A phase 2 study of decitabine with or without carboplatin and arsenic trioxide in patients with MDS and AML

Authors: Kropf, Patricia L. ^{1, 2, ∗}, Chung, Woonbok ^{3, 4}, Shameem, Raji ⁵, Xiao, Lianchun ⁶, Balch, Curt ⁴, Huang, Xuelin ⁶, Issa, Jean-Pierre J. ^{3, 4}

Source: In Blood Neoplasia December 2024

Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis

Authors: Majewski, Tadeusz, Yao, Hui, Bondaruk, Jolanta, Chung, Woonbok, Lee, Sangkyou, Lee, June Goo, Zhang, Shizhen, Cogdell, David, Yang, Guoliang, Choi, Woonyoung, Dinney, Colin, Grossman, H. Barton, Logothetis, Christopher, Scherer, Steven E., Guo, Charles C., Zhang, Li, Wei, Peng, Weinstein, John N., Issa, Jean-Pierre, Baggerly, Keith, McConkey, David J., Czerniak, Bogdan

Source: In Cell Reports 19 February 2019 26(8):2241-2256

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

Authors: Zhang, Hanghang, Pandey, Somnath, Travers, Meghan, Sun, Hongxing, Morton, George, Madzo, Jozef, Chung, Woonbok, Khowsathit, Jittasak, Perez-Leal, Oscar, Barrero, Carlos A., Merali, Carmen, Okamoto, Yasuyuki, Sato, Takahiro, Pan, Joshua, Garriga, Judit, Bhanu, Natarajan V., Simithy, Johayra, Patel, Bela, Huang, Jian, Raynal, Noël J.-M., Garcia, Benjamin A., Jacobson, Marlene A., Kadoch, Cigall, Merali, Salim, Zhang, Yi, Childers, Wayne, Abou-Gharbia, Magid, Karanicolas, John, Baylin, Stephen B., Zahnow, Cynthia A., Jelinek, Jaroslav, Graña, Xavier, Issa, Jean-Pierre J.

Source: In Cell 15 November 2018 175(5):1244-1258

Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia

Authors: Chung, Woonbok, Kelly, Andrew, Kropf, Patricia, Fung, Henry, Jelinek, Jaroslav, Su, Xiang, Roboz, Gail, Kantarjian, Hagop, Azab, Mohammad, Issa, Jean-Pierre

Source: Clinical epigenetics. 11(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189312552.0x000001&indx=1&recIds=ETOCvdc_100189312552.0x000001

Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study

Authors: Issa, Jean-Pierre J, Roboz, Gail, Rizzieri, David, Jabbour, Elias, Stock, Wendy, O'Connell, Casey, Yee, Karen, Tibes, Raoul, Griffiths, Elizabeth A, Walsh, Katherine, Daver, Naval, Chung, Woonbok, Naim, Sue, Taverna, Pietro, Oganesian, Aram, Hao, Yong, Lowder, James N, Azab, Mohammad, Kantarjian, Hagop

Source: In The Lancet Oncology September 2015 16(9):1099-1110

Colorectal Carcinomas With CpG Island Methylator Phenotype 1 Frequently Contain Mutations in Chromatin Regulators

Authors: Tahara, Tomomitsu, Yamamoto, Eiichiro, Madireddi, Priyanka, Suzuki, Hiromu, Maruyama, Reo, Chung, Woonbok, Garriga, Judith, Jelinek, Jaroslav, Yamano, Hiro-o, Sugai, Tamotsu, Kondo, Yutaka, Toyota, Minoru, Issa, Jean-Pierre J., Estécio, Marcos R.H.

Source: In Gastroenterology February 2014 146(2):530-538

Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas

Authors: Kleb, Brittany, Estécio, Marcos R.H., Zhang, Jiexin, Tzelepi, Vassiliki, Chung, Woonbok, Jelinek, Jaroslav, Navone, Nora M., Tahir, Salahaldin, Marquez, Victor E., Issa, Jean-Pierre, Maity, Sankar, Aparicio, Ana

Source: Epigenetics. 11(3):184-193

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100030747277.0x000001&indx=1&recIds=ETOCvdc_100030747277.0x000001

Sensitive and Specific Detection of Early Gastric Cancer with DNA Methylation Analysis of Gastric Washes

Authors: Watanabe, Yoshiyuki, Kim, Hyun Soo, Castoro, Ryan J., Chung, Woonbok, Estecio, Marcos R.H., Kondo, Kimie, Guo, Yi, Ahmed, Saira S., Toyota, Minoru, Itoh, Fumio, Suk, Ki Tae, Cho, Mee–Yon, Shen, Lanlan, Jelinek, Jaroslav, Issa, Jean–Pierre J.

Source: In Gastroenterology June 2009 136(7):2149-2158

Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse

Authors: Kroeger, Heike ^*, Jelinek, Jaroslav ^*, Estécio, Marcos R.H., He, Rong, Kondo, Kimie, Chung, Woonbok, Zhang, Li, Shen, Lanlan, Kantarjian, Hagop M., Bueso-Ramos, Carlos E., Issa, Jean-Pierre J.

Source: In Blood 15 August 2008 112(4):1366-1373

Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy

Authors: Majewski, Tadeusz, Lee, Sangkyou, Jeong, Joon, Yoon, Dong-Sup, Kram, Andrzej, Kim, Mi-Sook, Tuziak, Tomasz, Bondaruk, Jolanta, Lee, Sooyong, Park, Weon-Seo, Tang, Kuang S, Chung, Woonbok, Shen, Lanlan, Ahmed, Saira S, Johnston, Dennis A, Grossman, H Barton, Dinney, Colin P, Zhou, Jain-Hua, Harris, R Alan, Snyder, Carrie, Filipek, Slawomir, Narod, Steven A, Watson, Patrice, Lynch, Henry T, Gazdar, Adi, Bar-Eli, Menashe, Wu, Xifeng F, McConkey, David J, Baggerly, Keith, Issa, Jean-Pierre, Benedict, William F, Scherer, Steven E, Czerniak, Bogdan

Source: In Laboratory Investigation July 2008 88(7):694-721

Detection of bladder cancer

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Improved Survival for MDS/CMML Patients Treated with the Combination of Decitabine (DAC) and Arsenic Trioxide (ATO) in a Phase II Adaptive Three Arm Randomization Study: DAC Alone Vs. DAC +/- Carboplatin or ATO

Authors: Kropf, Patricia L., Shameem, Raji ^*, Pancari, Philip A., Fung, Henry ^*, Xiao, Lianchun ^*, Huang, Xuelin ^*, Chung, Woonbok ^*, Kantarjian, Hagop M., Issa, Jean-Pierre J. ^*

Source: In Blood 2 December 2016 128(22):3170-3170

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Multivariate Analysis Identifies Significant Correlations Between Baseline Biomarkers, DNA Demethylation and Clinical Responses in 122 Patients Treated in a Phase 1/2, Study of Guadecitabine (SGI-110), in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia (r/r AML)

Authors: Gottipati, Srikanth ^*, Rohatagi, Shashank ^*, Chung, Woonbok ^*, Taverna, Pietro ^*, Kantarjian, Hagop M., Roboz, Gail J., Kropf, Patricia L., Azab, Mohammad, Issa, Jean-Pierre

Source: In Blood 3 December 2015 126(23):2594-2594

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