Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)

Alternate Title: V Reunión de Hepatología Traslacional, organizada por la Asociación Española para el Estudio del Hígado (AEEH) (Spanish; Castilian)

Authors: Alvarado-Tapias, Edilmar, Maya-Miles, Douglas, Albillos, Agustin, Aller, Rocio, Ampuero, Javier, Andrade, Raul J., Arechederra, Maria, Aspichueta, Patricia, Banales, Jesus M., Blas-García, Ana, Caparros, Esther, Cardoso Delgado, Teresa, Carrillo-Vico, Antonio, Claria, Joan, Cubero, Francisco Javier, Díaz-Ruiz, Alberto, Fernández-Barrena, Maite G., Fernández-Iglesias, Anabel, Fernández-Veledo, Sonia, Francés, Ruben, Gallego-Durán, Rocío, Gracia-Sancho, Jordi, Irimia, Manuel, Lens, Sabela, Martínez-Chantar, María Luz, Mínguez, Beatriz, Muñoz-Hernández, Rocío, Nogueiras, Rubén, Ramos-Molina, Bruno, Riveiro-Barciela, Mar, Rodríguez-Perálvarez, Manuel L., Romero-Gómez, Manuel, Sabio, Guadalupe, Sancho-Bru, Pau, Ventura-Cots, Meritxell, Vidal, Silvia, Gahete, Manuel D.

Source: In Gastroenterologia y Hepatologia December 2024 47(10)

Palmitoylcarnitine impairs immunity in decompensated cirrhosis

Authors: Zhang, Ingrid Wei, Sánchez-Rodríguez, María Belén, López-Vicario, Cristina, Casulleras, Mireia, Duran-Güell, Marta, Flores-Costa, Roger, Aguilar, Ferran, Rothe, Michael, Segalés, Paula, García-Ruiz, Carmen, Fernández-Checa, José C., Trebicka, Jonel, Arroyo, Vicente, Clària, Joan

Source: In JHEP Reports November 2024 6(11)

Albumin reprograms the B cell transcriptional landscape and improves neutrophil antimicrobial function in patients with decompensated cirrhosis

Authors: Clària, Joan, Aguilar, Ferran, Lozano, Juan-José, Jiménez-Gracia, Laura, Nieto, Juan C., Romero-Grimaldo, Berta, Marcos-Fa, Xavi, Giarracco, Emma, Weiss, Emmanuel, Trebicka, Jonel, Hernàndez, Inmaculada, Fernandez, Javier, Casulleras, Mireia, López-Vicario, Cristina, Muldur, Sinan, Hopke, Alex, Vlagea, Alexandru, Aransay, Ana M., Marchese, Domenica, Bernardi, Mauro, Jalan, Rajiv, Angeli, Paolo, Magri, Giuliana, Cerutti, Andrea, Irimia, Daniel, Heyn, Holger, Arroyo, Vicente, Moreau, Richard

Source: In JHEP Reports November 2024 6(11)

Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure

Authors: Clària, Joan, Arroyo, Vicente, Moreau, Richard

Source: In JHEP Reports September 2023 5(9)

Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America

Authors: Ferreira, Caroline Marcondes, Benedita Terrabuio, Debora R., Fernandes da Costa, Roberto M., Signorelli, Izabelle Venturini, Pinto, Caroline A., Estanes-Hernández, Alma, Manriquez, Jesús Ruiz, Gutierrez-Acevedo, María N., Martinez-Garmendia, Agustina M., Ligia Aparecida, M., Macêdo, Everton, Mantovani, Augusto, Longo, Larisse, Vilela, Eduardo Garcia, Valderrama, María G., Santos-Rondon, Michelle V.S., Cardenas, Bertha, Rentería, Jorge Garavito, Torres-Made, Lilian Montserrat, Tenorio Castillo, Laura C., Aquino Ramos, José M., de Fátima Higuera de la Tijera, María, Aires, Rodrigo S., Salinas-Gómez, Diana C., Allendes, Francisca, Schacher, Fernando C., Neto, Guilherme John, Valdivia, Raúl Castro, Pagés, Josefina, Roblero, Juan P., Fainboim, Hugo, Souza, Fernanda Fernandes, Colombato, Luis, de Mello Peres, Renata, Miranda, Larissa O., Oliveira, Jade C., Ortiz, Leyla Nazal, Simian, Daniela, Puentes, Gabriel Mezzano, de Cássia Martins Alves da Silva, Rita, Gordon, Iaarah Montalvo, Chi Cervera, Luis A., Girala Salomón, Marcos A., Cuevas, María T., Montes, Pedro, Cattaneo Buteler, Máximo J., Farias, Alberto Queiroz, Curto Vilalta, Anna, Momoyo Zitelli, Patricia, Pereira, Gustavo, Goncalves, Luciana L., Torre, Aldo, Diaz, Juan Manuel, Gadano, Adrian C., Mattos, Angelo Z., Mendes, Liliana S.C., Alvares-da-Silva, Mario R., Bittencourt, Paulo L., Benitez, Carlos, Couto, Claudia Alves, Mendizabal, Manuel, Toledo, Claudio L., Mazo, Daniel F.C., Castillo Barradas, Mauricio, Uson Raposo, Eva M., Padilla-Machaca, P. Martín, Zarela Lozano Miranda, Adelina, Malé-Velázquez, René, Castro Lyra, André, Dávalos-Moscol, Milagros B., Pérez Hernández, José L., Ximenes, Rafael O., Faria Silva, Giovanni, Beltrán-Galvis, Oscar A., González Huezo, María S., Bessone, Fernando, Rocha, Tarciso D.S., Fassio, Eduardo, Terra, Carlos, Marín, Juan I., Sierra Casas, Patricia, de la Peña-Ramirez, Carlos, Aguilar Parera, Ferran, Fernandes, Flavia, da Penha Zago-Gomes, Maria, Méndez-Guerrero, Osvely, Marciano, Sebastián, Mattos, Angelo A., Oliveira, Joao C., Guerreiro, Gabriel T.S., Codes, Liana, Arrese, Marco, Nardelli, Mateus J., Silva, Marcelo O., Palma-Fernandez, Renato, Alcantara, Camila, Sánchez Garrido, Cristina, Trebicka, Jonel, Gustot, Thierry, Fernández, Javier, Clària, Joan, Jalan, Rajiv, Angeli, Paolo, Arroyo, Vicente, Moreau, Richard, Carrilho, Flair J.

Source: In Gastroenterology September 2023 165(3):696-716

Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure

Authors: Zhang, Ingrid W., Curto, Anna, López-Vicario, Cristina, Casulleras, Mireia, Duran-Güell, Marta, Flores-Costa, Roger, Colsch, Benoit, Aguilar, Ferran, Aransay, Ana M., Lozano, Juan José, Hernández-Tejero, María, Toapanta, David, Fernández, Javier, Arroyo, Vicente, Clària, Joan

Source: In Journal of Hepatology January 2022 76(1):93-106

Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit

Authors: Flores-Costa, Roger, Duran-Güell, Marta, Casulleras, Mireia, López-Vicario, Cristina, Alcaraz-Quiles, José, Diaz, Alba, Lozano, Juan J., Titos, Esther, Hall, Katherine, Sarno, Renee, Masferrer, Jaime L., Clària, Joan

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Nov 01. 117(45), 28263-28274.

Access URL: https://www.jstor.org/stable/26970726

Proresolving lipid mediators and liver disease

Authors: Clària, Joan, Flores-Costa, Roger, Duran-Güell, Marta, López-Vicario, Cristina

Source: In BBA - Molecular and Cell Biology of Lipids November 2021 1866(11)

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

Authors: Clària, Joan, Curto, Anna, Moreau, Richard, Colsch, Benoit, López-Vicario, Cristina, Lozano, Juan José, Aguilar, Ferran, Castelli, Florence A., Fenaille, François, Junot, Christophe, Zhang, Ingrid, Vinaixa, Maria, Yanes, Oscar, Caraceni, Paolo, Trebicka, Jonel, Fernández, Javier, Angeli, Paolo, Jalan, Rajiv, Arroyo, Vicente

Source: In Journal of Hepatology November 2021 75(5):1116-1127

Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction

Authors: Engelmann, Cornelius, Clària, Joan, Szabo, Gyongyi, Bosch, Jaume, Bernardi, Mauro

Source: In Journal of Hepatology July 2021 75 Supplement 1:S49-S66

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Authors: Maschmeier, Miriam, Semela, David, Elkrief, Laure, Elsharkawy, Ahmed, Tornai, Tamas, Tornai, Istvan, Altorjay, Istvan, Antognoli, Agnese, Baldassarre, Maurizio, Gagliardi, Martina, Bertoli, Eleonora, Mareso, Sara, Brocca, Alessandra, Campion, Daniela, Saracco, Giorgio Maria, Rizzo, Martina, Lehmann, Jennifer, Pohlmann, Alessandra, Brol, Maximilian J., Chang, Johannes, Schierwagen, Robert, Solà, Elsa, Amari, Nesrine, Rodriguez, Miguel, Nevens, Frederik, Clemente, Ana, Janicko, Martin, Markwardt, Daniel, Mandorfer, Mattias, Welsch, Christoph, Welzel, Tanja M., Ciraci, Emanuela, Patel, Vish, Ripoll, Cristina, Herber, Adam, Horn, Paul, Bendtsen, Flemming, Gluud, Lise Lotte, Schaapman, Jelte, Riggio, Oliviero, Rainer, Florian, Moritz, Jörg Tobiasch, Mesquita, Mónica, Alvarado-Tapias, Edilmar, Akpata, Osagie, Aamann, Luise, Samuel, Didier, Tresson, Sylvie, Strnad, Pavel, Amathieu, Roland, Simón-Talero, Macarena, Smits, Francois, van den Ende, Natalie, Martinez, Javier, Garcia, Rita, Rupprechter, Harald, Engelmann, Cornelius, Özdogan, Osman Cavit, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jansen, Christian, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Jarcuska, Peter, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Shawcross, Debbie L., Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Danielsen, Karen Vagner, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solé, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Kani, Haluk Tarik, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia-Lopez, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Praktiknjo, Michael, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Bernal, William, Aguilar, Ferran, Clària, Joan, Ponzo, Paola, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Gerbes, Alexander, Vargas, Victor, Alessandria, Carlo, Bernardi, Mauro, Ginès, Pere, Moreau, Richard, Angeli, Paolo, Jalan, Rajiv, Arroyo, Vicente

Source: In Journal of Hepatology May 2021 74(5):1097-1108

Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF

Authors: Zaccherini, Giacomo, Aguilar, Ferran, Caraceni, Paolo, Clària, Joan, Lozano, Juan José, Fenaille, François, Castelli, Florence, Junot, Christophe, Curto, Anna, Formentin, Chiara, Weiss, Emmanuel, Bernardi, Mauro, Jalan, Rajiv, Angeli, Paolo, Moreau, Richard, Arroyo, Vicente

Source: In Journal of Hepatology May 2021 74(5):1117-1131

The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis

Authors: Arroyo, Vicente, Angeli, Paolo, Moreau, Richard, Jalan, Rajiv, Clària, Joan, Trebicka, Jonel, Fernández, Javier, Gustot, Thierry, Caraceni, Paolo, Bernardi, Mauro

Source: In Journal of Hepatology March 2021 74(3):670-685

The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Authors: Maschmeier, Miriam, Semela, David, Elkrief, Laure, Elsharkawy, Ahmed, Tornai, Tamas, Tornai, Istvan, Altorjay, Istvan, Antognoli, Agnese, Baldassarre, Maurizio, Gagliardi, Martina, Bertoli, Eleonora, Mareso, Sara, Brocca, Alessandra, Campion, Daniela, Saracco, Giorgio Maria, Rizzo, Martina, Lehmann, Jennifer, Pohlmann, Alessandra, Praktiknjo, Michael, Schierwagen, Robert, Solà, Elsa, Amari, Nesrine, Rodriguez, Miguel, Nevens, Frederik, Clemente, Ana, Jarcuska, Peter, Gerbes, Alexander, Mandorfer, Mattias, Welsch, Christoph, Ciraci, Emanuela, Patel, Vish, Ripoll, Cristina, Herber, Adam, Horn, Paul, Danielsen, Karen Vagner, Gluud, Lise Lotte, Schaapman, Jelte, Riggio, Oliviero, Rainer, Florian, Moritz, Jörg Tobiasch, Mesquita, Mónica, Alvarado-Tapias, Edilmar, Akpata, Osagie, Lykke Eriksen, Peter, Samuel, Didier, Tresson, Sylvie, Strnad, Pavel, Amathieu, Roland, Simón-Talero, Macarena, Smits, Francois, van den Ende, Natalie, Martinez, Javier, Garcia, Rita, Markwardt, Daniel, Rupprechter, Harald, Engelmann, Cornelius, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Janicko, Martin, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Bernal, William, Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Bendtsen, Flemming, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solè, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Özdogan, Osman Cavit, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Shawcross, Debbie, Aguilar, Ferran, Clària, Joan, Ponzo, Paola, Jansen, Christian, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Vargas, Victor, Montagnese, Sara, Alessandria, Carlo, Bernardi, Mauro, Ginès, Pere, Jalan, Rajiv, Moreau, Richard, Angeli, Paolo, Arroyo, Vicente

Source: In Journal of Hepatology October 2020 73(4):842-854

Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis

Authors: López-Vicario, Cristina, Checa, Antonio, Urdangarin, Arantxa, Aguilar, Ferran, Alcaraz-Quiles, José, Caraceni, Paolo, Amorós, Alex, Pavesi, Marco, Gómez-Cabrero, David, Trebicka, Jonel, Oettl, Karl, Moreau, Richard, Planell, Núria, Arroyo, Vicente, Wheelock, Craig E., Clària, Joan

Source: In Journal of Hepatology October 2020 73(4):817-828

HDL-related biomarkers are robust predictors of survival in patients with chronic liver failure

Authors: Trieb, Markus, Rainer, Florian, Stadlbauer, Vanessa, Douschan, Philipp, Horvath, Angela, Binder, Lukas, Trakaki, Athina, Knuplez, Eva, Scharnagl, Hubert, Stojakovic, Tatjana, Heinemann, Ákos, Mandorfer, Mattias, Paternostro, Rafael, Reiberger, Thomas, Pitarch, Carla, Amorós, Alex, Gerbes, Alexander, Caraceni, Paolo, Alessandria, Carlo, Moreau, Richard, Clària, Joan, Marsche, Gunther, Stauber, Rudolf E.

Source: In Journal of Hepatology July 2020 73(1):113-120

Efficacy of Albumin Treatment for Patients with Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis

Authors: Fernández, Javier, Angeli, Paolo, Trebicka, Jonel, Merli, Manuela, Gustot, Thierry, Alessandria, Carlo, Aagaard, Niels Kristian, de Gottardi, Andrea, Welzel, Tania M., Gerbes, Alexander, Soriano, German, Vargas, Victor, Albillos, Agustin, Salerno, Francesco, Durand, Francois, Bañares, Rafael, Stauber, Rudolf, Prado, Verónica, Arteaga, Mireya, Hernández-Tejero, María, Aziz, Fátima, Morando, Filippo, Jansen, Christian, Lattanzi, Barbara, Moreno, Christophe, Campion, Daniela, Gronbaek, Henning, Garcia, Rita, Sánchez, Cristina, García, Elisabet, Amorós, Alex, Pavesi, Marco, Clària, Joan, Moreau, Richard, Arroyo, Vicente

Source: In Clinical Gastroenterology and Hepatology April 2020 18(4):963-973

Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF

Authors: Moreau, Richard, Clària, Joan, Aguilar, Ferran, Fenaille, François, Lozano, Juan José, Junot, Christophe, Colsch, Benoit, Caraceni, Paolo, Trebicka, Jonel, Pavesi, Marco, Alessandria, Carlo, Nevens, Frederik, Saliba, Faouzi, Welzel, Tania M., Albillos, Agustin, Gustot, Thierry, Fernández, Javier, Moreno, Christophe, Baldassarre, Maurizio, Zaccherini, Giacomo, Piano, Salvatore, Montagnese, Sara, Vargas, Victor, Genescà, Joan, Solà, Elsa, Bernal, William, Butin, Noémie, Hautbergue, Thaïs, Cholet, Sophie, Castelli, Florence, Jansen, Christian, Steib, Christian, Campion, Daniela, Mookerjee, Raj, Rodríguez-Gandía, Miguel, Soriano, German, Durand, François, Benten, Daniel, Bañares, Rafael, Stauber, Rudolf E., Gronbaek, Henning, Coenraad, Minneke J., Ginès, Pere, Gerbes, Alexander, Jalan, Rajiv, Bernardi, Mauro, Arroyo, Vicente, Angeli, Paolo

Source: In Journal of Hepatology April 2020 72(4):688-701

Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis

Authors: Fernández, Javier, Clària, Joan, Amorós, Alex, Aguilar, Ferrán, Castro, Miriam, Casulleras, Mireia, Acevedo, Juan, Duran-Güell, Marta, Nuñez, Laura, Costa, Montserrat, Torres, Mireia, Horrillo, Raquel, Ruiz-del-Árbol, Luis, Villanueva, Cándido, Prado, Verónica, Arteaga, Mireya, Trebicka, Jonel, Angeli, Paolo, Merli, Manuela, Alessandria, Carlo, Aagaard, Niels Kristian, Soriano, German, Durand, François, Gerbes, Alexander, Gustot, Thierry, Welzel, Tania M., Salerno, Francesco, Bañares, Rafael, Vargas, Victor, Albillos, Agustin, Silva, Aníbal, Morales-Ruiz, Manuel, Carlos García-Pagán, Juan, Pavesi, Marco, Jalan, Rajiv, Bernardi, Mauro, Moreau, Richard, Páez, Antonio, Arroyo, Vicente

Source: In Gastroenterology July 2019 157(1):149-162

Pro-resolving actions of SPM in adipose tissue biology

Authors: Clària, Joan, López-Vicario, Cristina, Rius, Bibiana, Titos, Esther

Source: In Molecular Aspects of Medicine December 2017 58:83-92