CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma

Authors: Laura M. Moser, Catrin Heim, Sebastian E. Koschade, Philipp Wendel, Süleyman Bozkurt, Sabine Harenkamp, Hermann Kreyenberg, Michael Merker, Christian Münch, Elise Gradhand, Meike Vogler, Evelyn Ullrich, Halvard Bönig, Jan-Henning Klusmann, Peter Bader, Winfried S. Wels, Eva Rettinger

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: cytokine-induced killer cells (CIK), CAR-T, rhabdomyosarcoma, solid tumors, ERBB2, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1485817/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/dc4bea898f8f4b188f2485cd1a023539

An AMP‐activated protein kinase‐PGC‐1α axis mediates metabolic plasticity in glioblastoma

Authors: Benedikt Sauer, Jan Kueckelhaus, Nadja I. Lorenz, Süleyman Bozkurt, Dorothea Schulte, Jan‐Béla Weinem, Mohaned Benzarti, Johannes Meiser, Hans Urban, Giulia Villa, Patrick N. Harter, Christian Münch, Johannes Rieger, Joachim P. Steinbach, Dieter Henrik Heiland, Michael W. Ronellenfitsch

Source: Clinical and Translational Medicine, Vol 14, Iss 11, Pp n/a-n/a (2024)

Subject Terms: AMP‐activated protein kinase, glioblastoma, hypoxia, metabolic plasticity, PGC‐1α, PPARGC1A, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/953fce7d5fd0419cb7f6878acc45a495

Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death

Authors: Benedikt Sauer, Nadja I. Lorenz, Iris Divé, Kevin Klann, Anna-Luisa Luger, Hans Urban, Jan-Hendrik Schröder, Joachim P. Steinbach, Christian Münch, Michael W. Ronellenfitsch

Source: Cell Death Discovery, Vol 10, Iss 1, Pp 1-10 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/9ab4a9c77f214ad88451e3c0fada1f73

Distinct and targetable role of calcium-sensing receptor in leukaemia

Authors: Raquel S. Pereira, Rahul Kumar, Alessia Cais, Lara Paulini, Alisa Kahler, Jimena Bravo, Valentina R. Minciacchi, Theresa Krack, Eric Kowarz, Costanza Zanetti, Parimala Sonika Godavarthy, Fabian Hoeller, Pablo Llavona, Tabea Stark, Georg Tascher, Daniel Nowak, Eshwar Meduri, Brian J. P. Huntly, Christian Münch, Francesco Pampaloni, Rolf Marschalek, Daniela S. Krause

Source: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/00699074cde14bba837f1807407edcf5

Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α

Authors: Mahil Lambert, Jakob Gebel, Charlotte Trejtnar, Nicole Wesch, Süleyman Bozkurt, Martin Adrian-Allgood, Frank Löhr, Christian Münch, Volker Dötsch

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0bcc9b700f734ed4a581d69e6765fd1c

Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients

Authors: Benjamin Koch, Mahmoud Shehata, Christin Müller-Ruttloff, Shady A. Gouda, Nils Wetzstein, Sammy Patyna, Anica Scholz, Tobias Schmid, Ursula Dietrich, Christian Münch, John Ziebuhr, Helmut Geiger, Luis Martinez-Sobrido, Patrick C. Baer, Ahmed Mostafa, Stephan Pleschka

Source: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Subject Terms: influenza A virus, acute kidney injury, distal tubular cells, transcriptomics, proteomics, regulated cell death, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2024.1363407/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/7ab24c6b07b54d538909b968359b9e77

An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

Authors: Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E. Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H. Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V. Rogov, Ramachandra M. Bhaskara, Stefan Müller

Source: Cell Reports, Vol 42, Iss 12, Pp 113484- (2023)

Subject Terms: CP: Cancer, CP: Molecular biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723014961; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/c6187d86919640fc8c826a912248ef14

Inhibition of mTOR signaling protects human glioma cells from hypoxia-induced cell death in an autophagy-independent manner

Authors: Iris Divé, Kevin Klann, Jonas B. Michaelis, Dennis Heinzen, Joachim P. Steinbach, Christian Münch, Michael W. Ronellenfitsch

Source: Cell Death Discovery, Vol 8, Iss 1, Pp 1-8 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/b2d083bc71b34d12a417806d3a467b6b

USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

Authors: Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Süleyman Bozkurt, Nikolett Pahor, Carmina Fuss, Andreas Schirbel, Christina Schülein‐Völk, Alexander Buchberger, Marco A. Calzado Canale, Mathias Rosenfeldt, Ivan Dikic, Christian Münch, Markus E. Diefenbacher

Source: Molecular Oncology, Vol 16, Iss 17, Pp 3082-3106 (2022)

Subject Terms: buparlisib, c‐MYC, gefitinib, lung cancer, USP28, vemurafenib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/dce85c56cd0547f996b0cfb97c5fb3dc

Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy

Authors: Jonas Benjamin Michaelis, Melinda Elaine Brunstein, Süleyman Bozkurt, Ludovico Alves, Martin Wegner, Manuel Kaulich, Christian Pohl, Christian Münch

Source: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/28bd4ad93a744efda167cac0232e31a7

PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy

Authors: Thomas Fischer, Oliver Hartmann, Michaela Reissland, Cristian Prieto-Garcia, Kevin Klann, Nikolett Pahor, Christina Schülein-Völk, Apoorva Baluapuri, Bülent Polat, Arya Abazari, Elena Gerhard-Hartmann, Hans-Georg Kopp, Frank Essmann, Mathias Rosenfeldt, Christian Münch, Michael Flentje, Markus E. Diefenbacher

Source: Cell & Bioscience, Vol 12, Iss 1, Pp 1-22 (2022)

Subject Terms: PTEN, ATM, IR, NSCLC, Radiotherapy, Cancer, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/6e2b77747e884b2d9b01fa05018ce46e

Monitoring Mitochondrial Protein Import Using Mitochondrial Targeting Sequence (MTS)-eGFP

Authors: Jonas Michaelis, Süleyman Bozkurt, Jasmin Schäfer, Christian Münch

Source: Bio-Protocol, Vol 12, Iss 24 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://bio-protocol.org/en/bpdetail?id=4578&type=0; https://doaj.org/toc/2331-8325

Access URL: https://doaj.org/article/7f4c09d093be4471bf3a1d48e7c685ee

Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide

Authors: Nadja I. Lorenz, Alina C. M. Sittig, Hans Urban, Anna-Luisa Luger, Anna L. Engel, Christian Münch, Joachim P. Steinbach, Michael W. Ronellenfitsch

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0736b208a57543ffb304b79c8033e560

A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins

Authors: Rodrigo A. Gama-Brambila, Jie Chen, Yasamin Dabiri, Georg Tascher, Václav Němec, Christian Münch, Guangqi Song, Stefan Knapp, Xinlai Cheng

Source: JACS Au, Vol 1, Iss 6, Pp 777-785 (2021)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2691-3704

Access URL: https://doaj.org/article/0ccedbc67d6646da9f452b993edbd843

SRSF3 and SRSF7 modulate 3′UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels

Authors: Oliver Daniel Schwich, Nicole Blümel, Mario Keller, Marius Wegener, Samarth Thonta Setty, Melinda Elaine Brunstein, Ina Poser, Igor Ruiz De Los Mozos, Beatrix Suess, Christian Münch, François McNicoll, Kathi Zarnack, Michaela Müller-McNicoll

Source: Genome Biology, Vol 22, Iss 1, Pp 1-34 (2021)

Subject Terms: SRSF3, SRSF7, APA, FIP1, CFIm, pPAS, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/636b189fddc14c0eaedf12314fffd4e1

The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1

Authors: Usman Nasrullah, Kristina Stanke, Victoria Recknagel, Süleyman Bozkurt, Patrick Wurzel, Stefan Gauer, Gergely Imre, Christian Münch, Josef Pfeilschifter, Wolfgang Eberhardt

Source: Cells, Vol 12, Iss 1, p 201 (2023)

Subject Terms: apoptosis, caspase-7, colon carcinoma cells, hnRNPH1, RNA-binding proteins, TRIM25, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/1/201; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/5ff8f1fb40bd42789addf87a4fcb2828

The beginning of a new era: pioneering direct screens for RNA modulators

Authors: F. X. Reymond Sutandy, Rebecca George Tharyan, Christian Münch

Source: Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-2 (2022)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/975bd6f56cf3437fb00c776453193525

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

Authors: Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Thomas Fischer, Susanne Walz, Christina Schülein‐Völk, Ursula Eilers, Carsten P Ade, Marco A Calzado, Amir Orian, Hans M Maric, Christian Münch, Mathias Rosenfeldt, Martin Eilers, Markus E Diefenbacher

Source: EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-25 (2020)

Subject Terms: ∆Np63, MYC, NOTCH, squamous cell carcinoma, USP28, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/1898fb6a9b9447fe970065bbeeb04bce

CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2

Authors: Jana Key, Suzana Gispert, Lieke Koornneef, Esther Sleddens-Linkels, Aneesha Kohli, Sylvia Torres-Odio, Gabriele Koepf, Shady Amr, Marina Reichlmeir, Patrick N. Harter, Andrew Phillip West, Christian Münch, Willy M. Baarends, Georg Auburger

Source: Cells, Vol 12, Iss 1, p 52 (2022)

Subject Terms: meiosis-I, pachytene–diplotene, homologous recombination, H3K9ac, acetyl–tubulin, acSMC3, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/1/52; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/bfcfed9fb52d4af5857419515812626b

Unbiased translation proteomics upon cell stress

Authors: Kevin Klann, Christian Münch

Source: Molecular & Cellular Oncology, Vol 7, Iss 4 (2020)

Subject Terms: translation proteomics, proteostasis, mtor, isr, integrated stress response, translatome, stress, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2372-3556

Access URL: https://doaj.org/article/9379f362e4f142c692fa29db198b6d11