Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide

Authors: Davide Schiroli, María J. Gómara, Eleonora Maurizi, Sarah D. Atkinson, Laura Mairs, Kathleen A. Christie, Diego F. Cobice, Cian M. McCrudden, M. Andrew Nesbit, Isabel Haro, Tara Moore

Source: Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 891-906 (2019)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253119302070; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/37a40799393b446e910c2cb79f80cc7c

Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide–PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer

Authors: Peng Lyu, Lilin Ge, Rui Ma, Ran Wei, Cian M. McCrudden, Tianbao Chen, Chris Shaw, Hang Fai Kwok

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Subject Terms: Pelophylax Esculentus, Bowman-Birk Protease Inhibitor (BBI), Skin Secretions, Anti-cancer Ability, Synthetic Replicates, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e47e647ee7894a52aaeccaa734ca8ee8

Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer

Authors: Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Emma M. McErlean, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy

Source: Cancer Nanotechnology, Vol 9, Iss 1, Pp 1-15 (2018)

Subject Terms: Prostate cancer, Nitric oxide, Non-viral gene therapy, Amphipathic peptide, iNOS, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12645-018-0040-x; https://doaj.org/toc/1868-6958; https://doaj.org/toc/1868-6966

Access URL: https://doaj.org/article/9ed2bf465afb41bba08a79b15b46f23a

The prognostic significance of Cdc6 and Cdt1 in breast cancer

Authors: Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, Yuchen Bai, Cian M. McCrudden, Hiu Fung Yuen, Qing Wen, Shu Dong Zhang, Hang Fai Kwok

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/5d67ca260d2d4a3ba651bf96ea3d89ef

Systemic RALA/iNOS Nanoparticles: A Potent Gene Therapy for Metastatic Breast Cancer Coupled as a Biomarker of Treatment

Authors: Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Ahlam A. Ali, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy

Source: Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 249-258 (2017)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S216225311630378X; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/6e5a1d3407dd4a3ab97c5e21c1d9b806

Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterization and RALA complexation

Authors: Grace Cole, Joanne McCaffrey, Ahlam A. Ali, John W. McBride, Cian M. McCrudden, Eva M. Vincente-Perez, Ryan F. Donnelly, Helen O. McCarthy

Source: Human Vaccines & Immunotherapeutics, Vol 13, Iss 1, Pp 50-62 (2017)

Subject Terms: dna vaccine, microneedle, nanoparticle, pva, rala, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X

Access URL: https://doaj.org/article/34001c2764484bf090f282e497651d6e

Correction: TAZ Expression as a Prognostic Indicator in Colorectal Cancer.

Authors: Hiu-Fung Yuen, Cian M McCrudden, Yu-Han Huang, Jill M Tham, Xiaoqian Zhang, Qi Zeng, Shu-Dong Zhang, WanJin Hong

Source: PLoS ONE, Vol 16, Iss 4, p e0250187 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0250187&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/7b8830a33a8548cea5c792e17f46688b

Vasoactivity of rucaparib, a PARP-1 inhibitor, is a complex process that involves myosin light chain kinase, P2 receptors, and PARP itself.

Authors: Cian M McCrudden, Martin G O'Rourke, Kim E Cherry, Hiu-Fung Yuen, Declan O'Rourke, Muhammad Babur, Brian A Telfer, Huw D Thomas, Patrick Keane, Thiagarajan Nambirajan, Chris Hagan, Joe M O'Sullivan, Chris Shaw, Kaye J Williams, Nicola J Curtin, David G Hirst, Tracy Robson

Source: PLoS ONE, Vol 10, Iss 2, p e0118187 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4331495?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/0041870469fb4ed7ba5bba882c646e79

TAZ expression as a prognostic indicator in colorectal cancer.

Authors: Hiu-Fung Yuen, Cian M McCrudden, Yu-Han Huang, Jill M Tham, Xiaoqian Zhang, Qi Zeng, Shu-Dong Zhang, WanJin Hong

Source: PLoS ONE, Vol 8, Iss 1, p e54211 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3553150?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/aeb67df3a4114cafa0a492b343604427