Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia

Authors: Stefano Zucchini, Stefano Tumini, Andrea Enzo Scaramuzza, Riccardo Bonfanti, Maurizio Delvecchio, Roberto Franceschi, Dario Iafusco, Lorenzo Lenzi, Enza Mozzillo, Stefano Passanisi, Claudia Piona, Ivana Rabbone, Novella Rapini, Andrea Rigamonti, Carlo Ripoli, Giuseppina Salzano, Silvia Savastio, Riccardo Schiaffini, Angela Zanfardino, Valentino Cherubini, Diabetes Study Group of the Italian Society for Pediatric Endocrinology Diabetes, Albino Claudia Accursia, Aloe Monica, Anzelotti Maria Teresa, Arnaldi Claudia, Barbetti Fabrizio, Bassi Marta, Berioli Maria Giulia, Bernardini Luca, Bertelli Enrica, Biagioni Martina, Bobbio Adriana, Bombaci Bruno, Bonfanti Riccardo, Bonura Clara, Bracciolini Giulia Patrizia, Bruzzese Mariella, Bruzzi Patrizia, Buono Pietro, Buscarino Piera, Cadario Francesco, Calcaterra Valeria, Calzi Elena, Cappa Marco, Cardani Roberta, Cardella Francesca, Cardinale Giuliana Marcella, Casertano Alberto, Castorani Valeria, Cauvin Vittoria, Cenciarelli Valentina, Ceruti Franco, Cherubini Valentino, Chiarelli Francesco, Chiari Giovanni, Cianfarani Stefano, Cicchetti Mario, Cipriano Paola, Cirillo Dante, Citriniti Felice, Coccioli Maria Susanna, Confetto Santino, Contreas Giovanna, Coro Anna, Correddu Antonella, Corsini Elisa, Crino’ Antonino, d’Annunzio Giuseppe, De Berardinis Fiorella, De Donno Valeria, De Filippo Gianpaolo, De Marco Rosaria, De Sanctis Luisa, Del Duca Elisabetta, Delvecchio Maurizio, Deodati Annalisa, Di Bonito Procolo, Di Candia Francesca, Faleschini Elena, Fattorusso Valentina, Favia Anna, Federico Giovanni, Felappi Barbara, Ferrari Mara, Ferrito Lucia, Fichera Graziella, Fontana Franco, Fornari Elena, Franceschi Roberto, Franco Francesca, Franzese Adriana, Frongia Anna Paola, Frontino Giulio, Gaiero Alberto, Galassi Sabrina Maria, Gallo Francesco, Gargantini Luigi, Giani Elisa, Gortan Anna Jolanda, Graziani Vanna, Grosso Caterina, Gualtieri Antonella, Guasti Monica, Guerraggio Lucia Paola, Guzzetti Chiara, Iafusco Dario, Iannicelli Gennaro, Iezzi Maria Laura, Ignaccolo Maria Giovanna, Innaurato Stefania, Inzaghi Elena, Iovane Brunella, Iughetti Lorenzo, Kaufmann Peter, La Loggia Alfonso, Lambertini Anna Giulia, Lapolla Rosa, Lasagni Anna, Lazzaro Nicola, Lazzeroni Pietro, Lenzi Lorenzo, Lera Riccardo, Levantini Gabriella, Lezzi Marilea, Lia Rosanna, Liguori Alice, Lo Presti Donatella, Lombardo Fortunato, Lonero Antonella, Longhi Silvia, Lorubbio Antonella, Lucchesi Sonia, Maccioni Rosella, Macedoni Maddalena, Macellaro Patrizia Cristiana, Madeo Simona Filomena, Maffeis Claudio, Mainetti Benedetta, Maltoni Giulio, Mameli Chiara, Mammì Francesco, Manca Bitti Maria Luisa, Mancioppi Valentina, Manco Melania, Marigliano Marco, Marino Monica, Marsciani Alberto, Matteoli Maria Cristina, Mazzali Elena, Minute Marta, Minuto Nicola, Monti Sara, Morandi Anita,, Morganti Gianfranco, Morotti Elisa, Mozzillo Enza, Musolino Gianluca, Olivieri Francesca, Ortolani Federica, Pampanini Valentina, Pardi Daniela, Pascarella Filomena, Pasquino Bruno, Passanisi Stefano, Patera Ippolita Patrizia, Pedini Annalisa, Pennati Maria Cristina, Peruzzi Sonia, Peverelli Paola, Pezzino Giulia, Piccini Barbara, Piccinno Elvira Eugenia Rosaria, Piona Claudia, Piredda Gavina, Piscopo Alessia, Pistone Carmelo, Pozzi Erica, Prandi Elena, Predieri Barbara, Prudente Sabrina, Pulcina Anna, Rabbone Ivana, Randazzo Emioli, Rapini Novella, Reinstadler Petra, Riboni Sara, Ricciardi Maria Rossella, Rigamonti Andrea, Ripoli Carlo, Rossi Virginia, Rossi Paolo, Rutigliano Irene, Sabbion Alberto, Salvatoni Alessandro, Salvo Caterina, Salzano Giuseppina, Sanseviero Mariateresa, Savastio Silvia, Savini Rosanna, Scanu Mariapiera, Scaramuzza Andrea Enzo, Schiaffini Riccardo, Schiavone Maurizio, Schieven Eleonardo, Scipione Mirella, Secco Andrea, Silvestri Francesca, Siri Giulia, Sogno Valin Paola, Sordelli Silvia, Spiri Daniele, Stagi Stefano, Stamati Filomena Andreina, Suprani Tosca, Talarico Valentina, Tiberi Valentina, Timpanaro Tiziana Antonia Lucia, Tinti Davide, Tirendi Antonina, Tomaselli Letizia Grazia, Toni Sonia, Torelli Cataldo, Tornese Gianluca, Trada Michela,, Trettene Adolfo Andrea, Tumini Stefano, Tumminelli Marilena, Valerio Giuliana, Vandelli Sara, Ventrici Claudia, Zampolli Maria, Zanatta Manuela, Zanfardino Angela, Zecchino Clara, Zonca Silvia, Zucchini Stefano

Source: Frontiers in Endocrinology, Vol 15 (2024)

Subject Terms: adolescents, automated insulin delivery, children, hypoglycemia, glucagon, oral glucose, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2024.1387537/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/04c5d7ea5bbf4c18b2fce4857d7be15d

System Architecture of TWIN: A New Digital Twin-Based Clinical Decision Support System for Type 1 Diabetes Management in Children

Authors: Cappon, Giacomo, Pellizzari, Elisa, Cossu, Luca, Sparacino, Giovanni, Deodati, Annalisa, Schiaffini, Riccardo, Cianfarani, Stefano, Facchinetti, Andrea

Source: 2023 IEEE 19th International Conference on Body Sensor Networks (BSN) Body Sensor Networks (BSN), 2023 IEEE 19th International Conference on. :1-4 Oct, 2023

Relation: 2023 IEEE 19th International Conference on Body Sensor Networks (BSN)

The Impact of Stress on Health in Childhood and Adolescence in the Era of the COVID-19 Pandemic

Authors: Cianfarani, Stefano, Pampanini, Valentina

Source: Hormone research in pædiatrics. 96(1):83-87

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176048803.0x000001&indx=1&recIds=ETOCvdc_100176048803.0x000001

Postnatal onset of severe growth retardation after in utero exposure to carbamazepine and phenobarbital: a case report

Authors: Liguori Alice, Cianfarani Stefano

Source: Journal of Medical Case Reports, Vol 3, Iss 1, p 7300 (2009)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.jmedicalcasereports.com/content/3/1/7300; https://doaj.org/toc/1752-1947

Access URL: https://doaj.org/article/b4ec8c15ebc648218826e04a8c6d5b59

Uteroplacental insufficiency down regulates insulin receptor and affects expression of key enzymes of long-chain fatty acid (LCFA) metabolism in skeletal muscle at birth

Authors: Puglianiello Antonella, Germani Daniela, Cianfarani Stefano

Source: Cardiovascular Diabetology, Vol 7, Iss 1, p 14 (2008)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.cardiab.com/content/7/1/14; https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/a1c3ca28cf1740d08da64d0914386ec6

Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children

Authors: Amodio, Donato, Pascucci, Giuseppe Rubens, Cotugno, Nicola, Rossetti, Chiara, Manno, Emma Concetta, Pighi, Chiara, Morrocchi, Elena, D'Alessandro, Annamaria, Perrone, Marco Alfonso, Valentini, Alessandra, Franceschini, Alessio, Chinali, Marcello, Deodati, Annalisa, Azzari, Chiara, Rossi, Paolo, Cianfarani, Stefano, Andreani, Marco, Porzio, Ottavia, Palma, Paolo

Source: In Clinical Immunology October 2023 255

Gene expression signature predicts rate of type 1 diabetes progression

Authors: Mathieu, Chantal, Gillard, Pieter, Casteels, Kristina, Overbergh, Lutgart, Dunger, David, Wallace, Chris, Evans, Mark, Thankamony, Ajay, Hendriks, Emile, Bruggraber, Sylvaine, Marcoveccchio, Loredana, Peakman, Mark, Tree, Timothy, Morgan, Noel G., Richardson, Sarah, Todd, John A., Wicker, Linda, Mander, Adrian, Dayan, Colin, Alhadj Ali, Mohammad, Pieber, Thomas, Eizirik, Decio L., Cnop, Myriam, Brunak, Søren, Pociot, Flemming, Johannesen, Jesper, Rossing, Peter, Quigley, Cristina Legido, Mallone, Roberto, Scharfmann, Raphael, Boitard, Christian, Knip, Mikael, Otonkoski, Timo, Veijola, Riitta, Lahesmaa, Riitta, Oresic, Matej, Toppari, Jorma, Danne, Thomas, Ziegler, Anette G., Achenbach, Peter, Rodriguez-Calvo, Teresa, Solimena, Michele, Bonifacio, Ezio E., Speier, Stephan, Holl, Reinhard, Dotta, Francesco, Chiarelli, Francesco, Marchetti, Piero, Bosi, Emanuele, Cianfarani, Stefano, Ciampalini, Paolo, De Beaufort, Carine, Dahl-Jørgensen, Knut, Skrivarhaug, Torild, Joner, Geir, Krogvold, Lars, Jarosz-Chobot, Przemka, Battelino, Tadej, Thorens, Bernard, Gotthardt, Martin, Roep, Bart O., Nikolic, Tanja, Zaldumbide, Arnaud, Lernmark, Ake, Lundgren, Marcus, Costacalde, Guillaume, Strube, Thorsten, Schulte, Anke M., Nitsche, Almut, Vela, Jose, Von Herrath, Matthias, Wesley, Johnna, Napolitano-Rosen, Antonella, Thomas, Melissa, Schloot, Nanette, Goldfine, Allison, Waldron-Lynch, Frank, Kompa, Jill, Vedala, Aruna, Hartmann, Nicole, Nicolas, Gwenaelle, van Rampelbergh, Jean, Bovy, Nicolas, Dutta, Sanjoy, Soderberg, Jeannette, Ahmed, Simi, Martin, Frank, Latres, Esther, Agiostratidou, Gina, Koralova, Anne, Willemsen, Ruben, Smith, Anne, Anand, Binu, Datta, Vipan, Puthi, Vijith, Zac-Varghese, Sagen, Dias, Renuka, Sundaram, Premkumar, Vaidya, Bijay, Patterson, Catherine, Owen, Katharine, Piel, Barbara, Heller, Simon, Randell, Tabitha, Gazis, Tasso, Reismen, Elise Bismuth, Carel, Jean-Claude, Riveline, Jean-Pierre, Gautier, Jean-Francoise, Andreelli, Fabrizion, Travert, Florence, Cosson, Emmanuel, Penfornis, Alfred, Petit, Catherine, Feve, Bruno, Lucidarme, Nadine, Beressi, Jean-Paul, Ajzenman, Catherina, Radu, Alina, Greteau-Hamoumou, Stephanie, Bibal, Cecile, Meissner, Thomas, Heidtmann, Bettina, Toni, Sonia, Rami-Merhar, Birgit, Eeckhout, Bart, Peene, Bernard, Vantongerloo, N., Maes, Toon, Gommers, Leen, Suomi, Tomi, Starskaia, Inna, Kalim, Ubaid Ullah, Rasool, Omid, Jaakkola, Maria K., Grönroos, Toni, Välikangas, Tommi, Brorsson, Caroline, Mazzoni, Gianluca, Overbergh, Lut, Chmura, Piotr, Elo, Laura L.

Source: In eBioMedicine June 2023 92

Sulfonylurea-Insensitive Permanent Neonatal Diabetes Caused by a Severe Gain-of-Function Tyr330His Substitution in Kir6.2

Authors: McClenaghan, Conor, Rapini, Novella, De Rose, Domenico Umberto, Gao, Jian, Roeglin, Jacob, Bizzarri, Carla, Schiaffini, Riccardo, Tiberi, Eloisa, Mucciolo, Mafalda, Deodati, Annalisa, Perri, Alessandro, Vento, Giovanni, Barbetti, Fabrizio, Nichols, Colin G., Cianfarani, Stefano

Source: Hormone research in pædiatrics. 95(3):215-223

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157415841.0x000001&indx=1&recIds=ETOCvdc_100157415841.0x000001

The application of precision medicine in monogenic diabetes

Authors: Barbetti, Fabrizio, Rapini, Novella, Schiaffini, Riccardo, Bizzarri, Carla, Cianfarani, Stefano

Source: Expert review of endocrinology & metabolism. 17(2):111-129

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100146778284.0x000001&indx=1&recIds=ETOCvdc_100146778284.0x000001

Crk Haploinsufficiency Is Associated with Intrauterine Growth Retardation and Severe Postnatal Growth Failure

Authors: Deodati, Annalisa, Inzaghi, Elena, Germani, Daniela, Fausti, Francesca, Cianfarani, Stefano

Source: Hormone research in pædiatrics. 94(11/12):456-466

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144632716.0x000001&indx=1&recIds=ETOCvdc_100144632716.0x000001

Recombinant GH Therapy: Expected Results, Modalities and Monitoring in Children.

Authors: Amodeo, Maria Elisa, Morgante, Cesare, Pampanini, Valentina, Deodati, Annalisa, Cianfarani, Stefano, Guaraldi, Federica, Mazzatenta, Diego

Source: Frontiers of Hormone Research; Nov2024, Vol. 55, p18-28, 11p

Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study

Authors: Sävendahl, Lars ^*, Cooke, Rosie, Tidblad, Anders, Beckers, Dominique, Butler, Gary, Cianfarani, Stefano, Clayton, Peter, Coste, Joël, Hokken-Koelega, Anita C S, Kiess, Wieland, Kuehni, Claudia E, Albertsson-Wikland, Kerstin, Deodati, Annalisa, Ecosse, Emmanuel, Gausche, Ruth, Giacomozzi, Claudio, Konrad, Daniel, Landier, Fabienne, Pfaeffle, Roland, Sommer, Grit, Thomas, Muriel, Tollerfield, Sally, Zandwijken, Gladys R J, Carel, Jean-Claude, Swerdlow, Anthony J

Source: In The Lancet Diabetes & Endocrinology August 2020 8(8):683-692

School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology

Authors: Schiaffini, Riccardo, Barbetti, Fabrizio, Rapini, Novella, Inzaghi, Elena, Deodati, Annalisa, Patera, Ippolita P., Matteoli, Maria C., Ciampalini, Paolo, Carducci, Chiara, Lorubbio, Antonella, Schiaffini, Gabriele, Cianfarani, Stefano

Source: In Diabetes Research and Clinical Practice August 2020 166

Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents: Data from LIFE PERSUADED project

Authors: Tait, Sabrina, Carli, Fabrizia, Busani, Luca, Buzzigoli, Emma, Della Latta, Veronica, Deodati, Annalisa, Fabbrizi, Enrica, Gaggini, Melania, Maranghi, Francesca, Tassinari, Roberta, Toffol, Giacomo, Cianfarani, Stefano, Gastaldelli, Amalia, La Rocca, Cinzia

Source: In Environmental Research June 2020 185

Prevalence of prediabetes and diabetes in children and adolescents with biopsy-proven non-alcoholic fatty liver disease

Authors: Nobili, Valerio, Mantovani, Alessandro, Cianfarani, Stefano, Alisi, Anna, Mosca, Antonella, Sartorelli, Maria Rita, Maffeis, Claudio, Loomba, Rohit, Byrne, Christopher D., Targher, Giovanni

Source: In Journal of Hepatology October 2019 71(4):802-810

The Changing Landscape of Neonatal Diabetes Mellitus in Italy Between 2003 and 2022.

Authors: Rapini, Novella, Delvecchio, Maurizio, Mucciolo, Mafalda, Ruta, Rosario, Rabbone, Ivana, Cherubini, Valentino, Zucchini, Stefano, Cianfarani, Stefano, Prandi, Elena, Schiaffini, Riccardo, Bizzarri, Carla, Piccini, Barbara, Maltoni, Giulio, Predieri, Barbara, Minuto, Nicola, Paola, Rossella Di, Giordano, Mara, Tinto, Nadia, Grasso, Valeria, Russo, Lucia

Source: Journal of Clinical Endocrinology & Metabolism; Sep2024, Vol. 109 Issue 9, p2349-2357, 9p

Subject Terms: PANCREATIC enzymes, MOLECULAR genetics, INSULIN resistance, DIABETES, NUCLEOTIDE sequencing

Time In Tight Range in children and adolescents with type 1 diabetes: A cross‐sectional observational single centre study evaluating efficacy of new advanced technologies.

Authors: Schiaffini, Riccardo, Lumaca, Alessandra, Martino, Mariangela, Rapini, Novella, Deodati, Annalisa, Amodeo, Maria Elisa, Ciampalini, Paolo, Matteoli, Maria Cristina, Pampanini, Valentina, Cianfarani, Stefano

Source: Diabetes/Metabolism Research & Reviews; Jul2024, Vol. 40 Issue 5, p1-8, 8p

Subject Terms: TYPE 1 diabetes, CONTINUOUS glucose monitoring, GLYCEMIC control, TEENAGERS

Oral glucose effectiveness and metabolic risk in obese children and adolescents

Authors: Spreghini, Nicola, Cianfarani, Stefano, Spreghini, Maria Rita, Brufani, Claudia, Morino, Giuseppe Stefano, Inzaghi, Elena, Convertino, Alessio, Fintini, Danilo, Manco, Melania

Source: Acta diabetologica. 56(8):955-962

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125384544.0x000001&indx=1&recIds=ETOCvdc_100125384544.0x000001

GHD Diagnostics in Europe and the US: An Audit of National Guidelines and Practice

Authors: Binder, Gerhard, Reinehr, Thomas, Ibáñez, Lourdes, Thiele, Susanne, Linglart, Agnès, Woelfle, Joachim, Saenger, Paul, Bettendorf, Markus, Zachurzok, Agnieszka, Gohlke, Bettina, Randell, Tabitha, Hauffa, Berthold P., Claahsen van der Grinten, Hedi L., Holterhus, Paul-Martin, Juul, Anders, Pfäffle, Roland, Cianfarani, Stefano

Source: Hormone research in pædiatrics. 92(3):150-156

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097728864.0x000001&indx=1&recIds=ETOCvdc_100097728864.0x000001

The Challenge of Defining and Investigating the Causes of Idiopathic Short Stature and Finding an Effective Therapy

Authors: Inzaghi, Elena, Reiter, Edward, Cianfarani, Stefano

Source: Hormone research in pædiatrics. 92(2):71-83

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096477293.0x000001&indx=1&recIds=ETOCvdc_100096477293.0x000001