Spatial multi-omics in whole skeletal muscle reveals complex tissue architecture

Authors: Clara Martínez Mir, Paola Pisterzi, Isabel De Poorter, Maria Rilou, Melissa van Kranenburg, Bram Heijs, Anna Alemany, Fanny Sage, Niels Geijsen

Source: Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/afeade6f482741f19de43bcbc0c2a250

Psychological interventions for suicidal behavior in adolescents: a comprehensive systematic review

Authors: Ainoa García-Fernández, Teresa Bobes-Bascarán, Clara Martínez-Cao, Leticia González-Blanco, Jennifer Fernández-Fernández, Paula Zurrón-Madera, Elisa Seijo Zazo, Luis Jiménez-Treviño, María Paz García-Portilla, Julio Bobes, Pilar A. Sáiz

Source: Translational Psychiatry, Vol 14, Iss 1, Pp 1-15 (2024)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/91394de6fba04cf2820e23ecbb6dd94a

Anticholinergic load: A commonly neglected and preventable risk to cognition during schizophrenia treatment?

Authors: Clara Martínez-Cao, Ainoa García-Fernández, Leticia González-Blanco, Pilar A. Sáiz, Julio Bobes, María Paz García-Portilla

Source: Schizophrenia Research: Cognition, Vol 37, Iss , Pp 100317- (2024)

Subject Terms: schizophrenia, cognition, anticholinergic burden, psychopathology, cognitive deficits, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2215001324000180; https://doaj.org/toc/2215-0013

Access URL: https://doaj.org/article/deb9972f82714efb8806391cb826b27e

Validation of the Spanish Childhood Trauma Questionnaire-Short Form in adolescents with suicide attempts

Authors: Ainoa García-Fernández, Clara Martínez-Cao, Alberto Sánchez-Fernández-Quejo, Teresa Bobes-Bascarán, Jorge Andreo-Jover, Wala Ayad-Ahmed, Ana Isabel Cebriá, Marina Díaz-Marsá, Nathalia Garrido-Torres, Sandra Gómez, Ana González-Pinto, Iria Grande, Noelia Iglesias, Katya B. March, Diego J. Palao, Iván Pérez-Díez, Natalia Roberto, Miguel Ruiz-Veguilla, Alejandro de la Torre-Luque, Iñaki Zorrilla, Víctor Pérez, SURVIVE Group, Pilar A. Sáiz, María Paz García-Portilla

Source: Frontiers in Psychology, Vol 15 (2024)

Subject Terms: CTQ-SF, reliability, validity, suicide attempt, adolescent, Psychology, BF1-990

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyg.2024.1378486/full; https://doaj.org/toc/1664-1078

Access URL: https://doaj.org/article/b1de06bf9ac64015b92db357c990a6a4

PsiOvi Staging Model for Schizophrenia (PsiOvi SMS): A New Internet Tool for Staging Patients with Schizophrenia

Authors: Clara Martínez-Cao, Fernando Sánchez-Lasheras, Ainoa García-Fernández, Leticia González-Blanco, Paula Zurrón-Madera, Pilar A. Sáiz, Julio Bobes, María Paz García-Portilla

Source: European Psychiatry, Vol 67 (2024)

Subject Terms: clinical tool, empirical staging model, multidimensional model, personalized intervention, schizophrenia, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.cambridge.org/core/product/identifier/S0924933824000178/type/journal_article; https://doaj.org/toc/0924-9338; https://doaj.org/toc/1778-3585

Access URL: https://doaj.org/article/0262e23a490c444694e7eadc8003e6c7

Study of Diagnostic Accuracy: Fundus Photography vs. Optical Coherence Tomography

Authors: Manuel Moriche Carretero, Ana de los Reyes Sánchez Parejo, Clara Martínez Pérez, Remedios Revilla Amores, Ángel Pérez Gómez, Marc Biarnés Pérez

Source: Applied Sciences, Vol 14, Iss 12, p 5314 (2024)

Subject Terms: optical coherence tomography, retina, fundus photography, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3417/14/12/5314; https://doaj.org/toc/2076-3417

Access URL: https://doaj.org/article/16dbcba804c54396a228f540011955f2

Laparoscopic Management of Ventral Hernias by Totally Extraperitoneal (eTEP) Approach: Initial Experience and Short-Term Results

Authors: Jeancarlos Jhosmer Trujillo-Díaz, Juan Ramón Gómez-López, Pilar Concejo-Cutoli, Clara Martínez-Moreno, Javier Atienza-Herrero, Juan Carlos Martín-del Olmo

Source: MedUNAB, Vol 25, Iss 3, Pp 359-384 (2022)

Subject Terms: hernia ventral, incisional hernia, hernia abdominal, laparoscopy, hernia, Medicine

File Description: electronic resource

Relation: https://revistas.unab.edu.co/index.php/medunab/article/view/4491; https://doaj.org/toc/2382-4603

Access URL: https://doaj.org/article/49adcb53471345718f9b8e72d0aa1c7c

Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS eventsResearch in context

Authors: Javier Martínez-Sanz, Jorge Díaz-Álvarez, Marta Rosas, Raquel Ron, José Antonio Iribarren, Enrique Bernal, Félix Gutiérrez, Andrés Ruiz Sancho, Noemi Cabello, Julián Olalla, Santiago Moreno, Sergio Serrano-Villar, Inma Jarrín, David Dalmau, M. Luisa Navarro, M. Isabel González, Federico Garcia, Eva Poveda, Jose Antonio Iribarren, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M. Ángeles Muñoz-Fernández, Inmaculada Jarrín, Cristina Moreno, Marta Rava, Rebeca Izquierdo, Elba Mauleón, Joaquín Portilla, Irene Portilla, Esperanza Merino, Gema García, Iván Agea, José Sánchez-Payá, Juan Carlos Rodríguez, Livia Giner, Sergio Reus, Vicente Boix, Diego Torrus, Verónica Pérez, Julia Portilla, Juan Luís Gómez, Jehovana Hernández, Ana López Lirola, Dácil García, Felicitas Díaz-Flores, M. Mar Alonso, Ricardo Pelazas, M. Remedios Alemán, Víctor Asensi, María Eugenia Rivas Carmenado, Tomás Suarez-Zarracina, Federico Pulido, Otilia Bisbal, M. Asunción Hernando, David Rial, María de Lagarde, Octavio Arce, Adriana Pinto, Laura Bermejo, Mireia Santacreu, Roser Navarro, Candela Gonzalez, M. José Aramburu, Xabier Camino, Miguel Ángel von Wichmann, Miguel Ángel Goenaga, M. Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Xabier Kortajarena, Ignacio Álvarez-Rodriguez, Leire Gil, Lourdes Martínez, Catalina Robledano, Mar Masiá, Sergio Padilla, Araceli Adsuar, Rafael Pascual, Marta Fernández, Antonio Galiana, José Alberto García, Xavier Barber, Vanessa Agullo, Javier Garcia Abellán, Reyes Pascual, Guillermo Telenti, Lucia Guillén, Ángela Botella, Roberto Muga, Arantza Sanvisens, Daniel Fuster, Isabel Gutierrez, Juan Carlos López, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldamiz-Echevarría, Francisco Tejerina, Cristina Diez, Leire Pérez, Chiara Fanciulli, Saray Corral, Anna Martí, Joaquín Peraire, Consuelo Viladés, Montserrat Vargas, Montserrat Olona, Anna Rull, Verónica Alba, Elena Yeregui, Jenifer Masip, Graciano García-Pardo, Frederic Gómez Bertomeu, Sonia Espineira, Marta Montero, Sandra Cuéllar, Marino Blanes, María Tasias, Eva Calabuig, Miguel Salavert, Juan Fernández, Inmaculada Segarra, Juan González-García, Ana Delgado, Francisco Arnalich, José Ramón Arribas, Jose Ignacio Bernardino, Juan Miguel Castro, Luis Escosa, Pedro Herranz, Victor Hontañón, Silvia García-Bujalance, Milagros García, Alicia González-Baeza, M. Luz Martín-Carbonero, Mario Mayoral, M. Jose Mellado, Rafael Esteban, Rocío Montejano, M. Luisa Montes, Victoria Moreno, Ignacio Pérez-Valero, Berta Rodés, Guadalupe Rúa, Talía Sainz, Elena Sendagorta, Eulalia Valencia, Carmen Busca, Joanna Cano, Julen Cardiñanos, Rosa de Miguel, Jose Ramón Blanco, Laura Pérez-Martínez, José Antonio Oteo, Valvanera Ibarra, Luis Metola, Mercedes Sanz, Piedad Arazo, Gloria Sampériz, Marina Martinez, Angels Jaén, Montse Sanmartí, Mireia Cairó, Javier Martinez-Lacasa, Pablo Velli, Roser Font, Mariona Xercavins, Noemí Alonso, Francesco Aiello, María Rivero, Beatriz Piérola, Maider Goikoetxea, María Gracia, Carlos Ibero, Estela Moreno, Jesús Repáraz, Gemma Navarro, Manel Cervantes Garcia, Sonia Calzado Isbert, Marta Navarro Vilasaro, Belen Lopez Garcia, Ignacio de los Santos, Alejandro de los Santos, Jesús Sanz, Lucio García-Fraile, Enrique Martín, Ildefonso Sánchez-Cerrillo, Marta Calvet, Ana Barrios, Azucena Bautista, Carmen Sáez, Marianela Ciudad, Ángela Gutiérrez, Santos del Campo, José Luis Casado, Fernando Dronda, Ana Moreno, M. Jesús Pérez, Sergio Serrano, Ma Jesús Vivancos, Alejandro Vallejo, Matilde Sanchez, Jose Antonio Pérez-Molina, José Manuel Hermida, Antonia Alcaraz, Joaquín Bravo, Ángeles Muñoz, Cristina Tomás, Mónica Martínez, M. Carmen Villalba, Federico García, Clara Martínez, José Hernández, Leopoldo Muñoz Medina, Marta Álvarez, Natalia Chueca, David Vinuesa, Adolfo de Salazar, Ana Fuentes, Emilio Guirao, Laura Viñuela, Andrés Ruiz-Sancho, Francisco Anguita, Jorge Del Romero, Montserrat Raposo, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Begoña Baza, Eva Orviz, Antonio Antela, Elena Losada, Melchor Riera, María Peñaranda, M. Angels Ribas, Antoni A. Campins, Mercedes Garcia-Gazalla, Francisco J. Fanjul, Javier Murillas, Francisco Homar, Helem H. Vilchez, Luisa Martin, Antoni Payeras, Jesús Santos, María López, Crisitina Gómez, Isabel Viciana, Rosario Palacios, Luis Fernando López-Cortés, Nuria Espinosa, Cristina Roca, Silvia Llaves, Juan Manuel Tiraboschi, Arkaitz Imaz, Ana Karina Silva, María Saumoy, Sofía Catalina Scévola, Adrián Curran, Vicenç Falcó, Jordi Navarro, Joaquin Burgos, Paula Suanzes, Jorge García, Vicente Descalzo, Patricia Álvarez, Bibiana Planas, Marta Sanchiz, Lucía Rodríguez, M José Sánchez, Javier Pérez, Alfonso del Arco, Javier de la Torre, José Luis Prada, Onofre Juan Martínez, Lorena Martinez, Francisco Jesús Vera, Josefina García, Begoña Alcaraz, Antonio Jesús Sánchez Guirao, Alvaro Mena, Angeles Castro, Berta Pernas, Pilar Vázquez, Soledad López, Sofía Ibarra, Guillermo García, Josu Mirena, Oscar Luis Ferrero, Josefina López, M. Mar Cámara, Mireia de la Peña, Miriam Lopez, Iñigo Lopez, Itxaso Lombide, Victor Polo, Joana de Miguel, Carlos Galera, Marian Fernández, Helena Albendin, Antonia Castillo, Asunción Iborra, Antonio Moreno, M. Angustias Merlos, Asunción Vidal, Concha Amador, Francisco Pasquau, Concepcion Gil, Jose Tomás Algado, Inés Suarez-García, Eduardo Malmierca, Patricia González-Ruano, M. Pilar Ruiz, José Francisco Pascual, Elena Sáez, Luz Balsalobre, M. Villa López, Mohamed Omar, Carmen Herrero, M. Amparo Gómez, Miguel Alberto de Zarraga, Desiré Pérez, Vicente Estrada, Nieves Sanz, Noemí Cabello, Jorge Vergas García, Maria Jose Núñez, Iñigo Sagastagoitia, Miguel Górgolas, Alfonso Cabello, Beatriz Álvarez, Laura Prieto, Irene Carrillo, José Sanz, Alberto Arranz, Cristina Hernández, María Novella, M. José Galindo, Ana Ferrer, Antonio Rivero Román, Inma Ruíz, Antonio Rivero Juárez, Pedro López, Isabel Machuca, Mario Frias, Ángela Camacho, Ignacio Pérez, Diana Corona, Miguel Cervero, Rafael Torres, Juan Antonio Pineda, Pilar Rincón, Juan Macías, Luis Miguel Real, Anais Corma, Alejandro Gonzalez-Serna, Alexandre Pérez, Luis Morano, Celia Miralles, Antonio Ocampo, Guillermo Pousada, Lucía Patiño, Carlos Dueñas, Sara Gutiérrez, Elena Tapia, Cristina Novoa, Xjoylin Egües, Pablo Telleria

Source: EBioMedicine, Vol 95, Iss , Pp 104773- (2023)

Subject Terms: HIV, Non-AIDS events, Neoplasia, Cardiovascular event, CD4/CD8 ratio, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423003390; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/58776bce09a046cdb96584187ca1fd3d

Is it possible to stage schizophrenia? A systematic review

Authors: Clara Martínez-Cao, Lorena de la Fuente-Tomás, Ainoa García-Fernández, Leticia González-Blanco, Pilar A. Sáiz, María Paz Garcia-Portilla, Julio Bobes

Source: Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/64bedfe90f9849e5804941b52528f2c0

What factors should we modify to promote high functioning and prevent functional decline in people with schizophrenia?

Authors: Clara Martínez-Cao, Ainoa García-Fernández, Leticia González-Blanco, Paula Zurrón-Madera, Pilar A. Sáiz, María Paz García-Portilla, Julio Bobes

Source: Frontiers in Psychiatry, Vol 14 (2023)

Subject Terms: real-world functioning, protective factors, risk, prevention, schizophrenia, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1181758/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/89a0244ee1b74f5d830c5ebb63211604

Phylogenetically and functionally diverse microorganisms reside under the Ross Ice Shelf

Authors: Clara Martínez-Pérez, Chris Greening, Sean K. Bay, Rachael J. Lappan, Zihao Zhao, Daniele De Corte, Christina Hulbe, Christian Ohneiser, Craig Stevens, Blair Thomson, Ramunas Stepanauskas, José M. González, Ramiro Logares, Gerhard J. Herndl, Sergio E. Morales, Federico Baltar

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4bdccf6b3afa4daf99ac9526201f6973

Limit on Supernova Emission in the Brightest Gamma-Ray Burst, GRB 221009A

Authors: Manisha Shrestha, David J. Sand, Kate D. Alexander, K. Azalee Bostroem, Griffin Hosseinzadeh, Jeniveve Pearson, Mojgan Aghakhanloo, József Vinkó, Jennifer E. Andrews, Jacob E. Jencson, M. J. Lundquist, Samuel Wyatt, D. Andrew Howell, Curtis McCully, Estefania Padilla Gonzalez, Craig Pellegrino, Giacomo Terreran, Daichi Hiramatsu, Megan Newsome, Joseph Farah, Saurabh W. Jha, Nathan Smith, J. Craig Wheeler, Clara Martínez-Vázquez, Julio A. Carballo-Bello, Alex Drlica-Wagner, David J. James, Burçin Mutlu-Pakdil, Guy S. Stringfellow, Joanna D. Sakowska, Noelia E. D. Noël, Clécio R. Bom, Kyler Kuehn

Source: The Astrophysical Journal Letters, Vol 946, Iss 1, p L25 (2023)

Subject Terms: Gamma-ray bursts, Supernovae, Type Ic supernovae, Photometry, Spectroscopy, Astrophysics, QB460-466

File Description: electronic resource

Relation: https://doaj.org/toc/2041-8205

Access URL: https://doaj.org/article/5bb1b00de35c4d388a4309c3c6fd49f9

Machine Learning Improves Risk Stratification in Myelofibrosis: An Analysis of the Spanish Registry of Myelofibrosis

Authors: Adrián Mosquera-Orgueira, Manuel Pérez-Encinas, Alberto Hernández-Sánchez, Teresa González-Martínez, Eduardo Arellano-Rodrigo, Javier Martínez-Elicegui, Ángela Villaverde-Ramiro, José-María Raya, Rosa Ayala, Francisca Ferrer-Marín, María-Laura Fox, Patricia Velez, Elvira Mora, Blanca Xicoy, María-Isabel Mata-Vázquez, María García-Fortes, Anna Angona, Beatriz Cuevas, María-Alicia Senín, Angel Ramírez-Payer, María-José Ramírez, Raúl Pérez-López, Sonia González de Villambrosía, Clara Martínez-Valverde, María-Teresa Gómez-Casares, Carmen García-Hernández, Mercedes Gasior, Beatriz Bellosillo, Juan-Luis Steegmann, Alberto Álvarez-Larrán, Jesús María Hernández-Rivas, Juan Carlos Hernández-Boluda, on behalf of the Spanish MPN Group (GEMFIN).

Source: HemaSphere, Vol 7, Iss 1, p e818 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000818; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/b80233d27d284aceb361680826fa5bb8

Conservation of Energetic Pathways for Electroautotrophy in the Uncultivated Candidate Order Tenderiales

Authors: Brian J. Eddie, Lina J. Bird, Claus Pelikan, Marc Mussmann, Clara Martínez-Pérez, Princess Pinamang, Anthony P. Malanoski, Sarah M. Glaven

Source: mSphere, Vol 7, Iss 5 (2022)

Subject Terms: Tenderiales, electroautotrophy, metagenome-assembled genomes, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/5235b780ad4541f298ef9cbdff614a58

Paraneoplastic Focal Outer Retinitis and Optic Neuropathy in a Patient with Small Cell Lung Carcinoma and Anti-CRMP5, Anti-HU and Anti-Amphiphysin Antibodies

Authors: Clara Martínez-Rubio, Lena Giralt, Inazio Lacambra, Joseba Artaraz, Alex Fonollosa

Source: Case Reports in Ophthalmology, Vol 11, Iss 3, Pp 507-515 (2020)

Subject Terms: retinitis, optic disc oedema, ataxia, collapsin response mediator protein 5, paraneoplastic syndrome, Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://www.karger.com/Article/FullText/509861; https://doaj.org/toc/1663-2699

Access URL: https://doaj.org/article/c6b773a60adb47109aff49feff307630

Anti-angiogenic therapy for ovarian cancer

Authors: Yolanda García García, Maria Marín Alcalá, Clara Martínez Vila

Source: EJC Supplements, Vol 15, Iss , Pp 77-86 (2020)

Subject Terms: ovarian cancer, antiangiogenic therapy, bevacizumab, aflibercept, trebananib, pazopanib, Medicine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1359634920300045; https://doaj.org/toc/1359-6349

Access URL: https://doaj.org/article/3456d6610b5844a1a7c9cc3d89fd337a

Bone marrow fibrosis, sequence variant of asxl1, and Sjögren syndrome: A case report

Authors: Marta Santaliestra, Elena Bussaglia, Marta Pratcorona, Anna Monter‐Rovira, Silvana Saavedra, Anna Mozos, Clara Martínez, Josep F. Nomdedéu

Source: Clinical Case Reports, Vol 8, Iss 7, Pp 1269-1273 (2020)

Subject Terms: ASXL1, autoimmune, bone marrow fibrosis, molecular, Sjögren syndrome, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0904

Access URL: https://doaj.org/article/91e5a0288be647f19adc11732e590e24

Estado nutricional, síndrome metabólico e inflamación en pacientes con enfermedad de Chagas

Authors: María Gracia Albornoz, Clara Martínez, Diamela Carías, Edgar Acosta, Hernán J.Carrasco

Source: Archivos Latinoamericanos de Nutrición, Vol 70, Iss 2, Pp 101-114 (2020)

Subject Terms: enfermedad de chagas, estado nutricional, inflamación, síndrome metabólico, t. cruzi, Nutrition. Foods and food supply, TX341-641, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.alanrevista.org/ediciones/2020/2/art-3/; https://doaj.org/toc/0004-0622; https://doaj.org/toc/2309-5806

Access URL: https://doaj.org/article/eac272451e404c4485f16c56d485144e

Célula caliciforme y ojo seco: análisis de redes de citación

Authors: Elena Fraga-Graells, Clara Martínez-Pérez, Cristina Álvarez-Peregrina, César Villa-Collar, Miguel Ángel Sánchez-Tena

Source: Revista Mexicana de Oftalmología, Vol 96, Iss 6 (2022)

Subject Terms: Célula caliciforme. Enfermedad del ojo seco. Mucinas. Ojo seco. Superficie ocular., Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://www.rmo.com.mx/frame_esp.php?id=341; https://doaj.org/toc/0187-4519

Access URL: https://doaj.org/article/0d9dc33dec6a4a6991c9787b7ab4c3fa

Early Fetal Growth Restriction of Both Twins in a Transgender Man

Authors: Alicia Martínez-Varea, Clara Martínez-Sáez, María Patrocinio Tarrazó-Millet, Vicente Diago-Almela

Source: Case Reports in Obstetrics and Gynecology, Vol 2022 (2022)

Subject Terms: Gynecology and obstetrics, RG1-991

File Description: electronic resource

Relation: https://doaj.org/toc/2090-6692

Access URL: https://doaj.org/article/8ee2979b227e43cbb04f4da99e5c9e03