Empagliflozin prevents oxidative stress in human coronary artery endothelial cells via the NHE/PKC/NOX axis

Authors: Xiaoling Li, Mengnan Wang, Jan-Ole Kalina, Benedikt Preckel, Markus W. Hollmann, Martin Albrecht, Coert J. Zuurbier, Nina C. Weber

Source: Redox Biology, Vol 69, Iss , Pp 102979- (2024)

Subject Terms: Sodium glucose co-transporter 2 inhibitor (SGLT2i), Cyclic stretch, Human coronary artery endothelial cells (HCAECs), Nicotinamide adenine dinucleotide phosphate oxidase (NOX), Reactive oxygen species (ROS), Intracellular calcium (Ca2+), Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213231723003804; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/2f33de2efafb4ef0b4548402cf79295b

Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells

Authors: Sha Chen, Cees A. Schumacher, Shirley C. M. Van Amersfoorth, Jan W. T. Fiolet, Antonius Baartscheer, Marieke W. Veldkamp, Ruben Coronel, Coert J. Zuurbier

Source: Frontiers in Physiology, Vol 14 (2023)

Subject Terms: SGLT2, NHE, protease XIV, empagliflozin, cardiomyocyte, Physiology, QP1-981

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Relation: https://www.frontiersin.org/articles/10.3389/fphys.2023.1179131/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/3781e8600e744784a56a10b45357c354

Direct cardiac effects of SGLT2 inhibitors

Authors: Sha Chen, Ruben Coronel, Markus W. Hollmann, Nina C. Weber, Coert J. Zuurbier

Source: Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-13 (2022)

Subject Terms: Sodium-glucose-cotransporter 2 inhibitors, Ion homeostasis, Oxidative stress, Inflammation, Metabolism, Cardiac function, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/3ea4326ec125483fa86d94129c64fd5f

NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy

Authors: Ye Liu, Lotte Kors, Loes M. Butter, Geurt Stokman, Nike Claessen, Coert J. Zuurbier, Stephen E. Girardin, Jaklien C. Leemans, Sandrine Florquin, Alessandra Tammaro

Source: Cells, Vol 13, Iss 1, p 23 (2023)

Subject Terms: NLRX1, macrophage polarization, OXPHOS, renal fibrosis, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/1/23; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/a19ace71ab7e4aec9b0f3be9ba50d498

Pharmacological Cardioprotection against Ischemia Reperfusion Injury—The Search for a Clinical Effective Therapy

Authors: Qian Wang, Coert J. Zuurbier, Ragnar Huhn, Carolin Torregroza, Markus W. Hollmann, Benedikt Preckel, Charissa E. van den Brom, Nina C. Weber

Source: Cells, Vol 12, Iss 10, p 1432 (2023)

Subject Terms: cardioprotection, ischemia-reperfusion injury, drug development, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/10/1432; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/7c2f903cb2d14ff5aa142cd8e9b5eddb

Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells

Authors: Laween Uthman, Anna Homayr, Rio P. Juni, Eva L. Spin, Raphaela Kerindongo, Marleen Boomsma, Markus W. Hollmann, Benedikt Preckel, Pieter Koolwijk, Victor W.M. van Hinsbergh, Coert J. Zuurbier, Martin Albrecht, Nina C. Weber

Source: Cellular Physiology and Biochemistry, Vol 53, Iss 5, Pp 865-886 (2019)

Subject Terms: Physiology, QP1-981, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://www.cellphysiolbiochem.com/Articles/000178/; https://doaj.org/toc/1015-8987

Access URL: https://doaj.org/article/233c649f9b894beab1e1f03e1375d2bb

Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infarct Size in Presence of Fentanyl, Midazolam and Cangrelor, but Not Propofol

Authors: Yang Xiao, Philippa Phelp, Qian Wang, Diane Bakker, Rianne Nederlof, Markus W. Hollmann, Coert J. Zuurbier

Source: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Subject Terms: cardioprotection, animal model, infarct size, NAD+ precursor, P2Y12 antagonist, propofol, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2021.712478/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/1854fe6a04bc4a3a9eb9b3e073d02e6b

Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts

Authors: Hong Zhang, Laween Uthman, Diane Bakker, Sahinda Sari, Sha Chen, Markus W. Hollmann, Ruben Coronel, Nina C. Weber, Sander M. Houten, Michel van Weeghel, Coert J. Zuurbier

Source: Frontiers in Cardiovascular Medicine, Vol 7 (2020)

Subject Terms: SGLT2, glycolysis, glucose oxidation, fatty acid oxidation, NHE, diastolic function, Diseases of the circulatory (Cardiovascular) system, RC666-701

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Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2020.592233/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/908a771a40ff4285a5ac4f1f00cafc9b

NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart

Authors: Hong Zhang, Yang Xiao, Rianne Nederlof, Diane Bakker, Pengbo Zhang, Stephen E. Girardin, Markus W. Hollmann, Nina C. Weber, Sander M. Houten, Michel van Weeghel, Richard G. Kibbey, Coert J. Zuurbier

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: cardiac metabolism, oxygen consumption, innate immunity, infarct size, duration of ischemia, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.591815/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9f4ad16a7fe64906b65a5a790d17cf85

Does acute treatment of dapagliflozin reduce cardiac infarct size through direct cardiac effects or reductions in blood glucose levels?

Authors: Coert J. Zuurbier

Source: Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-2 (2020)

Subject Terms: SGLT2i, Hyperglycemia, Xylazine, Infarct size, Ischemia-reperfusion, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12933-020-01119-z; https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/5b2df75182c04df39e80d2d198a7c591

A randomized trial of remote ischemic preconditioning and control treatment for cardioprotection in sevoflurane-anesthetized CABG patients

Authors: Rianne Nederlof, Nina C. Weber, Nicole P. Juffermans, Bas A. M. J. de Mol, Markus W. Hollmann, Benedikt Preckel, Coert J. Zuurbier

Source: BMC Anesthesiology, Vol 17, Iss 1, Pp 1-12 (2017)

Subject Terms: Coronary Artery Bypass Graft, Sevoflurane, Migration Inhibitory Factor, Nicorandil, Ticagrelor, Anesthesiology, RD78.3-87.3

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12871-017-0330-6; https://doaj.org/toc/1471-2253

Access URL: https://doaj.org/article/bdb1a8da2e3a44b0af5b7301a1b06a8b

Editorial: Diabetes and Heart Failure: Pathogenesis and Novel Therapeutic Approaches

Authors: Claudio de Lucia, Celestino Sardu, Laurent Metzinger, Coert J. Zuurbier

Source: Frontiers in Physiology, Vol 10 (2019)

Subject Terms: diabetes, heart failure, diastolic dysfunction, arrhythmia, SGLT2 (sodium-glucose cotransporter 2) inhibitor, GLP-1-glucagon-like peptide-1, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphys.2019.00253/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/9984308b5296472ca9104f3b85374155

Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients

Authors: Laween Uthman, Antonius Baartscheer, Cees A. Schumacher, Jan W. T. Fiolet, Marius C. Kuschma, Markus W. Hollmann, Ruben Coronel, Nina C. Weber, Coert J. Zuurbier

Source: Frontiers in Physiology, Vol 9 (2018)

Subject Terms: SGLT2 inhibitors, cardiomyocyte, endothelial cell, smooth muscle cell, cardiac fibroblast, isolated heart, Physiology, QP1-981

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Relation: https://www.frontiersin.org/article/10.3389/fphys.2018.01575/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/4f40533026864e7b8f7d08956deefdb3

Deletion of the innate immune NLRP3 receptor abolishes cardiac ischemic preconditioning and is associated with decreased Il-6/STAT3 signaling.

Authors: Coert J Zuurbier, Willeke M C Jong, Otto Eerbeek, Anneke Koeman, Wilco P Pulskens, Loes M Butter, Jaklien C Leemans, Markus W Hollmann

Source: PLoS ONE, Vol 7, Iss 7, p e40643 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3407219?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a94404d28503471b94ce215442b01358