Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity

Authors: Anđela Martinović, Matilde Mantovani, Natalia Trpchevska, Eva Novak, Nikolay B. Milev, Leonie Bode, Collin Y. Ewald, Evelyne Bischof, Tobias Reichmuth, Rebecca Lapides, Alexander Navarini, Babak Saravi, Elisabeth Roider

Source: Frontiers in Aging, Vol 5 (2024)

Subject Terms: longevity, healthcare, aging, lifestyle, preventive medicine, personalized medicine, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fragi.2024.1495029/full; https://doaj.org/toc/2673-6217

Access URL: https://doaj.org/article/1a2058cf581b49008e6f3ccbcbe9aeb9

Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans

Authors: Alina C. Teuscher, Cyril Statzer, Anita Goyala, Seraina A. Domenig, Ingmar Schoen, Max Hess, Alexander M. Hofer, Andrea Fossati, Viola Vogel, Orcun Goksel, Ruedi Aebersold, Collin Y. Ewald

Source: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c0e058623cd74bde8b2a47d1ff75c848

Food amyloid fibrils are safe nutrition ingredients based on in-vitro and in-vivo assessment

Authors: Dan Xu, Jiangtao Zhou, Wei Long Soon, Ines Kutzli, Adrian Molière, Sabine Diedrich, Milad Radiom, Stephan Handschin, Bing Li, Lin Li, Shana J. Sturla, Collin Y. Ewald, Raffaele Mezzenga

Source: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ce7f8e5aaaa94906b7e2d02f5de0ec33

Collagen constitutes about 12% in females and 17% in males of the total protein in mice

Authors: Katharina Tarnutzer, Devanarayanan Siva Sankar, Joern Dengjel, Collin Y. Ewald

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d30fe29a12b34a62ac52396303daf5a3

Fragment-based virtual screening identifies a first-in-class preclinical drug candidate for Huntington’s disease

Authors: Simon Marius Galyan, Collin Y. Ewald, Xavier Jalencas, Shyam Masrani, Selin Meral, Jordi Mestres

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e98c904096fc4a3d86ffffc25854d444

Translational longevity medicine: a Swiss perspective in an ageing country

Authors: Marco M. Ruckstuhl, Evelyne Bischof, Dana Blatch, Aliki Buhayer, Jörg Goldhahn, Edouard Battegay, Andre Tichelli, Collin Y. Ewald

Source: Swiss Medical Weekly, Vol 153, Iss 6 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://smw.ch/index.php/smw/article/view/3348; https://doaj.org/toc/1424-3997

Access URL: https://doaj.org/article/cb398a85dbc2425e98bbd8fd880315e1

Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review

Authors: Marie Knufinke, Michael R. MacArthur, Collin Y. Ewald, Sarah J. Mitchell

Source: Frontiers in Aging, Vol 4 (2023)

Subject Terms: sex differences, lifespan, healthspan, systematic review, pharmacological interventions, aging, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fragi.2023.1172789/full; https://doaj.org/toc/2673-6217

Access URL: https://doaj.org/article/8ef0eca8eaef48b6861919f0f7509de7

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

Authors: Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell, Collin Y. Ewald

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0b2d369bb38048e0accd70b4ceb4ae16

The non-modifiable factors age, gender, and genetics influence resistance exercise

Authors: Claudio Viecelli, Collin Y. Ewald

Source: Frontiers in Aging, Vol 3 (2022)

Subject Terms: resistance exercise, age, gender, genetics, modifier, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fragi.2022.1005848/full; https://doaj.org/toc/2673-6217

Access URL: https://doaj.org/article/1ffb1436209d40ca9bb089c4d64b3ec5

Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans

Authors: Richard Venz, Anastasiia Korosteleva, Elisabeth Jongsma, Collin Y. Ewald

Source: G3: Genes, Genomes, Genetics, Vol 10, Iss 11, Pp 3921-3928 (2020)

Subject Terms: lipid bilayer stress, lipotoxicity, unfolded protein stress, auxin-induced degradation, creb3, nrf2, mdt-15, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2160-1836

Access URL: https://doaj.org/article/d32d9d607c024f589f6c0cb2f118eb9a

Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease

Authors: Tinka Vidović, Collin Y. Ewald

Source: Frontiers in Aging, Vol 3 (2022)

Subject Terms: extracellular matrix, healthy aging, matrisome, collagen, mTOR signaling pathway, FOXO transcription factors, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fragi.2022.935220/full; https://doaj.org/toc/2673-6217

Access URL: https://doaj.org/article/e2ea52b4a0cf4905beba025e9a725ebf

Longevity interventions temporally scale healthspan in Caenorhabditis elegans

Authors: Cyril Statzer, Peter Reichert, Jürg Dual, Collin Y. Ewald

Source: iScience, Vol 25, Iss 3, Pp 103983- (2022)

Subject Terms: Biological sciences, Physiology, Biophysics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S258900422200253X; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/7ee0bf8665b84633a3aae41178ac2e23

The Human Extracellular Matrix Diseasome Reveals Genotype–Phenotype Associations with Clinical Implications for Age-Related Diseases

Authors: Cyril Statzer, Karan Luthria, Arastu Sharma, Maricel G. Kann, Collin Y. Ewald

Source: Biomedicines, Vol 11, Iss 4, p 1212 (2023)

Subject Terms: phenome, matrisome, matreotype, phenotype, extracellular matrix, data mining, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/4/1212; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/e80646181df74223a7a502bee055c53d

Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill

Authors: Collin Y. Ewald

Source: Frontiers in Aging, Vol 2 (2021)

Subject Terms: chondroitin sulfate, supplement, healthy aging, longevity, anti inflammatory, extracellar matrix, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fragi.2021.741843/full; https://doaj.org/toc/2673-6217

Access URL: https://doaj.org/article/7c4d51c16c6a4a3b8c817a808941cee0

Lifespan-Associated Gene Expression Signatures of Recombinant BXD Mice Implicates Coro7 and Set in Longevity

Authors: David Vitiello, Alexander Dakhovnik, Cyril Statzer, Collin Y. Ewald

Source: Frontiers in Genetics, Vol 12 (2021)

Subject Terms: healthy aging, BXD mice, gender-specific lifespan, coronin, SET, longevity, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2021.694033/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/838c954dc4694c1db9632c80cc1aaaef

Extracellular matrix gene expression signatures as cell type and cell state identifiers

Authors: Fabio Sacher, Christian Feregrino, Patrick Tschopp, Collin Y. Ewald

Source: Matrix Biology Plus, Vol 10, Iss , Pp 100069- (2021)

Subject Terms: Matrisome, Matreotype, Cell type, scRNA-seq, Limb development, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590028521000132; https://doaj.org/toc/2590-0285

Access URL: https://doaj.org/article/37040b7f078a419da78a2297a8971191

The extracellular matrix phenome across species

Authors: Cyril Statzer, Collin Y. Ewald

Source: Matrix Biology Plus, Vol 8, Iss , Pp 100039- (2020)

Subject Terms: Phenome, Genotype-to-phenotype, Matrisome, Extracellular matrix, Collagen, Data mining, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S259002852030020X; https://doaj.org/toc/2590-0285

Access URL: https://doaj.org/article/e2c4b81250e64e0389f93f4ef4693e82

The in-silico characterization of the Caenorhabditis elegans matrisome and proposal of a novel collagen classification

Authors: Alina C. Teuscher, Elisabeth Jongsma, Martin N. Davis, Cyril Statzer, Jan M. Gebauer, Alexandra Naba, Collin Y. Ewald

Source: Matrix Biology Plus, Vol 1, Iss , Pp - (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590028518300012; https://doaj.org/toc/2590-0285

Access URL: https://doaj.org/article/e3bcd596b0e7403e82be7ea3f28c72d4

Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging

Authors: Collin Y. Ewald

Source: Antioxidants, Vol 7, Iss 10, p 130 (2018)

Subject Terms: NOX, sulfenylation, Nrf2, SKN-1, centenarians, extracellular matrix, longevity, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.mdpi.com/2076-3921/7/10/130; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/7a97d173b6504b31b177b190620ca282

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