Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome

Authors: John A. Kink, Michael A. Bellio, Matthew H. Forsberg, Alexandra Lobo, Anna S. Thickens, Bryson M. Lewis, Irene M. Ong, Aisha Khan, Christian M. Capitini, Peiman Hematti

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Extracellular vesicles, Exosomes, Mesenchymal stromal cells, TLR4, Acute radiation syndrome, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/7f0ca311f8c14580a85604f16c531ec9

Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer

Authors: Jose M. Ayuso, Mehtab Farooqui, María Virumbrales-Muñoz, Katheryn Denecke, Shujah Rehman, Rebecca Schmitz, Jorge F. Guerrero, Cristina Sanchez-de-Diego, Sara Abizanda Campo, Elizabeth M. Maly, Matthew H. Forsberg, Sheena C. Kerr, Robert Striker, Nathan M. Sherer, Paul M. Harari, Christian M. Capitini, Melissa C. Skala, David J. Beebe

Source: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d8131a18a7bf40c7bef3be77d0080137

Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence

Authors: Dan Cappabianca, Dan Pham, Matthew H. Forsberg, Madison Bugel, Anna Tommasi, Anthony Lauer, Jolanta Vidugiriene, Brookelyn Hrdlicka, Alexandria McHale, Quaovi H. Sodji, Melissa C. Skala, Christian M. Capitini, Krishanu Saha

Source: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101249- (2024)

Subject Terms: gene editing, CAR T cells, cancer, metabolism, stem cell memory, CRISPR, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050124000652; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/74f39a1628344c7f928bd6f3024b4800

Non-viral expression of chimeric antigen receptors with multiplex gene editing in primary T cells

Authors: Dan Cappabianca, Jingling Li, Yueting Zheng, Cac Tran, Kassandra Kasparek, Pedro Mendez, Ricky Thu, Travis Maures, Christian M. Capitini, Robert Deans, Krishanu Saha

Source: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Subject Terms: multiplex gene editing, CRISPR/Cas9, GD2, chimeric antigen receptor T cells, PD-1, neuroblastoma, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2024.1379900/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/bbcd1d37f24e46079d2b72cfaf8b65af

Mediport use as an acceptable standard for CAR T cell infusion

Authors: Maya Eylon, Snehit Prabhu, Samuel John, Maxwell J. M. King, Dhruv Bhatt, Kevin J. Curran, Courtney Erickson, Nicole A. Karras, Christine L. Phillips, Prakash Satwani, Michelle Hermiston, Erica Southworth, Susanne H. C. Baumeister, Julie-An Talano, Margaret L. MacMillan, Jenna Rossoff, Challice L. Bonifant, Gary Doug Myers, Rayne H. Rouce, Keri Toner, Timothy A. Driscoll, Emmanuel Katsanis, Dana B. Salzberg, Deborah Schiff, Satiro N. De Oliveira, Christian M. Capitini, Holly L. Pacenta, Thomas Pfeiffer, Niketa C. Shah, Van Huynh, Jodi L. Skiles, Ellen Fraint, Kevin O. McNerney, Troy C. Quigg, Joerg Krueger, John A. Ligon, Vanessa A. Fabrizio, Christina Baggott, Theodore W. Laetsch, Liora M. Schultz

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: chimeric antigen receptor T cell, immunotherapy, cancer, immune cell engineering, mediport, implanted catheter, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239132/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/63c1f7316ab94ecab4e03921e246dcfd

Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques

Authors: Jason T. Weinfurter, Saritha S. D’Souza, Lea M. Matschke, Sarah Bennett, Laurel E. Kelnhofer-Millevolte, Kran Suknuntha, Akhilesh Kumar, Jennifer Coonen, Christian M. Capitini, Peiman Hematti, Thaddeus G. Golos, Igor I. Slukvin, Matthew R. Reynolds

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/22f7e78e3a994a308f11436196586bc8

Author Correction: Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer

Authors: Jose M. Ayuso, Mehtab Farooqui, María Virumbrales-Muñoz, Katheryn Denecke, Shujah Rehman, Rebecca Schmitz, Jorge F. Guerrero, Cristina Sanchez-de-Diego, Sara Abizanda Campo, Elizabeth M. Maly, Matthew H. Forsberg, Sheena C. Kerr, Robert Striker, Nathan M. Sherer, Paul M. Harari, Christian M. Capitini, Melissa C. Skala, David J. Beebe

Source: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6de22253fd77422a9d0bcadd8d281742

Exosomes from primed MSCs can educate monocytes as a cellular therapy for hematopoietic acute radiation syndrome

Authors: Matthew H. Forsberg, John A. Kink, Anna S. Thickens, Bryson M. Lewis, Charlie J. Childs, Peiman Hematti, Christian M. Capitini

Source: Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Mesenchymal stem cells, Exosomes, Monocytes, Lipopolysaccharide, Acute radiation syndrome, Hematopoiesis, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/95641a61dab94f71819b3c40c0f06193

Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies

Authors: Keerthana Shankar, Christian M. Capitini, Krishanu Saha

Source: Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)

Subject Terms: Human induced pluripotent stem cells, Somatic cell gene editing, CRISPR-Cas9, Cancer, Immunotherapy, Cell therapy, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13287-020-01741-4; https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/c7a5fc50745b4a59b7e9755ce5cb64c8

Hepatocellular Carcinoma Cells Are Protected From Immunolysis by Mesenchymal Stromal Cells Through Indoleamine 2,3 Dioxygenase

Authors: Raghavan Chinnadurai, Amanda Paige Porter, Mihir Patel, Ariel Joy Lipat, Mathews H. Forsberg, Devi Rajan, Peiman Hematti, Christian M. Capitini, Charles Bruker

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: mesenchymal stromal cells, indoleamine 2,3 dioxygenase (IDO), hepatocellular carcinoma, B7 family checkpoints, immunotherapy, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.715905/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/99ee81a0e482403ab182d77d66ad8b4a

Combining Immunocytokine and Ex Vivo Activated NK Cells as a Platform for Enhancing Graft-Versus-Tumor Effects Against GD2+ Murine Neuroblastoma

Authors: Paul D. Bates, Alexander L. Rakhmilevich, Monica M. Cho, Myriam N. Bouchlaka, Seema L. Rao, Joanna M. Hales, Rimas J. Orentas, Terry J. Fry, Stephen D. Gilles, Paul M. Sondel, Christian M. Capitini

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: immunocytokine, NK cells, neuroblastoma, graft-versus-tumor effect, cytokine release syndrome, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.668307/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/59b4d943249e454cb88073a70c022bf7

Dichotomic Potency of IFNγ Licensed Allogeneic Mesenchymal Stromal Cells in Animal Models of Acute Radiation Syndrome and Graft Versus Host Disease

Authors: Raghavan Chinnadurai, Paul D. Bates, Keith A. Kunugi, Kwangok P. Nickel, Larry A. DeWerd, Christian M. Capitini, Jacques Galipeau, Randall J. Kimple

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: mesenchymal stromal/stem cells, interferon-γ, cell therapy, acute radiation injury, bone marrow transplantation, animal model, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.708950/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9f6a95f5cd4c45778cceb90c01c5c952

GVHD Pathogenesis, Prevention and Treatment: Lessons From Humanized Mouse Transplant Models

Authors: Nicholas J. Hess, Matthew E. Brown, Christian M. Capitini

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: graft-versus host disease, xenogeneic transplantation, humanized mouse models, hematopoietic stem cell transplantation, T cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.723544/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/3d1b8617dfae413ea2befb82ca647e9b

Mesenchymal Stromal Cells and Exosomes: Progress and Challenges

Authors: Matthew H. Forsberg, John A. Kink, Peiman Hematti, Christian M. Capitini

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: MSCs, extracellular vesicles, exosomes, acute radiation syndrome, macrophages, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00665/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/3c1b4ea347784682abd2af453dccc894

An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells

Authors: Nicole A. P. Lieberman, Kole DeGolier, Kristen Haberthur, Harrison Chinn, Kara W. Moyes, Myriam N. Bouchlaka, Kirsti L. Walker, Christian M. Capitini, Courtney A. Crane

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: natural killer cells, immunotherapy, ex vivo expansion, adoptive transfer, clinical product, phenotypic analysis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2018.00150/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f1884bd5b0034f119a94708499566cb5

Society for Immunotherapy of Cancer (SITC) consensus statement on essential biomarkers for immunotherapy clinical protocols

Authors: Deborah Collyar, Christian M Capitini, Gary Kohanbash, Yana G Najjar, Carlo B Bifulco, Barbara Seliger, Holden T Maecker, Elizabeth Garrett-Mayer, Joe Yeong, Leslie Cope, Sacha Gnjatic, Sumit K Subudhi, Michael T Lotze, Saman Maleki Vareki, Alaa Ali, Laura Q M Chow, Tricia R Cottrell, Tullia C Bruno, Denise Goh, Codruta Chiuzan, Janis Taube, Ryan J Sullivan, Kristin G Anderson, Isabella C Glitza Oliva, Wim Vos, Paola Grandi, Susan Halabi, Julie Stein Deutsch, Ivan Diaz-Padilla, Anthony R Cillo, Genia Dubrovsky, Sarah Mullin, Elizabeth G Hill, Brian P Hobbs, Phyllis Pettit Nassi, Virgil H Simons, Chris H Takimoto

Source: Journal for ImmunoTherapy of Cancer, Vol 13, Iss 3 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/13/3/e010928.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/5662561fadc542eea2036b514532e4ce

Challenges and opportunities in cancer immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision

Authors: James L Gulley, Deborah Collyar, Pedro J Romero, Christian M Capitini, Leisha A Emens, Avery D Posey, Patrick Hwu, Jennifer A Wargo, Ann W Silk, Ana Carrizosa Anderson, Tullia C Bruno

Source: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/12/6/e009063.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/ba0feaa1364741509df21dfe108b7d2c

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression

Authors: Lei Shi, Christian M Capitini, Katherine P Mueller, Nicole J Piscopo, Matthew H Forsberg, Louise A Saraspe, Amritava Das, Brittany Russell, Madeline Smerchansky, Dan Cappabianca, Keerthana Shankar, Lauren Sarko, Namita Khajanchi, Nina La Vonne Denne, Apoorva Ramamurthy, Adeela Ali, Cicera R Lazzarotto, Shengdar Q Tsai, Krishanu Saha

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/9/e004446.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/6c37eb94c1884d72b00f0f0a6b96bab7

Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer

Authors: Fanny Chapelin, Christian M Capitini, Eric T Ahrens

Source: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-11 (2018)

Subject Terms: 19F MRI, Fluorine-19, Perfluorocarbon, Immunotherapy, Adoptive cell transfer, Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-018-0416-9; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/a2844ebce78740a8a19aea9d21190cd6