Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2.

Authors: Ghosh, Rajeshwary, Fatahian, Amir Nima, Rouzbehani, Omid M T, Hathaway, Marissa A, Mosleh, Tariq, Vinod, Vishaka, Vowles, Sidney, Stephens, Sophie L, Chung, Siu-Lai Desmond, Cao, Isaac D, Jonnavithula, Anila, Symons, J David, Boudina, Sihem

Source: Cardiovascular Research; Apr2024, Vol. 120 Issue 5, p531-547, 17p

Subject Terms: NUCLEAR factor E2 related factor, HYPOXIA-inducible factors, HEART diseases

Abstract 15056: Cardiac P62/sqstm1 Deficiency Exacerbates Hypoxic Stress viaImpaired Hypoxia Inducible Factor 1α Signaling

Authors: Ghosh, Rajeshwary, Fatahian, Nima, Hathaway, Marissa, Stephens, Sophie, Chung, Siu-Lai Desmond, Cao, Isaac D, Symons, John D, Boudina, Sihem

Source: Circulation (Ovid); November 2022, Vol. 146 Issue: Supplement 1 pA15056-A15056, 1p