Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer

Authors: Macarena Morillo-Huesca, Ignacio G. López-Cepero, Ryan Conesa-Bakkali, Mercedes Tomé, Colin Watts, Pablo Huertas, Gema Moreno-Bueno, Raúl V. Durán, Jonathan Martínez-Fábregas

Source: Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-26 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/00691fffcb9747028a701ac0ba714b9e

Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units

Authors: Sharon B. Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, Philip Pallmann, Lucy McParland, Louise Brown, Lindsey Masters, Francesca Schiavone, Dominic Hague, Stephen Townsend, Claire Amos, Annabelle South, Kate Sturgeon, Ruth Langley, Timothy Maughan, Nicholas James, Emma Hall, Sarah Kernaghan, Judith Bliss, Nick Turner, Andrew Tutt, Christina Yap, Charlotte Firth, Anthony Kong, Hisham Mehanna, Colin Watts, Robert Hills, Ian Thomas, Mhairi Copland, Sue Bell, David Sebag-Montefiore, Robert Jones, Mahesh K. B. Parmar, Matthew R. Sydes

Source: Trials, Vol 23, Iss 1, Pp 1-14 (2022)

Subject Terms: Platform protocols, Trial conduct, Multi-arm multi-stage trials, Umbrella trials, Basket trials, Stratified medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/f16f51eff76c45b9b2545597e35df8a3

Lysosomes and lysosome‐related organelles in immune responses

Authors: Colin Watts

Source: FEBS Open Bio, Vol 12, Iss 4, Pp 678-693 (2022)

Subject Terms: antigen processing, endocytosis, immune response, lysosome‐related organelles, lysosomes, proteases, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/d27b533554924d6f97dd71cdce4f574c

Imaging Timing After Surgery for Glioblastoma (INTERVAL GB): A multi-centre, UK and Ireland retrospective cohort study

Authors: Emily Rose Bligh, Conor Gillespie, Michael T.C. Poon, Georgios Solomou, Melissa Gough, Abdurrahman I. Islim, Christopher P. Millward, Ola Rominiyi, Rasheed Zakaria, Stephen J. Price, Colin Watts, Sophie Camp, Thomas C. Booth, Gerard Thompson, Samantha J. Mills, Adam Waldman, Paul Brennan, Michael D. Jenkinson

Source: Brain and Spine, Vol 3, Iss , Pp 102127- (2023)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772529423004150; https://doaj.org/toc/2772-5294

Access URL: https://doaj.org/article/7f53d8f63c514d8fa3efcec962d08813

A vascularized tumoroid model for human glioblastoma angiogenesis

Authors: Agavi Stavropoulou Tatla, Alexander W. Justin, Colin Watts, Athina E. Markaki

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/2a6e5c25be114acba644f4ae7b071551

FUTURE-GB: functional and ultrasound-guided resection of glioblastoma – a two-stage randomised control trial

Authors: Ruichong Ma, Jonathan Cook, Giles Critchley, Damian Holliman, Chittoor Rajaraman, Amy Taylor, Peter McCulloch, Michael D Jenkinson, Paul M Brennan, Vicki S Barber, Huan Chan, Jose Lavrador, Keyoumars Ashkan, Neil Barua, Matthew Williams, Colin Watts, Dipankar Nandi, Stuart Smith, Luke Dixon, Robert Corns, Linda Dirven, Stephen John Price, Puneet Plaha, Erminia Albanese, Anna Solth, Helen Bulbeck, Grainne McKenna, Martin J B Taphoorn, James Palmer, Anil Varma, Maria Velicu, George Eralil, Kathrin Whitehouse, Sophie Camp, Natalie Voets, Matthew Grech-Sollars, Adrian Lim, Vasileios Apostolopoulos, Shailendra Achawal, Ganamurthy Sivakumar, Farouk Olubajo, Edward McKintosh, Dimitrios Paraskevopoulos, Paul Grundy

Source: BMJ Open, Vol 12, Iss 11 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/12/11/e064823.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/ad4f8c642a8343079d2060d703b77bf6

Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients

Authors: Florent Mouliere, Christopher G Smith, Katrin Heider, Jing Su, Ymke van der Pol, Mareike Thompson, James Morris, Jonathan C M Wan, Dineika Chandrananda, James Hadfield, Marta Grzelak, Irena Hudecova, Dominique‐Laurent Couturier, Wendy Cooper, Hui Zhao, Davina Gale, Matthew Eldridge, Colin Watts, Kevin Brindle, Nitzan Rosenfeld, Richard Mair

Source: EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-14 (2021)

Subject Terms: cell‐free DNA, circulating tumor DNA, fragmentomics, gliomas, liquid biopsy, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/24159a2dc79e4f5a892d4bf85fcba5d8

Protocol for the Tessa Jowell BRAIN MATRIX Platform Study

Authors: Amit Patel, Gerard Thompson, Joshua Savage, Rhys Mant, Colin Watts, Olaf Ansorge, Victoria Wykes, Helen Bulbeck, Lucinda Billingham, Adam D Waldman, Rowena Sharpe, Ute Pohl, John Apps

Source: BMJ Open, Vol 12, Iss 9 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/12/9/e067123.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/4f97b946e2c5402daeff2a9291573e31

Development of a core outcome set and identification of patient-reportable outcomes for primary brain tumour trials: protocol for the COBra study

Authors: Ameeta Retzer, Melanie Calvert, Stephanie Sivell, Anthony Byrne, Annmarie Nelson, Robin Grant, Elin Baddeley, Hannah Scott, Kathy Seddon, Colin Watts, Linda Dirven, Richard Adams, Olalekan Lee Aiyegbusi, Samantha Cruz Rivera, Pamela Kearns

Source: BMJ Open, Vol 12, Iss 9 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/12/9/e057712.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/bac60d7de78c4d93b4cdf448d89ba6d2

Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study

Authors: Oliver Burton, Julie Woodfield, Daniel Richardson, Giles Critchley, Angelos Kolias, Thomas Santarius, Lewis Thorne, Peter Whitfield, Ola Rominiyi, Bharti Kewlani, Harsh Bhatt, Ahmed Ahmed, Michael O’Sullivan, Rasheed Zakaria, Michael D Jenkinson, Gerard Thompson, Paul M Brennan, Rory Piper, Seong Hoon Lee, Neil Barua, Engelbert Mthunzi, Sara Venturini, Daniel M Fountain, Najma Ahmed, Stephen J Price, Colin Watts, Michael T C Poon, Stuart Smith, Anand Pandit, Ryan K Mathew, Soham Bandyopadhyay, Rosa Sun, Setthasorn Zhi Yang Ooi, Victoria Wykes, William Bolton, Abdullah Egiz, Samantha J Mills, Babar Vaqas, Natalie Simon, Puneet Plaha, Georgios Solomou, Aswin Chari, Grainne McKenna, Melissa Gough, Simon Lammy, Sophie T Williams, Isabelle Williams, Andrew J Martin, Sam Hodgson, Robert Spencer, Adam Waldman, Armin Nazari, Joshua Erhabor, Omar Salim, Saad Moughal, Chinedu Brian Egu, Abdurrahman I Islim, Christopher P Millward, Suhaib Abualsaud, Michael Amoo, Neeraj Kalra, Agbolahan Sofela, Thomas C Booth, George E Richardson, Conor S Gillespie, Orla Mantle, Abigail Clynch, Jay J Park, Emily R Bligh, Avani Shanbhag, Moritz Steinruecke, Alvaro Yanez Touzet, Hannah Redpath, Gideon Adegboyega, Prithvi Bahu, Rosaline de Koning, Tomas Ferreira, Dana Hutton, Jashan Selvakumar, Tiffany TS Ye, Ashvin Kuri, Robin Borchert, Bea Duric, Elena Roman, Kristy Kehoe, Jeremy Cheong, Lauren Harris, Mohammad A Mustafa, Hidayatul Abdullmalek, Chinelo Afulukwe, Abdelsalam Nedal Al-Sousi, Yahia Al-Tamimi, Ajitesh Anand, Peter Bodkin, Ion Boiangiu, Abbey Boyle, Christiaan Bredell, Talhah Chaudri, Ana Cios, Iona Cleer, David Coope, Ian Coulter, Harriet Davis, Paolo Jose De Luna, Nayan Dey, Justyna O Ekert, Jinendra Ekanayake, Anna Elso, Tom Flannery, Kwan Wai Fung, Rahul Ganguly, Sanay Goyal, Emily Hardman, Theodore Hirst, Kelvin Sunn Hoah, Kismet Hossain-Ibrahim, Lena Mary Houlihan, Sami Squali Houssaini, Sadid Hoque, Mahnoor Javed, Siddarth Kannan, Efthymia Maria Kapasouri, Andrew Keenlyside, Prerna Khanna, Kunalika Sathish Kumar, Eunkyung Lee, Robert Magouirk, Riccardo Masina, Adele Mazzoleni, Patrick McAleavey, Daniel McSweeney, Trinh Ton Nu Ngoc, Shiva A Nischal, Jonathan Pesic-Smith, Peter Peterson, Isaac Phang, Shyam Pujara, Marwa Mohammed Elrasheed Saad, Shinjan Sangal, Veekshith Shetty, Irtiza Syed, Jesvin Tom Sunny, Anca-Mihaela Vasilica, Daniel O’Flaherty, Arslan Khaliq Raja, Daniele Ramsay, Renitha Reddi, Dorina Roy, Jeremiah Samkutty, Edward Jerome St George, Preethi Subramanian, Vaibhav Sundaresan, Kieron Sweeney, Boon Hoe Tan, Nicole Turnbull, Yuewei Tao, Rebecca Tweedie, Anastasia Tzatzidou, Kathrin Whitehouse, Jack Wildman, Karl Williams, Kelvin Sunn Yap, Mahir Yousuff, Asaad Zulfiqar, Sophie Camp, Setthasorn ZY Ooi

Source: BMJ Open, Vol 12, Iss 9 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/12/9/e063043.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/ea5706fc5b024e75ade614ef75919d03

Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review

Authors: Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

Source: BMJ Open, Vol 12, Iss 7 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/12/7/e056059.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/3b69d50d45e64d2e8cdcee587b7aa1fc

Multiparametric MRI: practical approach and pictorial review of a useful tool in the evaluation of brain tumours and tumour-like lesions

Authors: Vijay Sawlani, Markand Dipankumar Patel, Nigel Davies, Robert Flintham, Roman Wesolowski, Ismail Ughratdar, Ute Pohl, Santhosh Nagaraju, Vladimir Petrik, Andrew Kay, Saiju Jacob, Paul Sanghera, Victoria Wykes, Colin Watts, Harish Poptani

Source: Insights into Imaging, Vol 11, Iss 1, Pp 1-19 (2020)

Subject Terms: Diffusion MRI, Perfusion MRI, MR Spectroscopy, Multiparametric MRI, Neuroimaging, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13244-020-00888-1; https://doaj.org/toc/1869-4101

Access URL: https://doaj.org/article/b8e15c8b213848c4960814af0a071fe6

PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas

Authors: Imran Noorani, Jorge de la Rosa, Yoonha Choi, Alexander Strong, Hannes Ponstingl, M. S. Vijayabaskar, Jusung Lee, Eunmin Lee, Angela Richard-Londt, Mathias Friedrich, Federica Furlanetto, Rocio Fuente, Ruby Banerjee, Fengtang Yang, Frances Law, Colin Watts, Roland Rad, George Vassiliou, Jong Kyoung Kim, Thomas Santarius, Sebastian Brandner, Allan Bradley

Source: Genome Biology, Vol 21, Iss 1, Pp 1-36 (2020)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-020-02092-2; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/1eaeb70da58742019211422350f94ef2

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

Authors: Ravi S. Narayan, Piet Molenaar, Jian Teng, Fleur M. G. Cornelissen, Irene Roelofs, Renee Menezes, Rogier Dik, Tonny Lagerweij, Yoran Broersma, Naomi Petersen, Jhon Alexander Marin Soto, Eelke Brands, Philip van Kuiken, Maria C. Lecca, Kristiaan J. Lenos, Sjors G. J. G. In ‘t Veld, Wessel van Wieringen, Frederick F. Lang, Erik Sulman, Roel Verhaak, Brigitta G. Baumert, Lucas J. A. Stalpers, Louis Vermeulen, Colin Watts, David Bailey, Ben J. Slotman, Rogier Versteeg, David Noske, Peter Sminia, Bakhos A. Tannous, Tom Wurdinger, Jan Koster, Bart A. Westerman

Source: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/379bf84492484b43b2eac920159ae273

Development of ‘Core Outcome Sets’ for Meningioma in Clinical Studies (The COSMIC Project): protocol for two systematic literature reviews, eDelphi surveys and online consensus meetings

Authors: James Snyder, Nisaharan Srikandarajah, Boris Krischek, Matthias Preusser, Michael Weller, Timothy J Kaufmann, Thomas Santarius, Carole Turner, Michael D Cusimano, Paula R Williamson, Michael McDermott, Michael D Jenkinson, Justin Wang, Mohsen Javadpour, Andrea Saladino, Anthony G Marson, David James, Chaya Brodie, Daniel M Fountain, Roland Goldbrunner, Felix Sahm, Sylvia Kurz, Colin Watts, Julian Spears, Amir H Zamanipoor Najafabadi, Simon Walling, Andrew Morokoff, Ghazaleh Tabatabai, Helen Shih, Linda Dirven, Puneet Plaha, Helen Bulbeck, David Schultz, Christian Mawrin, Jens Schittenhelm, Farshad Nassiri, Martin J B Taphoorn, Manfred Westphal, Warren Selman, C Oliver Hanemann, Patrick Y Wen, Mirjam Renovanz, Evanthia Galanis, Alireza Mansouri, Priscilla K Brastianos, Christine Jungk, Heather Barrington, Aaron Cohen-Gadol, Gelareh Zadeh, Abdurrahman I Islim, Christopher P Millward, Theo Georgious, Andrew R Brodbelt, Karolyn Au, Felix Behling, Nicholas Butowski, Ana Castro, Marta Couce, Francesco Dimeco, Craig Erker, Michelle Felicella, Norbert Galldiks, Caterina Giannini, Christel Herold-Mende, Luke Hnenny, Craig Horbinski, Gerhard Jungwirth, Daniel Lachance, Christian Lafougere, Katrin Lamszus, Serge Makarenko, Tathiana Malta, Jennifer Moliterno-Gunel, Houtan Noushmehr, Arie Perry, Aditya Ragunathan, David Raleigh, Franz Ricklefs, Antonio Santacroce, Christian Schichor, Andrew Sloan, Matija Snuderl, Erik Sulman, Suganth Suppiah, Marcos Tatagiba, Marco Timmer, Andreas Von Deimling, Tobias Walbert, Stephen Yip, Gabriel Zada, Viktor Zherebitskiy, Derek Tsang, Kenneth Aldape, Terri S Armstrong, Sabrina Bell, Anna Crofton, Paul L Grundy, Sumirat M Keshwara, Shelli D Koszdin, Michael W McDermott, Torstein R Meling, Kathy Oliver, Jill Barnhartz-Sloan, Wenya Linda Bi, Carlos Carlotti, Katharine Drummond, Ian F Dunn, Brent Griffith, Rintaro Hashizume, Raymond Y Huang, Ian Lee, Jeff C Liu, Yasin Mamatjan, David Munoz, Ho-Keung Ng, Farhad Pirouzmand, Laila M Poisson, Bianca Pollo, Nils O Schmidt, Daniela Tirapelli, Joerg C Tonn, Michael A Vogelbaum, Adriana M Workewych

Source: BMJ Open, Vol 12, Iss 5 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/12/5/e057384.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/e6f0561f8df642f8988cb2020bf5eb8a

SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice

Authors: Ruth T. Casey, Rogier ten Hoopen, Eguzkine Ochoa, Benjamin G. Challis, James Whitworth, Philip S. Smith, Jose Ezequiel Martin, Graeme R. Clark, Fay Rodger, Mel Maranian, Kieren Allinson, Basetti Madhu, Thomas Roberts, Luis Campos, Joanne Anstee, Soo-Mi Park, Alison Marker, Colin Watts, Venkata R. Bulusu, Olivier T. Giger, Eamonn R. Maher

Source: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e8bf863475e349e4b6af0bc8e9781f47

Electrotherapies for Glioblastoma

Authors: Elise P. W. Jenkins, Alina Finch, Magda Gerigk, Iasonas F. Triantis, Colin Watts, George G. Malliaras

Source: Advanced Science, Vol 8, Iss 18, Pp n/a-n/a (2021)

Subject Terms: bioelectronics, electroporation, electrotherapy, glioblastoma, tumour‐treating fields, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/d83d2e76b67d49c590979fc59833f8ae

A Position Statement on the Utility of Interval Imaging in Standard of Care Brain Tumour Management: Defining the Evidence Gap and Opportunities for Future Research

Authors: Thomas C. Booth, Gerard Thompson, Helen Bulbeck, Florien Boele, Craig Buckley, Jorge Cardoso, Liane Dos Santos Canas, David Jenkinson, Keyoumars Ashkan, Jack Kreindler, Nicky Huskens, Aysha Luis, Catherine McBain, Samantha J. Mills, Marc Modat, Nick Morley, Caroline Murphy, Sebastian Ourselin, Mark Pennington, James Powell, David Summers, Adam D. Waldman, Colin Watts, Matthew Williams, Robin Grant, Michael D. Jenkinson

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: glioblastoma, high grade glioma, glioma, meningioma, interval imaging, magnetic resonance imaging, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.620070/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/b537137dce164a16aa4c45ace8329835

Comparison of outcomes of neurosurgical operations performed before and during the COVID-19 pandemic: a matched cohort study

Authors: Emma Toman, Colin Watts, Wai Cheong Soon, Gopiga Thanabalasundaram, Daniel Burns, Vladimir Petrik, Victoria Wykes, Anwen White

Source: BMJ Open, Vol 11, Iss 2 (2021)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/11/2/e047063.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/63f62b193dcf43b9bc9bcdb957d61be1

Impact of COVID-19 pandemic on surgical neuro-oncology multi-disciplinary team decision making: a national survey (COVID-CNSMDT Study)

Authors: Giles Critchley, Peter Hutchinson, Chittoor Rajaraman, Ola Rominiyi, Michael D Jenkinson, Alexis Joannides, Daniel M Fountain, Rory J Piper, Colin Watts, Stuart Smith, Ryan K Mathew, Victoria Wykes, Stephen John Price, Puneet Plaha, Fardad Taghizadeh Afshari, Erminia Albanese, Neil U Barua, Huan Wee Chan, Thomas Flannery, Michael TC Poon, Georgios Solomou, Anna Solth, Surash Surash, Helen Bulbeck

Source: BMJ Open, Vol 10, Iss 8 (2020)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/10/8/e040898.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/dc7a5511880a45a0b970dbac59f07d64