Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

Authors: Clark, Abbe R., Marshall, Jamie, Zhou, Yiming, Montesinos, Monica S., Chen, Haiqi, Nguyen, Lan, Chen, Fei, Greka, Anna

Source: American journal of pathology. 192(2):281-294

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155212094.0x000001&indx=1&recIds=ETOCvdc_100155212094.0x000001

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

Authors: Dvela-Levitt, Moran, Kost-Alimova, Maria, Emani, Maheswarareddy, Kohnert, Eva, Thompson, Rebecca, Sidhom, Eriene-Heidi, Rivadeneira, Ana, Sahakian, Nareh, Roignot, Julie, Papagregoriou, Gregory, Montesinos, Monica S., Clark, Abbe R., McKinney, David, Gutierrez, Juan, Roth, Mark, Ronco, Lucienne, Elonga, Esther, Carter, Todd A., Gnirke, Andreas, Melanson, Michelle, Hartland, Kate, Wieder, Nicolas, Hsu, Jane C.-H., Deltas, Constantinos, Hughey, Rebecca, Bleyer, Anthony J., Kmoch, Stanislav, Živná, Martina, Barešova, Veronika, Kota, Savithri, Schlondorff, Johannes, Heiman, Myriam, Alper, Seth L., Wagner, Florence, Weins, Astrid, Golub, Todd R., Lander, Eric S., Greka, Anna

Source: In Cell 25 July 2019 178(3):521-535

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Authors: Zhou, Yiming, Castonguay, Philip, Sidhom, Eriene-Heidi, Clark, Abbe R., Dvela-Levitt, Moran, Kim, Sookyung, Sieber, Jonas, Wieder, Nicolas, Jung, Ji Yong, Andreeva, Svetlana, Reichardt, Jana, Dubois, Frank, Hoffmann, Sigrid C., Basgen, John M., Montesinos, Mónica S., Weins, Astrid, Johnson, Ashley C., Lander, Eric S., Garrett, Michael R., Hopkins, Corey R., Greka, Anna

Source: Science, 2017 Dec 01. 358(6368), 1332-1336.

Access URL: https://www.jstor.org/stable/26401050

Obesity modulates Alzheimer's disease through accelerated immune ageing

Authors: Suzzi, Stefano, Croese, Tommaso, Ravid, Adi, Clark, Abbe R, Medina, Sedi, Colaiuta, Sara P, Vernon, Katherine, Gold, Or, Malitsky, Sergey, Itkin, Maxim, Cahalon, Liora, Greka, Anna, Habib, Naomi, Schwartz, Michal

Source: Alzheimer's & dementia. 17(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139016871.0x000001&indx=1&recIds=ETOCvdc_100139016871.0x000001

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

Authors: Kugel, Sita, Feldman, Jessica L., Klein, Mark A., Silberman, Dafne M., Sebastián, Carlos, Mermel, Craig, Dobersch, Stephanie, Clark, Abbe R., Getz, Gad, Denu, John M., Mostoslavsky, Raul

Source: Cell reports. 13(3):479-488

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129227932.0x000001&indx=1&recIds=ETOCvdc_100129227932.0x000001

N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer's disease mouse model.

Authors: Suzzi, Stefano, Croese, Tommaso, Ravid, Adi, Gold, Or, Clark, Abbe R., Medina, Sedi, Kitsberg, Daniel, Adam, Miriam, Vernon, Katherine A., Kohnert, Eva, Shapira, Inbar, Malitsky, Sergey, Itkin, Maxim, Brandis, Alexander, Mehlman, Tevie, Salame, Tomer M., Colaiuta, Sarah P., Cahalon, Liora, Slyper, Michal, Greka, Anna

Source: Nature Communications; 3/9/2023, Vol. 14 Issue 1, p1-19, 19p

Subject Terms: CD8 antigen, ALZHEIMER'S disease, FATIGUE (Physiology), SCOPOLAMINE, LABORATORY mice, MEMORY disorders, DISEASE risk factors, WEIGHT loss, ADIPOSE tissue physiology

A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury

Authors: Kost-Alimova, Maria, Sidhom, Eriene-Heidi, Satyam, Abhigyan, Chamberlain, Brian T., Dvela-Levitt, Moran, Melanson, Michelle, Alper, Seth L., Santos, Jean, Gutierrez, Juan, Subramanian, Ayshwarya, Byrne, Patrick J., Grinkevich, Elizabeth, Reyes-Bricio, Estefanía, Kim, Choah, Clark, Abbe R., Watts, Andrew J.B., Thompson, Rebecca, Marshall, Jamie, Pablo, Juan Lorenzo, Coraor, Juliana, Roignot, Julie, Vernon, Katherine A., Keller, Keith, Campbell, Alissa, Emani, Maheswarareddy, Racette, Matthew, Bazua-Valenti, Silvana, Padovano, Valeria, Weins, Astrid, McAdoo, Stephen P., Tam, Frederick W.K., Ronco, Luciene, Wagner, Florence, Tsokos, George C., Shaw, Jillian L., Greka, Anna

Source: In Cell Reports Medicine 17 November 2020 1(8)

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A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

Authors: Yiming Zhou^1,2, Castonguay, Philip^1,2, Sidhom, Eriene-Heidi^1,2, Clark, Abbe R.^1,2, Dvela-Levitt, Moran^1,2, Sookyung Kim^1,2, Sieber, Jonas^1,2, Wieder, Nicolas^1,2, Ji Yong Jung^1,3, Andreeva, Svetlana¹, Reichardt, Jana¹, Dubois, Frank¹, Hoffmann, Sigrid C.⁴, Basgen, John M.⁵, Montesinos, Mónica S.^1,2, Weins, Astrid^1,6, Johnson, Ashley C.⁷, Lander, Eric S.², Garrett, Michael R.⁷, Hopkins, Corey R.⁸

Source: Science; 12/8/2017, Vol. 358 Issue 6368, p1332-1336, 5p

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The power of one: advances in single-cell genomics in the kidney.

Authors: Clark, Abbe R.^1,2 (AUTHOR), Greka, Anna^1,2 (AUTHOR) agreka@bwh.harvard.edu

Source: Nature Reviews Nephrology. Feb2020, Vol. 16 Issue 2, p73-74. 2p.

Subject Terms: *KIDNEYS, *GENOMICS, *RNA sequencing, *KIDNEY development, *ORGANOIDS

Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

Authors: Clark, Abbe R., Marshall, Jamie, Zhou, Yiming, Montesinos, Monica S., Chen, Haiqi, Nguyen, Lan, Chen, Fei, Greka, Anna

Source: American Journal of Pathology; 20210101, Issue: Preprints

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