Implementation of a pharmacogenetic panel‐based test for pharmacotherapy‐based supportive care in an adult oncology clinic.

Authors: Cicali, Emily J.^1,2 (AUTHOR), Eddy, Elizabeth¹ (AUTHOR), Gong, Yan^1,2,3 (AUTHOR), Elchynski, Amanda L.^1,2 (AUTHOR), Pena del Aguila, Kim³ (AUTHOR), Basha, Tala¹ (AUTHOR), Daily, Karen C.^3,4 (AUTHOR), Dickson, Lauren¹ (AUTHOR), Fischer, Steven³ (AUTHOR), Hastings‐Monari, Erin³ (AUTHOR), Jones, Dennie^3,4 (AUTHOR), Ramnaraign, Brian H.^3,4 (AUTHOR), DeRemer, David L.^1,2,3 (AUTHOR), George, Thomas J.^3,4 (AUTHOR), Cooper‐DeHoff, Rhonda M.^1,2,5 (AUTHOR) dehoff@cop.ufl.edu

Source: CTS: Clinical & Translational Science. Jul2024, Vol. 17 Issue 7, p1-11. 11p.

Subject Terms: *CLINICAL decision support systems, *CANCER treatment, *CLINICS, *REMANUFACTURING

Company/Entity: UNIVERSITY of Florida

A Guide for Implementing DPYD Genotyping for Systemic Fluoropyrimidines into Clinical Practice.

Authors: Ho, Teresa T., Smith, D. Max, Aquilante, Christina L., Cicali, Emily J., El Rouby, Nihal, Hertz, Daniel L., Imanirad, Iman, Patel, Jai N., Scott, Stuart A., Swain, Sandra M., Tuteja, Sony, Hicks, J. Kevin

Source: Clinical Pharmacology & Therapeutics; May2025, Vol. 117 Issue 5, p1194-1208, 15p

Subject Terms: FLUOROPYRIMIDINES, GENETIC testing, SAFETY, FLUOROURACIL, PATIENT care, DIHYDROPYRIMIDINE dehydrogenase

Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension

Authors: Eadon, Michael T., Cavanaugh, Kerri L., Orlando, Lori A., Christian, David, Chakraborty, Hrishikesh, Steen-Burrell, Kady-Ann, Merrill, Peter, Seo, Janet, Hauser, Diane, Singh, Rajbir, Beasley, Cherry Maynor, Fuloria, Jyotsna, Kitzman, Heather, Parker, Alexander S., Ramos, Michelle, Ong, Henry H., Elwood, Erica N., Lynch, Sheryl E., Clermont, Sabrina, Cicali, Emily J., Starostik, Petr, Pratt, Victoria M., Nguyen, Khoa A., Rosenman, Marc B., Calman, Neil S., Robinson, Mimsie, Nadkarni, Girish N., Madden, Ebony B., Kucher, Natalie, Volpi, Simona, Dexter, Paul R., Skaar, Todd C., Johnson, Julie A., Cooper-DeHoff, Rhonda M., Horowitz, Carol R.

Source: In Contemporary Clinical Trials August 2022 119

Multisite investigation of strategies for the clinical implementation of pre-emptive pharmacogenetic testing

Authors: Duarte, Julio D., Dalton, Rachel, Elchynski, Amanda L., Smith, D. Max, Cicali, Emily J., Lee, James C., Duong, Benjamin Q., Petry, Natasha J., Aquilante, Christina L., Beitelshees, Amber L., Empey, Philip E., Johnson, Julie A., Obeng, Aniwaa Owusu, Pasternak, Amy L., Pratt, Victoria M., Ramsey, Laura B., Tuteja, Sony, Van Driest, Sara L., Wiisanen, Kristin, Hicks, J. Kevin, Cavallari, Larisa H.

Source: In Genetics in Medicine December 2021 23(12):2335-2341

Implementation of CYP2C19 genotyping to guide proton pump inhibitor use at an academic health center.

Authors: Cicali, Emily J^1,2 Emily.Cicali@cop.ufl.edu, Elchynski, Amanda³, Thomas, Cameron D^1,2, Alam, Benish^1,2, Dalton, Rachel⁴, Davis, Rick⁵, Eken, Eda^1,2, Estores, David⁵, Nguyen, Khoa⁴, Cavallari, Larisa H^1,2, Wiisanen, Kristin^1,2

Source: American Journal of Health-System Pharmacy. Aug2023, Vol. 80 Issue 15, p994-1003. 10p. 2 Diagrams, 2 Charts.

Subject Terms: *PHYSICIAN engagement, *PHARMACOGENOMICS, *CYTOCHROME P-450, *ACADEMIC medical centers, *CLINICAL decision support systems, *HUMAN services programs, *PROTON pump inhibitors, *MEDICAL protocols, *GENOTYPES, *AT-risk people

Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene–drug pairs across ambulatory care settings

Authors: Cicali, Emily J., Weitzel, Kristin Wiisanen, Elsey, Amanda R., Orlando, Frank A., Vinson, Michelle, Mosley, Scott, Smith, D. Max, Davis, Richard, Drum, Lori, Estores, David, Franciosi, James P., Hagen, Melanie Gross, Jerkins, Gabriel J., Mercado, Elvira S., Nainaparampil, Jaison, Padron, Adaixa, Rosenberg, Eric I., Wright, Ashleigh, Schmidt, Siegfried O., Mathews, Carol A., Cavallari, Larisa H., Johnson, Julie A.

Source: In Genetics in Medicine October 2019 21(10):2264-2274

4 - Pharmacogenetics

Authors: Cicali, Emily J., Mosley, Scott A., Cavallari, Larisa H.

Source: In Brody's Human Pharmacology Edition: Seventh Edition. 2025:41-48

Use of CYP2D6 Inhibitors with CYP2D6 Opioids: Association with Emergency Department Visits for Pain.

Authors: Nahid, Noor Ahmed, McDonough, Caitrin W., Wei, Yu‐Jung Jenny, Cicali, Emily J., Gong, Yan, Fillingim, Roger B., Johnson, Julie A.

Source: Clinical Pharmacology & Therapeutics; Oct2024, Vol. 116 Issue 4, p1005-1012, 8p

Subject Terms: EMERGENCY room visits, CYTOCHROME P-450, ELECTRONIC health records, CYTOCHROME P-450 CYP2D6, HOSPITAL emergency services, ANTIDEPRESSANTS

Strategies for DPYD testing prior to fluoropyrimidine chemotherapy in the US.

Authors: Tracksdorf, Tabea, Smith, D. Max, Pearse, Skyler, Cicali, Emily J., Aquilante, Christina L., Scott, Stuart A., Ho, Teresa T., Patel, Jai N., Hicks, J. Kevin, Hertz, Daniel L.

Source: Supportive Care in Cancer; Aug2024, Vol. 32 Issue 8, p1-10, 10p

Rationale and design for a pragmatic randomized trial to assess gene‐based prescribing for SSRIs in the treatment of depression.

Authors: Hines, Lindsay J., Wilke, Russell A., Myers, Rachel, Mathews, Carol A., Liu, Michelle, Baye, Jordan F., Petry, Natasha, Cicali, Emily J., Duong, Benjamin Q., Elwood, Erica, Hulvershorn, Leslie, Nguyen, Khoa, Ramos, Michelle, Sadeghpour, Azita, Wu, R. Ryanne, Williamson, Lloyda, Wiisanen, Kristin, Voora, Deepak, Singh, Rajbir, Blake, Kathryn V.

Source: CTS: Clinical & Translational Science; Jun2024, Vol. 17 Issue 6, p1-15, 15p

Subject Terms: ANTIDEPRESSANTS, PHARMACOGENOMICS, DULOXETINE, CLINICAL decision support systems, DRUG side effects, SEROTONIN uptake inhibitors, MENTAL depression, DRUG interactions

Assessing user perspectives on clinical pharmacogenomics consultation documentation: a user-centered evaluation.

Authors: Desai, Nina, Ravindra, Namratha, Hall, Bradley, Al Alshaykh, Hana, Lemke, Lauren, Eken, Eda, Cicali, Emily J., Wiisanen, Kristin, Cavallari, Larisa H., Nguyen, Khoa A.

Source: Frontiers in Pharmacology; 2024, p1-11, 11p

Subject Terms: PHARMACOGENOMICS, MEDICAL personnel, INDIVIDUALIZED medicine, SATISFACTION, DOCUMENTATION

Company/Entity: UNIVERSITY of Florida

Contributors

Authors: Abdel-Rahman, Abdel A., Aleksunes, Lauren M., Bagley, Elena E., Barrett, James E., Bjornsti, Mary-Ann, Block, Jeffrey S., Bohn, Laura M., Bumpus, Namandjé N., Call, Gerald B., Catalano, Glenn, Cavallari, Larisa H., Chapin, Benjamin A., Chunduru, Mythili, Cicali, Emily J., Conte, Michael, Copello, Julio A., Cuevas, Javier, DeKosky, Steven T., Doggett, Joseph Stone, Edwards, Joshua, Ehlert, Frederick J., Elmslie, Keith S., Fehrenbacher, Jill, Ferrante, Jennifer A., Gaffo, Angelo L., Garrison, James Carlton, II, Gilchrist, Annette, Gitman, Marina, Gowdy, Kymberly M., Griffin, LaToya M., Gruener, Robert, Guillory, Ashley N., Habecker, Beth A., Hadley, Robert W., Herrmann, Francis, Hinckley, Jesse D., Hollenberg, Paul F., Hopfer, Christian J., Hoshi, Naoto, Huang, R. Stephanie, Huang, Yingbo, Ingram, Susan L., Jaffee, Michael S., Karamyan, Vardan T., Karash, Angela, Karpa, Kelly D., Kim, Felix J., Klippel, Cory M., Kobeissi, Iyad, Kocis, Paul T., Kopf, Phillip G., Ladin, Daniel A., Lazo, John S., Lim, Miranda M., Mansoor, Steven E., McConnaughey, Mona M., McConnaughey, J. Scott, McCormick, James A., McCune, Dan F., McCurdy, Christopher R., McMahon, Lance R., Middlemas, David S., Mosley, Scott A., Nelson, Margaret, Obeng, Samuel, O'Donnell, James J., III, Ormseth, Michelle J., Ousterhout, Julia, Ozturk Topcu, Turkan, Pasternak, Jeffrey J., Paul, J. West, Philpot, Rex M., Piascik, Michael T., Pierce, Marsha L., Potter, Pamela E., Prozialeck, Walter, Rankin, Gary O., Reddy, D. Samba, Richardson, Jennelle D., Rogawski, Michael A., Rudick, Charles, Sanchez, Deborah L., Sanchez-Ramos, Juan R., Siegfried, Jill Marie, Soliman, Eman, Speth, Robert C., Sullivan, Greg, Tarhini, Ahmad, Taylor, David A., Tiwari, Amit K., Trejo, JoAnn, Tulis, David A., Valentovic, Monica A., Van Dross-Anderson, Rukiyah, Vrana, Kent E., Watts, Stephanie W., Wecker, Amy, Wecker, Lynn, Weinberg, Guy, Welch, Tasha L., Wicklund, Meredith, Wilson, Ryan, Zhang, Jian-Ting

Source: In Brody's Human Pharmacology Edition: Seventh Edition. 2025:v-viii

Clinician Response to Pharmacogenetic Clinical Decision Support Alerts.

Authors: Lemke, Lauren K., Cicali, Emily J., Williams, Roy, Nguyen, Khoa A., Cavallari, Larisa H., Wiisanen, Kristin

Source: Clinical Pharmacology & Therapeutics; Dec2023, Vol. 114 Issue 6, p1350-1357, 8p

Subject Terms: CLINICAL decision support systems, ACADEMIC medical centers, BIOMARKERS

Company/Entity: UNIVERSITY of Florida

Lessons from clinical implementation of a preemptive pharmacogenetic panel as part of a testing pilot program with an employer-sponsored medical plan.

Authors: Norris, Madeline, Dalton, Rachel, Alam, Benish, Eddy, Elizabeth, Nguyen, Khoa A., Cavallari, Larisa H., Sumfest, Jill, Wiisanen, Kristin, Cicali, Emily J.

Source: Frontiers in Genetics; 2023, p1-10, 10p

Subject Terms: PHARMACOGENOMICS, PILOT projects, PATIENTS' attitudes, ELECTRONIC health records, PATIENT education, PATIENT portals

Company/Entity: UNIVERSITY of Florida

Reimbursement of pharmacogenetic tests at a tertiary academic medical center in the United States.

Authors: Lemke, Lauren K., Alam, Benish, Williams, Roy, Starostik, Petr, Cavallari, Larisa H., Cicali, Emily J., Wiisanen, Kristin

Source: Frontiers in Pharmacology; 2023, p1-8, 8p

Subject Terms: ACADEMIC medical centers, REIMBURSEMENT, MEDICAL centers, CONFORMANCE testing

Geographic Terms: UNITED States

A Pharmacogenetics-Based Approach to Managing Gastroesophageal Reflux Disease: Current Perspectives and Future Steps.

Authors: Eken, Eda, Estores, David S, Cicali, Emily J, Wiisanen, Kristin K, Johnson, Julie A

Source: Pharmacogenomics & Personalized Medicine; Jun2023, Vol. 16, p645-664, 20p

Novel Implementation of Genotype‐Guided Proton Pump Inhibitor Medication Therapy in Children: A Pilot, Randomized, Multisite Pragmatic Trial.

Authors: Cicali, Emily J.¹, Blake, Kathryn², Gong, Yan¹, Mougey, Edward B.², Al‐Atrash, Hadeel^3,4, Chambers, Nancy³, Denham, Jolanda^3,4, Evans, Jonathan², George, Donald E.², Gomez, Roberto^3,4, Palomo, Pablo^3,4, Taufiq, Salik², Johnson, Julie A.¹, Lima, John J.², Franciosi, James P.^3,4 james.franciosi@nemours.org

Source: CTS: Clinical & Translational Science. Mar2019, Vol. 12 Issue 2, p172-179. 8p.

Subject Terms: *OMEPRAZOLE, *PROTON pump inhibitors, *DRUG prescribing, *GASTROESOPHAGEAL reflux in children, *SENSITIVITY analysis

How to implement a pharmacogenetics service at your institution.

Authors: Cicali, Emily J., Lemke, Lauren, Al Alshaykh, Hana, Nguyen, Khoa, Cavallari, Larisa H., Wiisanen, Kristin

Source: JACCP: Journal of the American College of Clinical Pharmacy; Nov2022, Vol. 5 Issue 11, p1161-1175, 15p

Subject Terms: PHARMACOGENOMICS, GENETIC testing, ELECTRONIC health records, DRUG therapy, MEDICAL care costs

How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial.

Authors: Cicali, Emily J., Elchynski, Amanda L., Cook, Kelsey J., Houder, John T., Thomas, Cameron D., Smith, D. Max, Elsey, Amanda, Johnson, Julie A., Cavallari, Larisa H., Wiisanen, Kristin

Source: Clinical Pharmacology & Therapeutics; Sep2021, Vol. 110 Issue 3, p677-687, 11p

Subject Terms: CYTOCHROME P-450 CYP2D6, PHARMACOGENOMICS, MEDICAL personnel, PHENOTYPES, INDIVIDUALIZED medicine

Company/Entity: UNIVERSITY of Florida

The Complex Roadmap to Infectious Disease Innovation: The Intersection of Bugs, Drugs, and Special Populations.

Authors: Nicol, Melanie R., Cicali, Emily J., Seo, Shirley K., Rao, Gauri G.

Source: Clinical Pharmacology & Therapeutics; Apr2021, Vol. 109 Issue 4, p793-796, 4p

Subject Terms: COMMUNICABLE diseases, DRUGS, COVID-19, CLINICAL pharmacology, ANTI-infective agents, PANDEMICS