Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage

Authors: Rita Rosado-Ramos, Gonçalo M. Poças, Daniela Marques, Alexandre Foito, David M. Sevillano, Mafalda Lopes-da-Silva, Luís G. Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C. Seabra, César S. Mendes, Tiago Fleming Outeiro, Pedro M. Domingos, Cláudia N. Santos

Source: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6e0052eb0e2b432c9b02cba0d241c7e9

Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity

Authors: Ana F. Raimundo, Sofia Ferreira, Maria I. Farrim, Cláudia N. Santos, Regina Menezes

Source: Frontiers in Microbiology, Vol 11 (2020)

Subject Terms: islet amyloid polypeptide, islet amyloid polypeptide-induced toxicity, oligomerization, protein aggregation, immature islet amyloid polypeptide, yeast model, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2020.02035/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/b714d5a3593246b8b4a3e0eb55a0b888

Polyphenols and Their Metabolites in Renal Diseases: An Overview

Authors: Íris Guerreiro, Cíntia Ferreira-Pêgo, Diogo Carregosa, Cláudia N. Santos, Regina Menezes, Ana S. Fernandes, João G. Costa

Source: Foods, Vol 11, Iss 7, p 1060 (2022)

Subject Terms: polyphenols, metabolites, renal diseases, acute kidney injury, chronic kidney disease, diabetic nephropathy, Chemical technology, TP1-1185

File Description: electronic resource

Relation: https://www.mdpi.com/2304-8158/11/7/1060; https://doaj.org/toc/2304-8158

Access URL: https://doaj.org/article/789b6c1ee7dc44709d52a2dba9266896

Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells

Authors: María-Carmen López de las Hazas, Joana Godinho-Pereira, Alba Macià, A. Filipa Almeida, M. Rita Ventura, Maria-José Motilva, Cláudia N. Santos

Source: Journal of Functional Foods, Vol 46, Iss , Pp 110-117 (2018)

Subject Terms: Bioactivity, Dopaminergic cells, Hydroxytyrosol, Neurodegeneration, Phase-II metabolites, Sulphation, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464618301671; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/061f8853a1c9436492135d3232cb78e1

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis

Authors: Diana Macedo, Carolina Jardim, Inês Figueira, A. Filipa Almeida, Gordon J. McDougall, Derek Stewart, Jose E. Yuste, Francisco A. Tomás-Barberán, Sandra Tenreiro, Tiago F. Outeiro, Cláudia N. Santos

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b63714c237644fb09216d02bf2765b49

(Poly)phenol metabolites from Arbutus unedo leaves protect yeast from oxidative injury by activation of antioxidant and protein clearance pathways

Authors: Carolina Jardim, Diana Macedo, Inês Figueira, Gary Dobson, Gordon J. McDougall, Derek Stewart, Ricardo B. Ferreira, Regina Menezes, Cláudia N. Santos

Source: Journal of Functional Foods, Vol 32, Iss , Pp 333-346 (2017)

Subject Terms: Polyphenols, Bioaccessibility, Oxidative stress, Saccharomyces cerevisiae, Yap1, Redox homoeostasis, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464617301275; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/7129294e6b06489f9bc1bacf4ab3a34f

Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

Authors: Regina Menezes, Alexandre Foito, Carolina Jardim, Inês Costa, Gonçalo Garcia, Rita Rosado-Ramos, Sabine Freitag, Colin James Alexander, Tiago Fleming Outeiro, Derek Stewart, Cláudia N. Santos

Source: Antioxidants, Vol 9, Iss 9, p 789 (2020)

Subject Terms: bioactivity-based assays, cyanidin, metabolomics, Rubus genus, (poly)phenols, yeast-based discovery platform, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/9/9/789; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/17aa39069a8c4061959311dd52e364d4

From the baker to the bedside: yeast models of Parkinson's disease

Authors: Regina Menezes, Sandra Tenreiro, Diana Macedo, Cláudia N. Santos, Tiago Fleming Outeiro

Source: Microbial Cell, Vol 2, Iss 8, Pp 262-279 (2015)

Subject Terms: protein misfolding, neurodegeneration, alpha-synuclein, Parkinson’s disease, synucleinopathies, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://microbialcell.com/researcharticles/from-the-baker-to-the-bedside-yeast-models-of-parkinsons-disease/; https://doaj.org/toc/2311-2638

Access URL: https://doaj.org/article/6ca87e7cd061427892b3e32a09e951dd

Valuing the Endangered Species Antirrhinum lopesianum: Neuroprotective Activities and Strategies for in vitro Plant Propagation

Authors: Andreia Gomes, Sofia Fortalezas, Rui Pimpão, Inês Figueira, João Maroco, Carlos Aguiar, Ricardo B. Ferreira, Célia Miguel, Cláudia N. Santos

Source: Antioxidants, Vol 2, Iss 4, Pp 273-292 (2013)

Subject Terms: Antirrhinum lopesianum, phytochemical profile, antioxidant capacity, neuroprotection, acetylcholinesterase inhibitor, ex situ conservation, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.mdpi.com/2076-3921/2/4/273; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/18b9323955ee48a0a7914167f1d61f9b

Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion

Authors: Francesca Giampieri, Sadia Afrin, Derek Stewart, Gordon J. McDougall, Rex Brennan, Lesley Blyth, Massimiliano Gasparrini, Luca Mazzoni, Franco Capocasa, Josè Miguel Alvarez-Suarez, Stefano Bompadre, Pedro Nogueira Brás de Oliveira, Claudia N. Santos, Manuel Masias, Pablo Agudo, Jorge Crespo, Bruno Mezzetti, Tamara Y. Forbes-Hernández, Maurizio Battino

Source: Molecules, Vol 23, Iss 8, p 1918 (2018)

Subject Terms: berry, polyphenols, in vitro gastrointestinal digestion, bioavailability, cytotoxicity, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/23/8/1918; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/5c0b5d8ace594f7785c40a0f8974db69

Protective Effect of a (Poly)phenol-Rich Extract Derived from Sweet Cherries Culls against Oxidative Cell Damage

Authors: Ana A. Matias, Rita Rosado-Ramos, Sara L. Nunes, Inês Figueira, Ana Teresa Serra, Maria R. Bronze, Claúdia N. Santos, Catarina M. M. Duarte

Source: Molecules, Vol 21, Iss 4, p 406 (2016)

Subject Terms: polyphenols, Saco cherry, oxidative stress, antioxidant, intestinal epithelium, neurodegeneration, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/21/4/406; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/b1630bb425444c1eb4e7ea31f1d7aeb6

Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease.

Authors: Sandra Tenreiro, Madalena M Reimão-Pinto, Pedro Antas, José Rino, Donata Wawrzycka, Diana Macedo, Rita Rosado-Ramos, Triana Amen, Meytal Waiss, Filipa Magalhães, Andreia Gomes, Cláudia N Santos, Daniel Kaganovich, Tiago Fleming Outeiro

Source: PLoS Genetics, Vol 10, Iss 5, p e1004302 (2014)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4014446?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/67a44edc2b0d4e2cab148e6ab173901e