Evaluating the impact of CRBN mutations on response to immunomodulatory drugs and novel cereblon E3 ligase modulators in myeloma

Authors: Chrisochoidou, Yakinthi ¹, Scarpino, Andrea ¹, Morales, Salomon ¹, Martin, Shannon ¹, Bird, Sarah ^{1, 2}, Li, Yigen ¹, Walker, Brian ³, Caldwell, John ¹, Le Bihan, Yann-Vaï ¹, Pawlyn, Charlotte ^{1, 2, ∗}

Source: In Blood December 2024

Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells.

Authors: Chrisochoidou, Yakinthi, Roy, Rajat, Farahmand, Pooyeh, Gonzalez, Guadalupe, Doig, Jennifer, Krasny, Lukas, Rimmer, Ella F., Willis, Anne E, MacFarlane, Marion, Huang, Paul H., Carragher, Neil O., Munro, Alison F., Murphy, Daniel J., Veselkov, Kirill, Seckl, Michael J., Moffatt, Miriam F., Cookson, William O. C., Pardo, Olivier E.

Source: Cell Death & Disease; Nov2023, Vol. 14 Issue 11, p1-20, 20p

EZH2 Inhibition Overcomes Immunomodulatory Drug (IMiD) Resistance in Multiple Myeloma Cell Lines in a Cereblon Pathway Dependent Manner

Authors: Li, Yigen, Barber, Amy, Martin, Shannon, Morales, Salomon, Bird, Sarah, Chrisochoidou, Yakinthi, Pawlyn, Charlotte

Source: In Blood 2 November 2023 142 Supplement 1:4187-4187

Investigating the Functional Impact of CRBN Mutations on Response to IMiD/Celmod Agents in Myeloma

Authors: Chrisochoidou, Yakinthi, LeBihan, Yann-Vai, Morales, Salomon, Martin, Shannon, Walker, Brian A., Li, Yigen, Bird, Sarah, Pawlyn, Charlotte

Source: In Blood 2 November 2023 142 Supplement 1:753-753

P-179 Altered lipid metabolism in IMiD/CELMoD resistant multiple myeloma confers novel and targetable vulnerabilities

Authors: Bird, Sarah, Xu, Yitao, Sialana, Fernando, Licciardello, Marco, Che, Harvey, Tamin, Saleh, Bouguenina, Habib, Grabovska, Yura, Liu, Enze, Morales, Salomon, Chrisochoidou, Yakinthi, Li, Yigen, Martin, Shannon, Wilson, Amy, Flynt, Erin, Walker, Brian, Choudhary, Jyoti, Clarke, Paul, Keun, Hector, Pawlyn, Charlotte

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 2:S134-S134

Multiomics Analysis of IMiD/CELMoD Resistant Multiple Myeloma Models Uncovers Novel and Targetable Vulnerabilities in the SREBP Lipid Synthesis Pathway

Authors: Bird, Sarah A., Barber, Amy ^*, Sialana, Fernando J. ^*, Licciardello, Marco P. ^*, Che, Harvey ^*, Bouguenina, Habib ^*, Grabovska, Yura ^*, Liu, Enze ^*, Chrisochoidou, Yakinthi ^*, Martin, Shannon ^*, Choudhary, Jyoti ^*, Walker, Brian A., Collins, Ian ^*, Clarke, Paul ^*, Pawlyn, Charlotte

Source: In Blood 15 November 2022 140 Supplement 1:600-601