High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production

Authors: Shen Y. Heazlewood, Tanveer Ahmad, Benjamin Cao, Huimin Cao, Melanie Domingues, Xuan Sun, Chad K. Heazlewood, Songhui Li, Brenda Williams, Madeline Fulton, Jacinta F. White, Tom Nebl, Christian M. Nefzger, Jose M. Polo, Benjamin T. Kile, Felix Kraus, Michael T. Ryan, Yu B. Sun, Peter F. M. Choong, Sarah L. Ellis, Minna-Liisa Anko, Susan K. Nilsson

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7defb2ab48b547d0b668ad9675392191

Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells

Authors: Patricia Gerdes, Sue Mei Lim, Adam D. Ewing, Michael R. Larcombe, Dorothy Chan, Francisco J. Sanchez-Luque, Lucinda Walker, Alexander L. Carleton, Cini James, Anja S. Knaupp, Patricia E. Carreira, Christian M. Nefzger, Ryan Lister, Sandra R. Richardson, Jose M. Polo, Geoffrey J. Faulkner

Source: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b8c17138d7be4d378e40d7894f019bb7

Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Authors: Christian M. Nefzger, Thierry Jardé, Akanksha Srivastava, Jan Schroeder, Fernando J. Rossello, Katja Horvay, Mirsada Prasko, Jacob M. Paynter, Joseph Chen, Chen-Fang Weng, Yu B. Y. Sun, Xiaodong Liu, Eva Chan, Nikita Deshpande, Xiaoli Chen, Y. Jinhua Li, Jahnvi Pflueger, Rebekah M. Engel, Anja S. Knaupp, Kirill Tsyganov, Susan K. Nilsson, Ryan Lister, Owen J. L. Rackham, Helen E. Abud, Jose M. Polo

Source: npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-8 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2057-3995

Access URL: https://doaj.org/article/325c54d2ea294a94afa02fa43f4f567c

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

Authors: Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose M. Polo, Marnie E. Blewitt

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/55d8f97f36464af78639b6d7c2a5c371

Breaking constraint of mammalian axial formulae

Authors: Gabriel M. Hauswirth, Victoria C. Garside, Lisa S. F. Wong, Heidi Bildsoe, Jan Manent, Yi-Cheng Chang, Christian M. Nefzger, Jaber Firas, Joseph Chen, Fernando J. Rossello, Jose M. Polo, Edwina McGlinn

Source: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2da6dd6edf0246ddb0e84b2cc0ddcf45

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Authors: Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y. Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schröder, Chad K. Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, Matthew J. Sweet, Robert G. Parton, Michael T. Ryan, Jose M. Polo, Christian M. Nefzger, Susan K. Nilsson

Source: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a2cd09ff347c4623848c6acc6789d348

Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions

Authors: Marina Naval-Sanchez, Nikita Deshpande, Minh Tran, Jingyu Zhang, Majid Alhomrani, Walaa Alsanie, Quan Nguyen, Christian M. Nefzger

Source: Frontiers in Molecular Biosciences, Vol 9 (2022)

Subject Terms: ATAC-seq, sequencing platform, benchmarking, BGI, DNBSEQ-G400, Illumina, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2022.900323/full; https://doaj.org/toc/2296-889X

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Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation

Authors: Enakshi Sinniah, Zhixuan Wu, Sophie Shen, Marina Naval-Sanchez, Xiaoli Chen, Junxian Lim, Abbigail Helfer, Abishek Iyer, Jiahui Tng, Andrew J. Lucke, Robert C. Reid, Meredith A. Redd, Christian M. Nefzger, David P. Fairlie, Nathan J. Palpant

Source: Cell Reports, Vol 39, Iss 7, Pp 110818- (2022)

Subject Terms: CP: Stem cell research, CP: Molecular biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124722005897; https://doaj.org/toc/2211-1247

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Bone Marrow Regulatory T Cells Are a Unique Population, Supported by Niche-Specific Cytokines and Plasmacytoid Dendritic Cells, and Required for Chronic Graft-Versus-Host Disease Control

Authors: Jemma Nicholls, Benjamin Cao, Laetitia Le Texier, Laura Yan Xiong, Christopher R. Hunter, Genesis Llanes, Ethan G. Aguliar, Wayne A. Schroder, Simon Phipps, Jason P. Lynch, Huimin Cao, Shen Y. Heazlewood, Brenda Williams, Andrew D. Clouston, Christian M. Nefzger, Jose M. Polo, Susan K. Nilsson, Bruce R. Blazar, Kelli P. A. MacDonald

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: regulatory T cells, bone marrow, stem-cell transplantation, GVHD, FoxP3, TIGIT, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.737880/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/27d02299a5ee475cab524537e8e3a0b4

Identification of dynamic undifferentiated cell states within the male germline

Authors: Hue M. La, Juho-Antti Mäkelä, Ai-Leen Chan, Fernando J. Rossello, Christian M. Nefzger, Julien M. D. Legrand, Mia De Seram, Jose M. Polo, Robin M. Hobbs

Source: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/87e119b967464304a757f01694a020cf

Cell Type of Origin Dictates the Route to Pluripotency

Authors: Christian M. Nefzger, Fernando J. Rossello, Joseph Chen, Xiaodong Liu, Anja S. Knaupp, Jaber Firas, Jacob M. Paynter, Jahnvi Pflueger, Sam Buckberry, Sue Mei Lim, Brenda Williams, Sara Alaei, Keshav Faye-Chauhan, Enrico Petretto, Susan K. Nilsson, Ryan Lister, Mirana Ramialison, David R. Powell, Owen J.L. Rackham, Jose M. Polo

Source: Cell Reports, Vol 21, Iss 10, Pp 2649-2660 (2017)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717316662; https://doaj.org/toc/2211-1247

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Generation of four iPSC lines from peripheral blood mononuclear cells (PBMCs) of an attention deficit hyperactivity disorder (ADHD) individual and a healthy sibling in an Australia-Caucasian family

Authors: Janette Tong, Kyung Min Lee, Xiaodong Liu, Christian M. Nefzger, Prasidhee Vijayakumar, Ziarih Hawi, Ken C. Pang, Clare L. Parish, Jose M. Polo, Mark A. Bellgrove

Source: Stem Cell Research, Vol 34, Iss , Pp - (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506118302836; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/3b99aa8f183c40f99a35f88233584ab9

A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells

Authors: Christian M. Nefzger, Thierry Jardé, Fernando J. Rossello, Katja Horvay, Anja S. Knaupp, David R. Powell, Joseph Chen, Helen E. Abud, Jose M. Polo

Source: Stem Cell Reports, Vol 6, Iss 3, Pp 321-329 (2016)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221367111600031X; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/428a720250f04bb9ad8c06e2f3b4fde0

Cell Surface Marker Mediated Purification of iPS Cell Intermediates from a Reprogrammable Mouse Model

Authors: Christian M. Nefzger, author^{1, 2}, Sara Alaei, author^{1, 2}, Anja S. Knaupp, author^{1, 2}, Melissa L. Holmes, author^{1, 2}, Jose M. Polo, author^{1, 2}

Source: Journal of Visualized Experiments. (91)

Availability: http://www.jove.com/video/51728

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity.

Authors: Jueqiong Wang, Carlos Farkas, Aissa Benyoucef, Catherine Carmichael, Katharina Haigh, Nick Wong, Danny Huylebroeck, Marc P Stemmler, Simone Brabletz, Thomas Brabletz, Christian M Nefzger, Steven Goossens, Geert Berx, Jose M Polo, Jody J Haigh

Source: PLoS Biology, Vol 19, Iss 9, p e3001394 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/924fefc9d60f4750bd8231e082078d7c

SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

Authors: Madara Ratnadiwakara, Stuart K Archer, Craig I Dent, Igor Ruiz De Los Mozos, Traude H Beilharz, Anja S Knaupp, Christian M Nefzger, Jose M Polo, Minna-Liisa Anko

Source: eLife, Vol 7 (2018)

Subject Terms: SR protein, RNA processing, pluripotent, reprogramming, mRNA export, alternative splicing, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/37419; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/f524e3ef382f48c884f4c109fc9e5eb6