Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment

Authors: Taghaddos, Dana, Saqib, Zarwa, Bai, Xiaopeng, Bercik, Premysl, Collins, Stephen M.

Source: In Digestive and Liver Disease November 2024 56(11):1805-1809

Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome

Authors: Barbaro, Maria Raffaella ¹, Cremon, Cesare ¹, Marasco, Giovanni ^{1, 2}, Savarino, Edoardo ³, Guglielmetti, Simone ⁴, Bonomini, Francesca ², Palombo, Marta ², Fuschi, Daniele ¹, Rotondo, Luca ¹, Mantegazza, Giacomo ⁴, Duncan, Robin ⁴, di Sabatino, Antonio ^{5, 6}, Valente, Sabrina ², Pasquinelli, Gianandrea ^{1, 2}, Vergnolle, Nathalie ⁷, Stanghellini, Vincenzo ^{1, 2}, Collins, Stephen M. ⁸, Barbara, Giovanni ^{1, 2, ∗}

Source: In Gastroenterology November 2024 167(6):1152-1166

Innate immune system signaling and intestinal dendritic cells migration to the brain underlie behavioral changes after microbial colonization in adult mice

Authors: Philip, Vivek ^{a, b, 1}, Kraimi, Narjis ^{a, 1}, Zhang, Hailong ^b, Lu, Jun ^a, Palma, Giada De ^a, Shimbori, Chiko ^a, McCoy, Kathy D. ^{c, f}, Hapfelmeier, Siegfried ^d, Schären, Olivier P. ^d, Macpherson, Andrew J ^c, Chirdo, Fernando ^e, Surette, Michael G. ^a, Verdu, Elena F. ^a, Liu, Fang ^b, Collins, Stephen M ^a, Bercik, Premysl ^{a, ⁎}

Source: In Brain Behavior and Immunity July 2025 127:238-250

Vasoactive Intestinal Polypeptide Plays a Key Role in the Microbial-Neuroimmune Control of Intestinal Motility

Authors: Bai, Xiaopeng, De Palma, Giada, Boschetti, Elisa, Nishiharo, Yuichiro, Lu, Jun, Shimbori, Chiko, Costanzini, Anna, Saqib, Zarwa, Kraimi, Narjis, Sidani, Sacha, Hapfelmeier, Siegfried, Macpherson, Andrew J., Verdu, Elena F., De Giorgio, Roberto, Collins, Stephen M., Bercik, Premysl

Source: In Cellular and Molecular Gastroenterology and Hepatology 2024 17(3):383-398

Gluten-Free Diet Reduces Symptoms, Particularly Diarrhea, in Patients With Irritable Bowel Syndrome and Antigliadin IgG

Authors: Pinto-Sanchez, María Inés, Nardelli, Andrea, Borojevic, Rajka, De Palma, Giada, Calo, Natalia Causada, McCarville, Justin, Caminero, Alberto, Basra, Daniel, Mordhorst, Alexa, Ignatova, Ekatherina, Hansen, Suzanne, Uhde, Melanie, Norman, Gary L., Murray, Joseph A., Smecuol, Edgardo, Armstrong, David, Bai, Julio C., Schuppan, Detlef, Collins, Stephen M., Alaedini, Armin, Moayyedi, Paul, Verdu, Elena F., Bercik, Premysl

Source: In Clinical Gastroenterology and Hepatology November 2021 19(11):2343-2352

458 MICROBIOTA FROM PATIENTS WITH CROHN'S DISEASE INDUCES BEHAVIOURAL CHANGES IN MICROBIOTA-HUMANIZED MICE

Authors: Vicentini, Fernando A., Pujo, Julien, Rueda, Gaston, Nardelli, Andrea, De Palma, Giada, Collins, Stephen M., Bercik, Premysl

Source: Gastroenterology. 164(6):S-87-S-87

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194431786.0x000001&indx=1&recIds=ETOCvdc_100194431786.0x000001

Tu1654 MICROBIAL PHOSPHOLIPIDS AS TRIGGERS OF VISCERAL HYPERALGESIA IN IRRITABLE BOWEL SYNDROME

Authors: Pujo, Julien, De Palma, Giada, Lu, Jun, Rueda, Gaston, Collins, Stephen M., Bercik, Premysl

Source: Gastroenterology. 164(6):S-1075-S-1075

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194459337.0x000001&indx=1&recIds=ETOCvdc_100194459337.0x000001

Tu1613 ROLE OF GUT MICROBIOTA IN SYMPTOM EPISODES OF IRRITABLE BOWEL SYNDROME

Authors: Mohan, Vidhyalakshmi, Sanchez, María Inés Pinto, Nardelli, Andrea, Magee, Megan, Borojevic, Rajka, De Palma, Giada, Mckibbin, Philip Britz, Collins, Stephen M., Bercik, Premysl

Source: Gastroenterology. 164(6):S-1057-S-1057

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194459766.0x000001&indx=1&recIds=ETOCvdc_100194459766.0x000001

Gut microbiota modulates visceral sensitivity through calcitonin gene-related peptide (CGRP) production

Authors: Pujo, Julien, De Palma, Giada, Lu, Jun, Galipeau, Heather J., Surette, Michael G., Collins, Stephen M., Bercik, Premysl

Source: Gut microbes. 15(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191616438.0x000001&indx=1&recIds=ETOCvdc_100191616438.0x000001

Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins

Authors: Caminero, Alberto, McCarville, Justin L., Zevallos, Victor F., Pigrau, Marc, Yu, Xuechen B., Jury, Jennifer, Galipeau, Heather J., Clarizio, Alexandra V., Casqueiro, Javier, Murray, Joseph A., Collins, Stephen M., Alaedini, Armin, Bercik, Premysl, Schuppan, Detlef, Verdu, Elena F.

Source: In Gastroenterology June 2019 156(8):2266-2280

Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis

Authors: Kwon, Yun Han, Wang, Huaqing, Denou, Emmanuel, Ghia, Jean-Eric, Rossi, Laura, Fontes, Michelle E., Bernier, Steve P., Shajib, Md. Sharif, Banskota, Suhrid, Collins, Stephen M., Surette, Michael G., Khan, Waliul I.

Source: In Cellular and Molecular Gastroenterology and Hepatology 2019 7(4):709-728

1247 REVERSAL OF SEVERE GUT DYSFUNCTION FOLLOWING CLOSTRIDIUM DIFFICILE INFECTION BY MICROBIOTA-DIRECTED DIETARY INTERVENTION

Authors: Saqib, Zarwa, Bai, Xiaopeng, De Palma, Giada, Lu, Jun, Bercik, Premysl, Collins, Stephen M.

Source: Gastroenterology. 164(6):S-258-S-259

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194422057.0x000001&indx=1&recIds=ETOCvdc_100194422057.0x000001

683 INVESTIGATING MECHANISMS THAT DRIVE SYMPTOMS IN PATIENTS WITH IRRITABLE BOWEL SYNDROME AND PERCEIVED GLUTEN SENSITIVITY

Authors: Seiler, Caroline, Rueda, Gaston, Miranda, Pedro, Nardelli, Andrea, Borojevic, Rajka, Schuppan, Detlef, Moayyedi, Paul, Verdu, Elena F., Collins, Stephen M., Pinto-Sanchez, M.I., Bercik, Premysl

Source: Gastroenterology. 164(6):S-136-S-137

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194428991.0x000001&indx=1&recIds=ETOCvdc_100194428991.0x000001

Gut bacteria interact directly with colonic mast cells in a humanized mouse model of IBS

Authors: Shimbori, Chiko, De Palma, Giada, Baerg, Lauren, Lu, Jun, Verdu, Elena F., Reed, David E., Vanner, Stephen, Collins, Stephen M., Bercik, Premysl

Source: Gut microbes. 14(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184893069.0x000001&indx=1&recIds=ETOCvdc_100184893069.0x000001

Mo1409: GUT MICROBIOTA MODULATES CGRP PRODUCTION BY DRG NEURONS IN FEMALE MICE

Authors: Pujo, Julien, Palma, Giada De, Lu, Jun, Collins, Stephen M., Bercik, Premysl

Source: Gastroenterology. 162(7):S-761-S-761

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167642738.0x000001&indx=1&recIds=ETOCvdc_100167642738.0x000001

Metformin-induced reductions in tumor growth involves modulation of the gut microbiome

Authors: Broadfield, Lindsay A., Saigal, Amna, Szamosi, Jake C., Hammill, Joanne A., Bezverbnaya, Ksenia, Wang, Dongdong, Gautam, Jaya, Tsakiridis, Evangelia E., Di Pastena, Fiorella, McNicol, Jamie, Wu, Jianhan, Syed, Saad, Lally, James S.V., Raphenya, Amogelang R., Blouin, Marie-Jose, Pollak, Michael, Sacconi, Andrea, Blandino, Giovanni, McArthur, Andrew G., Schertzer, Jonathan D., Surette, Michael G., Collins, Stephen M., Bramson, Jonathan L., Muti, Paola, Tsakiridis, Theodoros, Steinberg, Gregory R.

Source: Molecular metabolism. 61

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164696972.0x000001&indx=1&recIds=ETOCvdc_100164696972.0x000001

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

Authors: Pinto-Sanchez, Maria Ines, Hall, Geoffrey B., Ghajar, Kathy, Nardelli, Andrea, Bolino, Carolina, Lau, Jennifer T., Martin, Francois-Pierre, Cominetti, Ornella, Welsh, Christopher, Rieder, Amber, Traynor, Jenna, Gregory, Caitlin, De Palma, Giada, Pigrau, Marc, Ford, Alexander C., Macri, Joseph, Berger, Bernard, Bergonzelli, Gabriela, Surette, Michael G., Collins, Stephen M., Moayyedi, Paul, Bercik, Premysl

Source: In Gastroenterology August 2017 153(2):448-459

Oral tryptophan activates duodenal aryl hydrocarbon receptor in healthy subjects: a crossover randomized controlled trial.

Authors: Rueda, Gaston H., Causada-Calo, Natalia, Borojevic, Rajka, Nardelli, Andrea, Pinto-Sanchez, Maria Ines, Constante, Marco, Libertucci, Josie, Mohan, Vidhyalakshmi, Langella, Philippe, Loonen, Linda M. P., Wells, Jerry M., Collins, Stephen M., Sokol, Harry, Verdu, Elena F., Bercik, Premysl

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology; Jun2024, Vol. 326 Issue 6, pG687-G696, 10p

Subject Terms: TRYPTOPHAN, ARYL hydrocarbon receptors, LIQUID chromatography-mass spectrometry, ESSENTIAL amino acids, FECAL microbiota transplantation, MICROBIAL enzymes, MICROBIAL metabolites

735 DORSAL ROOT GANGLIA (DRG) NEURONAL RESPONSES AND SUBSTANCE P PRODUCTION ARE HIGHER IN MALE MICE AND SIMILAR BETWEEN CONVENTIONAL AND GERM-FREE MICE.

Authors: Pujo, Julien, De Palma, Giada, Lu, Jun, Collins, Stephen M., Bercik, Premysl

Source: Gastroenterology. 160(6):S-148-S-148

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140874855.0x000001&indx=1&recIds=ETOCvdc_100140874855.0x000001

Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome

Authors: Constante, Marco, De Palma, Giada, Lu, Jun, Jury, Jennifer, Rondeau, Liam, Caminero, Alberto, Collins, Stephen M., Verdu, Elena F., Bercik, Premysl

Source: Neurogastroenterology & motility. 33(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122960311.0x000001&indx=1&recIds=ETOCvdc_100122960311.0x000001