Enhanced tumor control and survival in preclinical models with adoptive cell therapy preceded by low-dose radiotherapy

Authors: Nahum Puebla-Osorio, Natalie Wall Fowlkes, Hampartsoum B. Barsoumian, Kristina Xega, Gitika Srivastava, Claudia Kettlun-Leyton, Sara Nizzero, Tiffany Voss, Thomas S. Riad, Christina Wong, Ailing Huang, Yun Hu, Joylise Mitchell, Mingee Kim, Zahid Rafiq, Kewen He, Duygu Sezen, Ethan Hsu, Fatemeh Masrorpour, Aurian Maleki, Carola Leuschner, Maria Angelica Cortez, Philipp Oertle, Marko Loparic, Marija Plodinec, Janet L. Markman, James W. Welsh

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: NSG, NOD-SCID-IL2R gamma mice, LDRT, low-dose radiotherapy, RT, radiotherapy, CAR-T cells, chimeric antigen receptor T cells, solid tumors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1407143/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e15d8e28463245d5a2e2e3d70c939f5b

Combining a nanoparticle-mediated immunoradiotherapy with dual blockade of LAG3 and TIGIT improves the treatment efficacy in anti-PD1 resistant lung cancer

Authors: Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Kewen He, Duygu Sezen, Dawei Chen, Mark Wasley, Jordan DA SILVA, Joylise A. Mitchell, Tiffany A. Voss, Fatemeh Masrorpour, Claudia Kettlun Leyton, Liangpeng Yang, Carola Leuschner, Nahum Puebla-Osorio, Saumil Gandhi, Quynh-Nhu Nguyen, Maria Angelica Cortez, James W. Welsh

Source: Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-19 (2022)

Subject Terms: Nanoparticle, NBTXR3, Immunoradiotherapy, Radiotherapy, Checkpoint blockade, Anti-PD1 resistance, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/a090d791bef0465c93bf5eb25e2451f7

575 Dual blockade of LAG3 and TIGIT improves the treatment efficacy of a nanoparticle-mediated immunoradiation in anti-PD1 resistant lung cancer in mice

Authors: James Welsh, Sébastien Paris, Hampartsoum Barsoumian, Yun Hu, Mark Wasley, Liangpeng Yang, Quynh-Nhu Nguyen, Fatemeh Masrorpour, Saumil Gandhi, Genevieve Bertolet, Lily Schuda, Kewen He, Duygu Sezen, Joylise Mitchell, Tiffany Voss, SILVA Jordan, Claudia Kettlun Leyton, Nahum Puebla-Osorio, Angelica Cortez

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/ac4c8f454ce64995a234fdcb51a58ba6