Establishing a cryopreserved biobank of living tumor tissues for drug sensitivity testing

Authors: Ping Chen, Jing-Bo Zhou, Xiang-Peng Chu, Yang-Yang Feng, Qi-Bing Zeng, Josh-Haipeng Lei, Ka-Pou Wong, Tai-Ip Chan, Chon-Wa Lam, Wen-Li Zhu, Wai-Kuok Chu, Feng Hu, Guang-Hui Luo, Kin-Iong Chan, Chu-Xia Deng

Source: Bioactive Materials, Vol 46, Iss , Pp 582-596 (2025)

Subject Terms: Biobank, Living tumor tissues, Patient-derived organoids (PDOs), Air-liquid interface (ALI) culture, Personalized therapy, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452199X24003955; https://doaj.org/toc/2452-199X

Access URL: https://doaj.org/article/ed6acc69243c4c45a333c99571e195b4

Oncogenic activation of SMYD3-SHCBP1 promotes breast cancer development and is coupled with resistance to immune therapy

Authors: Lihua Mo, Min Deng, Ragini Adhav, Yuni Chan, Josh Haipeng Lei, Sek Man Su, Xin Zhang, Tingting An, Jianlin Liu, Jianjie Li, Xiaodong Shu, Jun Xu, Yuqing Wang, Lin Chen, Yan-Gao Man, Ning-Yi Shao, Tingxiu Xiang, Chu-Xia Deng, Xiaoling Xu

Source: Cell Death and Disease, Vol 16, Iss 1, Pp 1-18 (2025)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/619b824f2aa04244816f35fa3753ff99

Lymphatic system is the mainstream for breast cancer dissemination and metastasis revealed by single-cell lineage tracing

Authors: Kai Miao, Aiping Zhang, Xiaodan Yang, Yipeng Zhang, Anqi Lin, Lijian Wang, Xin Zhang, Heng Sun, Jun Xu, Jingyao Zhang, Yuzhao Feng, Fangyuan Shao, Sen Guo, Zhihui Weng, Peng Luo, Dong Wang, Shuai Gao, Xiao-Yang Zhao, Xiaoling Xu, Chu-Xia Deng

Source: Molecular Cancer, Vol 24, Iss 1, Pp 1-10 (2025)

Subject Terms: Barcode system, Lymphatic metastasis, Lineage tracing, Tumor microenvironment, Soil-seed interaction, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/d18770ecb0694eb2ba25850feeb1794d

YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity

Authors: Haiyan Zhang, Xiaojing Luo, Wei Yang, Zhiying Wu, Zhicong Zhao, Xin Pei, Xue Zhang, Chonghao Chen, Josh Haipeng Lei, Qingxia Shi, Qi Zhao, Yanxing Chen, Wenwei Wu, Zhaolei Zeng, Huai-Qiang Ju, Miaozhen Qiu, Jun Liu, Bin Shen, Minshan Chen, Jianjun Chen, Chu-Xia Deng, Rui-Hua Xu, Jiajie Hou

Source: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/36a9495c82934abdac94acffc6f6a1c2

Carbon Dots Crosslinked Egg White Hydrogel for Tissue Engineering

Authors: Jun Wu, Josh Haipeng Lei, Moxin Li, Aiping Zhang, Yuan Li, Xiao Liang, Senio Campos deSouza, Zhen Yuan, Chunming Wang, Guokai Chen, Tzu‐Ming Liu, Chu‐Xia Deng, Zikang Tang, Songnan Qu

Source: Advanced Science, Vol 11, Iss 43, Pp n/a-n/a (2024)

Subject Terms: carbon dots, egg white, hair follicle regeneration, protein hydrogels, wound healing, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/cd9f3de012a64c99b06230c005d5922f

Drug screening on digital microfluidics for cancer precision medicine

Authors: Jiao Zhai, Yingying Liu, Weiqing Ji, Xinru Huang, Ping Wang, Yunyi Li, Haoran Li, Ada Hang-Heng Wong, Xiong Zhou, Ping Chen, Lianhong Wang, Ning Yang, Chi Chen, Haitian Chen, Pui-In Mak, Chu-Xia Deng, Rui Martins, Mengsu Yang, Tsung-Yi Ho, Shuhong Yi, Hailong Yao, Yanwei Jia

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0b96413517f94cd3a5bdbc4526edd9e0

Revealing the secret behind Epstein‐Barr virus‐specific tumor immune contexture

Authors: Chu‐Xia Deng

Source: Cancer Communications, Vol 44, Iss 4, Pp 491-494 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2523-3548

Access URL: https://doaj.org/article/b5350ad7e307419fb33de22859937cd5

The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations

Authors: Yangyang Feng, Ming Zhao, Lijian Wang, Ling Li, Josh Haipeng Lei, Jingbo Zhou, Jinghong Chen, Yumeng Wu, Kai Miao, Chu-Xia Deng

Source: Cell Death and Disease, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/883014c8faa04270b24b06a635cda57f

Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA

Authors: Ye Yi, Guihui Qin, Hongmei Yang, Hao Jia, Qibing Zeng, Dejin Zheng, Sen Ye, Zhiming Zhang, Tzu‐Ming Liu, Kathy Qian Luo, Chu‐Xia Deng, Ren‐He Xu

Source: Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)

Subject Terms: cGAS‐STING‐IFNβ‐HLA pathway, circulating tumor cells, mesenchymal stromal cells, natural killer cells, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/81bec5b643984496a2f427eec237ce8c

Standard: Human intestinal organoids

Authors: Yalong Wang, Hanqing Lin, Lianzheng Zhao, Fan Hong, Jie Hao, Zhen Zhang, Weiqi Sheng, Linhong Song, Chu-Xia Deng, Bing Zhao, Jiani Cao, Lei Wang, Liu Wang, Lingmin Liang, Wenli Kelly Chen, Chunping Yu, Zhijian Sun, Yingying Yang, Changlin Wang, Yong Zhang, Qiyuan Li, Ka Li, Aijin Ma, Tongbiao Zhao, Guoqiang Hua, Ye-Guang Chen

Source: Cell Regeneration, Vol 12, Iss 1, Pp 1-5 (2023)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2045-9769

Access URL: https://doaj.org/article/99a3ab1fa2af47958a73f133d678bdec

Standard: Human intestinal cancer organoids

Authors: Hanqing Lin, Yalong Wang, Chunyan Cheng, Yuxin Qian, Jie Hao, Zhen Zhang, Weiqi Sheng, Linhong Song, Chu-Xia Deng, Bing Zhao, Jiani Cao, Lei Wang, Liu Wang, Lingmin Liang, Wenli Kelly Chen, Chunping Yu, Zhijian Sun, Yingying Yang, Changlin Wang, Yong Zhang, Qiyuan Li, Ka Li, Aijin Ma, Tongbiao Zhao, Ye-Guang Chen, Guoqiang Hua

Source: Cell Regeneration, Vol 12, Iss 1, Pp 1-6 (2023)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2045-9769

Access URL: https://doaj.org/article/26a5684557e44f23b9d27f6534aa642f

Fueling sentinel node via reshaping cytotoxic T lymphocytes with a flex-patch for post-operative immuno-adjuvant therapy

Authors: Bei Li, Guohao Wang, Kai Miao, Aiping Zhang, Liangyu Sun, Xinwang Yu, Josh Haipeng Lei, Lisi Xie, Jie Yan, Wenxi Li, Chu-Xia Deng, Yunlu Dai

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b57bec54297c4828a50bc30a06c2d972

Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy

Authors: Josh Haipeng Lei, Mi‐Hye Lee, Kai Miao, Zebin Huang, Zhicheng Yao, Aiping Zhang, Jun Xu, Ming Zhao, Zenan Huang, Xin Zhang, Si Chen, NG Jiaying, Yuzhao Feng, Fuqiang Xing, Ping Chen, Heng Sun, Qiang Chen, Tingxiu Xiang, Lin Chen, Xiaoling Xu, Chu‐Xia Deng

Source: Advanced Science, Vol 10, Iss 36, Pp n/a-n/a (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/51fb3ba633264aa7bb12023e89f1b85f

Machine learning model for anti-cancer drug combinations: Analysis, prediction, and validation

Authors: Jing-Bo Zhou, Dongyang Tang, Lin He, Shiqi Lin, Josh Haipeng Lei, Heng Sun, Xiaoling Xu, Chu-Xia Deng

Source: Pharmacological Research, Vol 194, Iss , Pp 106830- (2023)

Subject Terms: Drug combination therapy, Machine learning, Three-dimensional tumor slice culture, Potential combination biomarkers, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S104366182300186X; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/96b73912b9154d6a84cfac543d5096ee

One step synthesis of efficient red emissive carbon dots and their bovine serum albumin composites with enhanced multi-photon fluorescence for in vivo bioimaging

Authors: Huiqi Zhang, Gang Wang, Zhiming Zhang, Josh Haipeng Lei, Tzu-Ming Liu, Guichuan Xing, Chu-Xia Deng, Zikang Tang, Songnan Qu

Source: Light: Science & Applications, Vol 11, Iss 1, Pp 1-14 (2022)

Subject Terms: Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467

File Description: electronic resource

Relation: https://doaj.org/toc/2047-7538

Access URL: https://doaj.org/article/57a3c37127474ede8acbd3d31d457047

Fluorescence intensity and lifetime imaging of lipofuscin-like autofluorescence for label-free predicting clinical drug response in cancer

Authors: Yinghan Yan, Fuqiang Xing, Jiayue Cao, Yiling Hu, Ling Li, Zhengyin Gao, Hao Jia, Kai Miao, Fangyuan Shao, Chu-Xia Deng, Kathy Qian Luo, Leo Tsz on Lee, Tzu-Ming Liu

Source: Redox Biology, Vol 59, Iss , Pp 102578- (2023)

Subject Terms: Apoptosis, Autofluorescence, Label-free, Lipofuscin, Necrosis, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231722003500; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/ee28eda6ed5549e3bf7e69fbd565226c

Photocatalytic Pt(IV)‐Coordinated Carbon Dots for Precision Tumor Therapy

Authors: Dongbo Guo, Josh Haipeng Lei, Dade Rong, Tesen Zhang, Bohan Zhang, Zikang Tang, Han‐Ming Shen, Chu‐Xia Deng, Songnan Qu

Source: Advanced Science, Vol 9, Iss 36, Pp n/a-n/a (2022)

Subject Terms: carbon dots, immunogenetic cell death, photocatalyst, Pt(IV) enriched prodrug, tumor therapy, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/e4ddc3bfca2c4421bdfbd50cadbe580f

Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics

Authors: Ren-Bo Ding, Ping Chen, Barani Kumar Rajendran, Xueying Lyu, Haitao Wang, Jiaolin Bao, Jianming Zeng, Wenhui Hao, Heng Sun, Ada Hang-Heng Wong, Monica Vishnu Valecha, Eun Ju Yang, Sek Man Su, Tak Kan Choi, Shuiming Liu, Kin Iong Chan, Ling-Lin Yang, Jingbo Wu, Kai Miao, Qiang Chen, Joong Sup Shim, Xiaoling Xu, Chu-Xia Deng

Source: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/87f829886bef4facb841e43c9c543db3

Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop

Authors: Leilei Qi, Reka Chakravarthy, Monica M. Li, Chu-Xia Deng, Rong Li, Yanfen Hu

Source: iScience, Vol 25, Iss 9, Pp 104944- (2022)

Subject Terms: Biological sciences, Biochemistry, Biochemistry applications, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222012160; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/6abdbaa5c21b408abc523b5ac4dabaa2

Corrigendum: An in vivo fluorescence resonance energy transfer-based imaging platform for targeted drug discovery and cancer therapy

Authors: Fuqiang Xing, Nana Ai, Shigao Huang, Cheng Jiang, Muhammad Jameel Mughal, Wei Ge, Guanyu Wang, Chu-Xia Deng

Source: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Subject Terms: apoptosis, cancer therapy, drug discovery, FRET technique, xenograft model, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2022.1039177/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/156c55e7cd034caf9e4af58cdb88f582