *IMIDAZOLES, *ANESTHESIA, *DRUG dosage, *EVALUATION, *DRUG administration, *CHILDREN

Geographic Terms: CHINA

Is general practitioner involvement in the initiation of opioids for chronic non-cancer pain associated with opioid dose and concurrent drug use?

Authors: Høibø, Trond^1,2 (AUTHOR) trondhoibo@gmail.com, Skurtveit, Svetlana^3,4 (AUTHOR), Lid, Torgeir Gilje^1,2 (AUTHOR)

Source: Scandinavian Journal of Primary Health Care. Mar2025, Vol. 43 Issue 1, p96-99. 4p.

Subject Terms: *BENZODIAZEPINES, *COMBINATION drug therapy, *SUBSTANCE abuse, *CHRONIC pain, *DRUG side effects, *PATIENT safety, *HEALTH insurance reimbursement, *RESEARCH funding, *DECISION making in clinical medicine, *TRANQUILIZING drugs, *SURVEYS, *OPIOID analgesics

Geographic Terms: NORWAY

Point of care ultrasound in rapid diagnosis of acute cholangitis and emphysematous cholecystitis: a case report.

Authors: Chae, Min Seok¹ (AUTHOR) Minseok.chae.qu@gmail.com, Kravchuk, Olga A.¹ (AUTHOR)

Source: International Journal of Emergency Medicine. 2/20/2025, Vol. 18 Issue 1, p1-5. 5p.

Subject Terms: *COMBINATION drug therapy, *BLOOD, *CHOLANGITIS, *ABDOMINAL pain, *COMPUTED tomography, *FLUID therapy, *RAPID diagnostic tests, *HOSPITAL emergency services, *AMPICILLIN, *BLOOD plasma substitutes, *CLOSTRIDIUM, *TREATMENT effectiveness, *ACALCULOUS cholecystitis, *SEPTIC shock, *INTUBATION, *CELL culture, *ESCHERICHIA coli, *NORADRENALINE, *INTENSIVE care units, *VOMITING, *CHOLECYSTOSTOMY, *DIABETES, *ENDOSCOPIC retrograde cholangiopancreatography, *GALLSTONES, *PENICILLIN

Possibilities of Overcoming Resistance to Osimertinib in NSCLC Patients with Mutations in the EGFR Gene.

Authors: Nicoś, Marcin¹ (AUTHOR) krapa@poczta.onet.pl, Sroka-Bartnicka, Anna² (AUTHOR) anna.sroka-bartnicka@umlub.pl, Kalinka, Ewa³ (AUTHOR) ewakalinka@wp.pl, Krawczyk, Paweł¹ (AUTHOR)

Source: Cancers. Feb2025, Vol. 17 Issue 4, p563. 20p.

Subject Terms: *THERAPEUTIC use of antineoplastic agents, *COMBINATION drug therapy, *DRUG resistance in cancer cells, *PATIENT safety, *PROTEIN-tyrosine kinase inhibitors, *CANCER patients, *COMBINED modality therapy, *LUNG cancer, *GENETIC mutation, *EPIDERMAL growth factor receptors

Combining Sulfonylureas with Anticancer Drugs: Evidence of Synergistic Efficacy with Doxorubicin In Vitro and In Vivo.

Authors: Tomczyk, Mateusz D.¹ (AUTHOR) mateusz.d.tomczyk@polsl.pl, Matczak, Karolina² (AUTHOR), Denel-Bobrowska, Marta³ (AUTHOR), Dzido, Grzegorz⁴ (AUTHOR), Kubicka, Anna^2,5 (AUTHOR), Gendosz de Carrillo, Daria^5,6 (AUTHOR), Cichoń, Tomasz⁷ (AUTHOR), Golec, Marlena⁸ (AUTHOR), Powieczko, Beata^1,9 (AUTHOR), Rzetelny, Waldemar^9,10 (AUTHOR), Olejniczak, Agnieszka B.^1,3 (AUTHOR), Pérez-Sánchez, Horacio^2,10 (AUTHOR)

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1429. 27p.

Subject Terms: *COMBINATION drug therapy, *P-glycoprotein, *ANTINEOPLASTIC agents, *CYTOTOXINS, *DRUG repositioning, *SERUM albumin

Ixekizumab as a successful treatment in pediatric generalized pustular psoriasis.

Authors: Esposito, Maria^1,2 (AUTHOR) maria.esposito3@univaq.it, Antonetti, Paolo^1,2 (AUTHOR), Vagnozzi, Emanuele^1,2 (AUTHOR), De Berardinis, Andrea² (AUTHOR), Bertelli, Roberta³ (AUTHOR), Brancati, Francesco^4,5 (AUTHOR), Fargnoli, Maria Concetta^1,2 (AUTHOR)

Source: Italian Journal of Pediatrics. 2/11/2025, Vol. 51 Issue 1, p1-5. 5p.

Subject Terms: *THERAPEUTIC use of monoclonal antibodies, *COMBINATION drug therapy, *PSORIASIS, *ERYTHEMA, *BLOOD testing, *RARE diseases, *TONSILLITIS, *NEUTROPHILS, *PREDNISONE, *FEVER, *PEDIATRICS, *MONOCLONAL antibodies, *LEUKOCYTE disorders, *INTERLEUKINS, *CHEMICAL inhibitors

HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm.

Authors: Zhou, Mengyao^1,2 (AUTHOR), Xu, Mengfan^1,3 (AUTHOR), Zhang, Xiangling⁴ (AUTHOR), Xing, Xiaochun⁴ (AUTHOR), Li, Yang⁵ (AUTHOR), Wang, Guanghui⁶ (AUTHOR), Yan, Guiying^1,2 (AUTHOR) yangy@amt.ac.cn

Source: PLoS ONE. 2/6/2025, Vol. 20 Issue 2, p1-15. 15p.

Subject Terms: *COMBINATION drug therapy, *ANGINA pectoris, *DRUG metabolism, *CHEMICAL formulas, *DRUG resistance

Efficacy and safety of sequential therapy for primary osteoporosis with bone formation promoters followed by bone resorption inhibitors: a meta-analysis.

Authors: Liu, Yuxin¹ liuyuxin_email@163.com, Liu, Xin¹ 2522804417@qq.com, Wu, Yuefeng¹ 1845166303@qq.com, Luo, Tao¹ luotao@hospital.cqmu.edu.cn

Source: Journal of Orthopaedic Surgery & Research. 2/7/2025, Vol. 20 Issue 1, p1-14. 14p.

Subject Terms: *BONE resorption, *COMBINATION drug therapy, *MEDICAL information storage & retrieval systems, *CLINICAL medicine, *BONE density, *PATIENT safety, *BONE growth, *TREATMENT effectiveness, *META-analysis, *DESCRIPTIVE statistics, *POSTMENOPAUSE, *EVALUATION of medical care, *SYSTEMATIC reviews, *MEDLINE, *FEMUR neck, *HIP joint, *MEDICAL databases, *OSTEOPOROSIS, *ONLINE information services, *CONFIDENCE intervals, *SPINE

The effect of hydroxocobalamin and methylene blue for vasoplegic syndromes: A systematic review.

Authors: Mananda, Wahyu^1,2, Musalim, Dian Anggraini Permatasari³, Oktavian, Puguh³, Budi, David Setyo³, Multazam, Chaq El Chaq Zamzam⁴, Wungu, Citrawati Dyah Kencono^5,6 citrawati.dyah@fk.unair.ac.id

Source: Electronic Journal of General Medicine. Feb2025, Vol. 22 Issue 1, p1-7. 7p.

Subject Terms: *METHYLENE blue, *COMBINATION drug therapy, *SURGERY, *PATIENTS, *VITAMIN B12, *HEMODYNAMICS, *SYSTEMATIC reviews, *MEDLINE, *DRUG efficacy, *MEDICAL databases, *POSTOPERATIVE period, *ONLINE information services, *LENGTH of stay in hospitals, *VASOCONSTRICTORS, *VASCULAR diseases

The Relationship Between Response Rate and Survival Benefits in Randomized Immunotherapy Studies.

Authors: Jain, Aditi¹ (AUTHOR) jainaditik@gmail.com, Stebbing, Justin² (AUTHOR) jainaditik@gmail.com

Source: Cancers. Feb2025, Vol. 17 Issue 3, p495. 16p.

Subject Terms: *COMBINATION drug therapy, *IMMUNOTHERAPY, *PROGRAMMED death-ligand 1, *PROTEIN-tyrosine kinase inhibitors, *RANDOMIZED controlled trials, *TREATMENT effectiveness, *IMMUNE checkpoint inhibitors, *CANCER chemotherapy, *MEDICAL research, *PROGRESSION-free survival, *TUMORS, *OVERALL survival, *EVALUATION

Opioid sparing anesthesia in patients with liver cirrhosis undergoing liver resection: a controlled randomized double-blind study.

Authors: Ibrahim, Eman Sayed^1,2,3 emansayed825@gmail.com, Metwally, Ahmed A.⁴, Abdullatif, Mohamed⁵, Eid, Essam A.¹, Mousa, Mahmoud G.¹, Sultan, Amany A.⁴

Source: BMC Anesthesiology. 2/1/2025, Vol. 25 Issue 1, p1-9. 9p.

Subject Terms: *COMBINATION drug therapy, *CIRRHOSIS of the liver, *KETAMINE, *POSTOPERATIVE pain, *BLIND experiment, *STATISTICAL sampling, *TREATMENT effectiveness, *RANDOMIZED controlled trials, *INTRAOPERATIVE care, *OPIOID analgesics, *PAIN management, *HEPATECTOMY, *ANESTHESIA, *IMIDAZOLES, *EVALUATION

Simultaneous Multi-Treatment Strategy for Brain Tumor Reduction via Nonlinear Control.

Authors: Arsalan, Muhammad¹ (AUTHOR) m_arsalan@mail.nwpu.edu.cn, Yu, Xiaojun¹ (AUTHOR) xjyu@nwpu.edu.cn, Sadiq, Muhammad Tariq² (AUTHOR) m.t.sadiq@essex.ac.uk, Almogren, Ahmad³ (AUTHOR) ahalmogren@ksu.edu.sa

Source: Brain Sciences (2076-3425). Feb2025, Vol. 15 Issue 2, p207. 23p.

Subject Terms: *TUMOR treatment, *COMBINATION drug therapy, *DRUG dosage, *BRAIN tumors, *TUMOR growth

Venetoclax Plus CyBorD Induction Therapy and Venetoclax Maintenance Treatment for Immunoglobulin Light Chain Amyloidosis with t(11;14) Translocation.

Authors: Garami, Gréta¹ (AUTHOR) garami.greta@med.unideb.hu, Obajed Al-Ali, Omar^1,2 (AUTHOR), Virga, István^1,2,3 (AUTHOR), Gulyás, Anita^1,2,4 (AUTHOR), Bedekovics, Judit³ (AUTHOR), Tornai, István⁴ (AUTHOR), Illés, Árpád^1,2 (AUTHOR), Magyari, Ferenc^1,2 (AUTHOR)

Source: Current Oncology. Feb2025, Vol. 32 Issue 2, p63. 9p.

Subject Terms: *VENETOCLAX, *COMBINATION drug therapy, *IMMUNOGLOBULIN light chains, *AUTOTRANSPLANTATION, *DISEASE remission, *THERAPEUTICS, *CHROMOSOMAL rearrangement

The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration.

Authors: Zhang, Xianxu^1,2, Li, Shicheng^1,2, Liu, Xin^1,2, Ma, Zhong^1,2, Zhang, Qiang^1,2, Zhang, Yuji^1,2, An, Jiangdong^1,2, Luo, Zhiqiang^1,2 luozhiq20000@163.com

Source: Journal of Orthopaedic Surgery & Research. 1/31/2025, Vol. 20 Issue 1, p1-14. 14p.

Subject Terms: *COMBINATION drug therapy, *BONE morphogenetic proteins, *STATINS (Cardiovascular agents), *MOLECULAR biology, *SPINE diseases, *LUMBAR pain, *BIOMARKERS, *DRUG synergism, *PHARMACODYNAMICS, *DISEASE risk factors

Sedoanalgesia with dexmedetomidine in daily anesthesia practices: a prospective randomized controlled trial.

Authors: Oğuz, Ali Kendal¹ kendalcejnan@gmail.com, Soyalp, Celaleddin² c.soyalp@hotmail.com, Tunçdemir, Yunus Emre^3,4 yunusemretunc@gmail.com, Tekeli, Arzu Esen^2,5 esentekeli190807@hotmail.com, Yüzkat, Nureddin^2,5 yuzkat@gmail.com

Source: BMC Anesthesiology. 1/29/2025, Vol. 25 Issue 1, p1-12. 12p.

Subject Terms: *REMIFENTANIL, *COMBINATION drug therapy, *OXYGEN saturation, *PAIN measurement, *PATIENT safety, *ACADEMIC medical centers, *SURGERY, *PATIENTS, *STATISTICAL sampling, *VISUAL analog scale, *FISHER exact test, *RANDOMIZED controlled trials, *PREOPERATIVE care, *ANESTHESIOLOGISTS, *DESCRIPTIVE statistics, *MANN Whitney U Test, *CHI-squared test, *SURGICAL therapeutics, *HEMODYNAMICS, *ANALGESIA, *PROPOFOL, *LONGITUDINAL method, *INTRAVENOUS therapy, *JOB satisfaction, *DRUG efficacy, *ELECTIVE surgery, *ARTIFICIAL respiration, *COMPARATIVE studies, *PATIENT satisfaction, *CONFIDENCE intervals, *ANESTHESIA, *IMIDAZOLES, *PERIOPERATIVE care, *HYSTEROSCOPY, *DRUG dosage, *EVALUATION, *DRUG administration

Geographic Terms: TURKEY

Physicians' and patients' perceived risks of chronic pain medication and co-medications in Quebec, Canada: a cross-sectional study.

Authors: De Clifford-Faugère, Gwenaëlle¹ (AUTHOR), Lacasse, Anaïs¹ (AUTHOR), Nguena Nguefack, Hermine Lore¹ (AUTHOR), Godbout-Parent, Marimée¹ (AUTHOR), Boulanger, Aline^2,3 (AUTHOR), Julien, Nancy¹ (AUTHOR) nancy.julien@uqat.ca

Source: BMC Primary Care. 1/14/2025, Vol. 26 Issue 1, p1-10. 10p.

Subject Terms: *COMBINATION drug therapy, *RISK assessment, *CROSS-sectional method, *NONSTEROIDAL anti-inflammatory agents, *BENZODIAZEPINES, *MEDICAL marijuana, *PATIENT education, *CHRONIC pain, *DRUG side effects, *RESEARCH funding, *STATISTICAL sampling, *INTERVIEWING, *PHYSICIANS' attitudes, *ANTIPSYCHOTIC agents, *TRANQUILIZING drugs, *SURVEYS, *ANTIDEPRESSANTS, *OPIOID analgesics, *DRUG interactions, *PHYSICIAN-patient relations, *COMPARATIVE studies, *PATIENTS' attitudes, *ACETAMINOPHEN

Geographic Terms: CANADA

Paracetamol did not improve the analgesic efficacy with regional block after video assisted thoracoscopic surgery: a randomized controlled trial.

Authors: Kim, Sujin¹, Song, Seung Woo¹, Lee, Haesung¹, Byun, Chun Sung², Park, Ji-Hyoung¹ killerjhjh@yonsei.ac.kr

Source: BMC Anesthesiology. 1/7/2025, Vol. 25 Issue 1, p1-7. 7p.

Subject Terms: *VIDEO-assisted thoracic surgery, *COMBINATION drug therapy, *RESEARCH funding, *POSTOPERATIVE pain, *STATISTICAL sampling, *BLIND experiment, *VISUAL analog scale, *RANDOMIZED controlled trials, *DESCRIPTIVE statistics, *DRUG efficacy, *COMPARATIVE studies, *PATIENT satisfaction, *NERVE block, *ACETAMINOPHEN, *PHARMACODYNAMICS

Alone or in combination, hyaluronic acid and chondroitin sulfate alleviate ECM degradation in osteoarthritis by inhibiting the NF-κB pathway.

Authors: Ma, Yiran¹, Yang, Xin¹, Jiang, Min¹, Ye, Wangjuan¹, Qin, Hong¹ hqin927@hotmail.com, Tan, Songwen² songwen.tan@monash.edu

Source: Journal of Orthopaedic Surgery & Research. 1/4/2025, Vol. 20 Issue 1, p1-12. 12p.

Subject Terms: *CARTILAGE analysis, *COMBINATION drug therapy, *NF-kappa B, *INFLAMMATORY mediators, *COLORIMETRY, *HYALURONIC acid, *ENZYME-linked immunosorbent assay, *CELLULAR signal transduction, *ANTERIOR cruciate ligament, *FLUORESCENT antibody technique, *CHONDROITIN sulfates, *RATS, *IMMUNOHISTOCHEMISTRY, *EXTRACELLULAR matrix proteins, *OSTEOARTHRITIS, *ANIMAL experimentation, *WESTERN immunoblotting, *EXTRACELLULAR matrix, *STAINS & staining (Microscopy), *CARTILAGE, *INTERLEUKINS

Outcome Predictors of Generalized Myasthenia Gravis: A Prospective Observational Study.

Authors: Kalita, Jayantee¹ jayanteek@yahoo.com, Gutti, Nagendra B¹, Ahamed, Faim¹

Source: Annals of Indian Academy of Neurology. Jan/Feb2025, Vol. 28 Issue 1, p58-65. 8p.

Subject Terms: *COMBINATION drug therapy, *PATIENT safety, *MYASTHENIA gravis, *SCIENTIFIC observation, *PREDNISOLONE, *DISEASE remission, *AZATHIOPRINE, *LONGITUDINAL method, *DRUG efficacy

Geographic Terms: INDIA