Distributable, metabolic PET reporting of tuberculosis

Authors: R. M. Naseer Khan, Yong-Mo Ahn, Gwendolyn A. Marriner, Laura E. Via, Francois D’Hooge, Seung Seo Lee, Nan Yang, Falguni Basuli, Alexander G. White, Jaime A. Tomko, L. James Frye, Charles A. Scanga, Danielle M. Weiner, Michelle L. Sutphen, Daniel M. Schimel, Emmanuel Dayao, Michaela K. Piazza, Felipe Gomez, William Dieckmann, Peter Herscovitch, N. Scott Mason, Rolf Swenson, Dale O. Kiesewetter, Keriann M. Backus, Yiqun Geng, Ritu Raj, Daniel C. Anthony, JoAnne L. Flynn, Clifton E. Barry, Benjamin G. Davis

Source: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/78179b9a20084b6790bf89a43f40ffbf

A systematic efficacy analysis of tuberculosis treatment with BPaL‐containing regimens using a multiscale modeling approach

Authors: Maral Budak, Laura E. Via, Danielle M. Weiner, Clifton E. Barry III, Pariksheet Nanda, Gabrielle Michael, Khisimuzi Mdluli, Denise Kirschner

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 673-685 (2024)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2163-8306

Access URL: https://doaj.org/article/ed57ab311edd4ce7b47a12de44090263

The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles

Authors: Helena I. Boshoff, Neha Malhotra, Clifton E. Barry, Sangmi Oh

Source: Pharmaceuticals, Vol 17, Iss 2, p 211 (2024)

Subject Terms: tuberculosis, mycobacteria, natural products, heterocycles, antitubercular activity, antibiotics, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/2/211; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/85007ad3f4864bfd8ade6f5af64aa29c

A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum

Authors: Jansy P. Sarathy, Min Xie, Richard M. Jones, Adrienne Chang, Paulina Osiecki, Danielle Weiner, Wen-Shan Tsao, Maureen Dougher, Landry Blanc, Nader Fotouhi, Laura E. Via, Clifton E. Barry, Iwijn De Vlaminck, David R. Sherman, Véronique A. Dartois

Source: mBio, Vol 14, Iss 2 (2023)

Subject Terms: caseum, nonreplicating Mycobacterium tuberculosis, persister, tuberculosis, vulnerable target, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/3362e75bb01a4154a6c86b4dffebc625

Phylogenomic analysis of the diversity of graspetides and proteins involved in their biosynthesis

Authors: Kira S. Makarova, Brittney Blackburne, Yuri I. Wolf, Anastasia Nikolskaya, Svetlana Karamycheva, Marlene Espinoza, Clifton E. Barry, Carole A. Bewley, Eugene V. Koonin

Source: Biology Direct, Vol 17, Iss 1, Pp 1-22 (2022)

Subject Terms: RiPPs, ATP-grasp ligase, Graspetides, Biosynthetic gene clusters, Lactones, Lactams, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6150

Access URL: https://doaj.org/article/91f78b3e86694fbfae915c075d626b9e

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

Authors: Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell

Source: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/dfbd7ac1fa2f42d49910fcdc7940c42e

Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

Authors: Stephanus T. Malherbe, Ray Y. Chen, Patrick Dupont, Ilse Kant, Magdalena Kriel, André G. Loxton, Bronwyn Smith, Caroline G. G. Beltran, Susan van Zyl, Shirely McAnda, Charmaine Abrahams, Elizna Maasdorp, Alex Doruyter, Laura E. Via, Clifton E. Barry, David Alland, Stephanie Griffith- Richards, Annare Ellman, Thomas Peppard, John Belisle, Gerard Tromp, Katharina Ronacher, James M. Warwick, Jill Winter, Gerhard Walzl

Source: EJNMMI Research, Vol 10, Iss 1, Pp 1-15 (2020)

Subject Terms: Tuberculosis, 18F-FDG, PET-CT, Tuberculosis treatment response, Mycobacterium tuberculosis, Quantitative imaging analysis, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2191-219X

Access URL: https://doaj.org/article/5d6e9e74073f4ab0a71f8f008e07ff38

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development

Authors: Tiago Beites, Kathryn O’Brien, Divya Tiwari, Curtis A. Engelhart, Shaun Walters, Jenna Andrews, Hee-Jeong Yang, Michelle L. Sutphen, Danielle M. Weiner, Emmanuel K. Dayao, Matthew Zimmerman, Brendan Prideaux, Prashant V. Desai, Thierry Masquelin, Laura E. Via, Véronique Dartois, Helena I. Boshoff, Clifton E. Barry, Sabine Ehrt, Dirk Schnappinger

Source: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b2df601988674fd2942c5f4b81e2ac98

Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets

Authors: Sangmi Oh, Lena Trifonov, Veena D. Yadav, Clifton E. Barry, Helena I. Boshoff

Source: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Subject Terms: tuberculosis, antitubercular agent, structure-activity relationship, drug target, cell wall, respiration, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2021.611304/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/a58dcef44f3d492db8b335bfb4af88ef

The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment

Authors: Trust Odia, Stephanus T. Malherbe, Stuart Meier, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G. Loxton, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Helena Kuivaniemi, Katharina Ronacher, Jill Winter, Gerhard Walzl, Gerard Tromp, the Catalysis TB-Biomarker Consortium, André G. Loxton, Annare Ellman, Bronwyn Smith, Caroline G. G. Beltran, Clifton E. Barry, David Alland, Friedrich Thienemann, James M. Warwick, Kim Stanley, Ilse Kant, Lani Thiart, Lance A. Lucas, Laura E. Via, Lori E. Dodd, Magdalena Kriel, Nelita Plessis Du, Patrick Dupont, Ray Y. Chen, Robert J. Wilkinson, Shubhada Shenai, Stephanie Griffith-Richards

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: gene expression, [18F]FDG PET-CT, RNA-sequencing, mixed-effect models, pathway analysis, transcription factor binding site, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.596173/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/70919f9b260c42568cd12c831dc3bbde

Development and Optimization of Chromosomally-Integrated Fluorescent Mycobacterium tuberculosis Reporter Constructs

Authors: Katharina Kolbe, Alice C. Bell, Gareth A. Prosser, Maike Assmann, Hee-Jeong Yang, He Eun Forbes, Sophia Gallucci, Katrin D. Mayer-Barber, Helena I. Boshoff, Clifton E. Barry III

Source: Frontiers in Microbiology, Vol 11 (2020)

Subject Terms: Mycobacterium tuberculosis, fluorescent protein, reporter strain, riboswitch, pH, magnesium, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2020.591866/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/eb56db4488294a2fb18e6b54d5fa9078

A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images

Authors: Stephanus T. Malherbe, Patrick Dupont, Ilse Kant, Petri Ahlers, Magdalena Kriel, André G. Loxton, Ray Y. Chen, Laura E. Via, Friedrich Thienemann, Robert J. Wilkinson, Clifton E. Barry, Stephanie Griffith-Richards, Annare Ellman, Katharina Ronacher, Jill Winter, Gerhard Walzl, James M. Warwick, the Catalysis Biomarker Consortium

Source: EJNMMI Research, Vol 8, Iss 1, Pp 1-14 (2018)

Subject Terms: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography, Tuberculosis, Image analysis, Lesion segmentation, Lesion quantification, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13550-018-0411-7; https://doaj.org/toc/2191-219X

Access URL: https://doaj.org/article/1f9bb2af447e42cc8e1a43a7b0bd78d0

Chemical constituents and antimycobacterial studies of the leaf extracts of Pavetta crassipes K. Schum

Authors: Nneka N. Ibekwe, Helena Boshoff, Joaquin Randle, Akinbo A. Adesomoju, Clifton E. Barry III, Joseph I. Okogun

Source: Tropical Plant Research, Vol 5, Iss 1, Pp 88-95 (2018)

Subject Terms: Pavetta crassipes, Spectroscopy, Antimycobacterial activity, Broth microdilution assay, Green fluorescent protein reporter microplate assay, Botany, QK1-989

File Description: electronic resource

Relation: http://www.tropicalplantresearch.com/download/258/13.pdf; https://doaj.org/toc/2349-1183

Access URL: https://doaj.org/article/4a852e3e384341e69bafacf55f12950d

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

Authors: Martin Gengenbacher, Maria A. Duque-Correa, Peggy Kaiser, Stefanie Schuerer, Doris Lazar, Ulrike Zedler, Stephen T. Reece, Amit Nayyar, Stewart T. Cole, Vadim Makarov, Clifton E. Barry III, Véronique Dartois, Stefan H. E. Kaufmann

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/653956e7764245f0bc27af8e6d730cfa

The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy

Authors: Andrej Trauner, Qingyun Liu, Laura E. Via, Xin Liu, Xianglin Ruan, Lili Liang, Huimin Shi, Ying Chen, Ziling Wang, Ruixia Liang, Wei Zhang, Wang Wei, Jingcai Gao, Gang Sun, Daniela Brites, Kathleen England, Guolong Zhang, Sebastien Gagneux, Clifton E. Barry, Qian Gao

Source: Genome Biology, Vol 18, Iss 1, Pp 1-17 (2017)

Subject Terms: Tuberculosis, Within-host evolution, Combination therapy, Drug resistance, Whole genome sequencing, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-017-1196-0; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/ebb36b859559438eaa6e2ee80399bb27

Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis

Authors: Taeksun Song, Myungsun Lee, Han-Seung Jeon, Yumi Park, Lori E. Dodd, Véronique Dartois, Dean Follman, Jing Wang, Ying Cai, Lisa C. Goldfeder, Kenneth N. Olivier, Yingda Xie, Laura E. Via, Sang Nae Cho, Clifton E. Barry III, Ray Y. Chen

Source: EBioMedicine, Vol 2, Iss 11, Pp 1627-1633 (2015)

Subject Terms: Mitochondrial toxicity, Adverse events, Linezolid, Tuberculosis, Drug resistant, Therapeutic drug monitoring, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396415301663; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/7beaa75555b04827aa0e2b13b0e0cec4

Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial [version 1; referees: 3 approved]

Authors: Ray Y. Chen, Laura E. Via, Lori E. Dodd, Gerhard Walzl, Stephanus T. Malherbe, André G. Loxton, Rodney Dawson, Robert J. Wilkinson, Friedrich Thienemann, Michele Tameris, Mark Hatherill, Andreas H. Diacon, Xin Liu, Jin Xing, Xiaowei Jin, Zhenya Ma, Shouguo Pan, Guolong Zhang, Qian Gao, Qi Jiang, Hong Zhu, Lili Liang, Hongfei Duan, Taeksun Song, David Alland, Michael Tartakovsky, Alex Rosenthal, Christopher Whalen, Michael Duvenhage, Ying Cai, Lisa C. Goldfeder, Kriti Arora, Bronwyn Smith, Jill Winter, Clifton E. Barry III, Predict TB Study Group

Source: Gates Open Research, Vol 1 (2017)

Subject Terms: Antimicrobials & Drug Resistance, Bacterial Infections, Immunological Biomarkers, Medicine

File Description: electronic resource

Relation: https://gatesopenresearch.org/articles/1-9/v1; https://doaj.org/toc/2572-4754

Access URL: https://doaj.org/article/2e9744f070dd42cc8f0373c77478494c

Major Global Killer Tamed by Hydrogen

Authors: Clifton E. Barry

Source: ACS Central Science, Vol 1, Iss 6, Pp 286-288 (2015)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2374-7943; https://doaj.org/toc/2374-7951

Access URL: https://doaj.org/article/2543db9262f848d0ad392a4c91bad762

Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes

Authors: Diego L. Costa, Sivaranjani Namasivayam, Eduardo P. Amaral, Kriti Arora, Alex Chao, Lara R. Mittereder, Mamoudou Maiga, Helena I. Boshoff, Clifton E. Barry, Celia W. Goulding, Bruno B. Andrade, Alan Sher

Source: mBio, Vol 7, Iss 5 (2016)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/64fdecdf902b4fefb96dcde0a01ffc15

Synthesis and Pharmacokinetic Evaluation of SiderophoreBiosynthesis Inhibitors for Mycobacterium tuberculosis.

Authors: KathrynM. Nelson, Kishore Viswanathan, Surendra Dawadi, BenjaminP. Duckworth, Helena I. Boshoff, Clifton E. Barry, Courtney C. Aldrich

Source: Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 14, p5459-5475, 17p