The utility of small nutation angle 1H pulses for NMR studies of methyl-containing side-chain dynamics in proteins

Authors: Tugarinov, Vitali, Clore, G. Marius

Source: In Progress in Nuclear Magnetic Resonance Spectroscopy November-December 2024 144-145:40-62

Quantitative NMR analysis of the kinetics of prenucleation oligomerization and aggregation of pathogenic huntingtin exon-1 protein

Authors: Ceccon, Alberto, Tugarinov, Vitali, Torricella, Francesco, Clore, G. Marius

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Jul . 119(29), 1-12.

Access URL: https://www.jstor.org/stable/27171801

Interaction of the bacterial division regulator MinE with lipid bicelles studied by NMR spectroscopy

Authors: Cai, Mengli, Tugarinov, Vitali, Chaitanya Chiliveri, Sai, Huang, Ying, Schwieters, Charles D., Mizuuchi, Kyoshi, Clore, G. Marius

Source: In Journal of Biological Chemistry April 2023 299(4)

Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca 2+ -ligated calmodulin

Authors: Schmidt, Thomas, Jeon, Jaekyun, Yau, Wai-Ming, Schwieters, Charles D., Tycko, Robert, Clore, G. Marius

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Feb 01. 119(6), 1-10.

Access URL: https://www.jstor.org/stable/27118481

Atomic view of cosolute-induced protein denaturation probed by NMR solvent paramagnetic relaxation enhancement

Authors: Okuno, Yusuke, Yoo, Janghyun, Schwieters, Charles D., Best, Robert B., Chung, Hoi Sung, Clore, G. Marius

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Aug . 118(34), 1-9.

Access URL: https://www.jstor.org/stable/27075496

Theory and Applications of Nitroxide-based Paramagnetic Cosolutes for Probing Intermolecular and Electrostatic Interactions on Protein Surfaces

Authors: Okuno, Yusuke, Schwieters, Charles D., Yang, Zhilin, Clore, G. Marius

Source: Journal of the American Chemical Society. 144(46):21371-21388

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630689855&indx=1&recIds=ETOCRN630689855

Quantitative Agreement between Conformational Substates of Holo Calcium-Loaded Calmodulin Detected by Double Electron—Electron Resonance EPR and Predicted by Molecular Dynamics Simulations

Authors: Schmidt, Thomas, Wang, David, Jeon, Jaekyun, Schwieters, Charles D., Clore, G. Marius

Source: Journal of the American Chemical Society. 144(27):12043-12051

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629774669&indx=1&recIds=ETOCRN629774669

NMR methods for exploring 'dark' states in ligand binding and protein-protein interactions

Authors: Tugarinov, Vitali, Ceccon, Alberto, Clore, G. Marius

Source: Progress in nuclear magnetic resonance spectroscopy. 128:1-24

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157374001.0x000001&indx=1&recIds=ETOCvdc_100157374001.0x000001

An S/T motif controls reversible oligomerization of the Hsp40 chaperone DNAJB6b through subtle reorganization of a β sheet backbone

Authors: Karamanos, Theodoros K., Tugarinov, Vitali, Clore, G. Marius

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Dec 01. 117(48), 30441-30450.

Access URL: https://www.jstor.org/stable/26971118

Quantitative Exchange NMR-Based Analysis of Huntingtin—SH3 Interactions Suggests an Allosteric Mechanism of Inhibition of Huntingtin Aggregation

Authors: Ceccon, Alberto, Tugarinov, Vitali, Clore, G. Marius

Source: Journal of the American Chemical Society. 143(25):9672-9681

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627020945&indx=1&recIds=ETOCRN627020945

Probing the Interaction of Huntingtin Exon‐1 Polypeptides with the Chaperonin Nanomachine GroEL

Authors: Wälti, Marielle A., Kotler, Samuel A., Clore, G. Marius

Source: Chembiochem. 22(11):1985-1991

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123024368.0x000001&indx=1&recIds=ETOCvdc_100123024368.0x000001

Transverse relaxation optimized spectroscopy of NH2 groups in glutamine and asparagine side chains of proteins.

Authors: Tugarinov, Vitali, Torricella, Francesco, Ying, Jinfa, Clore, G. Marius

Source: Journal of Biomolecular NMR; Dec2024, Vol. 78 Issue 4, p199-213, 15p

Subject Terms: PHYSICAL sciences, CHEMICAL relaxation, LIGAND binding (Biochemistry), GLUTAMINE, ASPARAGINE

A Closed-Form Expression for Analysis of Dark State Exchange Saturation Transfer (DEST) NMR Experiments.

Authors: Torricella, Francesco, Clore, G. Marius, Tugarinov, Vitali

Source: Journal of Physical Chemistry Letters; 11/7/2024, Vol. 15 Issue 44, p11007-11014, 8p

Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I

Authors: Ceccon, Alberto, Tugarinov, Vitali, Ghirlando, Rodolfo, Clore, G. Marius

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Mar . 117(11), 5844-5852.

Access URL: https://www.jstor.org/stable/26929345

Probing transient excited states of the bacterial cell division regulator MinE by relaxation dispersion NMR spectroscopy

Authors: Cai, Mengli, Huang, Ying, Shen, Yang, Li, Min, Mizuuchi, Michiyo, Ghirlando, Rodolfo, Mizuuchi, Kiyoshi, Clore, G. Marius

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Dec . 116(51), 25446-25455.

Access URL: https://www.jstor.org/stable/26863883

Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis

Authors: Karamanos, Theodoros K., Tugarinov, Vitali, Clore, G. Marius

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Oct . 116(43), 21529-21538.

Access URL: https://www.jstor.org/stable/26859750

Spatial domain organization in the HIV-1 reverse transcriptase p66 homodimer precursor probed by double electron-electron resonance EPR

Authors: Schmidt, Thomas, Schwieters, Charles D., Clore, G. Marius

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Sep 01. 116(36), 17809-17816.

Access URL: https://www.jstor.org/stable/26851216

Protein NMR: Boundless opportunities

Authors: Bax, Ad, Clore, G. Marius

Source: In Journal of Magnetic Resonance September 2019 306:187-191

Tm filtering by 1H-methyl labeling in a deuterated protein for pulsed double electron–electron resonance EPRElectronic supplementary information (ESI) available: Experimental methods, DEER echo curves and DEER-derived P(r) distributions. See DOI: 10.1039/d0cc04369a

Authors: Schmidt, Thomas, Clore, G. Marius

Source: Chemical communications. 56(74):10890-10893

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108002514.0x000001&indx=1&recIds=ETOCvdc_100108002514.0x000001

Quantitative Interpretation of Solvent Paramagnetic Relaxation for Probing Protein—Cosolute Interactions

Authors: Okuno, Yusuke, Szabo, Attila, Clore, G. Marius

Source: Journal of the American Chemical Society. 142(18):8281-8290

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623820864&indx=1&recIds=ETOCRN623820864