CD22 CAR-T cells secreting CD19 T-cell engagers for improved control of B-cell acute lymphoblastic leukemia progression

Authors: Manel Juan, Pablo Menendez, Alberto Orfao, Alba Martínez-Moreno, Anaïs Jiménez-Reinoso, Laura Díez-Alonso, Luis Álvarez-Vallina, Aida Falgas, Europa Azucena González-Navarro, Clara Bueno, Heleia Roca-Ho, Javier Arroyo-Ródenas, Francisco J. Gil-Etayo, Alba Pérez-Pons, Óscar Aguilar-Sopeña, Miriam Velasco-Sidro, Marina Gómez-Rosel, Beatriz Jiménez-Matías, Guillermo Muñoz-Sánchez, Yedra Pacheco, Clara Bravo-Martín, Ángel Ramírez-Fernández, Belén Blanco, Pedro Roda-Navarro

Source: Journal for ImmunoTherapy of Cancer, Vol 13, Iss 4 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/13/4/e009048.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/bf5e8f3d5a1544c299f02460fe575d5a

Oviductal extracellular matrix hydrogels enhance in vitro culture of rabbit embryos and reduce deficiencies during assisted reproductive technologies

Authors: Emilio Francés-Herrero, Laura Lorenzo-Rebenaque, Cristina Casto-Rebollo, José Salvador Vicente, Patricia Sebastian-Leon, Clara Bueno-Fernandez, Adolfo Rodríguez-Eguren, María Gómez-Álvarez, Amparo Faus, Patricia Diaz-Gimeno, Francisco Marco-Jiménez, Irene Cervelló

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Subject Terms: Decellularization, ECM hydrogel, Oviducts, Embryo culture, Phenotype effect, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f1257d7312794e4ca9b3a92e1f704361

Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends

Authors: Marcos Agustina-Hernández, Emilio Francés-Herrero, María Gómez-Álvarez, Paula Alonso-Frías, Mónica Romeu, Ana Monzó, Hortensia Ferrero, Clara Bueno-Fernandez, Irene Cervelló

Source: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Subject Terms: female reproduction, endometrial modelling, in vitro techniques, endometrial diseases, cell culture, tissue engineering, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2024.1495338/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/5b0850937591452d930e5df7e2a8197c

Beneficial Effects of Infiltration of Platelet-Rich Plasma in the Endometrium

Authors: Paula Alonso-Frías, Emilio Francés-Herrero, Clara Bueno-Fernandez, María Gómez-Álvarez, Marcos Agustina-Hernández, Irene Cervelló, Mauro Cozzolino

Source: Biology, Vol 14, Iss 4, p 319 (2025)

Subject Terms: endometrium, platelet-rich plasma, fertility, molecular mechanisms, endometrial pathologies, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2079-7737/14/4/319; https://doaj.org/toc/2079-7737

Access URL: https://doaj.org/article/fc212f1443a2432bab58883910f38d7b

Generation of an inducible dCas9-SAM human PSC line for endogenous gene activation

Authors: Paolo Petazzi, Francisco Gutierrez-Agüera, Heleia Roca-Ho, Julio Castaño, Clara Bueno, Niuska Alvarez, Lesley M. Forrester, Ana Sevilla, Antonella Fidanza, Pablo Menendez

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: human PSCs, ISAM, dead-Cas9 activation, gene expression, AAVS1 safe harbour locus, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1484955/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/a5c34ff86ef84f9495ad57c6c81b86fc

Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice

Authors: Julia Alcaide, Yaiza Gramuntell, Patrycja Klimczak, Clara Bueno-Fernandez, Erica Garcia-Verellen, Chiara Guicciardini, Carmen Sandi, Esther Castillo-Gómez, Carlos Crespo, Marta Perez-Rando, Juan Nacher

Source: Neurobiology of Disease, Vol 200, Iss , Pp 106642- (2024)

Subject Terms: Thalamic reticular nucleus, Peripubertal stress, Parvalbumin, Interneurons, Perineuronal nets, PSA-NCAM, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996124002420; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/b8f3f04f678c43e19b42186e53b85bf9

NSGS mice humanized with cord blood mononuclear cells show sustained and functional myeloid–lymphoid representation with limited graft-versus-host disease

Authors: Jorge Carrillo, Julià Blanco, Manel Juan, Pablo Menendez, Rosario Aschero, Alba Martínez-Moreno, Carla Panisello, Heleia Roca Ho, Aida Falgas, Europa Azucena González-Navarro, Julieta Carabelli, Edwards Pradenas, María Lázaro-Díez, Julia G Prado, Ángel M Carcaboso, Clara Bueno

Source: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/12/10/e009198.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/bed49f3854d84262911d96cc974169ac

Integrative single‐cell expression and functional studies unravels a sensitization to cytarabine‐based chemotherapy through HIF pathway inhibition in AML leukemia stem cells

Authors: Talia Velasco‐Hernandez, Juan L. Trincado, Meritxell Vinyoles, Adria Closa, Alba Martínez‐Moreno, Francisco Gutiérrez‐Agüera, Oscar Molina, Virginia C. Rodríguez‐Cortez, Pau Ximeno‐Parpal, Narcís Fernández‐Fuentes, Paolo Petazzi, Sergi Beneyto‐Calabuig, Lars Velten, Paola Romecin, Raquel Casquero, Fernando Abollo‐Jiménez, Rafael D. de laGuardia, Patricia Lorden, Alex Bataller, Hélène Lapillonne, Ronald W. Stam, Susana Vives, Montserrat Torrebadell, Jose L. Fuster, Clara Bueno, Jean‐Emmanuel Sarry, Eduardo Eyras, Holger Heyn, Pablo Menéndez

Source: HemaSphere, Vol 8, Iss 2, Pp n/a-n/a (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/5cf2e9d9f3b0488ebf1aab0a7234b697

Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution

Authors: Laureano Tomás-Daza, Llorenç Rovirosa, Paula López-Martí, Andrea Nieto-Aliseda, François Serra, Ainoa Planas-Riverola, Oscar Molina, Rebecca McDonald, Cedric Ghevaert, Esther Cuatrecasas, Dolors Costa, Mireia Camós, Clara Bueno, Pablo Menéndez, Alfonso Valencia, Biola M. Javierre

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ed82be97e08d48da9ae12e0781ecb041

The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)

Authors: Pablo Velasco, Francisco Bautista, Alba Rubio, Yurena Aguilar, Susana Rives, Jose L. Dapena, Antonio Pérez, Manuel Ramirez, Cristina Saiz-Ladera, Elisa Izquierdo, Adela Escudero, Mireia Camós, Nerea Vega-García, Margarita Ortega, Gloria Hidalgo-Gómez, Carlos Palacio, Pablo Menéndez, Clara Bueno, Joan Montero, Paola A. Romecín, Santiago Zazo, Federico Alvarez, Juan Parras, Carmen Ortega-Sabater, Salvador Chulián, María Rosa, Davide Cirillo, Elena García, Jorge García, Albert Manzano-Muñoz, Alfredo Minguela, Jose L. Fuster

Source: Frontiers in Pediatrics, Vol 11 (2023)

Subject Terms: relapsed acute lymphoblastic leukemia, precision medicine, cancer registry, artificial intelligence, functional assay, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fped.2023.1269560/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/5124b9f3d98a4c79a13549557a869a45

Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high‐hyperdiploid B‐cell acute lymphoblastic leukemia

Authors: Mireia Ramos‐Muntada, Juan L. Trincado, Joan Blanco, Clara Bueno, Virginia C. Rodríguez‐Cortez, Alex Bataller, Belén López‐Millán, Claire Schwab, Margarita Ortega, Pablo Velasco, Maria L. Blanco, Josep Nomdedeu, Manuel Ramírez‐Orellana, Alfredo Minguela, Jose L. Fuster, Esther Cuatrecasas, Mireia Camós, Paola Ballerini, Gabriele Escherich, Judith Boer, Monique DenBoer, Jesús M. Hernández‐Rivas, Maria J. Calasanz, Giovanni Cazzaniga, Christine J. Harrison, Pablo Menéndez, Oscar Molina

Source: Molecular Oncology, Vol 16, Iss 16, Pp 2899-2919 (2022)

Subject Terms: chromosomal gains, clonal heterogeneity, computational modeling, high‐hyperdiploid B‐ALL, risk predictors, sequential iFISH, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/c4efc3858e8a4dd59893e2d44eb72c0d

P718: EPIGENOME PROFILING REVEALS ABERRANT DNA METHYLATION SIGNATURE IN GATA2 DEFICIENCY

Authors: Oskar Marin-Bejar, Damia Romero-Moya, Javier Rodriguez-Ubreva, Maximiliano Distefano, Francesca Lessi, Paolo Aretini, Alessandro Liquori, Julio Castaño, Emilia Kozyra, Lili Kotmayer, Clara Bueno, José Cervera, José Carlos Rodriguez-Gallego, Josep F Nomdedeu, Laura Murillo-Sanjuán, Cristina Díaz de Heredia, Antonio Pérez-Martinez, Félix López-Cardenas, Carolina Martínez-Laperche, Nieves Dorado-Herrero, Francisco M Marco, Felipe Prósper, Pablo Menendez, David Valcárcel, Esteban Ballestar, Csaba Bödör, Anna Bigas, Albert Catalá, Marcin W Wlodarski, Alessandra Giorgetti

Source: HemaSphere, Vol 7, p e891194b (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000969776.89119.4b; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/73cdfb6289c94ebfa4e147d1498cc8f1

Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency

Authors: Oskar Marin-Bejar, Damia Romero-Moya, Javier Rodriguez-Ubreva, Maximiliano Distefano, Francesca Lessi, Paolo Aretini, Alessandro Liquori, Julio Castaño, Emilia Kozyra, Lili Kotmayer, Clara Bueno, José Cervera, José Carlos Rodriguez-Gallego, Josep F Nomdedeu, Laura Murillo-Sanjuán, Cristina Díaz de Heredia, Antonio Pérez-Martinez, Félix López-Cadenas, Carolina Martínez-Laperche, Nieves Dorado-Herrero, Francisco M Marco, Felipe Prósper, Pablo Menendez, David Valcárcel, Esteban Ballestar, Csaba Bödör, Anna Bigas, Albert Catalá, Marcin W Wlodarski, Alessandra Giorgetti

Source: Haematologica, Vol 108, Iss 9 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10996; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/64a9f674d5c1431a8af78aa2de7d0937

TIM3, a human acute myeloid leukemia stem cell marker, does not enrich for leukemia-initiating stem cells in B-cell acute lymphoblastic leukemia

Authors: Clara Bueno, Alba Martínez, Paola Alejandra Romecin, Samanta Romina Zanetti, Ricky Tirtakusuma, Eulalia Genesca, Mireia Camós, Manuel Ramírez-Orellana, Eduardo Anguita, Paola Ballerini, Franco Locatelli, José Luis Fuster, Pablo Menéndez

Source: Haematologica, Vol 108, Iss 8 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10943; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/75c274a961a94c758501a6a246554ef3

Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity

Authors: Marta Casquero-Veiga, Clara Bueno-Fernandez, Diego Romero-Miguel, Nicolás Lamanna-Rama, Juan Nacher, Manuel Desco, María Luisa Soto-Montenegro

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9a3eb597f59744ca85e2990175bc822f

Robustness of Catalytically Dead Cas9 Activators in Human Pluripotent and Mesenchymal Stem Cells

Authors: Paolo Petazzi, Raul Torres-Ruiz, Antonella Fidanza, Heleia Roca-Ho, Francisco Gutierrez-Agüera, Julio Castaño, Sandra Rodriguez-Perales, Rafael Díaz de la Guardia, Belén López-Millán, Anna Bigas, Lesley M. Forrester, Clara Bueno, Pablo Menéndez

Source: Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 196-204 (2020)

Subject Terms: dCas9 activators, SAM, SunTag, hPSCs, hMSCs, CRISPR, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253120300834; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/f77cc3d8fc8949cb8341a5d7065e2798

Impact of stress on inhibitory neuronal circuits, our tribute to Bruce McEwen

Authors: Marta Perez-Rando, Hector Carceller, Esther Castillo-Gomez, Clara Bueno-Fernandez, Clara García-Mompó, Javier Gilabert-Juan, Ramón Guirado, Ana Paula Pesarico, Juan Nacher

Source: Neurobiology of Stress, Vol 19, Iss , Pp 100460- (2022)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352289522000352; https://doaj.org/toc/2352-2895

Access URL: https://doaj.org/article/2544e83647914c10921e5349d14682be

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm

Authors: Julio Castaño, Sergi Aranda, Clara Bueno, Fernando J. Calero-Nieto, Eva Mejia-Ramirez, Jose Luis Mosquera, Enrique Blanco, Xiaonan Wang, Cristina Prieto, Lorea Zabaleta, Elisabetta Mereu, Meritxell Rovira, Senda Jiménez-Delgado, Daniel R. Matson, Holger Heyn, Emery H. Bresnick, Berthold Göttgens, Luciano Di Croce, Pablo Menendez, Angel Raya, Alessandra Giorgetti

Source: Stem Cell Reports, Vol 13, Iss 3, Pp 515-529 (2019)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213671119302619; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/3c12a065cf724a05845be10b176cf5d3

The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells

Authors: Virginia C Rodriguez-Cortez, Maria Pilar Navarrete-Meneses, Oscar Molina, Talia Velasco-Hernandez, Jessica Gonzalez, Paola Romecin, Francisco Gutierrez-Aguera, Heleia Roca-Ho, Meritxell Vinyoles, Eric Kowarz, Pedro Marin, Sandra Rodriguez-Perales, Carlos Gomez-Marin, Patricia Perez-Vera, Felipe Cortes-Ledesma, Anna Bigas, Andrea Terron, Clara Bueno, Pablo Menendez

Source: Haematologica, Vol 107, Iss 2 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10441; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/263476971eba4a109551d512d852e371

Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice

Authors: Clara Bueno-Fernandez, Marta Perez-Rando, Julia Alcaide, Simona Coviello, Carmen Sandi, Esther Castillo-Gómez, Juan Nacher

Source: Neurobiology of Stress, Vol 14, Iss , Pp 100322- (2021)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352289521000308; https://doaj.org/toc/2352-2895

Access URL: https://doaj.org/article/3389dd9939ff44d488c1f484d926d9e8