Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL‑1 with Antitumor Activity

Authors: Qineng Gong, Chunpu Li, Haojie Wang, Jinrui Cao, Zuo Li, Mi Zhou, Yan Li, Yong Chu, Hong Liu, Renxiao Wang

Source: ACS Omega, Vol 9, Iss 25, Pp 27369-27396 (2024)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/c0f68792be084e619db15d3e04ae777c

Predictive models of radiographic progression and pain progression in patients with knee osteoarthritis: data from the FNIH OA biomarkers consortium project

Authors: Xiaoyu Li, Chunpu Li, Peng Zhang

Source: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-11 (2024)

Subject Terms: Knee osteoarthritis, Predictive model, Radiographic progression, Pain progression, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/c6b5dea0bbf04bd8b37616c22a2ad8e8

Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors

Authors: Feifei Fang, Yang Dai, Hao Wang, Yinchun Ji, Xuewu Liang, Xia Peng, Jiyuan Li, Yangrong Zhao, Chunpu Li, Danyi Wang, Yazhou Li, Dong Zhang, Dan Zhang, Meiyu Geng, Hong Liu, Jing Ai, Yu Zhou

Source: Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 4918-4933 (2023)

Subject Terms: Potential AXL inhibitor, Antitumor activity, Structure-based drug design, Fused-pyrazolone carboxamide derivatives, Antitumor drug development, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383523003854; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/d516c2f765514631b7bf774badc1f3ce

Causal relationship between gut microbiota and immune thrombocytopenia: a Mendelian randomization study of two samples

Authors: Dongmei Guo, Qian Chen, Guojun Wang, ChunPu Li, FinnGen consortium

Source: Frontiers in Microbiology, Vol 14 (2023)

Subject Terms: immune thrombocytopenia, ITP, gut microbiota, Mendelian randomization study, the causal relationship, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2023.1190866/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/06dcd73883d8433c8d1e08b5977b6a76

A two-step method for paroxysmal atrial fibrillation event detection based on machine learning

Authors: Ya'nan Wang, Sen Liu, Haijun Jia, Xintao Deng, Chunpu Li, Aiguo Wang, Cuiwei Yang

Source: Mathematical Biosciences and Engineering, Vol 19, Iss 10, Pp 9877-9894 (2022)

Subject Terms: atrial fibrillation event detection, machine learning, phased training, two-step method, rr intervals, Biotechnology, TP248.13-248.65, Mathematics, QA1-939

File Description: electronic resource

Relation: https://doaj.org/toc/1551-0018

Access URL: https://doaj.org/article/96ed1e36197b453a947f21a833104442

Peptidomimetic-based antibody surrogate for HER2

Authors: Mengmeng Zheng, Chunpu Li, Mi Zhou, Ru Jia, Fengyu She, Lulu Wei, Feng Cheng, Qi Li, Jianfeng Cai, Yan Wang

Source: Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2645-2654 (2021)

Subject Terms: HER2, Anti-cancer, Peptidomimetics, γ-AApeptides, Antibody-surrogate, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383521001556; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/2f3cfecb2393444c98a962b9b02027c1

Surveillance of Borrelia miyamotoi-carrying ticks and genomic analysis of isolates in Inner Mongolia, China

Authors: Gaowa, Wulantuya, Kozue Sato, Dan Liu, Yunhong Cui, Xuhong Yin, Lihua Zhang, Hong Li, Tingfu Wang, Rongxin Liu, Lijing Wu, Saixia Lu, Ting Gao, Zitong Zhang, Minzhi Cao, Guodong Wang, Chunpu Li, Dacheng Yan, Norio Ohashi, Shuji Ando, Hiroki Kawabata

Source: Parasites & Vectors, Vol 14, Iss 1, Pp 1-8 (2021)

Subject Terms: Ixodes persulcatus, Borrelia miyamotoi, MLSA, Inner Mongolia, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1756-3305

Access URL: https://doaj.org/article/5dc2158d4fba4331b5ec2bdeebf0685d

Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors

Authors: Xiaowei Wu, Mengdi Dai, Rongrong Cui, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai, Mingyue Zheng, Hong Liu

Source: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 781-794 (2021)

Subject Terms: Tyrosine kinase, Covalent FGFR inhibitors, Virtual screening, Pyrazolo[3,4-d]pyridazinone, Structure−activity relationships, Antitumor efficacy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383520307024; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/1ba935fbaca3438c82b23137c0971ab9

Weighted gene co-expression network analysis revealed key biomarkers associated with the diagnosis of hypertrophic cardiomyopathy

Authors: Xin Li, Chenxin Wang, Xiaoqing Zhang, Jiali Liu, Yu Wang, Chunpu Li, Dongmei Guo

Source: Hereditas, Vol 157, Iss 1, Pp 1-11 (2020)

Subject Terms: Hypertrophic cardiomyopathy, WGCNA, Hub gene, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s41065-020-00155-9; https://doaj.org/toc/1601-5223

Access URL: https://doaj.org/article/27ece8721ad54464b3b0fa916fe17f44

Transgelin-2 Involves in the Apoptosis of Colorectal Cancer Cells Induced by Tanshinone-IIA

Authors: Yingru Zhang, Yiyang Zhao, Jingwen Liu, Chunpu Li, Ying Feng, Shasha Jiang, Xiaoting Sun, Xueqing Hu, Yan Wang

Source: Analytical Cellular Pathology, Vol 2022 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2210-7185

Access URL: https://doaj.org/article/9845b9130aa3461e983a2438afd3ad47

Identification of key gene modules and hub genes of human mantle cell lymphoma by coexpression network analysis

Authors: Dongmei Guo, Hongchun Wang, Li Sun, Shuang Liu, Shujing Du, Wenjing Qiao, Weiyan Wang, Gang Hou, Kaigang Zhang, Chunpu Li, Qingliang Teng

Source: PeerJ, Vol 8, p e8843 (2020)

Subject Terms: Mantle cell lymphoma, Coexpression network analysis, Modules, Hub genes, Survival, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/8843.pdf; https://peerj.com/articles/8843/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/385cbd9043f144cd8f9d6e382c2f0795

Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5

Authors: Haozhen Han, Chunpu Li, Man Li, Lisheng Yang, Sen Zhao, Zhifei Wang, Hong Liu, Dongxiang Liu

Source: Molecules, Vol 25, Iss 12, p 2755 (2020)

Subject Terms: sirtuins, inhibitor, structure–activity relationship, deacetylase, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/12/2755; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/84a301c261684fbf8e9f49d675babf44

Sulfoximines-Assisted Rh(III)-Catalyzed C–H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature

Authors: Bao Wang, Xu Han, Jian Li, Chunpu Li, Hong Liu

Source: Molecules, Vol 25, Iss 11, p 2515 (2020)

Subject Terms: sulfoximide, C–H activation, benzothiazine, rhodium, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/11/2515; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/79b2c88c8b66470993f9e159db16970e

A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline

Authors: Chunpu Li, Lei Zhang, Shuangjie Shu, Hong Liu

Source: Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 2441-2447 (2014)

Subject Terms: copper, one pot, synthetic methods, Science, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://doaj.org/toc/1860-5397

Access URL: https://doaj.org/article/a96daa36de6f45c3a7c158b884e9885c

Rh(III)-Catalyzed Annulation of Boc-Protected Benzamides with Diazo Compounds: Approach to Isocoumarins

Authors: Guangyu Dong, Chunpu Li, Hong Liu

Source: Molecules, Vol 24, Iss 5, p 937 (2019)

Subject Terms: rhodium, annulation, Boc-protected benzamides, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/24/5/937; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/545e9df58398458da5055acbda4de037

A Case of Rice Body Synovitis of the Knee Joint

Authors: Haibo, Zhao, Tianrui, Wang, Wenlian, Song, Shenjie, Sun, Chunpu, Li, Xia, Zhao, Tengbo, Yu, Yingze, Zhang

Source: Orthopaedic surgery. 14(3):628-632

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144230604.0x000001&indx=1&recIds=ETOCvdc_100144230604.0x000001

A two-step method for paroxysmal atrial fibrillation event detection based on machine learning.

Authors: Ya’nan Wang, Sen Liu, Haijun Jia, Xintao Deng, Chunpu Li, Aiguo Wang, Cuiwei Yang

Source: Mathematical Biosciences & Engineering; 2022, Vol. 19 Issue 10, p9877-9894, 18p

PTPRC Overexpression Predicts Poor Prognosis and Correlates with Immune Cell Infiltration in Pediatric Acute Myeloid Leukemia.

Authors: Gaili Guo, Banban Li, Qianpeng Li, Chunpu Li, Dongmei Guo

Source: Clinical Laboratory; 2022, Vol. 68 Issue 7, p1384-1393, 10p

Subject Terms: ACUTE myeloid leukemia, TUMOR-infiltrating immune cells, PROGNOSIS, PROTEIN-tyrosine phosphatase, GENETIC overexpression

Discovery of Novel Pyrrolo[2,3-d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors.

Authors: Xuewu Liang, Tang, Shuai, Xuyi Liu, Yingluo Liu, Qifu Xu, Xiaomin Wang, Saidahmatov, Abdusaid, Chunpu Li, Jiang Wang, Yu Zhou, Yingjie Zhang, Meiyu Geng, Min Huang, Hong Liu

Source: Journal of Medicinal Chemistry; 1/27/2022, Vol. 65 Issue 2, p1243-1264, 22p

Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation.

Authors: Xiaoqin Tan, Chunpu Li, Ruirui Yang, Sen Zhao, Fei Li, Xutong Li, Lifan Chen, Xiaozhe Wan, Xiaohong Liu, Tianbiao Yang, Xiaochu Tong, Tingyang Xu, Rongrong Cui, Hualiang Jiang, Sulin Zhang, Hong Liu, Mingyue Zheng

Source: Journal of Medicinal Chemistry; 1/13/2022, Vol. 65 Issue 1, p103-119, 17p