A rapid whole-blood adenosine triphosphate secretion test can be used to exclude platelet-dense granule deficiency

Authors: Beckers, Erik, Coppens, Michiel, Eikenboom, Jeroen, Hooimeijer, Louise, Jansen, Gerard, Schutgens, Roger, Urbanus, Rolf, Zivkovic, Minka, van den Akker, Emile, Al Arashi, Wala, Arisz, Ryanne, Baas, Lieke, Bierings, Ruben, van den Biggelaar, Maartje, Boender, Johan, van der Bom, Anske, Bos, Mettine, Brands, Martijn, Bredenoord, Annelien, Bukkems, Laura, Burdorf, Lex, Del Castillo Alferez, Jessica, Cloesmeijer, Michael, Cnossen, Marjon, Driessens, Mariëtte, Fijnvandraat, Karin, Fischer, Kathelijn, Goedhart, Geertje, Goedhart, Tine, Gouw, Samantha, van der Graaf, Rieke, de Haas, Masja, Haverman, Lotte, Hazelzet, Jan, van Hoorn, Shannon, Huisman, Elise, Jansen, Nathalie, Janssen, Alexander, de Jong, Sean, Koopman, Sjoerd, Kruip, Marieke, Laan, Sebastiaan, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, Mathôt, Ron, van der Meer, Felix, Meijer, Karina, Meijer, Sander, Meijer, Stephan, van Moort, Iris, Mussert, Caroline, Ploos van Amstel, Hans Kristian, Polinder, Suzanne, Prameyllawati, Diaz, Reitsma, Simone, Roest, Eliza, Romano, Lorenzo, Schols, Saskia, Uyl, Carin, Voorberg, Jan, Zhang, Huan, Schutgens, Roger E.G. ¹, van der Vegte, Vossa ^{1, 2}, Lukasse, Janoek A. ^{1, 2}, Roest, Mark ³, Huskens, Dana ³, de Moor, Annick S. ¹, Kremer Hovinga, Idske C.L. ¹, Urbanus, Rolf T. ^{1, 2, ∗}

Source: In Journal of Thrombosis and Haemostasis January 2025

Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist

Authors: Beckers, Erik, Coppens, Michiel, Eikenboom, Jeroen, Hooimeijer, Louise, Jansen, Gerard, Schutgens, Roger, Urbanus, Rolf, Zivkovic, Minka, Akker, Emile van den, Al Arashi, Wala, Arisz, Ryanne, Baas, Lieke, Bierings, Ruben, van den Biggelaar, Maartje, Boender, Johan, van der Bom, Anske, Bos, Mettine, Brands, Martijn, Bredenoord, Annelien, Bukkems, Laura, Burdorf, Lex, Del Castillo Alferez, Jessica, Cloesmeijer, Michael, Cnossen, Marjon, Driessens, Mariëtte, Fijnvandraat, Karin, Fischer, Kathelijn, Goedhart, Geertje, Goedhart, Tine, Gouw, Samantha, van der Graaf, Rieke, de Haas, Masja, Haverman, Lotte, Hazelzet, Jan, van Hoorn, Shannon, Huisman, Elise, Jansen, Nathalie, Janssen, Alexander, de Jong, Sean, Koopman, Sjoerd, Kruip, Marieke, Laan, Sebastiaan, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, Mathôt, Ron, van der Meer, Felix, Meijer, Karina, Meijer, Sander, Meijer, Stephan, van Moort, Iris, Mussert, Caroline, Ploos van Amstel, Hans Kristian, Polinder, Suzanne, Prameyllawati, Diaz, Reitsma, Simone, Roest, Eliza, Romano, Lorenzo, Schols, Saskia, Uyl, Carin, Voorberg, Jan, Zhang, Huan, Pols - van Veen, Elisabeth, van der Vegte, Vossa, Sebastian, Silvie A.E., de Moor, Annick S., Korporaal, Suzanne J.A., Schutgens, Roger E.G., Urbanus, Rolf T.

Source: In Research and Practice in Thrombosis and Haemostasis October 2024 8(7)

Transcriptional and functional profiling identifies inflammation and endothelial-to-mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of endothelial colony forming cells

Authors: Brands, Martijn, Koopman, Sjoerd, Bukkems, Laura, Cloesmeijer, Michael, Janssen, Alexander, Fijnvandraat, Karin, Gouw, Samantha, Mathôt, Ron, Haverman, Lotte, van den Akker, Emile, van den Biggelaar, Maartje, de Haas, Masja, Meijer, Sander, Voorberg, Jan, Del Castillo Alferez, Jessica, Zhang, Huan, Boender, Johan, Meijer, Stephan, Meijer, Karina, de Jong, Sean, Goedhart, Geertje, van der Bom, Anske, Bos, Mettine, Eikenboom, Jeroen, van der Meer, Felix, Laan, Sebastiaan, Schols, Saskia, Bierings, Ruben, Burdorf, Lex, Cnossen, Marjon, Hazelzet, Jan, Huisman, Elise, Kruip, Marieke, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, van Moort, Iris, Polinder, Suzanne, Reitsma, Simone, Roest, Eliza, Arisz, Ryanne, Romano, Lorenzo, Al Arashi, Wala, van Hoorn, Shannon, Goedhart, Tine, Mussert, Caroline, Prameyllawati, Diaz, Uyl, Carin, Jansen, Nathalie, Fischer, Kathelijn, Ploos van Amstel, Hans Kristian, Urbanus, Rolf, Zivkovic, Minka, Bredenoord, Annelien, van der Graaf, Rieke, Baas, Lieke, Schutgens, Roger, Driessens, Mariëtte, Laan, Sebastiaan N.J., de Boer, Suzan, Dirven, Richard J., Kuipers, Thomas B., Mei, Hailiang

Source: In Journal of Thrombosis and Haemostasis July 2024 22(7):2027-2038

Quantification of the relationship between desmopressin concentration and Von Willebrand factor in Von Willebrand disease type 1: A pharmacodynamic study

Authors: Heijdra, Jessica M., Cloesmeijer, Michael E., Jager, Nico C.B., Leebeek, Frank W.G., Kruip, Marieke H.J.A., Cnossen, Marjon H., Mathôt, Ron A.A.

Source: Haemophilia. 28(5):814-821

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166507118.0x000001&indx=1&recIds=ETOCvdc_100166507118.0x000001

SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders

Authors: Cnossen, Marjon H., Moort, Iris, Reitsma, Simone H., Maat, Moniek P. M., Schutgens, Roger E. G., Urbanus, Rolf T., Lingsma, Hester F., Mathot, Ron A. A., Gouw, Samantha C., Meijer, Karina, Bredenoord, Annelien L., Graaf, Rieke, Fijnvandraat, Karin, Meijer, Alexander B., Akker, Emile, Bierings, Ruben, Eikenboom, Jeroen C. J., Biggelaar, Maartje, Haas, Masja, Voorberg, Jan, Leebeek, Frank W. G., Arisz, Ryanne A., Zivkovic, Minka, Hoorn, E. Shannon, Bukkems, Laura H., Goedhart, Tine M. C. H. J., Romano, Lorenzo G. R., Al Arashi, Wala, Cloesmeijer, Michael E., Janssen, Alexander, Brands, Martijn R., Baas, Lieke, Castillo Alferez, Jessica, Zhang, Huan, Laan, Sebastiaan N. J., Boender, Johan, Bom, Johanna G., Bos, Mettine H. A., Burdorf, Lex, Coppens, Michiel, Driessens, Mariette, Fischer, Kathelijne F., Haverman, Lotte, Hazelzet, Jan A., Huisman, Elise J., Jansen, Natalie, Jong, Sean, Kruip, Marieke, Leeuwen, Nikki, Meer, Felix, Meijer, Stephan, Amstel, Hans Kristian Ploos, Polinder, Suzanne, Schols, Saskia E. M., Wijfjes, Guus, Kluft, Kees, Heerde, Waander L., Goedhart, Geertje, Uyl, Carin, Timp, Jasmijn, Stekelenburg, Anke, Moenen, Floor, Ypma, Paula, Nieuwenhuizen, Laurens, Plat, Arnoud

Source: Journal of thrombosis and haemostasis. 20(9):2001-2011

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163494924.0x000001&indx=1&recIds=ETOCvdc_100163494924.0x000001

Replacement therapy in pregnant women with von Willebrand disease during delivery: Factor levels and pharmacokinetics.

Authors: Al Arashi, Wala, Cloesmeijer, Michael E., Leebeek, Frank W. G., Duvekot, Johannes J., Kruip, Marieke J. H. A., Mathôt, Ron A. A., Cnossen, Marjon H.

Source: HemaSphere; Jan2025, Vol. 9 Issue 1, p1-9, 9p

Perioperative pharmacokinetic-guided factor VIII concentrate dosing in haemophilia (OPTI-CLOT trial): an open-label, multicentre, randomised, controlled trial

Authors: Cnossen, Marjon H., Leebeek, Frank W.G., Mathôt, Ron A.A., Fijnvandraat, Karin, Coppens, Michiel, Meijer, Karina, Kruip, Marieke J.H.A., Polinder, Suzanne, Lock, Janske, Hazendonk, Hendrika C.A.M., Van Moort, Iris, Heijdra, Jessica M., Goedhart, Marie C.H.J., Al Arashi, Wala, Preijers, Tim, De Jager, Nico C.B., Bukkems, Laura H., Cloesmeijer, Michael E., Janssen, Alexander, Tamminga, Rienk Y.J., Brons, Paul, Schols, Saskia E.M., Eikenboom, Jeroen C.J., Van der Meer, Felix J.M., Schutgens, Roger E.G., Fischer, Kathelijne, Van Galen, Karin P.M., Beckers, Erik E.A.M., Heubel-Moenen, Floor C.J.I., Nieuwenhuizen, Laurens, Ypma, Paula, Driessens, Mariëtte H.E., Van Vliet, Ineke, Collins, Peter W., Liesner, Ri, Chowdary, Pratima, Millar, Carolyn M., Hart, Dan, Keeling, David, van Moort, Iris, Bukkems, Laura H, Hazendonk, Hendrika C A M, van der Bom, Johanna G, Laros-van Gorkom, Britta A P, Beckers, Erik A M, van der Meer, Felix J M, Schutgens, Roger E G, Leebeek, Frank W G, Mathôt, Ron A A, Cnossen, Marjon H ^*

Source: In The Lancet Haematology July 2021 8(7):e492-e502

Impact of enantiomer‐specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis

Authors: Cloesmeijer, Michael E., Esdonk, Michiel J., Lynn, Anne M., Smits, Anne, Tibboel, Dick, Daali, Youssef, Olkkola, Klaus T., Allegaert, Karel, Mian, Paola

Source: British journal of clinical pharmacology. 87(3):1443-1454

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115842005.0x000001&indx=1&recIds=ETOCvdc_100115842005.0x000001

PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space.

Authors: Cloesmeijer, Michael E.¹ (AUTHOR), Sjögren, Erik^2,3 (AUTHOR), Koopman, Sjoerd F.¹ (AUTHOR), Lenting, Peter. J.⁴ (AUTHOR), Cnossen, Marjon H.⁵ (AUTHOR), Mathôt, Ron A. A.¹ (AUTHOR) r.mathot@amsterdamumc.nl

Source: CPT: Pharmacometrics & Systems Pharmacology. Oct2024, Vol. 13 Issue 10, p1630-1640. 11p.

Subject Terms: *BLOOD coagulation factor IX, *CHIMERIC proteins, *HEMOSTASIS, *COLLAGEN, *HEMOPHILIA

Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics

Authors: Cloesmeijer, Michael E., Oever, Huub L.A., Mathôt, Ron A.A., Zeeman, Marieke, Kruisdijk‐Gerritsen, Arriette, Bles, Carmen M.A., Nassikovker, Polina, Meijer, Arthur R., Steveninck, Fred L., Arbouw, Maurits E.L.

Source: British journal of clinical pharmacology. 86(8):1620-1631

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107398261.0x000001&indx=1&recIds=ETOCvdc_100107398261.0x000001

Pharmacokinetic–Pharmacodynamic Modelling in Hemophilia A: Relating Thrombin and Plasmin Generation to Factor VIII Activity After Administration of a VWF/FVIII Concentrate.

Authors: Valke, Lars L. F. G., Cloesmeijer, Michael E., Mansouritorghabeh, Hassan, Barteling, Wideke, Blijlevens, Nicole M. A., Cnossen, Marjon H., Mathôt, Ron A. A., Schols, Saskia E. M., van Heerde, Waander L.

Source: European Journal of Drug Metabolism & Pharmacokinetics; Mar2024, Vol. 49 Issue 2, p191-205, 15p

ChatGPT in pharmacometrics? Potential opportunities and limitations.

Authors: Cloesmeijer, Michael E.¹ (AUTHOR), Janssen, Alexander¹ (AUTHOR), Koopman, Sjoerd F.¹ (AUTHOR), Cnossen, Marjon H.² (AUTHOR), Mathôt, Ron A. A.¹ (AUTHOR) r.mathot@amsterdamumc.nl

Source: British Journal of Clinical Pharmacology. Jan2024, Vol. 90 Issue 1, p360-365. 6p.

Subject Terms: *CHATGPT, *RESEARCH personnel

A rapid whole-blood adenosine triphosphate secretion test can be used to exclude platelet-dense granule deficiency

Authors: Zivkovic, Minka, Schutgens, Roger E.G., van der Vegte, Vossa, Lukasse, Janoek A., Roest, Mark, Huskens, Dana, de Moor, Annick S., Kremer Hovinga, Idske C.L., Urbanus, Rolf T., Beckers, Erik, Coppens, Michiel, Eikenboom, Jeroen, Hooimeijer, Louise, Jansen, Gerard, Schutgens, Roger, Urbanus, Rolf, Zivkovic, Minka, van den Akker, Emile, Al Arashi, Wala, Arisz, Ryanne, Baas, Lieke, Bierings, Ruben, van den Biggelaar, Maartje, Boender, Johan, van der Bom, Anske, Bos, Mettine, Brands, Martijn, Bredenoord, Annelien, Bukkems, Laura, Burdorf, Lex, Del Castillo Alferez, Jessica, Cloesmeijer, Michael, Cnossen, Marjon, Driessens, Mariëtte, Eikenboom, Jeroen, Fijnvandraat, Karin, Fischer, Kathelijn, Goedhart, Geertje, Goedhart, Tine, Gouw, Samantha, van der Graaf, Rieke, de Haas, Masja, Haverman, Lotte, Hazelzet, Jan, van Hoorn, Shannon, Huisman, Elise, Jansen, Nathalie, Janssen, Alexander, de Jong, Sean, Koopman, Sjoerd, Kruip, Marieke, Laan, Sebastiaan, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, Mathôt, Ron, van der Meer, Felix, Meijer, Karina, Meijer, Sander, Meijer, Stephan, van Moort, Iris, Mussert, Caroline, Ploos van Amstel, Hans Kristian, Polinder, Suzanne, Prameyllawati, Diaz, Reitsma, Simone, Roest, Eliza, Romano, Lorenzo, Schols, Saskia, Schutgens, Roger, Urbanus, Rolf, Uyl, Carin, Voorberg, Jan, Zhang, Huan, Zivkovic, Minka

Source: Journal of Thrombosis and Haemostasis; 20250101, Issue: Preprints

SYMPHONYconsortium: Orchestrating personalized treatment for patients with bleeding disorders

Authors: Cnossen, Marjon H., Moort, Iris, Reitsma, Simone H., Maat, Moniek P. M., Schutgens, Roger E. G., Urbanus, Rolf T., Lingsma, Hester F., Mathot, Ron A. A., Gouw, Samantha C., Meijer, Karina, Bredenoord, Annelien L., Graaf, Rieke, Fijnvandraat, Karin, Meijer, Alexander B., Akker, Emile, Bierings, Ruben, Eikenboom, Jeroen C. J., Biggelaar, Maartje, Haas, Masja, Voorberg, Jan, Leebeek, Frank W. G., Cnossen, Marjon H., Reitsma, Simone H., Haas, Masja, Biggelaar, Maartje, Leebeek, Frank W. G., Voorberg, Jan, Maat, Moniek P. M., Schutgens, Roger E. G., Urbanus, Rolf T., Lingsma, Hester F., Mathot, Ron A. A., Gouw, Samantha C., Meijer, Karina, Bredenoord, Annelien L., Graaf, Rieke, Fijnvandraat, Karin, Meijer, Alexander B., Akker, Emile, Bierings, Ruben, Eikenboom, Jeroen C. J., Moort, Iris, Arisz, Ryanne A., Zivkovic, Minka, Hoorn, E. Shannon, Bukkems, Laura H., Goedhart, Tine M. C. H. J., Romano, Lorenzo G. R., Al Arashi, Wala, Cloesmeijer, Michael E., Janssen, Alexander, Brands, Martijn R., Baas, Lieke, Castillo Alferez, Jessica, Zhang, Huan, Laan, Sebastiaan N. J., Boender, Johan, Bom, Johanna G., Bos, Mettine H. A., Burdorf, Lex, Coppens, Michiel, Driessens, Mariette, Fischer, Kathelijne F., Haverman, Lotte, Hazelzet, Jan A., Huisman, Elise J., Jansen, Natalie, Jong, Sean, Kruip, Marieke, Leeuwen, Nikki, Meer, Felix, Meijer, Stephan, Amstel, Hans Kristian Ploos, Polinder, Suzanne, Schols, Saskia E. M., Wijfjes, Guus, Kluft, Kees, Heerde, Waander L., Goedhart, Geertje, Uyl, Carin, Timp, Jasmijn, Stekelenburg, Anke, Moenen, Floor, Ypma, Paula, Nieuwenhuizen, Laurens, Plat, Arnoud

Source: Journal of Thrombosis and Haemostasis; September 2022, Vol. 20 Issue: 9 p2001-2011, 11p

Perioperative pharmacokinetic-guided factor VIII concentrate dosing in haemophilia (OPTI-CLOT trial): an open-label, multicentre, randomised, controlled trial

Authors: van Moort, Iris, Preijers, Tim, Bukkems, Laura H, Hazendonk, Hendrika C A M, van der Bom, Johanna G, Laros-van Gorkom, Britta A P, Beckers, Erik A M, Nieuwenhuizen, Laurens, van der Meer, Felix J M, Ypma, Paula, Coppens, Michiel, Fijnvandraat, Karin, Schutgens, Roger E G, Meijer, Karina, Leebeek, Frank W G, Mathôt, Ron A A, Cnossen, Marjon H, Cnossen, Marjon H., Leebeek, Frank W.G., Mathôt, Ron A.A., Fijnvandraat, Karin, Coppens, Michiel, Meijer, Karina, Kruip, Marieke J.H.A., Polinder, Suzanne, Lock, Janske, Hazendonk, Hendrika C.A.M., Van Moort, Iris, Heijdra, Jessica M., Goedhart, Marie C.H.J., Al Arashi, Wala, Preijers, Tim, De Jager, Nico C.B., Bukkems, Laura H., Cloesmeijer, Michael E., Janssen, Alexander, Tamminga, Rienk Y.J., Brons, Paul, Schols, Saskia E.M., Eikenboom, Jeroen C.J., Van der Meer, Felix J.M., Schutgens, Roger E.G., Fischer, Kathelijne, Van Galen, Karin P.M., Beckers, Erik E.A.M., Heubel-Moenen, Floor C.J.I., Nieuwenhuizen, Laurens, Ypma, Paula, Driessens, Mariëtte H.E., Van Vliet, Ineke, Collins, Peter W., Liesner, Ri, Chowdary, Pratima, Millar, Carolyn M., Hart, Dan, Keeling, David

Source: The Lancet Haematology; July 2021, Vol. 8 Issue: 7 pe492-e502, 11p