To Treat or Not to Treat? Resolving the Question of Subretinal and Intraretinal Fluid in Age-Related Macular Degeneration: A Narrative Review

Authors: Alexander J. E. Foss, David Almeida, Chui Ming Gemmy Cheung, Yuichiro Ogura, Eduard de Cock, Theo Empeslidis

Source: Ophthalmology and Therapy, Vol 14, Iss 3, Pp 489-514 (2025)

Subject Terms: Anti-vascular endothelial growth factor (anti-VEGF), Intraretinal fluid (IRF), Neovascular age-related macular degeneration (nAMD), Macular atrophy, Prognosis, Sub-retinal fluid (SRF), Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8245; https://doaj.org/toc/2193-6528

Access URL: https://doaj.org/article/ac710ef514994e879a97498a9ae1995e

An atypical case of retinal pigment epithelium tear with remodeling and visual preservation

Authors: Charles Jit Teng Ong, Chui Ming Gemmy Cheung

Source: Taiwan Journal of Ophthalmology, Vol 14, Iss 4, Pp 614-618 (2024)

Subject Terms: polypoidal choroidal vasculopathy, age-related macular degeneration, retinal pigment epithelium, retinal pigment epithelium tear, tissue remodeling, multimodal imaging, Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/tjo.TJO-D-24-00051; https://doaj.org/toc/2211-5056; https://doaj.org/toc/2211-5072

Access URL: https://doaj.org/article/c62172e7d48842c18ebb2db5b94dd8f2

Global Insights from Patients, Providers, and Staff on Challenges and Solutions in Managing Neovascular Age-Related Macular Degeneration

Authors: Anat Loewenstein, Michelle Sylvanowicz, Winfried M. Amoaku, Tariq Aslam, Chui Ming Gemmy Cheung, Bora Eldem, Robert P. Finger, Richard P. Gale, Laurent Kodjikian, Adrian Koh, Jean-François Korobelnik, Xiaofeng Lin, Paul Mitchell, Moira Murphy, Mali Okada, Ian Pearce, Francisco J. Rodriguez, Jude Stern, S. James Talks, David T. Wong, Tien Yin Wong, Focke Ziemssen, Jane Barratt

Source: Ophthalmology and Therapy, Vol 14, Iss 1, Pp 211-228 (2024)

Subject Terms: nAMD, Neovascular age-related macular degeneration, Patient experience, Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8245; https://doaj.org/toc/2193-6528

Access URL: https://doaj.org/article/21c6b95a1b7944e986dd7a4a1f8ebcf6

To see with new eyes

Authors: Chui Ming Gemmy Cheung

Source: Taiwan Journal of Ophthalmology, Vol 14, Iss 4, Pp 461-463 (2024)

Subject Terms: Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/tjo.TJO-D-24-00123; https://doaj.org/toc/2211-5056; https://doaj.org/toc/2211-5072

Access URL: https://doaj.org/article/ef15f2903b7f4c10b158a220b743b5ff

Lipid-lowering drug and complement factor H genotyping–personalized treatment strategy for age-related macular degeneration

Authors: Can Can Xue, Kelvin Y.C. Teo, Yih Chung Tham, Hengtong Li, Sahil Thakur, Charumathi Sabanayagam, Qiao Fan, David L. Silver, Xiaomeng Wang, Chui Ming Gemmy Cheung, Tien Yin Wong, Usha Chakravarthy, Ching-Yu Cheng, Simon Nusinovici

Source: iScience, Vol 27, Iss 12, Pp 111344- (2024)

Subject Terms: Health sciences, Medicine, Medical specialty, Internal medicine, Cardiovascular medicine, Pharmacology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224025690; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/3f5c7cd9c7da45329967c157dbb7e1c0

Unexpected retinal fluid compartment responses with anti-VEGF therapy in polypoidal choroidal vasculopathy: a case report of four patients

Authors: Noa Gilead, Yu Jeat Chong, Farah N. I. Ibrahim, Christopher Sun, Kelvin Y. C. Teo, Chui Ming Gemmy Cheung

Source: Frontiers in Ophthalmology, Vol 4 (2024)

Subject Terms: polypoidal choroidal vasculopathy (PCV), subretinal fluid (SRF), pigment epithelial detachment (PED), unexpected response, retinal fluid compartments, case report, Medicine

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fopht.2024.1509065/full; https://doaj.org/toc/2674-0826

Access URL: https://doaj.org/article/d03acb3640544999a1252ea858ba252d

Artificial Intelligence-Based Disease Activity Monitoring to Personalized Neovascular Age-Related Macular Degeneration Treatment: A Feasibility Study

Authors: Zufar Mulyukov, PhD, Pearse A. Keane, FRCOphth, MD, Jayashree Sahni, FRCOphth, MD, Sandra Liakopoulos, MD, Katja Hatz, MD, Daniel Shu Wei Ting, MD, PhD, Roberto Gallego-Pinazo, MD, PhD, Tariq Aslam, PhD, DM(Oxon), Chui Ming Gemmy Cheung, FRCOphth, MD, Gabriella De Salvo, FRCOphth, MD, Oudy Semoun, MD, Gábor Márk Somfai, MD, PhD, Andreas Stahl, MD, Brandon J. Lujan, MD, Daniel Lorand, MSc

Source: Ophthalmology Science, Vol 4, Iss 6, Pp 100565- (2024)

Subject Terms: Artificial intelligence, Deep learning, Disease activity, Neovascular age-related macular degeneration, Optical coherence tomography, Ophthalmology, RE1-994

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666914524001015; https://doaj.org/toc/2666-9145

Access URL: https://doaj.org/article/891f7ebdf3bb49d0aba61b814b5cfd04

Defining the structure–function relationship of specific lesions in early and advanced age-related macular degeneration

Authors: Ting Fang Tan, Chun Lin Yap, Claire L. Peterson, Damon Wong, Tien Yin Wong, Chui Ming Gemmy Cheung, Leopold Schmetterer, Anna Cheng Sim Tan

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Age related macular degeneration, Imaging, Microperimetry, Multimodal, Visual function, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e7213f2e08c548a59c05b564b7ab0254

Six-Year Outcomes in Subjects with Polypoidal Choroidal Vasculopathy in the EVEREST II Study

Authors: Kelvin Yi Chong Teo, Kyu-Hyung Park, Nor Fariza Ngah, Shih-Jen Chen, Paisan Ruamviboonsuk, Ryusaburo Mori, Nagako Kondo, Won Ki Lee, Rajesh Rajagopalan, Ryo Obata, Ian Y. H. Wong, Caroline Chee, Hiroko Terasaki, Tetsuju Sekiryu, Shih-Chou Chen, Yasuo Yanagi, Shigeru Honda, Timothy Y. Y. Lai, Chui Ming Gemmy Cheung

Source: Ophthalmology and Therapy, Vol 13, Iss 4, Pp 935-954 (2024)

Subject Terms: Polypoidal choroidal vasculopathy, Long-term outcomes, EVEREST II, Anti-vascular endothelial growth factor (VEGF) therapies, BCVA, Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8245; https://doaj.org/toc/2193-6528

Access URL: https://doaj.org/article/7c0da20fff674871a1afe773e1ed28b1

Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes

Authors: Qiao Fan, Hengtong Li, Xiaomeng Wang, Yih-Chung Tham, Kelvin Yi Chong Teo, Masayuki Yasuda, Weng Khong Lim, Yuet Ping Kwan, Jing Xian Teo, Ching-Jou Chen, Li Jia Chen, Jeeyun Ahn, Sonia Davila, Masahiro Miyake, Patrick Tan, Kyu Hyung Park, Chi Pui Pang, Chiea Chuan Khor, Tien Yin Wong, Yasuo Yanagi, Chui Ming Gemmy Cheung, Ching-Yu Cheng

Source: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/24537311521441e4bb486f0f1797ecbd

Potential for Treatment Interval Extension in Eyes with nAMD Disease Activity Post Loading Phase in HAWK and HARRIER

Authors: Ramin Tadayoni, Glenn J. Jaffe, Frank G. Holz, Ursula Schmidt-Erfurth, Kanji Takahashi, Chui Ming Gemmy Cheung, Seenu M. Hariprasad, Kinfemichael Gedif, Rasmus Olsen, Catherine Best, Franklin Igwe, Peter K. Kaiser

Source: Ophthalmology and Therapy, Vol 12, Iss 4, Pp 2209-2216 (2023)

Subject Terms: Anti-VEGF therapy, Brolucizumab, Disease activity, Interval extension, Neovascular age-related macular degeneration, Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8245; https://doaj.org/toc/2193-6528

Access URL: https://doaj.org/article/7fdc7736c96b45888e4698c7d337b076

Initial experiences of switching to faricimab for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in an Asian population

Authors: Farah N. I. Ibrahim, Kelvin Y. C. Teo, Tien-En Tan, Hiok Hong Chan, Priya R. Chandrasekaran, Shu-Yen Lee, Anna C. S. Tan, Ranjana Mathur, Choi Mun Chan, Shaun S. Sim, Gavin Siew Wei Tan, Ian Y. S. Yeo, Chui Ming Gemmy Cheung

Source: Frontiers in Ophthalmology, Vol 3 (2024)

Subject Terms: ANG-2, anti-vegf, faricimab, neovascular age-related macular degeneration, polypoidal choroidal vasculopathy, switch therapy, Medicine

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fopht.2023.1346322/full; https://doaj.org/toc/2674-0826

Access URL: https://doaj.org/article/57f2acf667dc4a1a9b5ee5d36078a8a6

Relationship Between Retinal Layer Thickness and Genetic Susceptibility to Age-Related Macular Degeneration in Asian Populations

Authors: Kai Xiong Cheong, FRCOphth, Hengtong Li, MSc, Yih Chung Tham, PhD, Kelvin Yi Chong Teo, PhD, Anna Cheng Sim Tan, FRCSEd (Ophth), Leopold Schmetterer, PhD, Tien Yin Wong, PhD, Chui Ming Gemmy Cheung, FRCOphth, Ching-Yu Cheng, PhD, Qiao Fan, PhD

Source: Ophthalmology Science, Vol 3, Iss 4, Pp 100396- (2023)

Subject Terms: Age-related macular degeneration, Single nucleotide polymorphism, Polygenic risk score, Retinal thickness, Genetic loci, Ophthalmology, RE1-994

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666914523001288; https://doaj.org/toc/2666-9145

Access URL: https://doaj.org/article/986b7e2a6eb845ffa0942321da4bddac

Joint Multimodal Deep Learning-based Automatic Segmentation of Indocyanine Green Angiography and OCT Images for Assessment of Polypoidal Choroidal Vasculopathy Biomarkers

Authors: Jessica Loo, PhD, Kelvin Y.C. Teo, MD, Chinmayi H. Vyas, MD, Janice Marie N. Jordan-Yu, MD, Amalia B. Juhari, MD, Glenn J. Jaffe, MD, Chui Ming Gemmy Cheung, MD, Sina Farsiu, PhD

Source: Ophthalmology Science, Vol 3, Iss 3, Pp 100292- (2023)

Subject Terms: deep learning, multimodal image analysis, indocyanine green angiography, polypoidal choroidal vasculopathy, OCT, Ophthalmology, RE1-994

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666914523000246; https://doaj.org/toc/2666-9145

Access URL: https://doaj.org/article/73c74e1183d54a2e888e653a9cb16fc5

Different impact of early and late stages irreversible eye diseases on vision-specific quality of life domains

Authors: Preeti Gupta, Eva K. Fenwick, Ryan E. K. Man, Alfred T. L. Gan, Charumathi Sabanayagam, Debra Quek, Chaoxu Qian, Chui Ming Gemmy Cheung, Ching-Yu Cheng, Ecosse L. Lamoureux

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b37184cd662c42d9b84f2ed83932ccc6

Three-dimensional modelling of the choroidal angioarchitecture in a multi-ethnic Asian population

Authors: Kai Xiong Cheong, Kelvin Yi Chong Teo, Yih Chung Tham, Ralene Sim, Shivani Majithia, Jia Min Lee, Anna Cheng Sim Tan, Ching-Yu Cheng, Chui Ming Gemmy Cheung, Rupesh Agrawal

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b9951e44eafa4742a4e201d13f815035

Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

Authors: Kan Xing Wu, Natalie Jia Ying Yeo, Chun Yi Ng, Florence Wen Jing Chioh, Qiao Fan, Xianfeng Tian, Binxia Yang, Gunaseelan Narayanan, Hui Min Tay, Han Wei Hou, N. Ray Dunn, Xinyi Su, Chui Ming Gemmy Cheung, Christine Cheung

Source: BMC Biology, Vol 20, Iss 1, Pp 1-21 (2022)

Subject Terms: Endothelial dysfunction, Glycocalyx, Hyaluronidase-1, Polypoidal choroidal vasculopathy, Age-related macular degeneration, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/968f1f9c847d47cb800b55d9f3647416

Novel volumetric imaging biomarkers for assessing disease activity in eyes with PCV

Authors: Chinmayi Himanshuroy Vyas, Chui Ming Gemmy Cheung, Janice Marie N. Jordan-Yu, Hitoshi Shimizu, Anna Cheng Sim Tan, Shaun Sebastian Sim, Beau James Fenner, Masahiro Akiba, Usha Chakravarthy, Kelvin Yi Chong Teo

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/375237922f71487590828a1f8675fc86

Correlation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography

Authors: Chui Ming Gemmy Cheung, Kelvin Yi Chong Teo, Sai Bo Bo Tun, Joanna Marie Busoy, Veluchamy A. Barathi, Richard F. Spaide

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9c1c95a68cb24dafb2dd2eecd3e0f9ee

Macular neovascularization in eyes with pachydrusen

Authors: Kelvin Yi Chong Teo, Kai Xiong Cheong, Ricardo Ong, Haslina Hamzah, Yasuo Yanagi, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/35370a34ca6743838b3eb099ba40e8d2