Epistaxis Versus Nonepistaxis Bleeding in Anticoagulated Patients With Atrial Fibrillation: Results From the ENGAGE AF‐TIMI 48 Trial

Authors: Robert S. Semco, Regan W. Bergmark, Sabina A. Murphy, Abby L. Cange, Martin Unverdorben, Cathy Z. L. Chen, Christian T. Ruff, Elliott M. Antman, Robert P. Giugliano, Brian A. Bergmark

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 14, Iss 2 (2025)

Subject Terms: anticoagulation, atrial fibrillation, bleeding, discontinuation, epistaxis, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/eddebd5eb6c9484cbd94f4fc2964659f

Residual Stroke Risk Among Patients With Atrial Fibrillation Prescribed Oral Anticoagulants: A Patient‐Level Meta‐Analysis From COMBINE AF

Authors: Linda S. Johnson, Alexander P. Benz, Ashkan Shoamanesh, John W. Eikelboom, Michael Ezekowitz, Robert P. Giugliano, Lars Wallentin, Christian T. Ruff, Renato D. Lopes, Sanjit Jolly, Richard Whitlock, Christopher B. Granger, Stuart Connolly, Jeffrey S. Healey

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)

Subject Terms: anticoagulation, atrial fibrillation, stroke, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/e38e129fdb2844bbbc19f74922abbc68

Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes

Authors: Jennifer L. Halford, Valerie N. Morrill, Seung Hoan Choi, Sean J. Jurgens, Giorgio Melloni, Nicholas A. Marston, Lu-Chen Weng, Victor Nauffal, Amelia W. Hall, Sophia Gunn, Christina A. Austin-Tse, James P. Pirruccello, Shaan Khurshid, Heidi L. Rehm, Emelia J. Benjamin, Eric Boerwinkle, Jennifer A. Brody, Adolfo Correa, Brandon K. Fornwalt, Namrata Gupta, Christopher M. Haggerty, Stephanie Harris, Susan R. Heckbert, Charles C. Hong, Charles Kooperberg, Henry J. Lin, Ruth J. F. Loos, Braxton D. Mitchell, Alanna C. Morrison, Wendy Post, Bruce M. Psaty, Susan Redline, Kenneth M. Rice, Stephen S. Rich, Jerome I. Rotter, Peter F. Schnatz, Elsayed Z. Soliman, Nona Sotoodehnia, Eugene K. Wong, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Marc S. Sabatine, Christian T. Ruff, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz

Source: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/816988c3c3b240bbb3a8c919e46440d7

The genomics of heart failure: design and rationale of the HERMES consortium

Authors: R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans‐Peter Brunner‐La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G.F. Cleland, James P. Cook, Simon deDenus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van derHarst, Åsa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay‐Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried März, John J.V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton‐Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N.A. Palmer, Guillaume Paré, Markus Perola, Louis‐Philippe Lemieux Perreault, Eliana Portilla‐Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P.R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica vanSetten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garðar Sveinbjörnsson, Mari‐Liis Tammesoo, Jean‐Claude Tardif, Kent D. Taylor, Maris Teder‐Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp‐Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges‐Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Regeneron Genetics Center, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie‐Pierre Dubé, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith

Source: ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)

Subject Terms: Heart failure, Cardiomyopathy, Genetics, Biomarkers, Association studies, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5822

Access URL: https://doaj.org/article/77600c13420346d3a1c4c66140b2a3c7

The importance of dosing frequency on the safety of DOACs

Authors: Christian T. Ruff

Source: American Heart Journal Plus, Vol 23, Iss , Pp 100216- (2022)

Subject Terms: AF, DOACS, GI bleeding, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666602222001331; https://doaj.org/toc/2666-6022

Access URL: https://doaj.org/article/2ca69941623b495d87e380d37623aa75

No association between APOE genotype and lipid lowering with cognitive function in a randomized controlled trial of evolocumab

Authors: Laura E. Korthauer, Robert P. Giugliano, Jianping Guo, Marc S. Sabatine, Peter Sever, Anthony Keech, Dan Atar, Christopher Kurtz, Christian T. Ruff, Francois Mach, Brian R. Ott

Source: PLoS ONE, Vol 17, Iss 4 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000128/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c73dbca33a054b62bfe37a7775180551

Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes

Authors: Jennifer L. Halford, Valerie N. Morrill, Seung Hoan Choi, Sean J. Jurgens, Giorgio Melloni, Nicholas A. Marston, Lu-Chen Weng, Victor Nauffal, Amelia W. Hall, Sophia Gunn, Christina A. Austin-Tse, James P. Pirruccello, Shaan Khurshid, Heidi L. Rehm, Emelia J. Benjamin, Eric Boerwinkle, Jennifer A. Brody, Adolfo Correa, Brandon K. Fornwalt, Namrata Gupta, Christopher M. Haggerty, Stephanie Harris, Susan R. Heckbert, Charles C. Hong, Charles Kooperberg, Henry J. Lin, Ruth J. F. Loos, Braxton D. Mitchell, Alanna C. Morrison, Wendy Post, Bruce M. Psaty, Susan Redline, Kenneth M. Rice, Stephen S. Rich, Jerome I. Rotter, Peter F. Schnatz, Elsayed Z. Soliman, Nona Sotoodehnia, Eugene K. Wong, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Marc S. Sabatine, Christian T. Ruff, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz

Source: Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/001990be3a844416bee130cfd57f4151

Evaluation of Direct Oral Anticoagulant Prescribing in Patients With Moderate to Severe Renal Impairment

Authors: Clara Ting PharmD, Megan Rhoten PharmD, Jillian Dempsey PharmD, Hunter Nichols PharmD, John Fanikos RPh, MBA, Christian T. Ruff MD, MPH

Source: Clinical and Applied Thrombosis/Hemostasis, Vol 27 (2021)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1938-2723

Access URL: https://doaj.org/article/987bf33d47d44685bbed18ab5a50c1ad

Efficacy and Safety of Edoxaban in Patients With Active Malignancy and Atrial Fibrillation: Analysis of the ENGAGE AF‐TIMI 48 Trial

Authors: Christina L. Fanola, Christian T. Ruff, Sabina A. Murphy, James Jin, Anil Duggal, Noe A. Babilonia, Piyamitr Sritara, Michele F. Mercuri, Pieter W. Kamphuisen, Elliott M. Antman, Eugene Braunwald, Robert P. Giugliano

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 16 (2018)

Subject Terms: anticoagulants, atrial fibrillation, cancer, edoxaban, malignancy, warfarin, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/f40296bded45487d9e72511c1fa75950

Impact of Spontaneous Extracranial Bleeding Events on Health State Utility in Patients with Atrial Fibrillation: Results from the ENGAGE AF‐TIMI 48 Trial

Authors: Kaijun Wang, Haiyan Li, Winghan J. Kwong, Elliott M. Antman, Christian T. Ruff, Robert P. Giugliano, David J. Cohen, Elizabeth A. Magnuson

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 8 (2017)

Subject Terms: anticoagulation, bleeding, quality of life, utility, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/7f836dc2ddcf4cc3a351d0284c879298

Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure in the ENGAGE AF‐TIMI 48 Trial

Authors: Alon Eisen, Christian T. Ruff, Eugene Braunwald, Rose A. Hamershock, Basil S. Lewis, Christian Hassager, Tze‐Fan Chao, Jean Yves Le Heuzey, Michele Mercuri, Howard Rutman, Elliott M. Antman, Robert P. Giugliano

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 7 (2017)

Subject Terms: atrial fibrillation, digoxin, heart failure, mortality, sudden cardiac death, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/87920ea9ee804eefb5eba9e9047f7419

Sudden Cardiac Death in Patients With Atrial Fibrillation: Insights From the ENGAGE AF‐TIMI 48 Trial

Authors: Alon Eisen, Christian T. Ruff, Eugene Braunwald, Francesco Nordio, Ramón Corbalán, Anthony Dalby, Maria Dorobantu, Michele Mercuri, Hans Lanz, Howard Rutman, Stephen D. Wiviott, Elliott M. Antman, Robert P. Giugliano

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 7 (2016)

Subject Terms: atrial fibrillation, sudden cardiac death, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/d768011c03c045a78a472f4bb7ba2c31

Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF–TIMI 48 Trial

Authors: Eri Toda Kato, Robert P. Giugliano, Christian T. Ruff, Yukihiro Koretsune, Takeshi Yamashita, Robert Gabor Kiss, Francesco Nordio, Sabina A. Murphy, Tetsuya Kimura, James Jin, Hans Lanz, Michele Mercuri, Eugene Braunwald, Elliott M. Antman

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 5 (2016)

Subject Terms: antithrombotic, bleeding, death, elderly, stroke, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/0e6d79c903f14037ac0b1e32f6744c1c

Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF‐TIMI48 Trial

Authors: Haiyan Xu, Christian T. Ruff, Robert P. Giugliano, Sabina A. Murphy, Francesco Nordio, Indravadan Patel, Minggao Shi, Michele Mercuri, Elliott M. Antman, Eugene Braunwald

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 2 (2016)

Subject Terms: anticoagulant, antiplatelet, atrial fibrillation, edoxaban, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/91ed106b46234d5f981300d4c1a02676

No association between APOE genotype and lipid lowering with cognitive function in a randomized controlled trial of evolocumab.

Authors: Laura E Korthauer, Robert P Giugliano, Jianping Guo, Marc S Sabatine, Peter Sever, Anthony Keech, Dan Atar, Christopher Kurtz, Christian T Ruff, Francois Mach, Brian R Ott

Source: PLoS ONE, Vol 17, Iss 4, p e0266615 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/19a8dc035df44f85aea24a52419aaca7

Evaluating the effects of socioeconomic status on stroke and bleeding risk scores and clinical events in patients on oral anticoagulant for new onset atrial fibrillation.

Authors: Kourosh Ravvaz, John A Weissert, Arshad Jahangir, Christian T Ruff

Source: PLoS ONE, Vol 16, Iss 3, p e0248134 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248134&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/78abf9a24e554fb4970e7d49dbdaa376