Network analysis reveals protein modules associated with childhood respiratory diseases

Authors: Prince, Nicole ^{a, b}, Begum, Sofina ^{a, b}, Mendez, Kevin M. ^{a, b, c}, Ramirez, Lourdes G. ^{a, b, d}, Chen, Yulu ^{a, b}, Chen, Qingwen ^{a, b}, Chu, Su H. ^{a, b}, Kachroo, Priyadarshini ^{a, b}, Levy, Ofer ^{b, e}, Diray-Arce, Joann ^{b, e}, Palma, Paolo ^{f, g}, Litonjua, Augusto A. ^h, Weiss, Scott T. ^{a, b}, Kelly, Rachel S. ^{a, b, ∗}, Lasky-Su, Jessica A. ^{a, b, ∗, ∗}

Source: In The Journal of Allergy and Clinical Immunology February 2025

Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma

Authors: Mendez, Kevin M., Begum, Sofina, Tiwari, Anshul, Sharma, Rinku, Chen, Qingwen, Kelly, Rachel S., Prince, Nicole, Huang, Mengna, Kachroo, Priyadarshini, Chu, Su H., Chen, Yulu, Lee-Sarwar, Kathleen, Broadhurst, David I., Reinke, Stacey N., Gerszten, Robert, Clish, Clary, Avila, Lydiana, Celedón, Juan C., Wheelock, Craig E., Weiss, Scott T., McGeachie, Michael, Lasky-Su, Jessica A.

Source: In eBioMedicine April 2024 102

The value of prospective metabolomic susceptibility endotypes: broad applicability for infectious diseases

Authors: Chen, Yulu, Mendez, Kevin, Begum, Sofina, Dean, Emily, Chatelaine, Haley, Braisted, John, Fangal, Vrushali D., Cote, Margaret, Huang, Mengna, Chu, Su H., Stav, Meryl, Chen, Qingwen, Prince, Nicole, Kelly, Rachel, Christopher, Kenneth B., Diray-Arce, Joann, Mathé, Ewy A., Lasky-Su, Jessica

Source: In eBioMedicine October 2023 96

Phenotypically driven subgroups of ASD display distinct metabolomic profiles

Authors: Prince, Nicole, Chu, Su H., Chen, Yulu, Mendez, Kevin M., Hanson, Ellen, Green-Snyder, LeeAnne, Brooks, Elizabeth, Korrick, Susan, Lasky-Su, Jessica A., Kelly, Rachel S.

Source: In Brain Behavior and Immunity July 2023 111:21-29

Genetic Associations and Architecture of Asthma-COPD Overlap

Authors: John, Catherine, Guyatt, Anna L., Shrine, Nick, Packer, Richard, Olafsdottir, Thorunn A., Liu, Jiangyuan, Hayden, Lystra P., Chu, Su H., Koskela, Jukka T., Luan, Jian’an, Li, Xingnan, Terzikhan, Natalie, Xu, Hanfei, Bartz, Traci M., Petersen, Hans, Leng, Shuguang, Belinsky, Steven A., Cepelis, Aivaras, Hernández Cordero, Ana I., Obeidat, Ma’en, Thorleifsson, Gudmar, Meyers, Deborah A., Bleecker, Eugene R., Sakoda, Lori C., Iribarren, Carlos, Tesfaigzi, Yohannes, Gharib, Sina A., Dupuis, Josée, Brusselle, Guy, Lahousse, Lies, Ortega, Victor E., Jonsdottir, Ingileif, Sin, Don D., Bossé, Yohan, van den Berge, Maarten, Nickle, David, Quint, Jennifer K., Sayers, Ian, Hall, Ian P., Langenberg, Claudia, Ripatti, Samuli, Laitinen, Tarja, Wu, Ann C., Lasky-Su, Jessica, Bakke, Per, Gulsvik, Amund, Hersh, Craig P., Hayward, Caroline, Langhammer, Arnulf, Brumpton, Ben, Stefansson, Kari, Cho, Michael H., Wain, Louise V., Tobin, Martin D.

Source: In Chest May 2022 161(5):1155-1166

Low gestational vitamin D level and childhood asthma are related to impaired lung function in high-risk children

Authors: Knihtilä, Hanna M., Stubbs, Benjamin J., Carey, Vincent J., Laranjo, Nancy, Chu, Su H., Kelly, Rachel S., Zeiger, Robert S., Bacharier, Leonard B., O’Connor, George T., Lasky-Su, Jessica, Weiss, Scott T., Litonjua, Augusto A.

Source: In The Journal of Allergy and Clinical Immunology July 2021 148(1):110-119

Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity.

Authors: Aris, Izzuddin M., Wu, Allison J., Lin, Pi-I D., Zhang, Mingyu, Farid, Huma, Hedderson, Monique M., Zhu, Yeyi, Ferrara, Assiamira, Chehab, Rana F., Barrett, Emily S., Carnell, Susan, Camargo Jr, Carlos A., Chu, Su H., Mirzakhani, Hooman, Kelly, Rachel S., Comstock, Sarah S., Strakovsky, Rita S., O'Connor, Thomas G., Ganiban, Jody M., Dunlop, Anne L.

Source: JAMA Pediatrics; Nov2024, Vol. 178 Issue 11, p1172-1182, 11p

Metabolomic signatures of lead exposure in the VA Normative Aging Study

Authors: Kelly, Rachel S., Bayne, Haley, Spiro, Avron, II, Vokonas, Pantel, Sparrow, David, Weiss, Scott T., Schwartz, Joel, Nassan, Feiby L., Lee-Sarwar, Kathleen, Huang, Mengna, Kachroo, Priyadarshini, Chu, Su H., Litonjua, Augusto A., Lasky-Su, Jessica A.

Source: In Environmental Research November 2020 190

Stability of developmental status and risk of impairment at 24 and 36 months in late preterm infants

Authors: Mirzakhani, Hooman ^*, Kelly, Rachel S., Yadama, Aishwarya P., Chu, Su H., Lasky-Su, Jessica A., Litonjua, Augusto A., Weiss, Scott T.

Source: In Infant Behavior and Development August 2020 60

Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

Authors: Abe, Namiko, Abecasis, Goncalo, Albert, Christine, Palmer Allred, Nicholette (Nichole), Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Arking, Dan, Arnett, Donna K., Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Beaty, Terri, Becker, Diane, Becker, Lewis, Beer, Rebecca, Begum, Ferdouse, Beitelshees, Amber, Benjamin, Emelia, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Boerwinkle, Eric, Borecki, Ingrid, Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Bunting, Karen, Burchard, Esteban, Cardwell, Jonathan, Carty, Cara, Casaburi, Richard, Casella, James, Chaffin, Mark, Chang, Christy, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Chen, Yii-Der Ida, Cho, Michael H., Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, Das, Sayantan, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Do, Ron, Duan, Qing, Duggirala, Ravi, Durda, Peter, Dutcher, Susan, Eaton, Charles, Ekunwe, Lynette, Ellinor, Patrick, Emery, Leslie, Farber, Charles, Farnam, Leanna, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Yan, Gass, Margery, Gelb, Bruce, Geng, Xiaoqi (Priscilla), Germer, Soren, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Haessler, Jeff, Hall, Michael, Harris, Daniel, Hawley, Nicola, He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hokanson, John, Holly, Kramer, Hong, Elliott, Hoth, Karin, (Agnes) Hsiung, Chao, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Jhun, Min A., Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kachroo, Priyadarshini, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kathiresan, Sekar, Kaufman, Laura, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Krauter, Stephanie, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Seunggeun Shawn, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Yun, Lin, Honghuang, Lin, Keng Han, Liu, Simin, Liu, Yongmei, Loos, Ruth, Lubitz, Steven, Lunetta, Kathryn, Luo, James, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manson, JoAnn, Margolin, Lauren, Martin, Lisa, Mathai, Susan, Mathias, Rasika, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, Mei, Hao, Meyers, Deborah A., Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L., Mitchell, Braxton, Montasser, May E., Musani, Solomon, Mwasongwe, Stanford, Mychaleckyj, Josyf C., Nadkarni, Girish, Naik, Rakhi, Natarajan, Pradeep, Nekhai, Sergei, Nickerson, Deborah, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Pankow, James, Papanicolaou, George, Parker, Margaret, Parsa, Afshin, Penchev, Sara, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S., Phillips, Sam, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Prokopenko, Dmitry, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Ramachandran, Vasan, Rao, D.C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Regan, Elizabeth, Reiner, Alex, Rice, Ken, Rich, Stephen, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sakornsakolpat, Phuwanat, Salimi, Shabnam, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay, Scheller, Christopher, Schmidt, Ellen, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sheehan, Vivien, Shetty, Amol, Shetty, Aniket, Sheu, Wayne Hui-Heng, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne, Streeten, Elizabeth, Sung, Yun Ju, Su-Lasky, Jessica, Sylvia, Jody, Szpiro, Adam, Sztalryd, Carole, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Tinker, Lesley, Tirschwell, David, Tiwari, Hemant, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wan, Emily, Wang, Fei Fei, Watson, Karol, Weeks, Daniel E., Weir, Bruce, Weiss, Scott, Weng, Lu-Chen, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Wong, Quenna, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yang, Rongze, Zaghloul, Norann, Zekavat, Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zheng, Xiuwen, Zhi, Degui, Zhou, Xiang, Zody, Michael, Zoellner, Sebastian, Hecker, Julian, Chawes, Bo L., Ahluwalia, Tarunveer S., Kelly, Rachel S., Chu, Su H., Virkud, Yamini V., Huang, Mengna, Barnes, Kathleen C., Burchard, Esteban G., Eng, Celeste, Hu, Donglei, Celedón, Juan C., Levin, Albert M., Gui, Hongsheng, Forno, Erick, Mak, Angel C.Y., Avila, Lydiana, Soto-Quiros, Manuel E., Cloutier, Michelle M., Acosta-Pérez, Edna, Canino, Glorisa, Bønnelykke, Klaus, Bisgaard, Hans, Raby, Benjamin A., Weiss, Scott T., Lasky-Su, Jessica A.

Source: In Chest December 2019 156(6):1068-1079

The metabolic role of vitamin D in children's neurodevelopment: a network study.

Authors: De Marzio, Margherita, Lasky-Su, Jessica, Chu, Su H., Prince, Nicole, Litonjua, Augusto A., Weiss, Scott T., Kelly, Rachel S., Glass, Kimberly R.

Source: Scientific Reports; 7/23/2024, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: VITAMIN D, CHILD development, VITAMIN D deficiency, NEURAL development, AUTISM spectrum disorders, SEROTONIN receptors, ENVIRONMENTAL risk

Sphingolipid classes and the interrelationship with pediatric asthma and asthma risk factors.

Authors: Chen, Yulu, Checa, Antonio, Zhang, Pei, Huang, Mengna, Kelly, Rachel S., Kim, Min, Chen, Yih‐Chieh S., Lee‐Sarwar, Kathleen A., Prince, Nicole, Mendez, Kevin M., Begum, Sofina, Kachroo, Priyadarshini, Chu, Su H., Stokholm, Jakob, Bønnelykke, Klaus, Litonjua, Augusto A., Bisgaard, Hans, Weiss, Scott T., Chawes, Bo L., Wheelock, Craig E.

Source: Allergy; Feb2024, Vol. 79 Issue 2, p404-418, 15p

Subject Terms: ASTHMA in children, ASTHMA, VITAMIN D, WHEEZE, SPHINGOLIPIDS, RACIAL differences

Metabolomic data presents challenges for epidemiological meta-analysis: a case study of childhood body mass index from the ECHO consortium.

Authors: Prince, Nicole, Liang, Donghai, Tan, Youran, Alshawabkeh, Akram, Angel, Elizabeth Esther, Busgang, Stefanie A., Chu, Su H., Cordero, José F., Curtin, Paul, Dunlop, Anne L., Gilbert-Diamond, Diane, Giulivi, Cecilia, Hoen, Anne G., Karagas, Margaret R., Kirchner, David, Litonjua, Augusto A., Manjourides, Justin, McRitchie, Susan, Meeker, John D., Pathmasiri, Wimal

Source: Metabolomics; Feb2024, Vol. 20 Issue 1, p1-14, 14p

An independently validated, portable algorithm for the rapid identification of COPD patients using electronic health records.

Authors: Chu, Su H.^1,2 (AUTHOR) su.chu@channing.harvard.edu, Wan, Emily S.^1,2,3 (AUTHOR), Cho, Michael H.^1,2 (AUTHOR), Goryachev, Sergey⁴ (AUTHOR), Gainer, Vivian⁴ (AUTHOR), Linneman, James⁵ (AUTHOR), Scotty, Erica J.⁵ (AUTHOR), Hebbring, Scott J.⁵ (AUTHOR), Murphy, Shawn^4,6 (AUTHOR), Lasky-Su, Jessica^1,2 (AUTHOR), Weiss, Scott T.^1,2 (AUTHOR), Smoller, Jordan W.^2,6,7,8 (AUTHOR), Karlson, Elizabeth^2,9 (AUTHOR) ekarlson@bwh.harvard.edu

Source: Scientific Reports. 10/7/2021, Vol. 11 Issue 1, p1-9. 9p.

Subject Terms: *ELECTRONIC health records, *CHRONIC obstructive pulmonary disease, *ALGORITHMS, *POSITIVE pressure ventilation

Company/Entity: MASSACHUSETTS General Hospital

Nucleotide, Phospholipid, and Kynurenine Metabolites Are Robustly Associated with COVID-19 Severity and Time of Plasma Sample Collection in a Prospective Cohort Study.

Authors: Chatelaine, Haley A. S., Chen, Yulu, Braisted, John, Chu, Su H., Chen, Qingwen, Stav, Meryl, Begum, Sofina, Diray-Arce, Joann, Sanjak, Jaleal, Huang, Mengna, Lasky-Su, Jessica, Mathé, Ewy A.

Source: International Journal of Molecular Sciences; Jan2024, Vol. 25 Issue 1, p346, 17p

Subject Terms: COVID-19, KYNURENINE, METABOLITES, COHORT analysis, LONGITUDINAL method, URIDINE

Genome-wide Transcriptome Profiling Reveals the Functional Impact of Rare De Novo and Recurrent CNVs in Autism Spectrum Disorders

Authors: Luo, Rui, Sanders, Stephan J., Tian, Yuan, Voineagu, Irina, Huang, Ni, Chu, Su H., Klei, Lambertus, Cai, Chaochao, Ou, Jing, Lowe, Jennifer K., Hurles, Matthew E., Devlin, Bernie, State, Matthew W., Geschwind, Daniel H.

Source: In The American Journal of Human Genetics 13 July 2012 91(1):38-55

Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

Authors: Sanders, Stephan J., Ercan-Sencicek, A. Gulhan, Hus, Vanessa, Luo, Rui, Murtha, Michael T., Moreno-De-Luca, Daniel, Chu, Su H., Moreau, Michael P., Gupta, Abha R., Thomson, Susanne A., Mason, Christopher E., Bilguvar, Kaya, Celestino-Soper, Patricia B.S., Choi, Murim, Crawford, Emily L., Davis, Lea, Davis Wright, Nicole R., Dhodapkar, Rahul M., DiCola, Michael, DiLullo, Nicholas M., Fernandez, Thomas V., Fielding-Singh, Vikram, Fishman, Daniel O., Frahm, Stephanie, Garagaloyan, Rouben, Goh, Gerald S., Kammela, Sindhuja, Klei, Lambertus, Lowe, Jennifer K., Lund, Sabata C., McGrew, Anna D., Meyer, Kyle A., Moffat, William J., Murdoch, John D., O'Roak, Brian J., Ober, Gordon T., Pottenger, Rebecca S., Raubeson, Melanie J., Song, Youeun, Wang, Qi, Yaspan, Brian L., Yu, Timothy W., Yurkiewicz, Ilana R., Beaudet, Arthur L., Cantor, Rita M., Curland, Martin, Grice, Dorothy E., Günel, Murat, Lifton, Richard P., Mane, Shrikant M., Martin, Donna M., Shaw, Chad A., Sheldon, Michael, Tischfield, Jay A., Walsh, Christopher A., Morrow, Eric M., Ledbetter, David H., Fombonne, Eric, Lord, Catherine, Martin, Christa Lese, Brooks, Andrew I., Sutcliffe, James S., Cook, Edwin H., Jr., Geschwind, Daniel, Roeder, Kathryn, Devlin, Bernie, State, Matthew W.

Source: In Neuron 9 June 2011 70(5):863-885

Metabolomics and Self-Reported Depression, Anxiety, and Phobic Symptoms in the VA Normative Aging Study.

Authors: Prince, Nicole, Stav, Meryl, Cote, Margaret, Chu, Su H., Vyas, Chirag M., Okereke, Olivia I., Palacios, Natalia, Litonjua, Augusto A, Vokonas, Pantel, Sparrow, David, Spiro III, Avron, Lasky-Su, Jessica A., Kelly, Rachel S.

Source: Metabolites (2218-1989); Jul2023, Vol. 13 Issue 7, p851, 14p

Subject Terms: BRIEF Symptom Inventory, ANXIETY, MENTAL illness, SYMPTOMS, METABOLOMICS, MENTAL depression, VETERANS' health, SOCIAL anxiety

Elevated third trimester corticosteroid levels are associated with fewer offspring infections.

Authors: Prince, Nicole, Kelly, Rachel S., Chu, Su H., Kachroo, Priyadarshini, Chen, Yulu, Mendez, Kevin M., Begum, Sofina, Bisgaard, Hans, Bønnelykke, Klaus, Kim, Min, Levy, Ofer, Litonjua, Augusto A., Wheelock, Craig E., Weiss, Scott T., Chawes, Bo L., Lasky-Su, Jessica A.

Source: Scientific Reports; 6/28/2023, Vol. 13 Issue 1, p1-8, 8p

Subject Terms: THIRD trimester of pregnancy, ANDROGEN receptors, RESPIRATORY infections, CORTICOSTEROIDS, POISSON regression, LUNG infections

Neighborhood Opportunity and Vulnerability and Incident Asthma Among Children

Authors: Aris, Izzuddin M., Perng, Wei, Dabelea, Dana, Padula, Amy M., Alshawabkeh, Akram, Vélez-Vega, Carmen M., Aschner, Judy L., Camargo, Carlos A., Sussman, Tamara J., Dunlop, Anne L., Elliott, Amy J., Ferrara, Assiamira, Joseph, Christine L. M., Singh, Anne Marie, Breton, Carrie V., Hartert, Tina, Cacho, Ferdinand, Karagas, Margaret R., Lester, Barry M., Kelly, Nichole R., Ganiban, Jody M., Chu, Su H., O’Connor, Thomas G., Fry, Rebecca C., Norman, Gwendolyn, Trasande, Leonardo, Restrepo, Bibiana, Gold, Diane R., James, Peter, Oken, Emily

Source: JAMA Pediatrics; October 2023, Vol. 177 Issue: 10 p1055-1064, 10p