Multimodal AI predicts clinical outcomes of drug combinations from preclinical data

Authors: Huang, Yepeng, Su, Xiaorui, Ullanat, Varun, Liang, Ivy, Clegg, Lindsay, Olabode, Damilola, Ho, Nicholas, John, Bino, Gibbs, Megan, Zitnik, Marinka

Subject Terms: Quantitative Biology - Quantitative Methods, Computer Science - Artificial Intelligence, Computer Science - Machine Learning

Access URL: http://arxiv.org/abs/2503.02781

Cardiovascular and renal safety of metformin in patients with diabetes and moderate or severe chronic kidney disease: Observations from the EXSCEL and SAVOR‐TIMI 53 cardiovascular outcomes trials

Authors: Clegg, Lindsay E., Jing, Yankang, Penland, Robert C., Boulton, David W., Hernandez, Adrian F., Holman, Rury R., Vora, Jiten

Source: Diabetes, obesity & metabolism. 23(5):1101-1110

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131107197.0x000001&indx=1&recIds=ETOCvdc_100131107197.0x000001

RSV Neutralizing Antibodies Following Nirsevimab and Palivizumab Dosing.

Authors: Wilkins, Deidre, Hamrén, Ulrika Wählby, Yue Chang, Clegg, Lindsay E., Domachowske, Joseph, Englund, Janet A., Muller, William J., Leach, Amanda, Kelly, Elizabeth J., Villafana, Tonya

Source: Pediatrics; Nov2024, Vol. 154 Issue 5, p1-13, 15p

Effect of once‐weekly exenatide on estimated glomerular filtration rate slope depends on baseline renal risk: A post hoc analysis of the EXSCEL trial

Authors: van der Aart‐van der Beek, Annemarie B., Clegg, Lindsay E., Penland, Robert C., Boulton, David W., Sjöström, C. David, Mentz, Robert J., Holman, Rury R., Heerspink, Hiddo J. L.

Source: Diabetes, obesity & metabolism. 22(12):2493-2498

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110008430.0x000001&indx=1&recIds=ETOCvdc_100110008430.0x000001

Prediction and validation of exenatide risk marker effects on progression of renal disease: Insights from EXSCEL

Authors: Idzerda, Nienke M. A., Clegg, Lindsay E., Hernandez, Adrian F., Bakris, George, Penland, Robert C., Boulton, David W., Bethel, M. Angelyn, Holman, Rury R., Heerspink, Hiddo J. L.

Source: Diabetes, obesity & metabolism. 22(5):798-806

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107989197.0x000001&indx=1&recIds=ETOCvdc_100107989197.0x000001

Effects of exenatide and open-label SGLT2 inhibitor treatment, given in parallel or sequentially, on mortality and cardiovascular and renal outcomes in type 2 diabetes: insights from the EXSCEL trial

Authors: Clegg, Lindsay, Penland, Robert, Bachina, Srinivas, Boulton, David, Thuresson, Marcus, Heerspink, Hiddo, Gustavson, Stephanie, Sjöström, C., Ruggles, James, Hernandez, Adrian, Buse, John, Mentz, Robert, Holman, Rury

Source: Cardiovascular diabetology. 18(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190441124.0x000001&indx=1&recIds=ETOCvdc_100190441124.0x000001

Serum AZD7442 (tixagevimab–cilgavimab) concentrations and in vitroIC50 values predict SARS‐CoV‐2 neutralising antibody titres.

Authors: Clegg, Lindsay E¹ (AUTHOR), Stepanov, Oleg² (AUTHOR), Matthews, Sam³ (AUTHOR), White, Tom³ (AUTHOR), Seegobin, Seth³ (AUTHOR), Thomas, Steven⁴ (AUTHOR), Tuffy, Kevin M⁵ (AUTHOR), Någård, Mats¹ (AUTHOR), Esser, Mark T⁶ (AUTHOR), Streicher, Katie⁵ (AUTHOR), Cohen, Taylor S⁶ (AUTHOR), Aksyuk, Anastasia A⁵ (AUTHOR) anastasia.aksyuk@astrazeneca.com

Source: Clinical & Translational Immunology. 2024, Vol. 13 Issue 6, p1-15. 15p.

Subject Terms: *SARS-CoV-2, *ANTIBODY titer, *SARS-CoV-2 Omicron variant

Population Pharmacokinetics of Nirsevimab in Preterm and Term Infants.

Authors: Clegg, Lindsay¹, Freshwater, Ed², Leach, Amanda³, Villafana, Tonya³, Hamrén, Ulrika Wählby⁴ Ulrika.wahlby-hamren@astrazeneca.com

Source: Journal of Clinical Pharmacology. May2024, Vol. 64 Issue 5, p555-567. 13p.

Subject Terms: *RESEARCH funding, *POPULATION health, *BODY weight, *INTRAMUSCULAR injections, *RESPIRATORY syncytial virus infections, *AGE distribution, *MONOCLONAL antibodies, *DURATION of pregnancy, *LONGITUDINAL method, *RACE, *LUNG diseases, *CHILDREN

Geographic Terms: CANADA, UNITED States, UNITED Kingdom

Company/Entity: EUROPEAN Union

Potassium homeostasis and therapeutic intervention with sodium zirconium cyclosilicate: A model‐informed drug development case study.

Authors: Clegg, Lindsay E.¹ (AUTHOR) lindsay.clegg1@astrazeneca.com, Chu, Lulu² (AUTHOR), Nagard, Mats¹ (AUTHOR), Boulton, David W.¹ (AUTHOR), Penland, Robert C.² (AUTHOR)

Source: CPT: Pharmacometrics & Systems Pharmacology. Feb2024, Vol. 13 Issue 2, p296-307. 12p.

Subject Terms: *DRUG development, *ZIRCONIUM, *HOMEOSTASIS, *CHRONIC kidney failure, *POTASSIUM, *ARRHYTHMIA, *BRUGADA syndrome

Molecular mechanism matters: Benefits of mechanistic computational models for drug development

Authors: Clegg, Lindsay E., Mac Gabhann, Feilim

Source: In Pharmacological Research September 2015 99:149-154

A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands.

Authors: Clegg, Lindsay E.¹ lwendel2@jhmi.edu, Mac Gabhann, Feilim^1,2

Source: PLoS Computational Biology. 3/20/2017, Vol. 13 Issue 3, p1-33. 33p.

Subject Terms: *VASCULAR endothelial growth factors, *EXTRACELLULAR matrix, *PHENOTYPES, *PHOSPHORYLATION, *NEOVASCULARIZATION

Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model.

Authors: Clegg, Lindsay Wendel¹ lwendel2@jhmi.edu, Mac Gabhann, Feilim^1,2

Source: PLoS Computational Biology. Jun2015, Vol. 11 Issue 6, p1-36. 36p.

Subject Terms: *VASCULAR endothelial growth factor receptors, *PHOSPHORYLATION, *CELL receptors, *COMPUTER simulation of biological systems, *NEUROPILINS, *PHOSPHATASES

Assessing reproducibility and utility of clustering of patients with type 2 diabetes and established CV disease (SAVOR -TIMI 53 trial).

Authors: Aoki, Yasunori, Hamrén, Bengt, Clegg, Lindsay E., Stahre, Christina, Bhatt, Deepak L., Raz, Itamar, Scirica, Benjamin M., Oscarsson, Jan, Carlsson, Björn

Source: PLoS ONE; 11/19/2021, Vol. 16 Issue 11, p1-17, 17p

Subject Terms: TYPE 2 diabetes, PROPORTIONAL hazards models, DIABETES, K-means clustering, LOGNORMAL distribution, TREATMENT effectiveness, REPRODUCTION

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AZD3152 neutralizes SARS-CoV-2 historical and contemporary variants and is protective in hamsters and well tolerated in adults

Authors: Cai, Yingyun, Diallo, Seme, Rosenthal, Kim, Ren, Kuishu, Flores, Daniel J., Dippel, Andrew, Oganesyan, Vaheh, van Dyk, Nydia, Chen, Xiaoru, Cantu, Erin, Choudhary, Rakesh, Sulikowski, Michal, Adissu, Hibret, Chawla, Bhavna, Kar, Swagata, Liu, Chang, Dijokaite-Guraliuc, Aiste, Mongkolsapaya, Juthathip, Rajan, Saravanan, Loo, Yueh-Ming, Beavon, Rohini, Webber, Chris, Chang, Lee-Jah, Thomas, Steven, Clegg, Lindsay, Zhang, Huixia, Screaton, Gavin R., Philbin, Nora, Harre, Mark, Selim, Abdulhafez, Martinez-Alier, Nuria, Uriel, Alison, Cohen, Taylor S., Perez, John L., Esser, Mark T., Blair, Wade, Francica, Joseph R.

Source: Science Translational Medicine; June 2024, Vol. 16 Issue: 753

Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL.

Authors: Clegg, Lindsay E.¹ lindsay.clegg1@astrazeneca.com, Heerspink, Hiddo J. L.², Penland, Robert C.³, Weifeng Tang¹, Boulton, David W.¹, Bachina, Srinivas³, Fox, Robert D.³, Fenici, Peter⁴, Thuresson, Marcus⁵, Mentz, Robert J.⁶, Hernandez, Adrian F.⁶, Holman, Rury R.⁷, Tang, Weifeng⁸

Source: Diabetes Care. Feb2019, Vol. 42 Issue 2, p318-326. 9p. 3 Charts, 2 Graphs.

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Systems Pharmacology of VEGF165b in Peripheral Artery Disease.

Authors: Clegg, Lindsay E.¹ lwendel2@jhmi.edu, Ganta, Vijay C.², Annex, Brian H.^2,3, Mac Gabhann, Feilim^1,4

Source: CPT: Pharmacometrics & Systems Pharmacology. Dec2017, Vol. 6 Issue 12, p833-844. 12p.

Subject Terms: *VASCULAR endothelial growth factors, *ARTERIAL diseases, *EXTRACELLULAR matrix, *BINDING sites, *PHOSPHORYLATION

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