Kilogram-Scale Synthesis of 2′-C-Methyl-arabino-Uridine from Uridine via Dynamic Selective Dipivaloylation

Authors: Chung, John Y. L., Kassim, Amude M., Simmons, Bryon, Davis, Tyler A., Song, Zhiguo J., Limanto, John, Dalby, Stephen M., He, Cyndi Q., Calabria, Ralph, Wright, Timothy J.

Source: Organic process research & development. 26(3):698-709

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Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methodsElectronic supplementary information (ESI) available: Experimental procedures and spectroscopy data for new compounds. See DOI: 10.1039/d1sc01978c

Authors: Klapars, Artis, Chung, John Y. L., Limanto, John, Calabria, Ralph, Campeau, Louis-Charles, Campos, Kevin R., Chen, Wenyong, Dalby, Stephen M., Davis, Tyler A., DiRocco, Daniel A., Hyde, Alan M., Kassim, Amude M., Larsen, Mona Utne, Liu, Guiquan, Maligres, Peter E., Moment, Aaron, Peng, Feng, Ruck, Rebecca T., Shevlin, Michael, Simmons, Bryon L., Song, Zhiguo Jake, Tan, Lushi, Wright, Timothy J., Zultanski, Susan L.

Source: Chemical science. 12(26):9031-9036

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Development of a Commercial Manufacturing Route to 2-Fluoroadenine, The Key Unnatural Nucleobase of Islatravir

Authors: Hong, Cynthia M., Xu, Yingju, Chung, John Y. L., Schultz, Danielle M., Weisel, Mark, Varsolona, Richard J., Zhong, Yong-Li, Purohit, Akasha K., He, Cyndi Q., Gauthier, Donald R.

Source: Organic process research & development. 25(3):395-404

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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation—Cyclization Sequence to the Diaminopyrimidine Core

Authors: Basu, Kallol, Lehnherr, Dan, Martin, Gary E., Desmond, Richard A., Lam, Yu-hong, Peng, Feng, Chung, John Y. L., Arvary, Rebecca A., Zompa, Michael A., Zhang, Si-Wei

Source: Organic process research & development. 24(11):2462-2477

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Evolution of a Manufacturing Route to Omarigliptin, A Long-Acting DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

Authors: Chung, John Y. L., Scott, Jeremy P., Anderson, Camille, Bishop, Brian, Bremeyer, Nadine, Cao, Yang, Chen, Qinghao, Dunn, Robert, Kassim, Amude, Lieberman, David

Source: Organic process research & development. 19(11):1760-1768

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Synthesis of ((3R, 6R)-6-Methylpiperidin-3-yI)methanol via Biocatalytic Transamination and Crystallization-Induced Dynamic Resolution

Authors: Chung, John Y. L., Marcune, Benjamin, Strotman, Hallena R., Petrova, Rositza I., Moore, Jeffrey C., Dormer, Peter G.

Source: Organic process research & development. 19(10):1418-1423

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Crystalline polymorphic forms of an antidiabetic compound

Synthesis of a Naphthyridone p38 MAP Kinase Inhibitor.

Authors: Chung, John Y. L., Cvetovich, Raymond J., McLaughlin, Mark

Source: Journal of Organic Chemistry; October 27 2006, Vol. 71 Issue 22, p8602-8609, 8p

Efficient Synthesis of a Trisubstituted 1,6-Naphthyridone from Acetonedicarboxylate and Regioselective Suzuki Arylation.

Authors: Chung, John Y. L., Cai, Chaoxian, McWilliams, J. Christopher

Source: Journal of Organic Chemistry; December 9 2005, Vol. 70 Issue 25, p10342-10347, 6p

An Efficient Synthesis of a Dual PPAR α/γ Agonist and the Formation of a Sterically Congested α-Aryloxyisobutyric Acid via a Bargellini Reaction.

Authors: Cvetovich, Raymond J., Chung, John Y. L., Kress, Michael H.

Source: Journal of Organic Chemistry; October 14 2005, Vol. 70 Issue 21, p8560-8563, 4p

Enantioselective Nitrile Anion Cyclization to Substituted Pyrrolidines. A Highly Efficient Synthesis of (3S,4R)-N-tert-Butyl-4-Arylpyrrolidine-3-Carboxylic Acid.

Authors: Chung, John Y. L., Cvetovich, Raymond, Amato, Joseph

Source: Journal of Organic Chemistry; April 29 2005, Vol. 70 Issue 9, p3592-3601, 10p

Synthesis of 1-tert-Butyl-4-chloropiperidine: Generation of an N-tert-Butyl Group by the Reaction of a Dimethyliminium Salt with Methylmagnesium Chloride.

Authors: Amato, Joseph S., Chung, John Y. L., Cvetovich, Raymond J.

Source: Journal of Organic Chemistry; March 4 2005, Vol. 70 Issue 5, p1930-1933, 4p

Synthesis of 3-Aminopyrazinone Mediated by 2-Pyridylthioimidate-ZnCl2 Complexes. Development of an Efficient Route to a Thrombin Inhibitor.

Authors: Chung, John Y. L., Cvetovich, Raymond J., Tsay, Fuh-Rong

Source: Journal of Organic Chemistry; November 14 2003, Vol. 68 Issue 23, p8838-8846, 9p

N-(R)-(2-hydroxy-2-pyridine-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide

Process for N-Boc-N-(R)-2(3-pyridyl)-2-hydroxy-ethyl)-N-2(4-aminophenyl)ethyl amine and 2-(4-aminophenyl)-N-2-(2(R)-hydroxy-2-phyridin-S-yl-ethyl)acetamide

Pyridyl ethylation of lactam derivatives

Pyridyl ethylation of lactams

Peptide analog type-B CCK receptor ligands

Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene biosynthesis

Process for preparing fibrinogen receptor antagonists