Multiple Complexes of Long Aliphatic N-Acyltransferases Lead to Synthesis of 2,6-Diacylated/2-Acyl-Substituted Glycopeptide Antibiotics, Effectively Killing Vancomycin-Resistant Enterococcus.

Authors: Syue-Yi Lyu^1,2, Yu-Chen Liu¹, Chin-Yuan Chang¹, Chuen-Jiuan Huang³, Ya-Huang Chiu⁴, Chun-Man Huang^1,2, Ning-Shian Hsu¹, Kuan-Hung Lin¹, Chang-Jer Wu⁴, Ming-Daw Tsai³, Tsung-Lin Li^1,3, tlli@gate.sinica.edu.tw

Source: Journal of the American Chemical Society; 8/6/2014, Vol. 136 Issue 31, p10989-10995, 7p, 5 Diagrams, 1 Chart, 1 Graph

Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.

Authors: Yu-Chen Liu, Yi-Shan Li, Syue-Yi Lyu, Li-Jen Hsu, Yu-Hou Chen, Yu-Ting Huang, Hsiu-Chien Chan, Chuen-Jiuan Huang, Gan-Hong Chen, Chia-Cheng Chou, Ming-Daw Tsai, Tsung-Lin Li

Source: Nature Chemical Biology; May2011, Vol. 7 Issue 5, p304-309, 6p, 3 Diagrams, 1 Chart, 1 Graph

Subject Terms: FLAVINS, OXIDASES, VANCOMYCIN, GLYCOPEPTIDES, PROTEIN conformation, REACTION mechanisms (Chemistry)