Interplay between on-demand treatment trials for hereditary angioedema and treatment guidelines

Authors: Cohn, Danny M. ^a, Soteres, Daniel F. ^b, Craig, Timothy J. ^{c, d}, Lumry, William R. ^e, Magerl, Markus ^{f, g}, Riedl, Marc A. ^h, Audhya, Paul K. ⁱ, Maurer, Marcus ^{f, g, †}, Bernstein, Jonathan A. ^{j, ∗}

Source: In The Journal of Allergy and Clinical Immunology March 2025 155(3):726-739

Global frequency, diagnosis, and treatment of hereditary angioedema with normal C1 inhibitor

Authors: Magerl, Markus ^{a, b, ∗}, Riedl, Marc A. ^c, Arruda, Luisa Karla ^d, Bauer, Andrea ^e, Berardi, Alejandro ^f, Bernstein, Jonathan A. ^g, Bouillet, Laurence ^h, Buckland, Matthew ⁱ, Buttgereit, Thomas ^{a, b}, Cohn, Danny M. ^j, Craig, Timothy ^k, Criado, Roberta F. ^l, Du-Thanh, Aurélie ^m, Fain, Olivier ⁿ, Gonçalo, Margarida ^o, Greve, Jens ^p, Grumach, Anete Sevciovic ^q, Guilarte, Mar ^r, Katelaris, Constance ^s, Kinaciyan, Tamar ^t, Latysheva, Elena A. ^u, Lleonart, Ramon ^v, Llosa, Oscar Calderón ^w, Mansour, Eli ^x, Grivcheva-Panovska, Vesna ^y, Parisi, Claudio ^z, Rosario Filho, Nelson Augusto ^aa, Santos, Amélia Spínola ^bb, Staubach, Petra ^cc, Valerieva, Anna ^dd, Rodrigues Valle, Solange Oliveira ^ee, Danese, Sherry ^ff, Ulloa, Julie ^ff, Audhya, Paul K. ^gg, Maurer, Marcus ^{a, b}

Source: In Journal of Allergy and Clinical Immunology: Global January 2025

Antisense therapy to block the Kallikrein-kinin pathway in COVID-19: The ASKCOV randomized controlled trial

Authors: Zampieri, Fernando G., Westphal, Glauco Adrieno, Santos, Maria Adelaide Dos, Gomes, Samara P.C., Gomes, Jackeline O., Negrelli, Karina L., Santos, Renato H.N., Ishihara, Luciana M., Miranda, Tamiris A., Laranjeira, Ligia N., Valeis, Nanci, Santucci, Eliana Vieira, de Souza Dantas, Vicente Cés, Gebara, Otávio, Cohn, Danny M., Buchele, Gustavo, Janiszewski, Mariano, de Freitas, Flávio Geraldo, Dal-Pizzol, Felipe, de Matos Soeiro, Alexandre, Berti, Isabele Ribeiro, Germano, Almir, Schettini, Daniel Almeida, Rosa, Regis G., Falavigna, Maicon, Veiga, Viviane C., Azevedo, Luciano C.P., Damiani, Lucas P., Machado, Flávia R., Cavalcanti, Alexandre B.

Source: In Journal of Critical Care December 2024 84

Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

Authors: Reshef, Avner, Buttgereit, Thomas, Betschel, Stephen D., Caballero, Teresa, Farkas, Henriette, Grumach, Anete S., Hide, Michihiro, Jindal, Ankur K., Longhurst, Hilary, Peter, Jonathan, Riedl, Marc A., Zhi, Yuxiang, Aberer, Werner, Abuzakouk, Mohamed, Al Farsi, Tariq, Al Sukaiti, Nashat, Al-Ahmad, Mona, Altrichter, Sabine, Aygören-Pürsün, Emel, Baeza, Maria Luisa, Bara, Noemi Anna, Bauer, Andrea, Bernstein, Jonathan A., Boccon-Gibod, Isabelle, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Bygum, Anette, Calderon, Oscar, de Albuquerque Campos, Regis, Campos Romero, Freya Helena, Cancian, Mauro, Chong-Neto, Herberto Jose, Christoff, George, Cimbollek, Stefan, Cohn, Danny M., Craig, Timothy, Danilycheva, Inna, Darlenski, Razvigor, Du-Thanh, Aurélie, Ensina, Luis Felipe, Fomina, Daria, Fonacier, Luz, Fukunaga, Atsushi, Gelincik, Asli, Giavina-Bianchi, Pedro, Godse, Kiran, Gompels, Mark, Goncalo, Margarida, Gotua, Maia, Guidos-Fogelbach, Guillermo, Guilarte, Mar, Kasperska-Zajac, Alicja, Katelaris, Constance H., Kinaciyan, Tamar, Kolkhir, Pavel, Kulthanan, Kanokvalai, Kurowski, Marcin, Latysheva, Elena, Lauerma, Antti, Launay, David, Lleonart, Ramon, Lumry, William, Malbran, Alejandro, Ali, Ramzy Mohammed, Nasr, Iman, Nieto-Martinez, Sandra, Parisi, Claudio, Pawankar, Ruby, Piñero-Saavedra, Macarena, Popov, Todor A., Porebski, Grzegorz, Prieto Garcia, Alicia, Pyatilova, Polina, Rudenko, Michael, Sekerel, Bulent Enis, Serpa, Faradiba Sarquis, Sheikh, Farrukh, Siebenhaar, Frank, Soria, Angèle, Staevska, Maria, Staubach, Petra, Stobiecki, Marcin, Thomsen, Simon Francis, Triggiani, Massimo, Valerieva, Anna, Valle, Solange, Van Dinh, Nguyen, Vera Ayala, Carolina Elisa, Zalewska-Janowska, Anna, Zanichelli, Andrea, Magerl, Markus, Maurer, Marcus

Source: In The Journal of Allergy and Clinical Immunology August 2024 154(2):398-411

Deucrictibant for angioedema due to acquired C1-inhibitor deficiency: A randomized-controlled trial

Authors: Petersen, Remy S., Fijen, Lauré M., Kelder, Johannes P., Cohn, Danny M.

Source: In The Journal of Allergy and Clinical Immunology July 2024 154(1):179-183

A Core Outcome Set for Efficacy of Acute Treatment of Hereditary Angioedema

Authors: Petersen, Remy S. ^a, Fijen, Lauré M. ^a, Apfelbacher, Christian ^b, Magerl, Markus ^{c, d}, Weller, Karsten ^{c, d}, Aberer, Werner ^e, Adatia, Adil ^f, Audhya, Paul ^g, Bara, Noémi-Anna ^h, Betschel, Stephen ⁱ, Boccon-Gibod, Isabelle ^j, Bouillet, Laurence ^{j, k}, Brodszki, Nicholas ^l, Busse, Paula J. ^m, Buttgereit, Thomas ^{c, d}, Bygum, Anette ⁿ, Cancian, Mauro ^o, Craig, Timothy ^p, Csuka, Dorottya ^q, Farkas, Henriette ^q, Fomina, Daria ^{r, s, t}, Gil-Serrano, Johana ^{u, v}, Gompels, Mark ^w, Guidos Fogelbach, Guillermo ^x, Guilarte, Mar ^{u, v}, Hide, Michihiro ^y, Kiani-Alikhan, Sorena ^z, Kinaciyan, Tamar ^aa, Lenten, Annet ^bb, lleonart, Ramon ^cc, Longhurst, Hilary ^dd, Lumry, William R. ^ee, Malbran, Alejandro ^ff, Malinauskiene, Laura ^gg, Matta Campos, Juan J. ^hh, Mendivil, Joan ⁱⁱ, Nieto-Martinez, Sandra A. ^jj, Peter, Jonathan G. ^kk, Porebski, Grzegorz ^ll, Reshef, Avner ^mm, Riedl, Marc ⁿⁿ, Valerieva, Anna ^oo, Waserman, Susan ^pp, Maurer, Marcus ^{c, d}, Cohn, Danny M. ^{a, ∗}

Source: In The Journal of Allergy and Clinical Immunology: In Practice June 2024 12(6):1614-1621

An investigational oral plasma kallikrein inhibitor for on-demand treatment of hereditary angioedema: a two-part, randomised, double-blind, placebo-controlled, crossover phase 2 trial

Authors: Aygören-Pürsün, Emel, Zanichelli, Andrea, Cohn, Danny M, Cancian, Mauro, Hakl, Roman, Kinaciyan, Tamar, Magerl, Markus, Martinez-Saguer, Inmaculada, Stobiecki, Marcin, Farkas, Henriette, Kiani-Alikhan, Sorena, Grivcheva-Panovska, Vesna, Bernstein, Jonathan A, Li, H Henry, Longhurst, Hilary J, Audhya, Paul K, Smith, Michael D, Yea, Christopher M, Maetzel, Andreas, Lee, Daniel K, Feener, Edward P, Gower, Richard, Lumry, William R, Banerji, Aleena, Riedl, Marc A, Maurer, Marcus

Source: Lancet. 401(10375):458-469

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185462467.0x000001&indx=1&recIds=ETOCvdc_100185462467.0x000001

Hereditary Angioedema: A Review of the Current and Evolving Treatment Landscape

Authors: Betschel, Stephen D., Banerji, Aleena, Busse, Paula J., Cohn, Danny M., Magerl, Markus

Source: In The Journal of Allergy and Clinical Immunology: In Practice August 2023 11(8):2315-2325

The Disease Burden and Societal Costs of Hereditary Angioedema

Authors: Fijen, Lauré M., Klein, Philip C.G., Cohn, Danny M., Kanters, Tim A.

Source: In The Journal of Allergy and Clinical Immunology: In Practice August 2023 11(8):2468-2475

The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update

Authors: Maurer, Marcus, Magerl, Markus, Betschel, Stephen, Aberer, Werner, Ansotegui, Ignacio J., Aygören‐Pürsün, Emel, Banerji, Aleena, Bara, Noémi‐Anna, Boccon‐Gibod, Isabelle, Bork, Konrad, Bouillet, Laurence, Boysen, Henrik Balle, Brodszki, Nicholas, Busse, Paula J., Bygum, Anette, Caballero, Teresa, Cancian, Mauro, Castaldo, Anthony, Cohn, Danny M., Csuka, Dorottya, Farkas, Henriette, Gompels, Mark, Gower, Richard, Grumach, Anete S., Guidos‐Fogelbach, Guillermo, Hide, Michihiro, Kang, Hye‐Ryun, Kaplan, Allen Phillip, Katelaris, Constance, Kiani‐Alikhan, Sorena, Lei, Wei‐Te, Lockey, Richard, Longhurst, Hilary, Lumry, William R., MacGinnitie, Andrew, Malbran, Alejandro, Martinez Saguer, Inmaculada, Matta, Juan José, Nast, Alexander, Nguyen, Dinh, Nieto‐Martinez, Sandra A., Pawankar, Ruby, Peter, Jonathan, Porebski, Grzegorz, Prior, Nieves, Reshef, Avner, Riedl, Marc, Ritchie, Bruce, Rafique Sheikh, Farrukh, Smith, William B., Spaeth, Peter J., Stobiecki, Marcin, Toubi, Elias, Varga, Lilian Agnes, Weller, Karsten, Zanichelli, Andrea, Zhi, Yuxiang, Zuraw, Bruce, Craig, Timothy

Source: Allergy. 77(7):1961-1990

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187899226.0x000001&indx=1&recIds=ETOCvdc_100187899226.0x000001

CRISPR-Based Therapy for Hereditary Angioedema.

Authors: Cohn, Danny M.¹ d.m.cohn@amsterdamumc.nl, Gurugama, Padmalal², Magerl, Markus^3,4, Katelaris, Constance H.⁵, Launay, David^6,7,8, Bouillet, Laurence^9,10, Petersen, Remy S.¹, Lindsay, Karen¹¹, Aygören-Pürsün, Emel¹², Maag, David⁸, Butler, James S.⁸, Shah, Mrinal Y.⁸, Golden, Adele⁸, Yuanxin Xu⁸, Abdelhady, Ahmed M.⁸, Lebwohl, David^6,7,8, Longhurst, Hilary J.¹¹

Source: New England Journal of Medicine. 1/30/2025, Vol. 392 Issue 5, p458-467. 10p.

Subject Terms: *CLINICAL trials, *BLOOD proteins, *GENETIC disorders, *ANGIONEUROTIC edema, *FATIGUE (Physiology)

Skin autofluorescence of advanced glycation end products and mortality in affective disorders in the lifelines cohort study: A mediation analysis

Authors: Hagen, Julia M., Sutterland, Arjen L., Liefers, Tessa, Schirmbeck, Frederike, Cohn, Danny M., Lok, Anja, Tan, Hanno L., Zwinderman, Aeilko H., de Haan, Lieuwe

Source: In Journal of Affective Disorders 1 March 2021 282:1082-1089

Targeting factor XIIa for therapeutic interference with hereditary angioedema.

Authors: Cohn, Danny M.¹ (AUTHOR), Renné, Thomas^2,3,4 (AUTHOR) thomas@renne.net

Source: Journal of Internal Medicine. Oct2024, Vol. 296 Issue 4, p311-326. 16p.

Subject Terms: *BLOOD coagulation factors, *PEPTIDES, *GENETIC disorders, *BRADYKININ, *ANGIONEUROTIC edema

Hereditary Angioedema: The Clinical Picture of Excessive Contact Activation.

Authors: Petersen, Remy S., Fijen, Lauré M., Levi, Marcel, Cohn, Danny M.

Source: Seminars in Thrombosis & Hemostasis; Oct2024, Vol. 50 Issue 7, p978-988, 11p

Subject Terms: COMPLEMENT activation, GENETIC disorders, ANGIONEUROTIC edema, BRADYKININ, BLOOD coagulation

Skin autofluorescence of advanced glycation end products and course of affective disorders in the lifelines cohort study, a prospective investigation

Authors: Hagen, Julia M., Sutterland, Arjen L., Schirmbeck, Frederike, Cohn, Danny M., Lok, Anja, Tan, Hanno L., Zwinderman, Aeilko H., de Haan, Lieuwe

Source: In Journal of Affective Disorders 1 November 2020 276:424-432

Association between skin autofluorescence of advanced glycation end products and affective disorders in the lifelines cohort study

Authors: Hagen, Julia M., Sutterland, Arjen L., da Fonseca Pereira de Sousa, Paulo A.L., Schirmbeck, Frederike, Cohn, Danny M., Lok, Anja, Tan, Hanno L., Zwinderman, Aeilko H., de Haan, Lieuwe

Source: In Journal of Affective Disorders 1 October 2020 275:230-237

Evaluation of patient‐reported outcome measures for on‐demand treatment of hereditary angioedema attacks and design of KONFIDENT, a phase 3 trial of sebetralstat

Authors: Cohn, Danny M., Aygören‐Pürsün, Emel, Bernstein, Jonathan A., Farkas, Henriette, Lumry, William R., Maurer, Marcus, Zanichelli, Andrea, Iverson, Matthew, Hao, James, Smith, Michael D., Yea, Christopher M., Audhya, Paul K., Riedl, Marc A.

Source: Clinical and translational allergy. 13(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194158065.0x000001&indx=1&recIds=ETOCvdc_100194158065.0x000001

Outcome measures in randomized controlled studies of acute therapy for hereditary angioedema: A systematic review

Authors: Fijen, Lauré M., Petersen, Remy S., Cohn, Danny M.

Source: Allergy. 77(7):2222-2224

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187899547.0x000001&indx=1&recIds=ETOCvdc_100187899547.0x000001

The Role of Complement in Hereditary Angioedema

Authors: Levi, Marcel, Cohn, Danny M

Source: In Transfusion Medicine Reviews October 2019 33(4):243-247

Definition, aims, and implementation of GA2LEN/HAEi Angioedema Centers of Reference and Excellence

Authors: Maurer, Marcus, Aberer, Werner, Agondi, Rosana, Al‐Ahmad, Mona, Al‐Nesf, Maryam Ali, Ansotegui, Ignacio, Arnaout, Rand, Arruda, Luisa Karla, Asero, Riccardo, Aygören‐Pürsün, Emel, Banerji, Aleena, Bauer, Andrea, Ben‐Shoshan, Moshe, Berardi, Alejandro, Bernstein, Jonathan A., Betschel, Stephen, Bindslev‐Jensen, Carsten, Bizjak, Mojca, Boccon‐Gibod, Isabelle, Bork, Konrad, Bouillet, Laurence, Boysen, Henrik Balle, Brodszki, Nicholas, Broesby‐Olsen, Sigurd, Busse, Paula, Buttgereit, Thomas, Bygum, Anette, Caballero, Teresa, Campos, Régis A., Cancian, Mauro, Cherrez‐Ojeda, Ivan, Cohn, Danny M., Costa, Célia, Craig, Timothy, Criado, Paulo Ricardo, Criado, Roberta F., Csuka, Dorottya, Dissemond, Joachim, Du‐Thanh, Aurélie, Ensina, Luis Felipe, Ertaş, Ragıp, Fabiani, José E., Fantini, Claudio, Farkas, Henriette, Ferrucci, Silvia Mariel, Figueras‐Nart, Ignasi, Fili, Natalia L., Fomina, Daria, Fukunaga, Atsushi, Gelincik, Asli, Giménez‐Arnau, Ana, Godse, Kiran, Gompels, Mark, Gonçalo, Margarida, Gotua, Maia, Gower, Richard, Grumach, Anete S., Guidos‐Fogelbach, Guillermo, Hide, Michihiro, Ilina, Natalia, Inomata, Naoko, Jakob, Thilo, Josviack, Dario O., Kang, Hye‐Ryun, Kaplan, Allen, Kasperska‐Zając, Alicja, Katelaris, Constance, Kessel, Aharon, Kleinheinz, Andreas, Kocatürk, Emek, Košnik, Mitja, Krasowska, Dorota, Kulthanan, Kanokvalai, Kumaran, M. Sendhil, Larco Sousa, José Ignacio, Longhurst, Hilary J., Lumry, William, MacGinnitie, Andrew, Magerl, Markus, Makris, Michael P., Malbrán, Alejandro, Marsland, Alexander, Martinez‐Saguer, Inmaculada, Medina, Iris V., Meshkova, Raisa, Metz, Martin, Nasr, Iman, Nicolay, Jan, Nishigori, Chikako, Ohsawa, Isao, Özyurt, Kemal, Papadopoulos, Nikolaos G., Parisi, Claudio A. S., Peter, Jonathan Grant, Pfützner, Wolfgang, Popov, Todor, Prior, Nieves, Ramon, German D., Reich, Adam, Reshef, Avner, Riedl, Marc A., Ritchie, Bruce, Röckmann‐Helmbach, Heike, Rudenko, Michael, Salman, Andaç, Sanchez‐Borges, Mario, Schmid‐Grendelmeier, Peter, Serpa, Faradiba S., Serra‐Baldrich, Esther, Sheikh, Farrukh R., Smith, William, Soria, Angèle, Staubach, Petra, Steiner, Urs C., Stobiecki, Marcin, Sussman, Gordon, Tagka, Anna, Thomsen, Simon Francis, Treudler, Regina, Valle, Solange, Doorn, Martijn, Varga, Lilian, Vázquez, Daniel O., Wagner, Nicola, Wang, Liangchun, Weber‐Chrysochoou, Christina, Ye, Young‐Min, Zalewska‐Janowska, Anna, Zanichelli, Andrea, Zhao, Zuotao, Zhi, Yuxiang, Zuberbier, Torsten, Zwiener, Ricardo D., Castaldo, Anthony

Source: Allergy. 75(8):2115-2123

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110308116.0x000001&indx=1&recIds=ETOCvdc_100110308116.0x000001